Carbidopa (monohydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.171924
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.167905
VIM vimentin 0.119423
HOOK2 hook microtubule-tethering protein 2 0.104939
PDE4D phosphodiesterase 4D, cAMP-specific 0.103792
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.10159
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0973593
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.090852
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0896491
ERRFI1 ERBB receptor feedback inhibitor 1 0.0849719
ELL2 elongation factor, RNA polymerase II, 2 0.0841304
PTMA prothymosin, alpha 0.0791502
RBM39 RNA binding motif protein 39 0.0730255
NAMPT nicotinamide phosphoribosyltransferase 0.071924
PRRC2C proline-rich coiled-coil 2C 0.0701675
GPC6 glypican 6 0.0688165
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0664043
CXCL8 chemokine (C-X-C motif) ligand 8 0.0614059
ENO1 enolase 1, (alpha) 0.0581414
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0563842
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0521151
RUNX1 runt-related transcription factor 1 0.0521078
IGF2 insulin-like growth factor 2 0.051641
ACTG1 actin gamma 1 0.0512529
NAP1L1 nucleosome assembly protein 1-like 1 0.0492392
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0486711
FN1 fibronectin 1 0.0485246
ANXA1 annexin A1 0.0473666
IGFBP3 insulin-like growth factor binding protein 3 0.0464848
MT2A metallothionein 2A 0.0459807
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0456647
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0455917
RPS8 ribosomal protein S8 0.0449947
RTN4 reticulon 4 0.0449812
KMT2E lysine (K)-specific methyltransferase 2E 0.0446479
EGFR epidermal growth factor receptor 0.0435244
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0434393
STC1 stanniocalcin 1 0.0430983
OGA O-GlcNAcase 0.0426265
JMJD1C jumonji domain containing 1C 0.0405668
LDHA lactate dehydrogenase A 0.0402375
ZFAND3 zinc finger, AN1-type domain 3 0.0401137
WDR43 WD repeat domain 43 0.0396177
FAM13A family with sequence similarity 13, member A 0.0391186
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0390604
CCNY cyclin Y 0.0387469
CCNI cyclin I 0.0386554
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0384217
TMSB10 thymosin beta 10 0.0368101
SIK3 SIK family kinase 3 0.0367346
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0361776
GARS1 glycyl-tRNA synthetase 1 0.0357959
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0355518
ZEB1 zinc finger E-box binding homeobox 1 0.0353334
FXR1 fragile X mental retardation, autosomal homolog 1 0.0347396
AKAP12 A kinase (PRKA) anchor protein 12 0.0346173
CELF1 CUGBP, Elav-like family member 1 0.0345893
KDM5B lysine (K)-specific demethylase 5B 0.0342909
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0334599
RPS6 ribosomal protein S6 0.0332404
COPA coatomer protein complex, subunit alpha 0.0329591
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0326272
BHLHE40 basic helix-loop-helix family, member e40 0.0326161
RPL11 ribosomal protein L11 0.0323919
IER3 immediate early response 3 0.0319
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0316245
AHNAK AHNAK nucleoprotein 0.031373
GPHN gephyrin 0.0312508
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.031094
RAB6A RAB6A, member RAS oncogene family 0.030905
FLNB filamin B, beta 0.0306714
ZNF292 zinc finger protein 292 0.0304541
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0302375
DST dystonin 0.0301894
RPLP1 ribosomal protein, large, P1 0.0299782
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0294083
WAC WW domain containing adaptor with coiled-coil 0.0293456
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0290899
RPL31 ribosomal protein L31 0.029079
SSBP2 single-stranded DNA binding protein 2 0.029012
ELF2 E74-like factor 2 (ets domain transcription factor) 0.029009
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0288278
FTL ferritin, light polypeptide 0.0287921
RPS24 ribosomal protein S24 0.0284634
PDE10A phosphodiesterase 10A 0.0284595
KTN1 kinectin 1 (kinesin receptor) 0.0283772
RAB1A RAB1A, member RAS oncogene family 0.0282905
RPL35A ribosomal protein L35a 0.0281753
RNF145 ring finger protein 145 0.0281146
RNMT RNA (guanine-7-) methyltransferase 0.0280163
EIF1 eukaryotic translation initiation factor 1 0.0278824
PKM pyruvate kinase, muscle 0.0276041
PAPOLA poly(A) polymerase alpha 0.0275028
PTBP3 polypyrimidine tract binding protein 3 0.0266864
RPL26 ribosomal protein L26 0.0263736
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0261219
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0260895
GOLGA4 golgin A4 0.025697
ARFGEF3 ARFGEF family member 3 0.0256832
ATXN1 ataxin 1 0.0256523

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.187632
MUC16 mucin 16, cell surface associated -0.125967
CEMIP cell migration inducing protein, hyaluronan binding -0.115092
