Carbidopa (monohydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.122431
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.112197
NDRG1 N-myc downstream regulated 1 0.0899587
FNDC3B fibronectin type III domain containing 3B 0.0688649
GRB10 growth factor receptor-bound protein 10 0.0672071
UBA6 ubiquitin-like modifier activating enzyme 6 0.0626906
RNF145 ring finger protein 145 0.052578
ELL2 elongation factor, RNA polymerase II, 2 0.0512461
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0491483
FAM13A family with sequence similarity 13, member A 0.0465613
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0432099
FAM3C family with sequence similarity 3, member C 0.0430305
CCNL1 cyclin L1 0.0423696
KMT2E lysine (K)-specific methyltransferase 2E 0.0404409
TFG TRK-fused gene 0.0370976
NPEPPS aminopeptidase puromycin sensitive 0.0353495
TRIO trio Rho guanine nucleotide exchange factor 0.035135
STRN3 striatin, calmodulin binding protein 3 0.033403
FXR1 fragile X mental retardation, autosomal homolog 1 0.0325671
MXD1 MAX dimerization protein 1 0.0296476
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0296131
USP3 ubiquitin specific peptidase 3 0.0293974
CDK17 cyclin-dependent kinase 17 0.0288942
COPA coatomer protein complex, subunit alpha 0.0286376
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0283828
NUP58 nucleoporin 58 0.0282547
ZNF292 zinc finger protein 292 0.0282314
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0278558
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0267449
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.026661
CDC73 cell division cycle 73 0.0265074
PRRC1 proline-rich coiled-coil 1 0.0262804
PTK2 protein tyrosine kinase 2 0.0261124
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0253322
RYBP RING1 and YY1 binding protein 0.0237651
NRIP1 nuclear receptor interacting protein 1 0.0237013
ADAM9 ADAM metallopeptidase domain 9 0.0233283
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0228926
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0226289
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0223617
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0220888
MARCHF6 membrane associated ring-CH-type finger 6 0.0216452
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.021628
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0206718
CPNE8 copine VIII 0.0206071
FOSL1 FOS-like antigen 1 0.0203866
NAMPT nicotinamide phosphoribosyltransferase 0.0201525
ARHGAP29 Rho GTPase activating protein 29 0.0200523
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0193778
UGCG UDP-glucose ceramide glucosyltransferase 0.018993
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0188095
ANXA5 annexin A5 0.0187392
FAM162A family with sequence similarity 162, member A 0.0186401
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0185261
TMEM165 transmembrane protein 165 0.0184417
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0183641
IGFBP3 insulin-like growth factor binding protein 3 0.0181768
TRAM1 translocation associated membrane protein 1 0.0180462
GARS1 glycyl-tRNA synthetase 1 0.0180155
ITCH itchy E3 ubiquitin protein ligase 0.0178637
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0177771
KDM6A lysine (K)-specific demethylase 6A 0.0176898
ATP13A3 ATPase type 13A3 0.0174669
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0173498
WAC WW domain containing adaptor with coiled-coil 0.0168159
RICTOR RPTOR independent companion of MTOR, complex 2 0.0164016
KMT2C lysine (K)-specific methyltransferase 2C 0.0162715
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0160862
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0160062
TOP1 topoisomerase (DNA) I 0.0157542
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0155417
TRA2B transformer 2 beta homolog (Drosophila) 0.015535
WDFY2 WD repeat and FYVE domain containing 2 0.0155208
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0155016
MRPS6 mitochondrial ribosomal protein S6 0.0153262
QKI QKI, KH domain containing, RNA binding 0.0153028
MYO1B myosin IB 0.0152783
MTMR3 myotubularin related protein 3 0.0151948
SEC23A Sec23 homolog A (S. cerevisiae) 0.0151522
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0150389
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0147382
ZNF207 zinc finger protein 207 0.0146764
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0146422
ECT2 epithelial cell transforming 2 0.0145153
MCTP2 multiple C2 domains, transmembrane 2 0.01421
PDE8A phosphodiesterase 8A 0.0141372
ATP11B ATPase, class VI, type 11B 0.0140839
RCOR1 REST corepressor 1 0.0139683
OSBPL3 oxysterol binding protein-like 3 0.013958
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0139296
HP1BP3 heterochromatin protein 1, binding protein 3 0.0138565
FERMT2 fermitin family member 2 0.0138336
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0138027
