| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Carbidopa (monohydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.127723 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.113513 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.106177 |
| NDRG1 | N-myc downstream regulated 1 | 0.105887 |
| CD44 | CD44 molecule (Indian blood group) | 0.100494 |
| CDCP1 | CUB domain containing protein 1 | 0.0950262 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0809944 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0748764 |
| HMGA2 | high mobility group AT-hook 2 | 0.0643449 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0633222 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0599579 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0567919 |
| TUBB6 | tubulin, beta 6 class V | 0.0460554 |
| NAV2 | neuron navigator 2 | 0.0448248 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0439144 |
| NAV1 | neuron navigator 1 | 0.0434403 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0431772 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0431527 |
| AHNAK | AHNAK nucleoprotein | 0.0424217 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0405114 |
| PRELID2 | PRELI domain containing 2 | 0.0404132 |
| SEPTIN9 | septin 9 | 0.0375035 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0366925 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0365501 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0363929 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0357273 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.03506 |
| VCL | vinculin | 0.0348376 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0342182 |
| MAP1B | microtubule-associated protein 1B | 0.0339684 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.033753 |
| ASPH | aspartate beta-hydroxylase | 0.033522 |
| NGLY1 | N-glycanase 1 | 0.0321914 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0317034 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0317034 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0303924 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0300917 |
| DNMBP | dynamin binding protein | 0.0300202 |
| ACTN4 | actinin, alpha 4 | 0.0288853 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0286723 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0286136 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0282071 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.0276261 |
| GLIS3 | GLIS family zinc finger 3 | 0.0275342 |
| CENPF | centromere protein F, 350/400kDa | 0.0273465 |
| RRM2 | ribonucleotide reductase M2 | 0.0261037 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0260188 |
| WWOX | WW domain containing oxidoreductase | 0.0260101 |
| RTN4 | reticulon 4 | 0.0258348 |
| SMYD3 | SET and MYND domain containing 3 | 0.0256867 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0250968 |
| MT2A | metallothionein 2A | 0.0246239 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0235941 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.023519 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0234897 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0234632 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0233581 |
| VASP | vasodilator-stimulated phosphoprotein | 0.0232324 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0229179 |
| SGO2 | shugoshin 2 | 0.0223118 |
| RAD51B | RAD51 paralog B | 0.022298 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0217768 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0216797 |
| ATXN1 | ataxin 1 | 0.0211907 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0211586 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0207384 |
| SP3 | Sp3 transcription factor | 0.0206589 |
| CEP192 | centrosomal protein 192kDa | 0.0203225 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0202933 |
| CLIC4 | chloride intracellular channel 4 | 0.0200652 |
| CAPRIN2 | caprin family member 2 | 0.0199437 |
| DST | dystonin | 0.0197975 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0195896 |
| PDE8A | phosphodiesterase 8A | 0.0194776 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0194315 |
| PRKCA | protein kinase C, alpha | 0.019349 |
| ETV6 | ets variant 6 | 0.0192925 |
| DUSP6 | dual specificity phosphatase 6 | 0.0191758 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0190121 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0188047 |
| FHIT | fragile histidine triad | 0.0186648 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0186136 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0184622 |
| TENM2 | teneurin transmembrane protein 2 | 0.0182644 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0180544 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0178296 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0177852 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0177499 |
| ARFGEF3 | ARFGEF family member 3 | 0.0177029 |
| KLF12 | Kruppel-like factor 12 | 0.0176077 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0175369 |
| EFNA5 | ephrin-A5 | 0.017518 |
| DIAPH2 | diaphanous-related formin 2 | 0.0171998 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0170256 |
| CCDC91 | coiled-coil domain containing 91 | 0.0169434 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0168699 |
| MT1X | metallothionein 1X | 0.0168204 |
| CENPE | centromere protein E, 312kDa | 0.0167946 |
