| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0904114 |
| NDRG1 | N-myc downstream regulated 1 | 0.087905 |
| PDE10A | phosphodiesterase 10A | 0.0688694 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0663445 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0575436 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0561574 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0549056 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0517963 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0500702 |
| VEGFA | vascular endothelial growth factor A | 0.0489678 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0481031 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0421633 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0378109 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0349401 |
| NAV2 | neuron navigator 2 | 0.0345167 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0303913 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0298085 |
| RUNX1 | runt-related transcription factor 1 | 0.0294378 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0278998 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0274897 |
| EFNA5 | ephrin-A5 | 0.0259524 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0251036 |
| PRELID2 | PRELI domain containing 2 | 0.0244455 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0244448 |
| VEGFC | vascular endothelial growth factor C | 0.0243183 |
| COL5A1 | collagen, type V, alpha 1 | 0.0241587 |
| TMEM165 | transmembrane protein 165 | 0.0234501 |
| YEATS2 | YEATS domain containing 2 | 0.0224883 |
| HMGA2 | high mobility group AT-hook 2 | 0.0224776 |
| GLIS3 | GLIS family zinc finger 3 | 0.0220676 |
| PTK2 | protein tyrosine kinase 2 | 0.0217806 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0216212 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0213893 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.021287 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0212764 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0212214 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0210686 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0210341 |
| SBF2 | SET binding factor 2 | 0.0208965 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.020446 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0204336 |
| DOCK7 | dedicator of cytokinesis 7 | 0.0203447 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0202478 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.019944 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0197695 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0197111 |
| RIGI | RNA sensor RIG-I | 0.0194259 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0189653 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0186865 |
| FNIP1 | folliculin interacting protein 1 | 0.018162 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0181119 |
| NAV1 | neuron navigator 1 | 0.0180605 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0180284 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0179192 |
| CDH13 | cadherin 13 | 0.017772 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0177208 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0175548 |
| AHNAK | AHNAK nucleoprotein | 0.0175055 |
| PDE8A | phosphodiesterase 8A | 0.0174947 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0174835 |
| MRTFA | myocardin related transcription factor A | 0.0171942 |
| FMNL2 | formin-like 2 | 0.0169817 |
| NUMB | numb homolog (Drosophila) | 0.0168873 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.016834 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.0167132 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0164029 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0161637 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0160456 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0158862 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0158321 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0157261 |
| CPQ | carboxypeptidase Q | 0.0156373 |
| EPHB1 | EPH receptor B1 | 0.0155962 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0155847 |
| ATXN1 | ataxin 1 | 0.0153865 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0153229 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0152791 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0152706 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0151739 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0150745 |
| PRR16 | proline rich 16 | 0.015031 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0149707 |
| ASPH | aspartate beta-hydroxylase | 0.0149555 |
| FAM219A | family with sequence similarity 219, member A | 0.0149365 |
| NBEAL1 | neurobeachin-like 1 | 0.014873 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0148645 |
| MED13L | mediator complex subunit 13-like | 0.0147996 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0147853 |
| TRAM2 | translocation associated membrane protein 2 | 0.0147581 |
| PRKCA | protein kinase C, alpha | 0.0147075 |
| VCL | vinculin | 0.014564 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0145633 |
| ZNF644 | zinc finger protein 644 | 0.0145318 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0144537 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0144174 |
| SMYD3 | SET and MYND domain containing 3 | 0.0143428 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0141349 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0140586 |
