Carbidopa (monohydrate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.124835
EPS8 epidermal growth factor receptor pathway substrate 8 0.113651
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0872887
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0870278
PTPRR protein tyrosine phosphatase, receptor type, R 0.0860836
PLAC8 placenta-specific 8 0.0811691
CALB1 calbindin 1, 28kDa 0.0724572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0702155
AKAP9 A kinase (PRKA) anchor protein 9 0.0677983
ARHGAP29 Rho GTPase activating protein 29 0.0658088
FOXO1 forkhead box O1 0.0640097
GOLGA4 golgin A4 0.0622542
FAT1 FAT atypical cadherin 1 0.0620578
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0573361
PRELID2 PRELI domain containing 2 0.0560582
AUTS2 autism susceptibility candidate 2 0.0556923
PTBP3 polypyrimidine tract binding protein 3 0.0556134
GDA guanine deaminase 0.0535798
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0513074
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0506044
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0504549
PTEN phosphatase and tensin homolog 0.0487731
PKP2 plakophilin 2 0.0487134
MON2 MON2 homolog (S. cerevisiae) 0.048431
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0479765
CCPG1 cell cycle progression 1 0.0466302
PPARG peroxisome proliferator-activated receptor gamma 0.0452053
LIMA1 LIM domain and actin binding 1 0.0447582
PDE4D phosphodiesterase 4D, cAMP-specific 0.0439931
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0432356
LRRC1 leucine rich repeat containing 1 0.0431438
PCBP2 poly(rC) binding protein 2 0.0428323
ZNF292 zinc finger protein 292 0.0420728
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0406234
BIRC6 baculoviral IAP repeat containing 6 0.0403742
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0399565
GARS1 glycyl-tRNA synthetase 1 0.0393332
KTN1 kinectin 1 (kinesin receptor) 0.0391406
EREG epiregulin 0.0384347
KMT2C lysine (K)-specific methyltransferase 2C 0.0379706
MYO6 myosin VI 0.0377746
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0375725
MYOF myoferlin 0.0372482
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0372453
DSCAM Down syndrome cell adhesion molecule 0.0368133
ARHGAP26 Rho GTPase activating protein 26 0.0366181
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.036182
UBA6 ubiquitin-like modifier activating enzyme 6 0.03594
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0358824
PCDHB16 protocadherin beta 16 0.0355288
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0352861
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0350979
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0347884
TRIM2 tripartite motif containing 2 0.0341984
NFIA nuclear factor I/A 0.0339611
ANO6 anoctamin 6 0.033952
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0337928
TMEM41B transmembrane protein 41B 0.0336859
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.0336425
MLEC malectin 0.0330203
CDC42SE2 CDC42 small effector 2 0.0327944
TTC3 tetratricopeptide repeat domain 3 0.0327749
KDM7A lysine (K)-specific demethylase 7A 0.0325011
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0320629
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0316983
CDK19 cyclin-dependent kinase 19 0.0313803
ITGA6 integrin, alpha 6 0.0313464
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0310303
ERBIN erbb2 interacting protein 0.0307413
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0306036
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0303794
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0303085
CARD16 caspase recruitment domain family, member 16 0.0303015
MAML2 mastermind-like 2 (Drosophila) 0.0300594
SETD5 SET domain containing 5 0.0299202
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0295964
RARS1 arginyl-tRNA synthetase 1 0.0295861
EEF2 eukaryotic translation elongation factor 2 0.0293053
KMT2E lysine (K)-specific methyltransferase 2E 0.0288564
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0286926
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0286867
EHF ets homologous factor 0.0282257
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0281778
DGKD diacylglycerol kinase, delta 130kDa 0.0280904
DENND4C DENN/MADD domain containing 4C 0.0278074
SLTM SAFB-like, transcription modulator 0.0272191
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.0269972
ETV6 ets variant 6 0.0268972
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0268106
RNF145 ring finger protein 145 0.0267777
WWC1 WW and C2 domain containing 1 0.0267192
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0266637
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0266619
BBX bobby sox homolog (Drosophila) 0.0266021
RB1CC1 RB1-inducible coiled-coil 1 0.0264104
