| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.153108 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0765472 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0633595 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0618896 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.059079 |
| GOLGA4 | golgin A4 | 0.0586347 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0532625 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0528753 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0484304 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0463034 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0451881 |
| FAM13A | family with sequence similarity 13, member A | 0.043988 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0435609 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0431243 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0426714 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0411006 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0410174 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0403042 |
| OGA | O-GlcNAcase | 0.0386277 |
| LYZ | lysozyme | 0.0379907 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0376204 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0370541 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0368199 |
| RNF43 | ring finger protein 43 | 0.0362459 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0362394 |
| HELZ | helicase with zinc finger | 0.0354895 |
| USP3 | ubiquitin specific peptidase 3 | 0.035452 |
| PTEN | phosphatase and tensin homolog | 0.0353349 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0352551 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0351654 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.0340951 |
| PTK2 | protein tyrosine kinase 2 | 0.03397 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0328102 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0325898 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0325708 |
| SBF2 | SET binding factor 2 | 0.0322829 |
| COG5 | component of oligomeric golgi complex 5 | 0.0322352 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0308968 |
| HYOU1 | hypoxia up-regulated 1 | 0.0308295 |
| CALR | calreticulin | 0.0306863 |
| RIOK3 | RIO kinase 3 | 0.0297726 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | 0.0297592 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0294536 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0293569 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0292733 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0292657 |
| CCDC186 | coiled-coil domain containing 186 | 0.0292095 |
| ZNF292 | zinc finger protein 292 | 0.0291917 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0290205 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0285479 |
| ZNF638 | zinc finger protein 638 | 0.028278 |
| RNF145 | ring finger protein 145 | 0.0280378 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0277184 |
| INTS6 | integrator complex subunit 6 | 0.0276851 |
| NBEAL1 | neurobeachin-like 1 | 0.0275337 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0273733 |
| RTN3 | reticulon 3 | 0.0269097 |
| NFIA | nuclear factor I/A | 0.026805 |
| DSTN | destrin (actin depolymerizing factor) | 0.026454 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0263571 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.026276 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0259927 |
| HOXB3 | homeobox B3 | 0.0256137 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0255371 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0254521 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0253664 |
| WDR26 | WD repeat domain 26 | 0.0252139 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0250616 |
| MAPK6 | mitogen-activated protein kinase 6 | 0.0249396 |
| PARD6B | par-6 family cell polarity regulator beta | 0.0247392 |
| PDS5B | PDS5 cohesin associated factor B | 0.0246613 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0245287 |
| EREG | epiregulin | 0.0244261 |
| TMEM165 | transmembrane protein 165 | 0.0238687 |
| XPO1 | exportin 1 | 0.0235236 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0230719 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0229629 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0227057 |
| TNS4 | tensin 4 | 0.0226751 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.0226503 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0226154 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0225769 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0224101 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.022347 |
| RPL21 | ribosomal protein L21 | 0.0222971 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0222839 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0221828 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0220796 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0220427 |
| TMEM135 | transmembrane protein 135 | 0.0217585 |
| INSIG2 | insulin induced gene 2 | 0.0217045 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0216129 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0211651 |
| FBXO42 | F-box protein 42 | 0.0209747 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0209091 |
| EHF | ets homologous factor | 0.0205737 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.0203261 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0202367 |
| CDK8 | cyclin-dependent kinase 8 | 0.0200962 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0199638 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | -0.17018 |
| LMO7 | LIM domain 7 | -0.155024 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.129855 |
| KRT20 | keratin 20, type I | -0.120352 |
| TJP1 | tight junction protein 1 | -0.11909 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.117802 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.114701 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0969597 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0927526 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0848793 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0798943 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0734951 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0710185 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0701318 |
| EGR1 | early growth response 1 | -0.0675287 |
| MYO1E | myosin IE | -0.0642725 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0631151 |
| LAMA4 | laminin, alpha 4 | -0.0619134 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0570178 |
| JUN | jun proto-oncogene | -0.05461 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0540916 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0524583 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0521234 |
| SQSTM1 | sequestosome 1 | -0.0511839 |
| STK24 | serine/threonine kinase 24 | -0.0503674 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0488905 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0486685 |
| TRIB1 | tribbles pseudokinase 1 | -0.0466929 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0460034 |
| TMSB10 | thymosin beta 10 | -0.0441297 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0438073 |
| KRT18 | keratin 18, type I | -0.0436728 |
| FTL | ferritin, light polypeptide | -0.0436255 |
| DIAPH2 | diaphanous-related formin 2 | -0.0425712 |
| TMC5 | transmembrane channel-like 5 | -0.0420828 |
| ACTG1 | actin gamma 1 | -0.0419984 |
| ETV6 | ets variant 6 | -0.041765 |
| MKI67 | marker of proliferation Ki-67 | -0.0416468 |
| AHNAK | AHNAK nucleoprotein | -0.0415253 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0407474 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0403774 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0403619 |
| FLNB | filamin B, beta | -0.0403038 |
| ANXA2 | annexin A2 | -0.0396526 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0392312 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0391884 |
| EXPH5 | exophilin 5 | -0.0386412 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0381223 |
| SMAD3 | SMAD family member 3 | -0.0371401 |
| ITGA6 | integrin, alpha 6 | -0.0369614 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0368567 |
| ACTN4 | actinin, alpha 4 | -0.036828 |
| SGMS2 | sphingomyelin synthase 2 | -0.036059 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0360268 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0350839 |
| SEPTIN9 | septin 9 | -0.0346313 |
| SULF2 | sulfatase 2 | -0.0337716 |
| BCL2L1 | BCL2-like 1 | -0.0336541 |
| MYO5B | myosin VB | -0.033256 |
| MUC13 | mucin 13, cell surface associated | -0.0332159 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0332093 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0328607 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0326229 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.032529 |
| WWC1 | WW and C2 domain containing 1 | -0.0323124 |
| RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) | -0.0322955 |
| PGCKA1 | PDCD10 and GCKIII kinases associated 1 | -0.0322228 |
| RPL13A | ribosomal protein L13a | -0.0320943 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0319896 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0319734 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0319596 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.031829 |
| NTN4 | netrin 4 | -0.0315334 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0315108 |
| PRR5L | proline rich 5 like | -0.031489 |
| EZR | ezrin | -0.0312687 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0310982 |
| HKDC1 | hexokinase domain containing 1 | -0.0309788 |
| RNF24 | ring finger protein 24 | -0.0305089 |
| HDLBP | high density lipoprotein binding protein | -0.0303152 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0302867 |
| RND3 | Rho family GTPase 3 | -0.0302542 |
| CAPN8 | calpain 8 | -0.0301442 |
| LAMB3 | laminin, beta 3 | -0.0300638 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0298395 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0297134 |
| ASPH | aspartate beta-hydroxylase | -0.0296485 |
| FHL2 | four and a half LIM domains 2 | -0.0293263 |
| AREG | amphiregulin | -0.0289277 |
| DUSP16 | dual specificity phosphatase 16 | -0.0284165 |
| ARHGAP23 | Rho GTPase activating protein 23 | -0.0282119 |
| TXNRD1 | thioredoxin reductase 1 | -0.0281535 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0276089 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0274719 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0273786 |
| PTMA | prothymosin, alpha | -0.0273232 |
| RPL34 | ribosomal protein L34 | -0.0271244 |
| EXOC4 | exocyst complex component 4 | -0.0270299 |
| POF1B | premature ovarian failure, 1B | -0.0269994 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0265872 |