| LOXL2 | lysyl oxidase-like 2 | 0.0167678 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0164917 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.166127 |
| FN1 | fibronectin 1 | -0.0974209 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0728842 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.071798 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0633015 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0621552 |
| INHBA | inhibin, beta A | -0.0611291 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0605378 |
| IGF2 | insulin-like growth factor 2 | -0.0589584 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0541876 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0537431 |
| EGR1 | early growth response 1 | -0.0525888 |
| TMSB10 | thymosin beta 10 | -0.0475529 |
| FTL | ferritin, light polypeptide | -0.0443506 |
| CDH13 | cadherin 13 | -0.0434289 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.043108 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0430577 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0406951 |
| GOLGA4 | golgin A4 | -0.0403895 |
| ADM | adrenomedullin | -0.0397149 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0380231 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0376374 |
| MORF4L2 | mortality factor 4 like 2 | -0.0353059 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0352761 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.034934 |
| IER3 | immediate early response 3 | -0.0339828 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0336653 |
| VIM | vimentin | -0.0334431 |
| CANX | calnexin | -0.0320961 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0319171 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0318718 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0318117 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0312865 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0301433 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0298282 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0297205 |
| RLF | rearranged L-myc fusion | -0.0289783 |
| RAI14 | retinoic acid induced 14 | -0.0283905 |
| LOX | lysyl oxidase | -0.0281765 |
| IL1B | interleukin 1, beta | -0.0280923 |
| RAB2A | RAB2A, member RAS oncogene family | -0.027909 |
| RND3 | Rho family GTPase 3 | -0.0274745 |
| LAMB3 | laminin, beta 3 | -0.0269718 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0267921 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0259847 |
| SQSTM1 | sequestosome 1 | -0.0258996 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0257357 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0250951 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.025074 |
| JUN | jun proto-oncogene | -0.0246693 |
| CADM1 | cell adhesion molecule 1 | -0.0245686 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0242216 |
| HELZ | helicase with zinc finger | -0.0240904 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0240122 |
| PCBP2 | poly(rC) binding protein 2 | -0.0235717 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0233785 |
| QKI | QKI, KH domain containing, RNA binding | -0.0231245 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0230016 |
| HDLBP | high density lipoprotein binding protein | -0.0226329 |
| RPL12 | ribosomal protein L12 | -0.0225135 |
| CLMP | CXADR-like membrane protein | -0.0223304 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0223131 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0222153 |
| SRP54 | signal recognition particle 54kDa | -0.0220184 |
| SEC24A | SEC24 family member A | -0.0215074 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0214444 |
| ATP13A3 | ATPase type 13A3 | -0.0213109 |
| MCL1 | myeloid cell leukemia 1 | -0.0211833 |
| USP36 | ubiquitin specific peptidase 36 | -0.0209472 |
| ANXA1 | annexin A1 | -0.0209245 |
| GOLGB1 | golgin B1 | -0.0209165 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0202003 |
| RACK1 | receptor for activated C kinase 1 | -0.0200808 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.019738 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.019731 |
| RBM39 | RNA binding motif protein 39 | -0.019718 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0196653 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.0196507 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0195887 |
| COPA | coatomer protein complex, subunit alpha | -0.0195415 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0194417 |
| CALU | calumenin | -0.0193516 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0193026 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0192791 |
| FMNL2 | formin-like 2 | -0.0190874 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0188172 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0187729 |
| RPLP1 | ribosomal protein, large, P1 | -0.0186267 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0185035 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0184284 |
| BRD2 | bromodomain containing 2 | -0.0183291 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0183057 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0182747 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0180557 |
| RPS19 | ribosomal protein S19 | -0.0179046 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0178806 |
| RPL8 | ribosomal protein L8 | -0.0178581 |
| RPLP0 | ribosomal protein, large, P0 | -0.0176523 |
| CD109 | CD109 molecule | -0.0176521 |
| COL5A1 | collagen, type V, alpha 1 | -0.0175941 |
