Carbidopa (monohydrate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.130174
ZFAND3 zinc finger, AN1-type domain 3 0.0810483
TSC22D2 TSC22 domain family, member 2 0.0733887
KMT2C lysine (K)-specific methyltransferase 2C 0.0667494
TRIO trio Rho guanine nucleotide exchange factor 0.0652855
ADAM9 ADAM metallopeptidase domain 9 0.0639355
ZEB2 zinc finger E-box binding homeobox 2 0.063253
SRP54 signal recognition particle 54kDa 0.054643
MTF2 metal response element binding transcription factor 2 0.0541589
SPAG9 sperm associated antigen 9 0.0499244
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0469789
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.044365
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0438482
PRR16 proline rich 16 0.0410883
AKAP9 A kinase (PRKA) anchor protein 9 0.0408383
KDM6A lysine (K)-specific demethylase 6A 0.0402316
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.039951
PCBP2 poly(rC) binding protein 2 0.0390678
NAMPT nicotinamide phosphoribosyltransferase 0.0390122
PLPP1 phospholipid phosphatase 1 0.0380063
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0376526
CDC73 cell division cycle 73 0.0373329
PUM2 pumilio RNA-binding family member 2 0.0357208
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0354438
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0351522
FXR1 fragile X mental retardation, autosomal homolog 1 0.034616
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0345707
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0345678
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0344654
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0344131
EVI5 ecotropic viral integration site 5 0.034151
PDS5B PDS5 cohesin associated factor B 0.0340747
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0339878
MB21D2 Mab-21 domain containing 2 0.0339592
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0334809
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0333913
ARHGAP15 Rho GTPase activating protein 15 0.0332211
MIER1 mesoderm induction early response 1, transcriptional regulator 0.03317
STRN3 striatin, calmodulin binding protein 3 0.0320754
CPNE8 copine VIII 0.0319861
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0319539
IGF1R insulin-like growth factor 1 receptor 0.0309989
GLS2 glutaminase 2 (liver, mitochondrial) 0.0307093
PDGFC platelet derived growth factor C 0.0302185
NCKAP1 NCK-associated protein 1 0.0299026
FNDC3B fibronectin type III domain containing 3B 0.0298978
NPEPPS aminopeptidase puromycin sensitive 0.0296089
TRPS1 trichorhinophalangeal syndrome I 0.029554
U2SURP U2 snRNP-associated SURP domain containing 0.0294319
INTS13 integrator complex subunit 13 0.0292617
THOC2 THO complex 2 0.0292203
MON2 MON2 homolog (S. cerevisiae) 0.0291472
TBC1D12 TBC1 domain family, member 12 0.0288254
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0288183
RBM26 RNA binding motif protein 26 0.0286849
MYO10 myosin X 0.0284661
ATP11B ATPase, class VI, type 11B 0.0283765
MED13L mediator complex subunit 13-like 0.028281
ZNF207 zinc finger protein 207 0.028191
CAMKMT calmodulin-lysine N-methyltransferase 0.0280041
ADGRL3 adhesion G protein-coupled receptor L3 0.027979
ECT2 epithelial cell transforming 2 0.0279747
RIOK3 RIO kinase 3 0.0275276
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.027492
CLASP2 cytoplasmic linker associated protein 2 0.0273326
XPO1 exportin 1 0.0272446
AHCTF1 AT hook containing transcription factor 1 0.0270624
RYBP RING1 and YY1 binding protein 0.0268
RASAL2 RAS protein activator like 2 0.0267876
TCERG1 transcription elongation regulator 1 0.0265878
TENM2 teneurin transmembrane protein 2 0.0265632
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.026195
CLINT1 clathrin interactor 1 0.0261886
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0260712
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0256361
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0256259
WDR43 WD repeat domain 43 0.0256165
RFX7 regulatory factor X, 7 0.025614
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0253253
PAXBP1 PAX3 and PAX7 binding protein 1 0.0252132
TMEM64 transmembrane protein 64 0.0251196
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0249839
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0249688
IWS1 IWS1 homolog (S. cerevisiae) 0.0249566
ITGAV integrin, alpha V 0.0249033
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0247983
FAM168A family with sequence similarity 168, member A 0.0247059
RPL21 ribosomal protein L21 0.0246897
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0245144
SRPK2 SRSF protein kinase 2 0.0245088
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0244941
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0242549
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0242304
ASXL1 additional sex combs like transcriptional regulator 1 0.024074
SOX5 SRY (sex determining region Y)-box 5 0.024021
LAMP2 lysosomal-associated membrane protein 2 0.0237138
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0236138
