Carbidopa (monohydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.0424959
ETNK1 ethanolamine kinase 1 0.0396035
KDM2A lysine (K)-specific demethylase 2A 0.0387148
TPM3 tropomyosin 3 0.0376815
TMEM165 transmembrane protein 165 0.035842
XPO1 exportin 1 0.0355335
ANO6 anoctamin 6 0.0346967
ZCCHC7 zinc finger, CCHC domain containing 7 0.0339087
GATAD2B GATA zinc finger domain containing 2B 0.0335419
BIRC6 baculoviral IAP repeat containing 6 0.0317439
ERRFI1 ERBB receptor feedback inhibitor 1 0.0317018
PABPC1 poly(A) binding protein, cytoplasmic 1 0.03138
BBX bobby sox homolog (Drosophila) 0.031078
KMT2E lysine (K)-specific methyltransferase 2E 0.0305394
MMP12 matrix metallopeptidase 12 0.0290969
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0285255
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0250735
CSDE1 cold shock domain containing E1, RNA-binding 0.0244652
COPA coatomer protein complex, subunit alpha 0.0240644
CEP192 centrosomal protein 192kDa 0.0232002
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0225757
USP34 ubiquitin specific peptidase 34 0.0222423
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.021943
AVL9 AVL9 homolog (S. cerevisiase) 0.0216513
SRPK1 SRSF protein kinase 1 0.0214675
FAF1 Fas (TNFRSF6) associated factor 1 0.0211254
CSNK1A1 casein kinase 1, alpha 1 0.0210974
N4BP2L2 NEDD4 binding protein 2-like 2 0.0208665
ERBIN erbb2 interacting protein 0.0207698
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0202404
ZMYM2 zinc finger, MYM-type 2 0.0196943
MED13L mediator complex subunit 13-like 0.0196724
NOTCH2 notch 2 0.0192578
AKAP9 A kinase (PRKA) anchor protein 9 0.0191025
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0187634
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0186354
NUP58 nucleoporin 58 0.0184849
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0182805
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0182789
RFX7 regulatory factor X, 7 0.0181162
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0175808
ITSN1 intersectin 1 (SH3 domain protein) 0.0174544
SINHCAF SIN3-HDAC complex associated factor 0.0174495
OGA O-GlcNAcase 0.0174437
SNX13 sorting nexin 13 0.0174252
PTEN phosphatase and tensin homolog 0.016879
LATS2 large tumor suppressor kinase 2 0.0168148
DENND5B DENN/MADD domain containing 5B 0.0167457
HELB helicase (DNA) B 0.0166905
GGNBP2 gametogenetin binding protein 2 0.0166583
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0164955
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0164824
CLOCK clock circadian regulator 0.0164681
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0163534
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0163447
ZNF609 zinc finger protein 609 0.0163259
TPX2 TPX2, microtubule-associated 0.0162736
SNX6 sorting nexin 6 0.0160814
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0157858
UBA6 ubiquitin-like modifier activating enzyme 6 0.0156908
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0155585
KCMF1 potassium channel modulatory factor 1 0.0153935
KDM5A lysine (K)-specific demethylase 5A 0.0153255
ZNF207 zinc finger protein 207 0.0151394
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.01513
ANKRD36 ankyrin repeat domain 36 0.0151102
TMCC1 transmembrane and coiled-coil domain family 1 0.0150343
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0150068
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0150039
DIAPH1 diaphanous-related formin 1 0.0149627
BRWD1 bromodomain and WD repeat domain containing 1 0.0149385
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.014859
MARCHF7 membrane associated ring-CH-type finger 7 0.0147836
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0147375
EXOC1 exocyst complex component 1 0.014558
RICTOR RPTOR independent companion of MTOR, complex 2 0.0145559
PLAC8 placenta-specific 8 0.0144185
NBAS neuroblastoma amplified sequence 0.0143005
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0140771
NCKAP1 NCK-associated protein 1 0.0140617
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0139998
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0139605
AKAP10 A kinase (PRKA) anchor protein 10 0.0139408
UBE3C ubiquitin protein ligase E3C 0.0139294
CHD1L chromodomain helicase DNA binding protein 1-like 0.0139284
STXBP3 syntaxin binding protein 3 0.0139281
FNIP1 folliculin interacting protein 1 0.0139079
PNN pinin, desmosome associated protein 0.0138949
RNF213 ring finger protein 213 0.0138725
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0138556
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0137191
BICRAL BICRA like chromatin remodeling complex associated protein 0.0135638
MELK maternal embryonic leucine zipper kinase 0.0135394
ZNF638 zinc finger protein 638 0.0135215
GSK3B glycogen synthase kinase 3 beta 0.0134904
