Carbidopa (monohydrate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DLG1 discs, large homolog 1 (Drosophila) 0.178872
TSC22D1 TSC22 domain family, member 1 0.0890409
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0859287
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0757854
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.075654
SLC38A2 solute carrier family 38, member 2 0.0679
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0676551
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.065214
EHBP1 EH domain binding protein 1 0.0643986
CD44 CD44 molecule (Indian blood group) 0.054744
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0512386
RIGI RNA sensor RIG-I 0.0475686
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0472958
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0463897
ADGRG6 adhesion G protein-coupled receptor G6 0.0447864
RAD51B RAD51 paralog B 0.0442688
EPHA4 EPH receptor A4 0.0441733
DPYD dihydropyrimidine dehydrogenase 0.0441437
DST dystonin 0.0431535
EFNA5 ephrin-A5 0.0418254
PSD3 pleckstrin and Sec7 domain containing 3 0.0418197
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0406026
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0387884
VIM vimentin 0.0381733
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0381643
MBNL2 muscleblind-like splicing regulator 2 0.0374452
CADM2 cell adhesion molecule 2 0.0373464
CFAP299 cilia and flagella associated protein 299 0.0369954
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0352411
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0348134
PTK2 protein tyrosine kinase 2 0.034241
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0340351
ZDHHC14 zinc finger, DHHC-type containing 14 0.0339499
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0333028
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0315221
PIAS2 protein inhibitor of activated STAT, 2 0.0307465
RNF213 ring finger protein 213 0.0306459
FNIP1 folliculin interacting protein 1 0.030491
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0291788
WARS1 tryptophanyl-tRNA synthetase 1 0.0287344
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0287136
EXOC4 exocyst complex component 4 0.0285816
ADAM10 ADAM metallopeptidase domain 10 0.0284763
VCL vinculin 0.0279514
TMEM123 transmembrane protein 123 0.0274108
ANKRD12 ankyrin repeat domain 12 0.0273632
TBC1D5 TBC1 domain family, member 5 0.0269506
RBM25 RNA binding motif protein 25 0.0268843
SMYD3 SET and MYND domain containing 3 0.0261365
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0259078
CDK6 cyclin-dependent kinase 6 0.0250956
PGAP1 post-GPI attachment to proteins 1 0.0243838
TTC28 tetratricopeptide repeat domain 28 0.0242828
DOCK11 dedicator of cytokinesis 11 0.0239496
THOC2 THO complex 2 0.0235085
ZMYND8 zinc finger, MYND-type containing 8 0.0232685
ARHGAP12 Rho GTPase activating protein 12 0.0231446
CHD9 chromodomain helicase DNA binding protein 9 0.0230838
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0229399
EPB41 erythrocyte membrane protein band 4.1 0.022866
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0228258
CCDC91 coiled-coil domain containing 91 0.0225911
COL5A2 collagen, type V, alpha 2 0.0225732
TNS3 tensin 3 0.0224363
ANKRD17 ankyrin repeat domain 17 0.0223151
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0222501
ZNF148 zinc finger protein 148 0.0219678
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0219376
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0218299
ITGB4 integrin, beta 4 0.021707
LRRC49 leucine rich repeat containing 49 0.0215663
FNDC3B fibronectin type III domain containing 3B 0.0212043
VEGFC vascular endothelial growth factor C 0.021179
LPP LIM domain containing preferred translocation partner in lipoma 0.0207026
TRERF1 transcriptional regulating factor 1 0.0202982
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0202145
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0201063
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.0199342
PDGFC platelet derived growth factor C 0.0199082
RUNX1 runt-related transcription factor 1 0.0197551
NF1 neurofibromin 1 0.0195715
ATM ATM serine/threonine kinase 0.0195339
CALD1 caldesmon 1 0.0194364
TOP1 topoisomerase (DNA) I 0.0193899
DPH6 diphthamine biosynthesis 6 0.019202
CDK19 cyclin-dependent kinase 19 0.0190869
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0185284
SETD5 SET domain containing 5 0.0184146
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0181063
MBD5 methyl-CpG binding domain protein 5 0.018103
PTPRF protein tyrosine phosphatase, receptor type, F 0.0180125
BABAM2 BRISC and BRCA1 A complex member 2 0.0179441
PMP22 peripheral myelin protein 22 0.0179439
CD109 CD109 molecule 0.0178703
RTTN rotatin 0.0178055
ESYT2 extended synaptotagmin-like protein 2 0.0177733