GPBP1 GC-rich promoter binding protein 1 0.0235673
TMEM123 transmembrane protein 123 0.0234927
RNF130 ring finger protein 130 0.0234859

decreased expression

Symbol Name Standardized Value
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.197805
COL11A1 collagen, type XI, alpha 1 -0.19184
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.125733
VIM vimentin -0.115146
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.113826
TMSB10 thymosin beta 10 -0.109557
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.104527
RPS16 ribosomal protein S16 -0.0982416
PCDH9 protocadherin 9 -0.0949339
ACTG1 actin gamma 1 -0.093339
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0884543
RPS8 ribosomal protein S8 -0.0881205
WSB1 WD repeat and SOCS box containing 1 -0.084906
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0715669
RPS6 ribosomal protein S6 -0.0705135
TPT1 tumor protein, translationally-controlled 1 -0.0645577
GNAS GNAS complex locus -0.0644535
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0630682
LDHA lactate dehydrogenase A -0.0630437
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.060099
MDK midkine (neurite growth-promoting factor 2) -0.0600673
PTMA prothymosin, alpha -0.0599289
ENO1 enolase 1, (alpha) -0.0587165
RPLP1 ribosomal protein, large, P1 -0.056062
LOC102724023 ES1 protein homolog, mitochondrial -0.0555488
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0546281
AHNAK AHNAK nucleoprotein -0.053876
SOX2 SRY (sex determining region Y)-box 2 -0.0523046
COL3A1 collagen, type III, alpha 1 -0.0522768
RPL11 ribosomal protein L11 -0.0498702
RPL35A ribosomal protein L35a -0.0498492
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0482396
FTL ferritin, light polypeptide -0.0478039
MYL12B myosin, light chain 12B, regulatory -0.0473319
PDIA3 protein disulfide isomerase family A, member 3 -0.0463772
PGK1 phosphoglycerate kinase 1 -0.0463102
CALR calreticulin -0.0447114
SFRP4 secreted frizzled-related protein 4 -0.0446114
ADGRV1 adhesion G protein-coupled receptor V1 -0.0443767
NEBL nebulette -0.0443681
RPL37 ribosomal protein L37 -0.0419497
RAD51B RAD51 paralog B -0.041264
THBS1 thrombospondin 1 -0.0409875
RACK1 receptor for activated C kinase 1 -0.0400358
RPS3 ribosomal protein S3 -0.0398884
CNRIP1 cannabinoid receptor interacting protein 1 -0.0395323
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.03908
H1-0 H1.0 linker histone -0.0384707
PCLO piccolo presynaptic cytomatrix protein -0.0382542
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0380927
SLIT2 slit homolog 2 (Drosophila) -0.0378622
RPL19 ribosomal protein L19 -0.0372225
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0371323
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0362118
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0359587
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0346687
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0344777
RPS2 ribosomal protein S2 -0.0343938
RPL7A ribosomal protein L7a -0.0337379
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0337087
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0333296
HMCN1 hemicentin 1 -0.0332884
LIMS1 LIM and senescent cell antigen-like domains 1 -0.033257
CAVIN1 caveolae associated protein 1 -0.0327631
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0326876
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0326627
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0326561
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0319985
SIK2 salt-inducible kinase 2 -0.0318682
MACF1 microtubule-actin crosslinking factor 1 -0.0313096
RPS19 ribosomal protein S19 -0.0312554
MYADM myeloid-associated differentiation marker -0.0309343
RPL34 ribosomal protein L34 -0.0309279
ARF1 ADP-ribosylation factor 1 -0.0308695
RPLP0 ribosomal protein, large, P0 -0.0307903
COL1A2 collagen, type I, alpha 2 -0.0305197
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0304492
RPL30 ribosomal protein L30 -0.0304053
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0297368
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0297083
RPL32 ribosomal protein L32 -0.0296943
NACA nascent polypeptide-associated complex alpha subunit -0.0296136
ANXA1 annexin A1 -0.0293057
RPL36 ribosomal protein L36 -0.0292406
SLC44A5 solute carrier family 44, member 5 -0.0291973
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0291289
TTC3 tetratricopeptide repeat domain 3 -0.0288343
HMGA2 high mobility group AT-hook 2 -0.0287979
RPS25 ribosomal protein S25 -0.0283453
SREBF2 sterol regulatory element binding transcription factor 2 -0.0280888
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0280539
S100A9 S100 calcium binding protein A9 -0.0276724
EEF2 eukaryotic translation elongation factor 2 -0.0275464
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0274682
RPL28 ribosomal protein L28 -0.0274078
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0271893
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0271237
WASF2 WAS protein family, member 2 -0.0269031
SERF2 small EDRK-rich factor 2 -0.0268425