| HMBOX1 | homeobox containing 1 | 0.013875 |
| FBN1 | fibrillin 1 | 0.0137705 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.310268 |
| MT2A | metallothionein 2A | -0.251956 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.203389 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.20203 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.200246 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.171008 |
| TMSB10 | thymosin beta 10 | -0.140997 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.133906 |
| FN1 | fibronectin 1 | -0.131042 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.129097 |
| CALR | calreticulin | -0.104824 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.099404 |
| FTL | ferritin, light polypeptide | -0.0988126 |
| ENO1 | enolase 1, (alpha) | -0.0963647 |
| LDHA | lactate dehydrogenase A | -0.0941509 |
| PTMA | prothymosin, alpha | -0.0930769 |
| COL1A1 | collagen, type I, alpha 1 | -0.0906629 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0890746 |
| COL1A2 | collagen, type I, alpha 2 | -0.081063 |
| B2M | beta-2-microglobulin | -0.0806528 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0788352 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0788101 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.076107 |
| RPS8 | ribosomal protein S8 | -0.0649816 |
| IER3 | immediate early response 3 | -0.0629092 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0628477 |
| TPM4 | tropomyosin 4 | -0.0627798 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0591639 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0569388 |
| RPL35A | ribosomal protein L35a | -0.0568923 |
| RPLP0 | ribosomal protein, large, P0 | -0.0547725 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0542002 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0538861 |
| CADM1 | cell adhesion molecule 1 | -0.0537562 |
| MT1X | metallothionein 1X | -0.053397 |
| CALU | calumenin | -0.0532818 |
| RPL12 | ribosomal protein L12 | -0.0529079 |
| RPS6 | ribosomal protein S6 | -0.052673 |
| STC1 | stanniocalcin 1 | -0.0526183 |
| POTEF | POTE ankyrin domain family, member F | -0.0519525 |
| RPL23 | ribosomal protein L23 | -0.0515026 |
| UBC | ubiquitin C | -0.051413 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0503236 |
| PKM | pyruvate kinase, muscle | -0.0491544 |
| RACK1 | receptor for activated C kinase 1 | -0.0468981 |
| RPS19 | ribosomal protein S19 | -0.0466925 |
| RPL11 | ribosomal protein L11 | -0.0465326 |
| RPL8 | ribosomal protein L8 | -0.0462248 |
| RPL19 | ribosomal protein L19 | -0.0460349 |
| CD44 | CD44 molecule (Indian blood group) | -0.0436013 |
| YBX1 | Y box binding protein 1 | -0.042695 |
| CTSB | cathepsin B | -0.0423818 |
| ACTG1 | actin gamma 1 | -0.0421804 |
| MAP1B | microtubule-associated protein 1B | -0.041941 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0417295 |
| S100A6 | S100 calcium binding protein A6 | -0.0411723 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0411002 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0409161 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.040604 |
| S100A10 | S100 calcium binding protein A10 | -0.040248 |
| PFN1 | profilin 1 | -0.0402351 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0395276 |
| RPLP1 | ribosomal protein, large, P1 | -0.0389369 |
| VCAN | versican | -0.0383483 |
| RPL7 | ribosomal protein L7 | -0.0382207 |
| RPS12 | ribosomal protein S12 | -0.03766 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0365085 |
| RPL18 | ribosomal protein L18 | -0.0363116 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0360974 |
| ANXA2 | annexin A2 | -0.0358429 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0357767 |
| S100A9 | S100 calcium binding protein A9 | -0.0353907 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.035331 |
| TPI1 | triosephosphate isomerase 1 | -0.0352658 |
| INHBA | inhibin, beta A | -0.0352637 |
| HMGA1 | high mobility group AT-hook 1 | -0.0351639 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0341648 |
| TMSB4X | thymosin beta 4, X-linked | -0.0340442 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0340379 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0339233 |
| POSTN | periostin, osteoblast specific factor | -0.0337028 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0335801 |
| RPL36 | ribosomal protein L36 | -0.0335144 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0333458 |
| HLA-B | major histocompatibility complex, class I, B | -0.0332483 |
| HLA-A | major histocompatibility complex, class I, A | -0.0330977 |
| RPS11 | ribosomal protein S11 | -0.0326977 |
| RPL28 | ribosomal protein L28 | -0.0326393 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0325595 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0321559 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0320252 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0319949 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0312006 |
| RPS14 | ribosomal protein S14 | -0.0310921 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0310826 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0309205 |
| RPS3 | ribosomal protein S3 | -0.0307191 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0299911 |
| RPS16 | ribosomal protein S16 | -0.0292412 |
| CANX | calnexin | -0.0292386 |
