| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.154429 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0977186 |
| FAM13A | family with sequence similarity 13, member A | 0.0950353 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0734714 |
| GRAMD1B | GRAM domain containing 1B | 0.0675239 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0669722 |
| NDRG1 | N-myc downstream regulated 1 | 0.0589571 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0576094 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0561238 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0548405 |
| NGLY1 | N-glycanase 1 | 0.053469 |
| CES1 | carboxylesterase 1 | 0.0499369 |
| MT2A | metallothionein 2A | 0.0492849 |
| ARRDC3 | arrestin domain containing 3 | 0.0491717 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0447823 |
| SMAD3 | SMAD family member 3 | 0.0411758 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0408425 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.040767 |
| RUNX1 | runt-related transcription factor 1 | 0.0401913 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0377761 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0368263 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0362456 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0338193 |
| ZNF292 | zinc finger protein 292 | 0.0335434 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.032057 |
| DTNA | dystrobrevin, alpha | 0.0318748 |
| PDE8A | phosphodiesterase 8A | 0.0314982 |
| HELZ | helicase with zinc finger | 0.0314967 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0310547 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0304952 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0282643 |
| TMEM165 | transmembrane protein 165 | 0.0281466 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0278383 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0264824 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0263693 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0258384 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0255176 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0254046 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0253557 |
| RNF145 | ring finger protein 145 | 0.02409 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0238246 |
| CDCP1 | CUB domain containing protein 1 | 0.0235581 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0232197 |
| SPAG9 | sperm associated antigen 9 | 0.0231103 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.023042 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0223621 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.02232 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0218506 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0216965 |
| STC1 | stanniocalcin 1 | 0.0210549 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.020794 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0203749 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0200209 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0198149 |
| SLTM | SAFB-like, transcription modulator | 0.0193709 |
| CCNL1 | cyclin L1 | 0.0193176 |
| OGA | O-GlcNAcase | 0.0189808 |
| ZFR | zinc finger RNA binding protein | 0.0186057 |
| TBK1 | TANK-binding kinase 1 | 0.018477 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0181715 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0179524 |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.0178227 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0175081 |
| YEATS2 | YEATS domain containing 2 | 0.0174867 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0174785 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0173908 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0169658 |
| CUL4A | cullin 4A | 0.0168541 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0167745 |
| MT1X | metallothionein 1X | 0.0167073 |
| CPE | carboxypeptidase E | 0.0165736 |
| RNF24 | ring finger protein 24 | 0.016539 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0165057 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.016471 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.016459 |
| USP34 | ubiquitin specific peptidase 34 | 0.016329 |
| MSN | moesin | 0.016321 |
| ZNF654 | zinc finger protein 654 | 0.0163072 |
| SUCO | SUN domain containing ossification factor | 0.0162197 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0162043 |
| GPHN | gephyrin | 0.0161522 |
| GPC6 | glypican 6 | 0.016078 |
| PYGL | phosphorylase, glycogen, liver | 0.0159843 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0159303 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0159264 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0158071 |
| ATP13A3 | ATPase type 13A3 | 0.0157332 |
| CUL3 | cullin 3 | 0.015651 |
| NUP58 | nucleoporin 58 | 0.0156412 |
| XPO1 | exportin 1 | 0.0155364 |
| ZNF638 | zinc finger protein 638 | 0.0153694 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0152693 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0152586 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0152225 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0150378 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0149941 |
| MATR3 | matrin 3 | 0.0148637 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0148611 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0147231 |
