| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.321618 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.185704 |
| VIM | vimentin | 0.171722 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.150047 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.115521 |
| FNDC3B | fibronectin type III domain containing 3B | 0.102252 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0930503 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0733902 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0728427 |
| SEPTIN9 | septin 9 | 0.0682603 |
| DST | dystonin | 0.0676567 |
| SMAD3 | SMAD family member 3 | 0.067098 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0667967 |
| AFAP1 | actin filament associated protein 1 | 0.066275 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0644099 |
| ZNF292 | zinc finger protein 292 | 0.0643647 |
| MYOF | myoferlin | 0.0634655 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0629589 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0614111 |
| CDK19 | cyclin-dependent kinase 19 | 0.0612089 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0598997 |
| ACTN4 | actinin, alpha 4 | 0.056057 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0550683 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0538549 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0528937 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0527528 |
| ANGPTL4 | angiopoietin-like 4 | 0.0516423 |
| FOSL1 | FOS-like antigen 1 | 0.0511824 |
| PTK2 | protein tyrosine kinase 2 | 0.0492865 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0472544 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.046614 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0463327 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0458888 |
| ZNF638 | zinc finger protein 638 | 0.0456032 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0441346 |
| MED13L | mediator complex subunit 13-like | 0.0441302 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0438253 |
| SNX14 | sorting nexin 14 | 0.0436448 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0428268 |
| RTN4 | reticulon 4 | 0.0427548 |
| FBXO17 | F-box protein 17 | 0.0419712 |
| EGFR | epidermal growth factor receptor | 0.0407204 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 0.0406884 |
| NAV2 | neuron navigator 2 | 0.0406117 |
| CDCP1 | CUB domain containing protein 1 | 0.040295 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0399549 |
| FBL | fibrillarin | 0.0398603 |
| XPO1 | exportin 1 | 0.039724 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.039086 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0385646 |
| SBF2 | SET binding factor 2 | 0.0378699 |
| PKM | pyruvate kinase, muscle | 0.0375267 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0373796 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0371638 |
| ASPH | aspartate beta-hydroxylase | 0.0355071 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0349553 |
| YAP1 | Yes-associated protein 1 | 0.0347307 |
| RNF220 | ring finger protein 220 | 0.0346557 |
| PRELID2 | PRELI domain containing 2 | 0.0346545 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0346417 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0345749 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0343746 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0341811 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0341136 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.033515 |
| NHSL1 | NHS-like 1 | 0.0329008 |
| OGA | O-GlcNAcase | 0.032532 |
| JMJD1C | jumonji domain containing 1C | 0.0323235 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0322601 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0320853 |
| ATXN1 | ataxin 1 | 0.0320267 |
| TNS3 | tensin 3 | 0.0314652 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0309377 |
| CD109 | CD109 molecule | 0.030437 |
| TMEM123 | transmembrane protein 123 | 0.0303523 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.0301656 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0299955 |
| THOC2 | THO complex 2 | 0.0297588 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0297438 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.029292 |
| FMNL2 | formin-like 2 | 0.0286932 |
| MEF2A | myocyte enhancer factor 2A | 0.0283203 |
| CEP170 | centrosomal protein 170kDa | 0.0282607 |
| CCDC88A | coiled-coil domain containing 88A | 0.0281985 |
| PGK1 | phosphoglycerate kinase 1 | 0.0280945 |
| YEATS2 | YEATS domain containing 2 | 0.0280912 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0279003 |
| CENPF | centromere protein F, 350/400kDa | 0.0279 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0278476 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0277983 |
| SYNJ2 | synaptojanin 2 | 0.0277597 |
| UTRN | utrophin | 0.0277529 |
| SLC35F3 | solute carrier family 35, member F3 | 0.027748 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0277005 |
| ZNF780B | zinc finger protein 780B | 0.0270025 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0268497 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0268341 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0264597 |
| PDE10A | phosphodiesterase 10A | 0.0264561 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0264163 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.185521 |
