| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.111915 |
| GRAMD1B | GRAM domain containing 1B | 0.111372 |
| TXNRD1 | thioredoxin reductase 1 | 0.0793799 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0770139 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0730819 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0649474 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0593844 |
| PTGR1 | prostaglandin reductase 1 | 0.0577543 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.056947 |
| NEK7 | NIMA-related kinase 7 | 0.049561 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0470511 |
| MFF | mitochondrial fission factor | 0.0470083 |
| TNPO1 | transportin 1 | 0.0425148 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0412909 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0409305 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0399858 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0390976 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0374858 |
| COL5A2 | collagen, type V, alpha 2 | 0.0371606 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.03679 |
| CENPF | centromere protein F, 350/400kDa | 0.0361391 |
| NRCAM | neuronal cell adhesion molecule | 0.0357433 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0352404 |
| RTN4 | reticulon 4 | 0.0348563 |
| EFNA5 | ephrin-A5 | 0.0346981 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.034545 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0339701 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0333171 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0315952 |
| OGA | O-GlcNAcase | 0.0315613 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0315436 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0307778 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.030386 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0295537 |
| MKI67 | marker of proliferation Ki-67 | 0.0291373 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0290987 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0289478 |
| PHIP | pleckstrin homology domain interacting protein | 0.0288472 |
| PRDX1 | peroxiredoxin 1 | 0.0284951 |
| CTSC | cathepsin C | 0.0284948 |
| ZNF292 | zinc finger protein 292 | 0.0284279 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0281607 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.027866 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0271642 |
| XPO1 | exportin 1 | 0.0266585 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0262303 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0253597 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0250381 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0246885 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0241307 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0240458 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0230119 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0229963 |
| MALT1 | MALT1 paracaspase | 0.022957 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0225887 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0225084 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0224871 |
| BDNF | brain-derived neurotrophic factor | 0.0222294 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0222185 |
| PRKD3 | protein kinase D3 | 0.0219007 |
| USP3 | ubiquitin specific peptidase 3 | 0.0218926 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0216091 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0215664 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0210668 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0208721 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.0204597 |
| ANLN | anillin, actin binding protein | 0.0203766 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0202772 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0201018 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0200179 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.019889 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0195857 |
| RNF145 | ring finger protein 145 | 0.0195129 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0193571 |
| MT2A | metallothionein 2A | 0.0193011 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0189969 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0188815 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0188249 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.018738 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0187347 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0186887 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0185063 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0181738 |
| MEF2C | myocyte enhancer factor 2C | 0.0179055 |
| CENPE | centromere protein E, 312kDa | 0.0178003 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0177527 |
| FAM13A | family with sequence similarity 13, member A | 0.0177271 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0174972 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0174682 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0174264 |
| DIAPH3 | diaphanous-related formin 3 | 0.0173969 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0172947 |
| CNTN1 | contactin 1 | 0.0172658 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.0172617 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0172586 |
| EPHA5 | EPH receptor A5 | 0.0172175 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0171611 |
| SSH1 | slingshot protein phosphatase 1 | 0.0170003 |
| KIF14 | kinesin family member 14 | 0.0169503 |
| KIF4A | kinesin family member 4A | 0.0168488 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.296847 |
| FN1 | fibronectin 1 | -0.290518 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.177165 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.134501 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.116602 |
| CDH13 | cadherin 13 | -0.0999681 |
| VIM | vimentin | -0.0827876 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0808701 |
| CANX | calnexin | -0.0765319 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0724472 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0702984 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0631373 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.060956 |
| MCL1 | myeloid cell leukemia 1 | -0.0588402 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0586767 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0552616 |
| TMSB10 | thymosin beta 10 | -0.0538436 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0509918 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.049892 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0486816 |
| EGR1 | early growth response 1 | -0.0468954 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.046025 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.043143 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0425449 |
| PCBP3 | poly(rC) binding protein 3 | -0.041516 |
| DNER | delta/notch-like EGF repeat containing | -0.0397869 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0396747 |
| CUX1 | cut-like homeobox 1 | -0.0395917 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0389627 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0381107 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0380262 |
| SMAD2 | SMAD family member 2 | -0.0371103 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0365336 |
| IL6 | interleukin 6 | -0.0365225 |
| DENND1A | DENN/MADD domain containing 1A | -0.0354322 |
| AUTS2 | autism susceptibility candidate 2 | -0.0346132 |
| NCKAP5 | NCK-associated protein 5 | -0.0343136 |
| VCL | vinculin | -0.0339256 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0334033 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0325988 |
| RPL31 | ribosomal protein L31 | -0.0324473 |
| FNIP1 | folliculin interacting protein 1 | -0.032168 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0321015 |
| HLA-A | major histocompatibility complex, class I, A | -0.0316581 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0316382 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0314689 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0311809 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.031034 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0309942 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0304035 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0300708 |
| SQSTM1 | sequestosome 1 | -0.0298101 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0295849 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0294737 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0291067 |
| HDLBP | high density lipoprotein binding protein | -0.0289423 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0289191 |
| STEAP1B | STEAP family member 1B | -0.0284248 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.027802 |
| HDAC4 | histone deacetylase 4 | -0.0276556 |
| CALR | calreticulin | -0.0269434 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0267945 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0267222 |
| HLA-B | major histocompatibility complex, class I, B | -0.0265345 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0264142 |
| SFTPA2 | surfactant protein A2 | -0.0262769 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0262271 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0262048 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.025954 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0257608 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0256643 |
| STC1 | stanniocalcin 1 | -0.0252636 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0250161 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0249931 |
| COPA | coatomer protein complex, subunit alpha | -0.0249606 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0248222 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0243768 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0242006 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0236113 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0233352 |
| S100A6 | S100 calcium binding protein A6 | -0.0232468 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0231391 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0229621 |
| TPM4 | tropomyosin 4 | -0.0228978 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0226524 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0226375 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0225967 |
| GRB10 | growth factor receptor-bound protein 10 | -0.022544 |
| FMNL2 | formin-like 2 | -0.0224938 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0221086 |
| SMYD3 | SET and MYND domain containing 3 | -0.0220963 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0219262 |
| INHBA | inhibin, beta A | -0.02172 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0216274 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0215978 |
| RAB31 | RAB31, member RAS oncogene family | -0.0215921 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0213837 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0213057 |
| B2M | beta-2-microglobulin | -0.0212485 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0211336 |
