Carbidopa (monohydrate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

193 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COG5 component of oligomeric golgi complex 5 0.166907
ESYT2 extended synaptotagmin-like protein 2 0.152643
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.148495
ZCCHC7 zinc finger, CCHC domain containing 7 0.143325
ELL2 elongation factor, RNA polymerase II, 2 0.140356
WDFY2 WD repeat and FYVE domain containing 2 0.139094
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.137797
FN1 fibronectin 1 0.13749
RPLP1 ribosomal protein, large, P1 0.13317
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.131844
NUMB numb homolog (Drosophila) 0.124687
RUNX1 runt-related transcription factor 1 0.121718
FRMD5 FERM domain containing 5 0.118363
SBF2 SET binding factor 2 0.113897
FNDC3A fibronectin type III domain containing 3A 0.111906
CSNK1A1 casein kinase 1, alpha 1 0.108827
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.105713
PRKCA protein kinase C, alpha 0.105336
TMSB10 thymosin beta 10 0.0947616
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0917721
STC1 stanniocalcin 1 0.0894194
PDE4D phosphodiesterase 4D, cAMP-specific 0.0891002
AOPEP aminopeptidase O (putative) 0.0830245
NAV2 neuron navigator 2 0.0819844
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0807417
B2M beta-2-microglobulin 0.0756273
EFNA5 ephrin-A5 0.0749638
NF1 neurofibromin 1 0.0640427
FMNL2 formin-like 2 0.0637554
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0625713
TXNRD1 thioredoxin reductase 1 0.0619644
CARD16 caspase recruitment domain family, member 16 0.0617049
PKM pyruvate kinase, muscle 0.0597743
PGK1 phosphoglycerate kinase 1 0.0593258
USP34 ubiquitin specific peptidase 34 0.0590717
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0587396
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0585948
OGA O-GlcNAcase 0.0585478
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0576516
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0554564
CMIP c-Maf inducing protein 0.0533319
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0502415
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0479361
PRRC2C proline-rich coiled-coil 2C 0.0476226
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0471391
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0444276
KMT2C lysine (K)-specific methyltransferase 2C 0.0407194
FNIP1 folliculin interacting protein 1 0.0395999
AKAP9 A kinase (PRKA) anchor protein 9 0.0386507
PTK2 protein tyrosine kinase 2 0.0381951
AKAP13 A kinase (PRKA) anchor protein 13 0.0362023
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0350316
PUM2 pumilio RNA-binding family member 2 0.0344905
RPL15 ribosomal protein L15 0.0343196
ANKRD12 ankyrin repeat domain 12 0.0337585
TBC1D22A TBC1 domain family, member 22A 0.0337425
TRIO trio Rho guanine nucleotide exchange factor 0.0317669
GOLGA4 golgin A4 0.0315907
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0315101
SETD5 SET domain containing 5 0.0305161
ENO1 enolase 1, (alpha) 0.0290446
GPC6 glypican 6 0.0289002
CANX calnexin 0.0254223
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0253051
JMJD1C jumonji domain containing 1C 0.0251607
AKAP12 A kinase (PRKA) anchor protein 12 0.0240095
LPP LIM domain containing preferred translocation partner in lipoma 0.0232916
ERRFI1 ERBB receptor feedback inhibitor 1 0.0225868
TTC3 tetratricopeptide repeat domain 3 0.0222258
MYH9 myosin, heavy chain 9, non-muscle 0.0220582
MARCHF6 membrane associated ring-CH-type finger 6 0.0206019
KTN1 kinectin 1 (kinesin receptor) 0.0197897
PTPRM protein tyrosine phosphatase, receptor type, M 0.0182552
FUBP1 far upstream element (FUSE) binding protein 1 0.018121
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.016761
HELZ helicase with zinc finger 0.0159643
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0135369
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0128746
CNKSR3 CNKSR family member 3 0.0115872
VCL vinculin 0.00988023
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.00924364
MYOF myoferlin 0.00914594
FBXO11 F-box protein 11 0.00742287
SND1 staphylococcal nuclease and tudor domain containing 1 0.00669907
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.00641178
NKD1 naked cuticle homolog 1 (Drosophila) 0.00417485
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.00300037
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.00294328
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00232791
RPL7 ribosomal protein L7 0.00202944
DST dystonin 0.00110131
SYAP1 synapse associated protein 1 4.36602E-4
INTS6 integrator complex subunit 6 1.714E-4

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.166829
PTMA prothymosin, alpha -0.147886
NDRG1 N-myc downstream regulated 1 -0.140267
RPS8 ribosomal protein S8 -0.132907
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.119162
IGF2 insulin-like growth factor 2 -0.117876