| RPS16 | ribosomal protein S16 | -0.0771289 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0751791 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0677091 |
| EGR1 | early growth response 1 | -0.0572939 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0353352 |
| RPLP0 | ribosomal protein, large, P0 | -0.0344446 |
| FTL | ferritin, light polypeptide | -0.0342147 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0325113 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0322166 |
| TMSB10 | thymosin beta 10 | -0.0320489 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | -0.0317744 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0316134 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0312408 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0303539 |
| MORF4L2 | mortality factor 4 like 2 | -0.0302658 |
| MYO1E | myosin IE | -0.0301952 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0294324 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0288014 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0287018 |
| H1-0 | H1.0 linker histone | -0.0285046 |
| RPL35A | ribosomal protein L35a | -0.0259395 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0251465 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0247587 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0232359 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0232111 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0228945 |
| RSU1 | Ras suppressor protein 1 | -0.0221596 |
| ACTG1 | actin gamma 1 | -0.0218709 |
| RPL12 | ribosomal protein L12 | -0.0218525 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0214797 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0205737 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0204305 |
| PMM2 | phosphomannomutase 2 | -0.0201772 |
| ATF6 | activating transcription factor 6 | -0.0195509 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0194459 |
| HDLBP | high density lipoprotein binding protein | -0.018865 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0186714 |
| NUP98 | nucleoporin 98kDa | -0.0186655 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0184517 |
| ARF1 | ADP-ribosylation factor 1 | -0.0182005 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0181676 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0180593 |
| INTS6 | integrator complex subunit 6 | -0.0175594 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0173462 |
| BMP6 | bone morphogenetic protein 6 | -0.0172187 |
| NABP1 | nucleic acid binding protein 1 | -0.0170927 |
| USP15 | ubiquitin specific peptidase 15 | -0.0169319 |
| ATF3 | activating transcription factor 3 | -0.0168645 |
| BRD2 | bromodomain containing 2 | -0.0165957 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.0165684 |
| ZNF644 | zinc finger protein 644 | -0.0165111 |
| HMGB2 | high mobility group box 2 | -0.0165036 |
| NUP58 | nucleoporin 58 | -0.0162329 |
| PDLIM5 | PDZ and LIM domain 5 | -0.016031 |
| HDAC9 | histone deacetylase 9 | -0.0159126 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0154671 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -0.015319 |
| RPL4 | ribosomal protein L4 | -0.015288 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0152131 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0150875 |
| RPL35 | ribosomal protein L35 | -0.0150412 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0149112 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0148539 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | -0.0147293 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0146685 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0145389 |
| CALU | calumenin | -0.014508 |
| ARF4 | ADP-ribosylation factor 4 | -0.0144635 |
| CRY1 | cryptochrome circadian clock 1 | -0.01435 |
| WDR45B | WD repeat domain 45B | -0.0143202 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0143052 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0142377 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0141082 |
| FN1 | fibronectin 1 | -0.0140921 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | -0.0140307 |
| RPLP1 | ribosomal protein, large, P1 | -0.0140145 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0138734 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0137854 |
| COPA | coatomer protein complex, subunit alpha | -0.0137555 |
| GOLT1A | golgi transport 1A | -0.0137256 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.013631 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0133885 |
| RPS5 | ribosomal protein S5 | -0.013277 |
| RPL13A | ribosomal protein L13a | -0.0132296 |
| S100A10 | S100 calcium binding protein A10 | -0.0132026 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0131753 |
| JUN | jun proto-oncogene | -0.0131556 |
| SERINC1 | serine incorporator 1 | -0.0130825 |
| CLINT1 | clathrin interactor 1 | -0.0130457 |
| JAK1 | Janus kinase 1 | -0.0130256 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0128508 |
| RPL34 | ribosomal protein L34 | -0.0128479 |
| CAVIN1 | caveolae associated protein 1 | -0.0126914 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0125823 |
| CLTC | clathrin, heavy chain (Hc) | -0.0124905 |
| CLTA | clathrin, light chain A | -0.0124892 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0123364 |
| FERMT2 | fermitin family member 2 | -0.0123158 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0122357 |