SSBP2 single-stranded DNA binding protein 2 0.0137599
KCTD9 potassium channel tetramerization domain containing 9 0.0137488
NPTN neuroplastin 0.013653
NKTR natural killer cell triggering receptor 0.0135811
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0135125
RNASE3 ribonuclease, RNase A family, 3 0.013409
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0133728

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.213759
TMSB10 thymosin beta 10 -0.172092
ACTG1 actin gamma 1 -0.137141
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135141
PTMA prothymosin, alpha -0.132274
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127176
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.127006
TPT1 tumor protein, translationally-controlled 1 -0.101186
RPLP1 ribosomal protein, large, P1 -0.097931
UBC ubiquitin C -0.0949175
POTEF POTE ankyrin domain family, member F -0.0884187
S100A6 S100 calcium binding protein A6 -0.0874797
LAMB3 laminin, beta 3 -0.0847589
SQSTM1 sequestosome 1 -0.0845319
RACK1 receptor for activated C kinase 1 -0.0821597
RPL23 ribosomal protein L23 -0.0818314
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0804864
ENO1 enolase 1, (alpha) -0.0758202
EIF1 eukaryotic translation initiation factor 1 -0.0753743
KRT7 keratin 7, type II -0.0752425
RPS3 ribosomal protein S3 -0.0743443
RPLP2 ribosomal protein, large, P2 -0.0725436
LAMC2 laminin, gamma 2 -0.0719691
RPL34 ribosomal protein L34 -0.0716982
RPL35A ribosomal protein L35a -0.070955
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0691442
RPS19 ribosomal protein S19 -0.068431
RPS8 ribosomal protein S8 -0.0683913
RPL12 ribosomal protein L12 -0.0650558
RPS23 ribosomal protein S23 -0.0647635
RPL8 ribosomal protein L8 -0.0641306
CALR calreticulin -0.059744
RPS29 ribosomal protein S29 -0.0586247
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0584808
RPLP0 ribosomal protein, large, P0 -0.0584675
ALCAM activated leukocyte cell adhesion molecule -0.0580738
TMSB4X thymosin beta 4, X-linked -0.0580409
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0577421
RPL37 ribosomal protein L37 -0.0576168
S100A10 S100 calcium binding protein A10 -0.0569314
FN1 fibronectin 1 -0.0557404
RPS27A ribosomal protein S27a -0.0545241
ISG15 ISG15 ubiquitin-like modifier -0.0543627
RPL32 ribosomal protein L32 -0.0520958
EXT1 exostosin glycosyltransferase 1 -0.0518487
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0517254
RPS6 ribosomal protein S6 -0.0516867
FTH1 ferritin, heavy polypeptide 1 -0.0505276
TM4SF1 transmembrane 4 L six family member 1 -0.0496394
RPS13 ribosomal protein S13 -0.0492872
RPL37A ribosomal protein L37a -0.0491324
CANX calnexin -0.0485774
HMGB2 high mobility group box 2 -0.0485618
RPL9 ribosomal protein L9 -0.0484578
IFI27 interferon, alpha-inducible protein 27 -0.0482585
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0482103
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0478338
VIM vimentin -0.0470665
RPS12 ribosomal protein S12 -0.0468468
FBXO32 F-box protein 32 -0.0461942
RPS27 ribosomal protein S27 -0.0460908
DSPP dentin sialophosphoprotein -0.0459146
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0458923
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0458817
RPL19 ribosomal protein L19 -0.0449345
RPL31 ribosomal protein L31 -0.044912
MYH9 myosin, heavy chain 9, non-muscle -0.0445785
RPL11 ribosomal protein L11 -0.0427426
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0423465
TPM4 tropomyosin 4 -0.0409767
LDHA lactate dehydrogenase A -0.0405457
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0396841
RPS14 ribosomal protein S14 -0.0395089
KRT18 keratin 18, type I -0.039142
RPL7 ribosomal protein L7 -0.0389393
HLA-A major histocompatibility complex, class I, A -0.0384869
RPL36 ribosomal protein L36 -0.0382839
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0381296
IFITM3 interferon induced transmembrane protein 3 -0.0378175
AHNAK AHNAK nucleoprotein -0.0375049
EEF2 eukaryotic translation elongation factor 2 -0.0374878
RPL27A ribosomal protein L27a -0.037083
RPS16 ribosomal protein S16 -0.0370038
MT2A metallothionein 2A -0.036936
S100A9 S100 calcium binding protein A9 -0.0368853
ANXA2 annexin A2 -0.0365153
RPS17 ribosomal protein S17 -0.0364202
CSTB cystatin B (stefin B) -0.0359626
CTSB cathepsin B -0.035938
IFI6 interferon, alpha-inducible protein 6 -0.0357625
LOC112694756 uncharaterized LOC112694756 -0.0352386
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0351363
RPL15 ribosomal protein L15 -0.0345961
SLC38A1 solute carrier family 38, member 1 -0.0340952
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.033921
RPS24 ribosomal protein S24 -0.0339031
LPP LIM domain containing preferred translocation partner in lipoma -0.0338301
LMNA lamin A/C -0.0336339
MCL1 myeloid cell leukemia 1 -0.0325464
RPL28 ribosomal protein L28 -0.0322536