Carbidopa (monohydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.130305
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.097647
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0936174
ERRFI1 ERBB receptor feedback inhibitor 1 0.0767461
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0510787
GOLGA4 golgin A4 0.0491726
ZNF292 zinc finger protein 292 0.0490987
PRELID2 PRELI domain containing 2 0.0460357
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0394492
OGA O-GlcNAcase 0.0355405
HELZ helicase with zinc finger 0.035171
YEATS2 YEATS domain containing 2 0.0343018
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0343016
GOLGB1 golgin B1 0.0338745
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0337688
INSIG2 insulin induced gene 2 0.0337299
SRP54 signal recognition particle 54kDa 0.0326972
COPB1 coatomer protein complex, subunit beta 1 0.0326041
CANX calnexin 0.0323075
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0321501
SEC24D SEC24 family member D 0.0320347
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0312292
TBC1D22A TBC1 domain family, member 22A 0.0309291
FNDC3B fibronectin type III domain containing 3B 0.0304907
MYH9 myosin, heavy chain 9, non-muscle 0.0304244
NUP58 nucleoporin 58 0.0303112
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0298208
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0290802
FNIP1 folliculin interacting protein 1 0.0287467
TMEM41B transmembrane protein 41B 0.0287373
COPA coatomer protein complex, subunit alpha 0.0287252
ZC3H11A zinc finger CCCH-type containing 11A 0.0285509
DSCAM Down syndrome cell adhesion molecule 0.0285308
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0280347
KDM7A lysine (K)-specific demethylase 7A 0.0279233
KMT2C lysine (K)-specific methyltransferase 2C 0.02723
SEC24A SEC24 family member A 0.0270379
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0266655
SEC31A SEC31 homolog A (S. cerevisiae) 0.0261945
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0260597
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0260204
CDK19 cyclin-dependent kinase 19 0.0259269
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.025398
USP34 ubiquitin specific peptidase 34 0.0251527
RBM26 RNA binding motif protein 26 0.0247178
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0245923
ZNF638 zinc finger protein 638 0.0245778
COG6 component of oligomeric golgi complex 6 0.0243932
WDR26 WD repeat domain 26 0.0242995
SPAG9 sperm associated antigen 9 0.0242616
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0240441
NBAS neuroblastoma amplified sequence 0.0238795
PLAUR plasminogen activator, urokinase receptor 0.0237152
PDIA4 protein disulfide isomerase family A, member 4 0.0236975
RNMT RNA (guanine-7-) methyltransferase 0.0236029
CLTC clathrin, heavy chain (Hc) 0.0234347
GARS1 glycyl-tRNA synthetase 1 0.0232722
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0232281
SUCO SUN domain containing ossification factor 0.0229248
TMEM39A transmembrane protein 39A 0.0226778
BRWD3 bromodomain and WD repeat domain containing 3 0.0225546
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0225351
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0222095
PGM3 phosphoglucomutase 3 0.0221438
YME1L1 YME1-like 1 ATPase 0.0220845
KDM6A lysine (K)-specific demethylase 6A 0.0220171
AKAP9 A kinase (PRKA) anchor protein 9 0.021735
CEP95 centrosomal protein 95kDa 0.0215984
ITCH itchy E3 ubiquitin protein ligase 0.0214589
ZMYM2 zinc finger, MYM-type 2 0.0210809
GSK3B glycogen synthase kinase 3 beta 0.0210475
SEC63 SEC63 homolog (S. cerevisiae) 0.0208311
RCOR1 REST corepressor 1 0.0206846
UBA6 ubiquitin-like modifier activating enzyme 6 0.0205244
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0204226
ZFC3H1 zinc finger, C3H1-type containing 0.0204029
MBD5 methyl-CpG binding domain protein 5 0.0203869
ZNF654 zinc finger protein 654 0.0199014
ESRP1 epithelial splicing regulatory protein 1 0.0198872
HMBOX1 homeobox containing 1 0.0198808
AFF4 AF4/FMR2 family, member 4 0.0197686
ACBD3 acyl-CoA binding domain containing 3 0.0197165
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0196844
ZFAND3 zinc finger, AN1-type domain 3 0.0194935
MON2 MON2 homolog (S. cerevisiae) 0.0194852
RBM39 RNA binding motif protein 39 0.0193323
FAM117B family with sequence similarity 117, member B 0.0190802
WWC2 WW and C2 domain containing 2 0.0188906
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0188742
MORF4L2 mortality factor 4 like 2 0.0187027
PRRC1 proline-rich coiled-coil 1 0.0186254
RLF rearranged L-myc fusion 0.0185928
