| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0915595 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0822007 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0787231 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0745576 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0741394 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0722402 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0716668 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0679206 |
| CCNL1 | cyclin L1 | 0.0668933 |
| FMNL2 | formin-like 2 | 0.0618616 |
| ZNF207 | zinc finger protein 207 | 0.0611413 |
| TPD52 | tumor protein D52 | 0.057274 |
| PUM1 | pumilio RNA-binding family member 1 | 0.056397 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0555536 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0545755 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0543884 |
| VIM | vimentin | 0.0540262 |
| PCBP2 | poly(rC) binding protein 2 | 0.0521545 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0513342 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.051131 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0509676 |
| FLNB | filamin B, beta | 0.0505634 |
| FNBP1L | formin binding protein 1-like | 0.05026 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0499453 |
| RBM25 | RNA binding motif protein 25 | 0.0498854 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0487777 |
| TFG | TRK-fused gene | 0.0486324 |
| COPA | coatomer protein complex, subunit alpha | 0.0482787 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0454104 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0448181 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0444502 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0439483 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0424604 |
| RNF145 | ring finger protein 145 | 0.0417475 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0395678 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0390983 |
| NUP58 | nucleoporin 58 | 0.0390416 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0389376 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0386873 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0380233 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0379743 |
| PDE8A | phosphodiesterase 8A | 0.0378401 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0376783 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0373281 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0370253 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0369802 |
| MATR3 | matrin 3 | 0.0362882 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0362416 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0362313 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.036205 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0356506 |
| ZNHIT6 | zinc finger, HIT-type containing 6 | 0.0349546 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0349526 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0342986 |
| XPO1 | exportin 1 | 0.0340705 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0340007 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0338514 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0335761 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0335175 |
| SLMAP | sarcolemma associated protein | 0.032983 |
| FTL | ferritin, light polypeptide | 0.0329154 |
| CHN1 | chimerin 1 | 0.0327182 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0327171 |
| HMGA1 | high mobility group AT-hook 1 | 0.0327065 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0323591 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0322109 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0320224 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.030663 |
| PKM | pyruvate kinase, muscle | 0.0303045 |
| RHEB | Ras homolog enriched in brain | 0.0302978 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0301847 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0297979 |
| RBM6 | RNA binding motif protein 6 | 0.0294091 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0293867 |
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | 0.0291226 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0290732 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0289887 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0289374 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.028874 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | 0.0288435 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0287818 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0287589 |
| SNX14 | sorting nexin 14 | 0.0286102 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0282207 |
| SRP54 | signal recognition particle 54kDa | 0.0280325 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0278257 |
| VMP1 | vacuole membrane protein 1 | 0.0276615 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.027162 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.027127 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0270217 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0269994 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0266855 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0266608 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0264701 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0261939 |
| PARD3 | par-3 family cell polarity regulator | 0.0260883 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0260138 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0259605 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0256375 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0255693 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TM4SF1 | transmembrane 4 L six family member 1 | -0.158594 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.13735 |
| GRAMD1B | GRAM domain containing 1B | -0.123531 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.111861 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.105391 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0943972 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0855906 |
| BICC1 | BicC family RNA binding protein 1 | -0.0843798 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0738811 |
| OSMR | oncostatin M receptor | -0.0736982 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0691636 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0657273 |
| RPL4 | ribosomal protein L4 | -0.0648523 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.064453 |
| ASPH | aspartate beta-hydroxylase | -0.0627927 |
| TXNRD1 | thioredoxin reductase 1 | -0.0625357 |
| EGR1 | early growth response 1 | -0.0612432 |
| HDAC9 | histone deacetylase 9 | -0.0574554 |
| MKI67 | marker of proliferation Ki-67 | -0.054375 |
| SVIL | supervillin | -0.0534686 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0513127 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0511418 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0499518 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0493271 |
| WWOX | WW domain containing oxidoreductase | -0.0486958 |
| NNMT | nicotinamide N-methyltransferase | -0.0478342 |
| DENND4A | DENN/MADD domain containing 4A | -0.0459273 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0455818 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0444808 |
| CENPF | centromere protein F, 350/400kDa | -0.0436599 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0427471 |
| KYNU | kynureninase | -0.0418427 |
| FAM107B | family with sequence similarity 107, member B | -0.0412253 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0411414 |
| TMSB10 | thymosin beta 10 | -0.0395786 |
| GLIS3 | GLIS family zinc finger 3 | -0.0395199 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0392257 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0387727 |
| RPL26 | ribosomal protein L26 | -0.0378625 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0374103 |
| CAVIN1 | caveolae associated protein 1 | -0.0368988 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0368685 |
| AGO2 | argonaute RISC catalytic component 2 | -0.036198 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0359436 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0354639 |
| RPS21 | ribosomal protein S21 | -0.0354137 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0352713 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0352553 |
| KLF6 | Kruppel-like factor 6 | -0.0351487 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0348309 |
| USP34 | ubiquitin specific peptidase 34 | -0.0345042 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0342154 |
| ANXA2 | annexin A2 | -0.0339303 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0335415 |
| NRG1 | neuregulin 1 | -0.032454 |
| IGF2 | insulin-like growth factor 2 | -0.0315283 |
| ENO1 | enolase 1, (alpha) | -0.0312518 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0311975 |
| GOLGB1 | golgin B1 | -0.0310964 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0310413 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0309228 |
| LDHA | lactate dehydrogenase A | -0.0306408 |
| DST | dystonin | -0.0305997 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0305054 |
| NTN4 | netrin 4 | -0.0303088 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0300257 |
| RACK1 | receptor for activated C kinase 1 | -0.0298896 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0297737 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0296467 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0291376 |
| MCL1 | myeloid cell leukemia 1 | -0.0291167 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0290152 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0289751 |
| DOCK4 | dedicator of cytokinesis 4 | -0.028949 |
| LAMB1 | laminin, beta 1 | -0.0289445 |
| BMP5 | bone morphogenetic protein 5 | -0.0287394 |
| IER3 | immediate early response 3 | -0.0286939 |
| NABP1 | nucleic acid binding protein 1 | -0.0286297 |
| CDK12 | cyclin-dependent kinase 12 | -0.0284136 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0283754 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.028365 |
| MORF4L2 | mortality factor 4 like 2 | -0.0280861 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0277594 |
| CANX | calnexin | -0.027652 |
| RPS24 | ribosomal protein S24 | -0.0274933 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0274573 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0274175 |
| TDP2 | tyrosyl-DNA phosphodiesterase 2 | -0.027061 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0270427 |
| RUNX1 | runt-related transcription factor 1 | -0.0268013 |
| NEGR1 | neuronal growth regulator 1 | -0.0267845 |
| EIF3J | eukaryotic translation initiation factor 3, subunit J | -0.026577 |
| MAP1B | microtubule-associated protein 1B | -0.0264972 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0263234 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0261963 |
| TCF12 | transcription factor 12 | -0.0259643 |
| RPS8 | ribosomal protein S8 | -0.0258631 |
| RPS5 | ribosomal protein S5 | -0.0257191 |
| SQSTM1 | sequestosome 1 | -0.0254656 |
| RPL30 | ribosomal protein L30 | -0.0253719 |