CFDP1 craniofacial development protein 1 0.0177483
TMCC1 transmembrane and coiled-coil domain family 1 0.0177431
AKAP9 A kinase (PRKA) anchor protein 9 0.0176918
N4BP2L2 NEDD4 binding protein 2-like 2 0.0176152

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.469759
MT2A metallothionein 2A -0.191114
TM4SF1 transmembrane 4 L six family member 1 -0.148358
ERRFI1 ERBB receptor feedback inhibitor 1 -0.145625
TXNRD1 thioredoxin reductase 1 -0.102144
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0974034
SPAG9 sperm associated antigen 9 -0.0897293
TMSB10 thymosin beta 10 -0.0872501
FTL ferritin, light polypeptide -0.0872099
LOC112694756 uncharaterized LOC112694756 -0.0810214
TPT1 tumor protein, translationally-controlled 1 -0.0741918
RPS2 ribosomal protein S2 -0.0673209
EZR ezrin -0.0607579
HSPA8 heat shock 70kDa protein 8 -0.0583718
EEF2 eukaryotic translation elongation factor 2 -0.0558729
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0555465
RPL12 ribosomal protein L12 -0.0543918
LDHA lactate dehydrogenase A -0.050475
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.049701
RPS6 ribosomal protein S6 -0.0495577
MT1E metallothionein 1E -0.0473866
MACF1 microtubule-actin crosslinking factor 1 -0.0466198
POTEF POTE ankyrin domain family, member F -0.0461641
UBC ubiquitin C -0.0455172
MT1X metallothionein 1X -0.0455083
RPS8 ribosomal protein S8 -0.0449013
RPL26 ribosomal protein L26 -0.0437321
RPS19 ribosomal protein S19 -0.0422303
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0421842
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0412103
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0390759
KMT2E lysine (K)-specific methyltransferase 2E -0.0387614
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0386201
EMP1 epithelial membrane protein 1 -0.0374944
BRD2 bromodomain containing 2 -0.0370053
HOOK2 hook microtubule-tethering protein 2 -0.0366094
EIF1 eukaryotic translation initiation factor 1 -0.0365779
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0365126
JUN jun proto-oncogene -0.0358632
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.035845
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0356645
ZEB1 zinc finger E-box binding homeobox 1 -0.0355763
NAMPT nicotinamide phosphoribosyltransferase -0.0354226
ACTG1 actin gamma 1 -0.0346562
RPS12 ribosomal protein S12 -0.0344725
FTH1 ferritin, heavy polypeptide 1 -0.0342319
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0340894
ANXA1 annexin A1 -0.034034
RACK1 receptor for activated C kinase 1 -0.0339557
RPL36 ribosomal protein L36 -0.0333957
KDM3A lysine (K)-specific demethylase 3A -0.0327388
HMGA1 high mobility group AT-hook 1 -0.0319529
EREG epiregulin -0.0316982
CLTC clathrin, heavy chain (Hc) -0.0313321
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0311432
UPP1 uridine phosphorylase 1 -0.030998
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0309614
RPL11 ribosomal protein L11 -0.0309401
RPL38 ribosomal protein L38 -0.030651
MCL1 myeloid cell leukemia 1 -0.0303737
YBX3 Y box binding protein 3 -0.0301091
S100A6 S100 calcium binding protein A6 -0.0296016
MYH9 myosin, heavy chain 9, non-muscle -0.0293114
USP34 ubiquitin specific peptidase 34 -0.0291024
TSC22D2 TSC22 domain family, member 2 -0.0289843
RPS18 ribosomal protein S18 -0.0286972
NUP58 nucleoporin 58 -0.0285587
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0285458
MKI67 marker of proliferation Ki-67 -0.0273687
EIF4A1 eukaryotic translation initiation factor 4A1 -0.027288
EGR1 early growth response 1 -0.0272222
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0271349
RAB7A RAB7A, member RAS oncogene family -0.0270497
RPLP0 ribosomal protein, large, P0 -0.0265853
RPL37 ribosomal protein L37 -0.0259505
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0256586
RPL3 ribosomal protein L3 -0.0256179
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0253701
PRDX1 peroxiredoxin 1 -0.0250879
RPS23 ribosomal protein S23 -0.0250843
RPL23 ribosomal protein L23 -0.0248987
RPS27 ribosomal protein S27 -0.0248653
S100A10 S100 calcium binding protein A10 -0.0248646
SPRY4 sprouty homolog 4 (Drosophila) -0.0246114
RPS3 ribosomal protein S3 -0.0245305
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0244895
RPL31 ribosomal protein L31 -0.0243593
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0242904
RPS13 ribosomal protein S13 -0.0240765
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0240569
RPL19 ribosomal protein L19 -0.0238404
RPL28 ribosomal protein L28 -0.0236151
RPL7 ribosomal protein L7 -0.0235606
RPLP2 ribosomal protein, large, P2 -0.0235245
RPL36A ribosomal protein L36a -0.0233639
ARRDC3 arrestin domain containing 3 -0.0230523
CSNK1A1 casein kinase 1, alpha 1 -0.0229545
RPS5 ribosomal protein S5 -0.0228867
CENPF centromere protein F, 350/400kDa -0.0228104
HPCAL1 hippocalcin-like 1 -0.0227274