TPR translocated promoter region, nuclear basket protein 0.0182071
XPO1 exportin 1 0.0180678
CTNND1 catenin (cadherin-associated protein), delta 1 0.0179749
ATM ATM serine/threonine kinase 0.017883
SEC23A Sec23 homolog A (S. cerevisiae) 0.0178794
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0177713
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0177385
GOLGA2 golgin A2 0.0177367

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.49601
TMSB10 thymosin beta 10 -0.199505
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.173053
PTMA prothymosin, alpha -0.169646
TPT1 tumor protein, translationally-controlled 1 -0.142596
RPS6 ribosomal protein S6 -0.134719
RPL35A ribosomal protein L35a -0.102551
RPS8 ribosomal protein S8 -0.0992376
FTL ferritin, light polypeptide -0.0941646
MT2A metallothionein 2A -0.0892204
RPLP1 ribosomal protein, large, P1 -0.0863904
RPS19 ribosomal protein S19 -0.0778639
RPLP2 ribosomal protein, large, P2 -0.0737904
LOC112694756 uncharaterized LOC112694756 -0.071101
EGR1 early growth response 1 -0.0666727
RPL23 ribosomal protein L23 -0.0642471
RPL34 ribosomal protein L34 -0.0619492
S100A10 S100 calcium binding protein A10 -0.0575307
ACTG1 actin gamma 1 -0.057387
RPL37A ribosomal protein L37a -0.056658
PKM pyruvate kinase, muscle -0.0556029
RPL31 ribosomal protein L31 -0.0542733
RPL5 ribosomal protein L5 -0.0537517
RPS25 ribosomal protein S25 -0.0521457
RPS29 ribosomal protein S29 -0.0512506
RPL36 ribosomal protein L36 -0.0510027
RPL19 ribosomal protein L19 -0.0504676
RPL12 ribosomal protein L12 -0.0502676
RPS13 ribosomal protein S13 -0.0495931
RPS3 ribosomal protein S3 -0.0490738
RPL26 ribosomal protein L26 -0.0461711
RPL11 ribosomal protein L11 -0.0458343
RPS24 ribosomal protein S24 -0.0456434
KRT18 keratin 18, type I -0.0456381
RPS27A ribosomal protein S27a -0.0448852
TPI1 triosephosphate isomerase 1 -0.0447402
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0446287
RACK1 receptor for activated C kinase 1 -0.0444691
RPS15 ribosomal protein S15 -0.043642
ENO1 enolase 1, (alpha) -0.0430114
RPLP0 ribosomal protein, large, P0 -0.0418722
RPS10 ribosomal protein S10 -0.0417901
FAT1 FAT atypical cadherin 1 -0.0415499
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0413048
HMGA1 high mobility group AT-hook 1 -0.0409593
HLA-A major histocompatibility complex, class I, A -0.0407959
RPS12 ribosomal protein S12 -0.0405675
S100A9 S100 calcium binding protein A9 -0.0402505
RPL7A ribosomal protein L7a -0.039905
RPL35 ribosomal protein L35 -0.0394675
RPL8 ribosomal protein L8 -0.0394522
RPS16 ribosomal protein S16 -0.0394048
RPS21 ribosomal protein S21 -0.0385314
KRT19 keratin 19, type I -0.038366
RPL37 ribosomal protein L37 -0.037954
RPS11 ribosomal protein S11 -0.0369144
RPS17 ribosomal protein S17 -0.0359322
RPL28 ribosomal protein L28 -0.0358518
RPL38 ribosomal protein L38 -0.0352284
TUBB4B tubulin, beta 4B class IVb -0.0338699
RPS14 ribosomal protein S14 -0.0338502
RPS27 ribosomal protein S27 -0.0335383
FUS FUS RNA binding protein -0.0335132
RPL32 ribosomal protein L32 -0.0332556
RPS23 ribosomal protein S23 -0.0331355
EIF1 eukaryotic translation initiation factor 1 -0.0329438
MIDN midnolin -0.032666
RPL27 ribosomal protein L27 -0.0323846
RPL13A ribosomal protein L13a -0.0322321
YBX1 Y box binding protein 1 -0.032162
RPL9 ribosomal protein L9 -0.0314446
HLA-B major histocompatibility complex, class I, B -0.0313953
EIF5B eukaryotic translation initiation factor 5B -0.0313683
RPL15 ribosomal protein L15 -0.031217
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.031072
LDHA lactate dehydrogenase A -0.0301799
KTN1 kinectin 1 (kinesin receptor) -0.0300179
RPL27A ribosomal protein L27a -0.0298362
PRDX2 peroxiredoxin 2 -0.0293588
PFN1 profilin 1 -0.0289323
RPL7 ribosomal protein L7 -0.0288592
POTEF POTE ankyrin domain family, member F -0.0280875
IFITM3 interferon induced transmembrane protein 3 -0.0269915
LMNA lamin A/C -0.0269114
ANXA2 annexin A2 -0.0265608
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0264477
CCND1 cyclin D1 -0.0262747
RPS20 ribosomal protein S20 -0.0262374
RPL30 ribosomal protein L30 -0.0260147
RPS5 ribosomal protein S5 -0.0257016
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0255193
HMGB1 high mobility group box 1 -0.0253399
LDHB lactate dehydrogenase B -0.0252576
LOC102724023 ES1 protein homolog, mitochondrial -0.0250076
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245567
KRT8 keratin 8, type II -0.0244232
RPL36AL ribosomal protein L36a-like -0.0242379
B2M beta-2-microglobulin -0.0240542
FAF1 Fas (TNFRSF6) associated factor 1 -0.0239069
PA2G4 proliferation-associated 2G4, 38kDa -0.0236789