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0133146
NSD1 nuclear receptor binding SET domain protein 1 0.013296
ZNF462 zinc finger protein 462 0.0132796
RYK receptor-like tyrosine kinase 0.013271
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0132624

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.421139
TMSB10 thymosin beta 10 -0.187653
TFPI2 tissue factor pathway inhibitor 2 -0.132081
YBX3 Y box binding protein 3 -0.11587
RPLP1 ribosomal protein, large, P1 -0.0810834
TPT1 tumor protein, translationally-controlled 1 -0.0752414
TPI1 triosephosphate isomerase 1 -0.075216
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0741837
PTMA prothymosin, alpha -0.0709252
RPL37 ribosomal protein L37 -0.0703188
RPL12 ribosomal protein L12 -0.068719
RPL35A ribosomal protein L35a -0.0674672
RPS8 ribosomal protein S8 -0.0663073
RPL23 ribosomal protein L23 -0.0636084
RPS3 ribosomal protein S3 -0.0629173
RPL34 ribosomal protein L34 -0.061277
EGR1 early growth response 1 -0.0612122
MT2A metallothionein 2A -0.061127
TXNRD1 thioredoxin reductase 1 -0.0597735
RPS21 ribosomal protein S21 -0.0557003
TM4SF1 transmembrane 4 L six family member 1 -0.0556213
RPS19 ribosomal protein S19 -0.0555244
RPL26 ribosomal protein L26 -0.0544706
RPL38 ribosomal protein L38 -0.0535965
RPL32 ribosomal protein L32 -0.0535047
RPS27 ribosomal protein S27 -0.0530535
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0525093
FTL ferritin, light polypeptide -0.0523542
RACK1 receptor for activated C kinase 1 -0.0509883
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0505229
RPS15 ribosomal protein S15 -0.0504168
RPL31 ribosomal protein L31 -0.0500207
RPL8 ribosomal protein L8 -0.0493407
RPL19 ribosomal protein L19 -0.049133
RPL5 ribosomal protein L5 -0.0481272
IGF1R insulin-like growth factor 1 receptor -0.0474526
NACA nascent polypeptide-associated complex alpha subunit -0.0473363
RPL36 ribosomal protein L36 -0.0467701
RPL37A ribosomal protein L37a -0.0466312
RPS29 ribosomal protein S29 -0.0464633
RPLP2 ribosomal protein, large, P2 -0.0464386
RPLP0 ribosomal protein, large, P0 -0.0460713
EIF1 eukaryotic translation initiation factor 1 -0.0460438
ENO1 enolase 1, (alpha) -0.0446511
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0441252
EEF2 eukaryotic translation elongation factor 2 -0.0432905
ACTG1 actin gamma 1 -0.0428763
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0428012
RPL13A ribosomal protein L13a -0.04191
MYL12B myosin, light chain 12B, regulatory -0.0418942
OSMR oncostatin M receptor -0.0406487
RPL35 ribosomal protein L35 -0.0403583
ATP5F1E ATP synthase F1 subunit epsilon -0.0394082
RPL9 ribosomal protein L9 -0.0392324
RPS27A ribosomal protein S27a -0.0385768
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0385433
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0380567
RPS6 ribosomal protein S6 -0.0377354
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0375876
RPS4X ribosomal protein S4, X-linked -0.0368135
RBM39 RNA binding motif protein 39 -0.0367181
RPL11 ribosomal protein L11 -0.0366792
VIM vimentin -0.0358433
LOC112694756 uncharaterized LOC112694756 -0.0356607
HLA-B major histocompatibility complex, class I, B -0.0353818
MORF4L2 mortality factor 4 like 2 -0.0342352
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0342181
NAP1L1 nucleosome assembly protein 1-like 1 -0.0341492
RPS17 ribosomal protein S17 -0.0338591
S100A11 S100 calcium binding protein A11 -0.0334928
YBX1 Y box binding protein 1 -0.0327698
RPL27 ribosomal protein L27 -0.0308605
KLF6 Kruppel-like factor 6 -0.0305436
RPS10 ribosomal protein S10 -0.0303227
DEK DEK proto-oncogene -0.029823
FUS FUS RNA binding protein -0.0296196
UBB ubiquitin B -0.0291562
RPL4 ribosomal protein L4 -0.0290556
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0285823
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0283355
RPS14 ribosomal protein S14 -0.0282282
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0279568
PRRC2C proline-rich coiled-coil 2C -0.0277193
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0271939
RPS24 ribosomal protein S24 -0.0269091
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0266612
RAB7A RAB7A, member RAS oncogene family -0.0265609
RPS23 ribosomal protein S23 -0.0264312
RPL27A ribosomal protein L27a -0.0260086
IFI6 interferon, alpha-inducible protein 6 -0.0257147
GSTP1 glutathione S-transferase pi 1 -0.0256095
RPS13 ribosomal protein S13 -0.0255873
ELL2 elongation factor, RNA polymerase II, 2 -0.0253696
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0252819
VDAC1 voltage-dependent anion channel 1 -0.0250042
BASP1 brain abundant, membrane attached signal protein 1 -0.0249886
B2M beta-2-microglobulin -0.024678
RPL30 ribosomal protein L30 -0.0246228
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0245564
IER3 immediate early response 3 -0.0241656