| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.202927 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.141942 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.116226 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.104143 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.101512 |
| FAM13A | family with sequence similarity 13, member A | 0.0896618 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0896052 |
| SMAD3 | SMAD family member 3 | 0.0854866 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0753573 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0698873 |
| GOLGA4 | golgin A4 | 0.0697695 |
| OGA | O-GlcNAcase | 0.0671174 |
| PCBP2 | poly(rC) binding protein 2 | 0.0661695 |
| RBM39 | RNA binding motif protein 39 | 0.061927 |
| ATP13A3 | ATPase type 13A3 | 0.0611233 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0605274 |
| LOX | lysyl oxidase | 0.0577944 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0561824 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.054778 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0546175 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0545939 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0513103 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0512866 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0510733 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0505459 |
| SPAG9 | sperm associated antigen 9 | 0.0468989 |
| ZNF292 | zinc finger protein 292 | 0.0464998 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0454576 |
| NGLY1 | N-glycanase 1 | 0.0433928 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0433051 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0426089 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0420357 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0420325 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0416498 |
| USP3 | ubiquitin specific peptidase 3 | 0.0414377 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0412029 |
| XPO1 | exportin 1 | 0.0408075 |
| SBF2 | SET binding factor 2 | 0.0390826 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0390777 |
| PRELID2 | PRELI domain containing 2 | 0.0387169 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0386511 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0372449 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0371988 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0370382 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0361079 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0360418 |
| YEATS2 | YEATS domain containing 2 | 0.0353912 |
| KIF5B | kinesin family member 5B | 0.034777 |
| RIOK3 | RIO kinase 3 | 0.0347583 |
| SRP54 | signal recognition particle 54kDa | 0.0345707 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0345273 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0339927 |
| FLNB | filamin B, beta | 0.0339008 |
| HELZ | helicase with zinc finger | 0.0336543 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0335074 |
| COG5 | component of oligomeric golgi complex 5 | 0.0330466 |
| CD109 | CD109 molecule | 0.03295 |
| RUNX1 | runt-related transcription factor 1 | 0.032863 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.032616 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0323254 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0322537 |
| WAC | WW domain containing adaptor with coiled-coil | 0.03096 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0307752 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0304889 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0303641 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0299092 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.029702 |
| ANXA1 | annexin A1 | 0.0295398 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0293364 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0290735 |
| MYOF | myoferlin | 0.0290234 |
| SLTM | SAFB-like, transcription modulator | 0.0289313 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.028846 |
| ARRDC3 | arrestin domain containing 3 | 0.0287823 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0286531 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0285922 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0285427 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0285397 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0285172 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0284411 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0282571 |
| PFKP | phosphofructokinase, platelet | 0.0279797 |
| FOXO3 | forkhead box O3 | 0.0279191 |
| PHIP | pleckstrin homology domain interacting protein | 0.0277405 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0275589 |
| NBAS | neuroblastoma amplified sequence | 0.0274839 |
| RNF149 | ring finger protein 149 | 0.0274486 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.027438 |
| TPR | translocated promoter region, nuclear basket protein | 0.0272973 |
| OTUD7B | OTU deubiquitinase 7B | 0.0272704 |
| USP37 | ubiquitin specific peptidase 37 | 0.0272548 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0272028 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0270831 |
| RLF | rearranged L-myc fusion | 0.0270793 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0270109 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0267119 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0266917 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.026619 |
| CANX | calnexin | 0.0265474 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0262249 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.130469 |
| CDH13 | cadherin 13 | -0.126725 |
| TMSB10 | thymosin beta 10 | -0.103527 |
| NRG1 | neuregulin 1 | -0.0995521 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0945508 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0873356 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0854583 |
| HMGA2 | high mobility group AT-hook 2 | -0.0821915 |
| GLCCI1 | glucocorticoid induced 1 | -0.081306 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0795467 |
| FN1 | fibronectin 1 | -0.0792556 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0760466 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0663447 |
| MTSS1 | metastasis suppressor 1 | -0.064762 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0624661 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0596652 |
| FTL | ferritin, light polypeptide | -0.0590295 |
| VIM | vimentin | -0.053892 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0515756 |
| RPL35A | ribosomal protein L35a | -0.0515096 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0480391 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0456266 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0454417 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.045161 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0450454 |
| HMGA1 | high mobility group AT-hook 1 | -0.0450239 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0419731 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0419307 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0409921 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0406808 |
| AADAC | arylacetamide deacetylase | -0.0403691 |
| PKM | pyruvate kinase, muscle | -0.0398541 |
| RPLP1 | ribosomal protein, large, P1 | -0.0396983 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0393683 |
| RPS29 | ribosomal protein S29 | -0.0390744 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.038818 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0388026 |
| CUX1 | cut-like homeobox 1 | -0.0387702 |
| HLA-B | major histocompatibility complex, class I, B | -0.0380112 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0378497 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0373111 |
| RPS6 | ribosomal protein S6 | -0.0371567 |
| SEPTIN9 | septin 9 | -0.0370114 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0369043 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0367838 |
| B2M | beta-2-microglobulin | -0.0365295 |
| CLMP | CXADR-like membrane protein | -0.0361374 |
| RPS8 | ribosomal protein S8 | -0.0356579 |
| CDK14 | cyclin-dependent kinase 14 | -0.0356572 |
| PRRX1 | paired related homeobox 1 | -0.0354677 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0350156 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0348741 |
| RPL31 | ribosomal protein L31 | -0.0346782 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0346618 |
| ZNF804A | zinc finger protein 804A | -0.0338054 |
| ANTXR2 | anthrax toxin receptor 2 | -0.033424 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0333039 |
| RASAL2 | RAS protein activator like 2 | -0.0329395 |
| EGR1 | early growth response 1 | -0.0327142 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0326046 |
| IFI44L | interferon-induced protein 44-like | -0.0317582 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0317112 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0308813 |
| NLK | nemo-like kinase | -0.0307381 |
| RAI14 | retinoic acid induced 14 | -0.0306636 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0304447 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0301338 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0300824 |
| VEGFA | vascular endothelial growth factor A | -0.0296516 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.029594 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0291549 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0289365 |
| HM13 | histocompatibility (minor) 13 | -0.0289094 |
| RPL28 | ribosomal protein L28 | -0.0287875 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0285201 |
| INTS6 | integrator complex subunit 6 | -0.0284495 |
| NRP1 | neuropilin 1 | -0.0282794 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0281015 |
| RPS19 | ribosomal protein S19 | -0.0280066 |
| RPS11 | ribosomal protein S11 | -0.0278534 |
| MECOM | MDS1 and EVI1 complex locus | -0.0278222 |
| DIAPH2 | diaphanous-related formin 2 | -0.0278157 |
| WLS | wntless Wnt ligand secretion mediator | -0.027524 |
| FBN1 | fibrillin 1 | -0.0273473 |
| RPS23 | ribosomal protein S23 | -0.0272859 |
| CLIC4 | chloride intracellular channel 4 | -0.02707 |
| COL7A1 | collagen, type VII, alpha 1 | -0.027013 |
| ATG7 | autophagy related 7 | -0.0264146 |
| SLC38A2 | solute carrier family 38, member 2 | -0.026406 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0264021 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0260456 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0258618 |
| RSU1 | Ras suppressor protein 1 | -0.0257945 |
| NAV1 | neuron navigator 1 | -0.0256374 |
| RPS13 | ribosomal protein S13 | -0.0255731 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0255251 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0254221 |
| IL1B | interleukin 1, beta | -0.0254 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0252901 |
| DST | dystonin | -0.0250403 |