ZFC3H1 zinc finger, C3H1-type containing 0.0262403
RIN2 Ras and Rab interactor 2 0.0261604
CAB39 calcium binding protein 39 0.0261511
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0260305
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0259452

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.172715
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.170412
RPLP1 ribosomal protein, large, P1 -0.142498
LMO7 LIM domain 7 -0.142148
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119957
TMSB10 thymosin beta 10 -0.0915006
MYO1E myosin IE -0.0873714
RPL34 ribosomal protein L34 -0.0783726
ZSWIM6 zinc finger, SWIM-type containing 6 -0.068759
RPL26 ribosomal protein L26 -0.0664049
FRMD5 FERM domain containing 5 -0.0662817
RPS8 ribosomal protein S8 -0.0625604
RPS19 ribosomal protein S19 -0.0614167
RPL35A ribosomal protein L35a -0.06137
RPS6 ribosomal protein S6 -0.0588945
RPS23 ribosomal protein S23 -0.0585169
RPLP2 ribosomal protein, large, P2 -0.0564412
ANXA2 annexin A2 -0.0564069
INTS6 integrator complex subunit 6 -0.054608
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0508226
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0481679
LAMB3 laminin, beta 3 -0.0472402
RPS13 ribosomal protein S13 -0.0470333
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.046953
RPL12 ribosomal protein L12 -0.0463945
RPL31 ribosomal protein L31 -0.0463777
CATSPERB catsper channel auxiliary subunit beta -0.0463463
GMDS GDP-mannose 4,6-dehydratase -0.0459353
RPS29 ribosomal protein S29 -0.045689
SP100 SP100 nuclear antigen -0.0455562
RPL32 ribosomal protein L32 -0.0453601
RIMKLB ribosomal modification protein rimK-like family member B -0.0443541
TJP1 tight junction protein 1 -0.0432767
RPL13A ribosomal protein L13a -0.0426945
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0424342
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0419903
MUC13 mucin 13, cell surface associated -0.0418531
RPS21 ribosomal protein S21 -0.0410974
CTBP2 C-terminal binding protein 2 -0.0410608
OXSR1 oxidative stress responsive 1 -0.0406168
MYO5B myosin VB -0.0405329
ACTG1 actin gamma 1 -0.0402861
RPL36 ribosomal protein L36 -0.039955
ITPRID2 ITPR interacting domain containing 2 -0.0397107
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0389361
RPL4 ribosomal protein L4 -0.0388142
RIGI RNA sensor RIG-I -0.0387614
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0386077
SLC38A2 solute carrier family 38, member 2 -0.0377912
RPL19 ribosomal protein L19 -0.0373078
DSPP dentin sialophosphoprotein -0.0367876
RPL11 ribosomal protein L11 -0.0364667
RPS24 ribosomal protein S24 -0.0359719
RPL37A ribosomal protein L37a -0.0351295
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0351064
EZR ezrin -0.0347789
RPS5 ribosomal protein S5 -0.0347306
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0342728
LAMA4 laminin, alpha 4 -0.0339962
FUS FUS RNA binding protein -0.0339049
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0338166
NABP1 nucleic acid binding protein 1 -0.033452
RAB7A RAB7A, member RAS oncogene family -0.032543
RPL37 ribosomal protein L37 -0.0321648
MX1 MX dynamin-like GTPase 1 -0.0317445
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0317417
FBXO11 F-box protein 11 -0.0316147
IFI6 interferon, alpha-inducible protein 6 -0.0316006
RPL5 ribosomal protein L5 -0.0315379
RPS15 ribosomal protein S15 -0.0307441
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0305828
PTPRB protein tyrosine phosphatase, receptor type, B -0.030298
RPS12 ribosomal protein S12 -0.0301464
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.029816
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0296642
RPL8 ribosomal protein L8 -0.0296372
CLDN4 claudin 4 -0.0296139
LOC102724023 ES1 protein homolog, mitochondrial -0.0294575
EGR1 early growth response 1 -0.0293609
RPL28 ribosomal protein L28 -0.029322
PDLIM5 PDZ and LIM domain 5 -0.0292476
DSG3 desmoglein 3 -0.0292329
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0288969
RPS25 ribosomal protein S25 -0.0288723
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0286955
RCOR1 REST corepressor 1 -0.0284461
KLF6 Kruppel-like factor 6 -0.0283646
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.028219
ACTN4 actinin, alpha 4 -0.0280767
RPL38 ribosomal protein L38 -0.027763
RPL23 ribosomal protein L23 -0.0274598
NAP1L1 nucleosome assembly protein 1-like 1 -0.0266589
TC2N tandem C2 domains, nuclear -0.0263538
MTAP methylthioadenosine phosphorylase -0.0262973
EIF1 eukaryotic translation initiation factor 1 -0.0261966
RPS3 ribosomal protein S3 -0.0257428
MT2A metallothionein 2A -0.025246
RPS16 ribosomal protein S16 -0.0248473
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0245809
UBAP2 ubiquitin associated protein 2 -0.0245039