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.110991
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.101076
ATOSA atos homolog A -0.100036
MYO1E myosin IE -0.0970087
LAMC2 laminin, gamma 2 -0.091934
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0915959
LMO7 LIM domain 7 -0.0885686
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0799396
KYNU kynureninase -0.0711294
ABHD17C abhydrolase domain containing 17C -0.0678855
SAMD4A sterile alpha motif domain containing 4A -0.0651423
RCOR1 REST corepressor 1 -0.0617911
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0617319
BACE2 beta-site APP-cleaving enzyme 2 -0.0607525
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0603421
SPNS2 spinster homolog 2 (Drosophila) -0.0601873
KIF13B kinesin family member 13B -0.0565762
ANTXR2 anthrax toxin receptor 2 -0.0562101
RBM47 RNA binding motif protein 47 -0.0546534
ANKRD36C ankyrin repeat domain 36C -0.0543343
SVIL supervillin -0.0537122
PTPRM protein tyrosine phosphatase, receptor type, M -0.0514769
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0511199
STEAP4 STEAP family member 4 -0.0508823
PARD3 par-3 family cell polarity regulator -0.0495584
SMOC1 SPARC related modular calcium binding 1 -0.0491509
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.046433
SAMD9 sterile alpha motif domain containing 9 -0.0462839
RIGI RNA sensor RIG-I -0.0458741
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0453191
CATSPERB catsper channel auxiliary subunit beta -0.0451591
SCEL sciellin -0.0451275
ZNF185 zinc finger protein 185 (LIM domain) -0.0446613
ERBIN erbb2 interacting protein -0.0446494
TMPRSS4 transmembrane protease, serine 4 -0.0445935
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.044328
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0441388
IL1RN interleukin 1 receptor antagonist -0.0441382
AKAP13 A kinase (PRKA) anchor protein 13 -0.043824
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0431014
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0425507
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0424139
TGFA transforming growth factor, alpha -0.0424104
AKAP9 A kinase (PRKA) anchor protein 9 -0.0417159
ESYT2 extended synaptotagmin-like protein 2 -0.040595
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0405803
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0391753
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0389848
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0386698
MYO6 myosin VI -0.0384546
TJP2 tight junction protein 2 -0.0379497
MACC1 metastasis associated in colon cancer 1 -0.0378252
SHB Src homology 2 domain containing adaptor protein B -0.0376481
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0374543
MTUS1 microtubule associated tumor suppressor 1 -0.0370128
FOSL2 FOS-like antigen 2 -0.0367024
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0366931
ATF6 activating transcription factor 6 -0.036016
IGF1R insulin-like growth factor 1 receptor -0.0358374
SAMD12 sterile alpha motif domain containing 12 -0.0355026
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0354609
INTS6 integrator complex subunit 6 -0.0353218
CAPN2 calpain 2, (m/II) large subunit -0.0352601
CLDN7 claudin 7 -0.0352228
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0351658
MACF1 microtubule-actin crosslinking factor 1 -0.0351262
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0350781
NCOR2 nuclear receptor corepressor 2 -0.0350636
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0349829
THRB thyroid hormone receptor, beta -0.0349035
DUSP5 dual specificity phosphatase 5 -0.0349013
EXT1 exostosin glycosyltransferase 1 -0.0347234
PMM2 phosphomannomutase 2 -0.0340061
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0338904
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0337704
NEBL nebulette -0.0332745
LAMB3 laminin, beta 3 -0.0331496
GCC2 GRIP and coiled-coil domain containing 2 -0.0328381
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0327111
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0321435
ARHGAP21 Rho GTPase activating protein 21 -0.0319774
ZNF638 zinc finger protein 638 -0.0318893
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0315989
GLCCI1 glucocorticoid induced 1 -0.0315926
LIMCH1 LIM and calponin homology domains 1 -0.0314134
FBXO34 F-box protein 34 -0.0312291
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0309625
IGSF1 immunoglobulin superfamily, member 1 -0.0308564
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0307857
EXOC6B exocyst complex component 6B -0.0307469
TMEM165 transmembrane protein 165 -0.0307037
FHIT fragile histidine triad -0.030703
MUC13 mucin 13, cell surface associated -0.0304143
TNS1 tensin 1 -0.0303502
AFF4 AF4/FMR2 family, member 4 -0.0302703
CARD11 caspase recruitment domain family, member 11 -0.0302613
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0302336