| RNF149 | ring finger protein 149 | 0.0146731 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.321254 |
| TMSB10 | thymosin beta 10 | -0.162336 |
| LMO7 | LIM domain 7 | -0.144945 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.105789 |
| ACTG1 | actin gamma 1 | -0.100341 |
| ASPH | aspartate beta-hydroxylase | -0.0901513 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0879605 |
| LAMC2 | laminin, gamma 2 | -0.0788567 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0735084 |
| SCEL | sciellin | -0.0643732 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0628482 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0586592 |
| DSPP | dentin sialophosphoprotein | -0.0583737 |
| HDLBP | high density lipoprotein binding protein | -0.0579749 |
| ANXA2 | annexin A2 | -0.057323 |
| AHNAK | AHNAK nucleoprotein | -0.0568729 |
| FTL | ferritin, light polypeptide | -0.0568507 |
| LAMA4 | laminin, alpha 4 | -0.055957 |
| TXNRD1 | thioredoxin reductase 1 | -0.0547235 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0547162 |
| EGR1 | early growth response 1 | -0.0518039 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0501764 |
| KRT18 | keratin 18, type I | -0.0501716 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0499817 |
| S100A10 | S100 calcium binding protein A10 | -0.0465044 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0455376 |
| PTMA | prothymosin, alpha | -0.0449342 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0446603 |
| OSMR | oncostatin M receptor | -0.0440443 |
| LDHA | lactate dehydrogenase A | -0.0434781 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0427549 |
| CST3 | cystatin C | -0.0423836 |
| KRT7 | keratin 7, type II | -0.0416548 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0413372 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0408495 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0397245 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0378635 |
| MYO1D | myosin ID | -0.0374693 |
| H1-0 | H1.0 linker histone | -0.0373882 |
| CUX1 | cut-like homeobox 1 | -0.0372932 |
| TES | testin LIM domain protein | -0.0367001 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0366395 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0366076 |
| LAMB3 | laminin, beta 3 | -0.0364525 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0346727 |
| CCND1 | cyclin D1 | -0.0344974 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0343928 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0331138 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0328243 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0325348 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0324336 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0324295 |
| RPL35A | ribosomal protein L35a | -0.0322186 |
| VCL | vinculin | -0.0318462 |
| RAB10 | RAB10, member RAS oncogene family | -0.0318129 |
| EHBP1 | EH domain binding protein 1 | -0.031431 |
| MCU | mitochondrial calcium uniporter | -0.0307141 |
| FLNB | filamin B, beta | -0.0284818 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0283468 |
| RPL31 | ribosomal protein L31 | -0.0282325 |
| S100P | S100 calcium binding protein P | -0.0282027 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0281901 |
| KRT8 | keratin 8, type II | -0.0281577 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0277444 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0274983 |
| MYOF | myoferlin | -0.0266114 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0265051 |
| MYO1E | myosin IE | -0.0260567 |
| TNS3 | tensin 3 | -0.0260492 |
| EZR | ezrin | -0.0260391 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0251029 |
| NABP1 | nucleic acid binding protein 1 | -0.0248809 |
| EMP1 | epithelial membrane protein 1 | -0.0246213 |
| S100A11 | S100 calcium binding protein A11 | -0.0246032 |
| SH3D19 | SH3 domain containing 19 | -0.0241185 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0236952 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.023546 |
| EFNA5 | ephrin-A5 | -0.0233689 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0232907 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0232775 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0232722 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0230591 |
| TPM4 | tropomyosin 4 | -0.0228834 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0227967 |
| CTBP2 | C-terminal binding protein 2 | -0.0227669 |
| B2M | beta-2-microglobulin | -0.0223488 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0222058 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.021978 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0219445 |
| GM2A | GM2 ganglioside activator | -0.0219333 |
| ENO1 | enolase 1, (alpha) | -0.0218883 |
| MGAT4C | MGAT4 family, member C | -0.0213029 |
| HLA-B | major histocompatibility complex, class I, B | -0.0212584 |
| MCL1 | myeloid cell leukemia 1 | -0.0212374 |
| DSG2 | desmoglein 2 | -0.0212233 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0212111 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0211896 |
| GOLGB1 | golgin B1 | -0.021142 |
| RPL34 | ribosomal protein L34 | -0.0210103 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0209879 |