TENM3 teneurin transmembrane protein 3 -0.113134
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.110803
IGFBP3 insulin-like growth factor binding protein 3 -0.110076
ACTG1 actin gamma 1 -0.106616
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106373
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105701
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0999655
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0956433
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0924491
RPL19 ribosomal protein L19 -0.0907375
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0905832
MED13L mediator complex subunit 13-like -0.084398
NAP1L1 nucleosome assembly protein 1-like 1 -0.0832423
RAP1B RAP1B, member of RAS oncogene family -0.0822596
GLS2 glutaminase 2 (liver, mitochondrial) -0.0814391
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0800352
RORA RAR-related orphan receptor A -0.0761181
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0752184
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0735251
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0720697
NCOR1 nuclear receptor corepressor 1 -0.0714329
RPL23 ribosomal protein L23 -0.0699819
VMP1 vacuole membrane protein 1 -0.0696297
VIM vimentin -0.0678795
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0614622
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0604806
EIF1 eukaryotic translation initiation factor 1 -0.0577339
FLNB filamin B, beta -0.057539
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0570868
NCOA3 nuclear receptor coactivator 3 -0.0539241
RPS6 ribosomal protein S6 -0.0528724
HDLBP high density lipoprotein binding protein -0.0528386
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0511649
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0481874
MBD5 methyl-CpG binding domain protein 5 -0.0479178
SQSTM1 sequestosome 1 -0.0477086
FNDC3B fibronectin type III domain containing 3B -0.0474152
GRB10 growth factor receptor-bound protein 10 -0.0467695
ZBTB20 zinc finger and BTB domain containing 20 -0.0461734
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0460684
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0447929
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0441737
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0421953
TPT1 tumor protein, translationally-controlled 1 -0.0418591
MSI2 musashi RNA-binding protein 2 -0.0418497
SMYD3 SET and MYND domain containing 3 -0.0410065
DLG1 discs, large homolog 1 (Drosophila) -0.0409933
TRA2A transformer 2 alpha homolog (Drosophila) -0.0402909
ZFAND3 zinc finger, AN1-type domain 3 -0.0397813
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0354836
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0354388
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0352849
NAMPT nicotinamide phosphoribosyltransferase -0.0352453
CD2AP CD2-associated protein -0.0343505
AFDN afadin, adherens junction formation factor -0.0342544
NALF1 NALCN channel auxiliary factor 1 -0.0326129
FAM162A family with sequence similarity 162, member A -0.0311355
ANKRD11 ankyrin repeat domain 11 -0.0308434
ANXA2 annexin A2 -0.0306503
MAML2 mastermind-like 2 (Drosophila) -0.0299308
MACF1 microtubule-actin crosslinking factor 1 -0.0295384
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0283228
HMGA2 high mobility group AT-hook 2 -0.027435
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0273569
SLC38A2 solute carrier family 38, member 2 -0.0267113
EXT1 exostosin glycosyltransferase 1 -0.0255941
EGR1 early growth response 1 -0.0252357
AHNAK AHNAK nucleoprotein -0.0248484
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0247769
ZNF638 zinc finger protein 638 -0.0246362
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0240839
MYO1E myosin IE -0.0236912
RPL9 ribosomal protein L9 -0.0236414
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0235551
ASPH aspartate beta-hydroxylase -0.0220526
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0216905
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0211848
RB1CC1 RB1-inducible coiled-coil 1 -0.0207888
GLG1 golgi glycoprotein 1 -0.0207086
RBM39 RNA binding motif protein 39 -0.0200248
SOS1 son of sevenless homolog 1 (Drosophila) -0.0180224
RPS19 ribosomal protein S19 -0.0180192
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0172401
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0166557
RABGAP1L RAB GTPase activating protein 1-like -0.0163876
ZNF292 zinc finger protein 292 -0.0151209
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0130414
DSCAM Down syndrome cell adhesion molecule -0.0123968
ITCH itchy E3 ubiquitin protein ligase -0.0123013
SYT1 synaptotagmin I -0.0122876
POTEF POTE ankyrin domain family, member F -0.0121589
HMGA1 high mobility group AT-hook 1 -0.00937936
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.00919529
DENND1A DENN/MADD domain containing 1A -0.00886563