Carbidopa (monohydrate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYO6 myosin VI 0.0870785
ERRFI1 ERBB receptor feedback inhibitor 1 0.0599154
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.054576
OGA O-GlcNAcase 0.0520453
FAM3C family with sequence similarity 3, member C 0.0474236
LAMC2 laminin, gamma 2 0.0420769
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0418948
ARHGAP29 Rho GTPase activating protein 29 0.0409501
KDM3A lysine (K)-specific demethylase 3A 0.0375671
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0367158
CANX calnexin 0.0343387
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0328101
DSCAM Down syndrome cell adhesion molecule 0.0319685
XPO1 exportin 1 0.0304444
NRIP1 nuclear receptor interacting protein 1 0.0298188
BZW1 basic leucine zipper and W2 domains 1 0.0278122
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0273155
KDM6A lysine (K)-specific demethylase 6A 0.0264317
FNDC3B fibronectin type III domain containing 3B 0.026307
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0258553
NAV2 neuron navigator 2 0.0254674
ATP13A3 ATPase type 13A3 0.0240876
ITCH itchy E3 ubiquitin protein ligase 0.023511
ELL2 elongation factor, RNA polymerase II, 2 0.0234269
NCEH1 neutral cholesterol ester hydrolase 1 0.0231082
SPAG9 sperm associated antigen 9 0.0227263
ZFAND3 zinc finger, AN1-type domain 3 0.0225906
ECT2 epithelial cell transforming 2 0.0219593
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0218239
NPEPPS aminopeptidase puromycin sensitive 0.0215672
HMGB2 high mobility group box 2 0.0212757
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.020896
USP9X ubiquitin specific peptidase 9, X-linked 0.0205792
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0203671
ARRDC3 arrestin domain containing 3 0.0201614
RNF149 ring finger protein 149 0.020107
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0199558
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0198559
SOCS5 suppressor of cytokine signaling 5 0.019766
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0193787
SAMD4A sterile alpha motif domain containing 4A 0.0191668
DSPP dentin sialophosphoprotein 0.0188576
CALR calreticulin 0.0186565
HDLBP high density lipoprotein binding protein 0.0186286
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0185291
DDIT4 DNA-damage-inducible transcript 4 0.0183949
KRT17 keratin 17, type I 0.0183472
VCL vinculin 0.0183016
MYH9 myosin, heavy chain 9, non-muscle 0.0182244
NCOA3 nuclear receptor coactivator 3 0.0181884
TM9SF2 transmembrane 9 superfamily member 2 0.0181604
TMEM123 transmembrane protein 123 0.0179904
ANLN anillin, actin binding protein 0.0179475
CDC27 cell division cycle 27 0.017893
HBP1 HMG-box transcription factor 1 0.0178721
EIF4A2 eukaryotic translation initiation factor 4A2 0.0178449
RAD21 RAD21 homolog (S. pombe) 0.0177423
SLMAP sarcolemma associated protein 0.0176681
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0176181
TFG TRK-fused gene 0.017427
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0174169
USP3 ubiquitin specific peptidase 3 0.0172634
CTNND1 catenin (cadherin-associated protein), delta 1 0.0170083
ELP2 elongator acetyltransferase complex subunit 2 0.0169984
SMAD3 SMAD family member 3 0.016592
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0165569
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0164691
FAM168A family with sequence similarity 168, member A 0.0164359
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0164181
TNIP1 TNFAIP3 interacting protein 1 0.0161658
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0161305
MACF1 microtubule-actin crosslinking factor 1 0.0160409
FAM107B family with sequence similarity 107, member B 0.0160314
FAR1 fatty acyl CoA reductase 1 0.0159273
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.015773
JARID2 jumonji, AT rich interactive domain 2 0.0156891
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0155777
PUM2 pumilio RNA-binding family member 2 0.0154198
CKAP5 cytoskeleton associated protein 5 0.0154083
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0153598
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0152546
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0152299
UBQLN1 ubiquilin 1 0.0151501
PDIA4 protein disulfide isomerase family A, member 4 0.0151484
RBM26 RNA binding motif protein 26 0.015052
CEP95 centrosomal protein 95kDa 0.0149315
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0148819
UBA6 ubiquitin-like modifier activating enzyme 6 0.0148652
NIPBL Nipped-B homolog (Drosophila) 0.0147598
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0147588
AFF4 AF4/FMR2 family, member 4 0.014599
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0145545
SERINC1 serine incorporator 1 0.0144207
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0144105
THOC2 THO complex 2 0.0143956
COPB1 coatomer protein complex, subunit beta 1 0.0142248
ATOSA atos homolog A 0.014185
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0141667
NUMA1 nuclear mitotic apparatus protein 1 0.0141538
DENND4C DENN/MADD domain containing 4C 0.0140922

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.498112
RPS6 ribosomal protein S6 -0.139154
TMSB10 thymosin beta 10 -0.132638
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.106578
MUC4 mucin 4, cell surface associated -0.102528
RPL35A ribosomal protein L35a -0.10152
IFI27 interferon, alpha-inducible protein 27 -0.101418
MT2A metallothionein 2A -0.101118
RPS19 ribosomal protein S19 -0.0987275
RPLP1 ribosomal protein, large, P1 -0.0955135
RPL23 ribosomal protein L23 -0.0916073
KRT19 keratin 19, type I -0.0893945
HMGA1 high mobility group AT-hook 1 -0.0891327
RPS8 ribosomal protein S8 -0.0870124
FTL ferritin, light polypeptide -0.0864552
B2M beta-2-microglobulin -0.0801182
ACTG1 actin gamma 1 -0.0781556
LOC102724023 ES1 protein homolog, mitochondrial -0.0729489
EGR1 early growth response 1 -0.0719649
HLA-A major histocompatibility complex, class I, A -0.0712008
HLA-B major histocompatibility complex, class I, B -0.0701457
POTEF POTE ankyrin domain family, member F -0.0696598
LY6E lymphocyte antigen 6 complex, locus E -0.0696128
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0694595
C3 complement component 3 -0.0669465
RPS13 ribosomal protein S13 -0.0664588
RPL28 ribosomal protein L28 -0.0649944
TPT1 tumor protein, translationally-controlled 1 -0.0635525
RPL19 ribosomal protein L19 -0.0625538
EIF1 eukaryotic translation initiation factor 1 -0.0601279
RPL34 ribosomal protein L34 -0.0582601
RPS14 ribosomal protein S14 -0.0580548
RPS3 ribosomal protein S3 -0.0577494
RPS23 ribosomal protein S23 -0.0566969
RPLP2 ribosomal protein, large, P2 -0.0561821
RPS29 ribosomal protein S29 -0.0557882
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0551999
RPL8 ribosomal protein L8 -0.0547142
RPL31 ribosomal protein L31 -0.054242
IFITM3 interferon induced transmembrane protein 3 -0.0535333
RPS15 ribosomal protein S15 -0.0530081
RPL37A ribosomal protein L37a -0.052179
TAPBP TAP binding protein (tapasin) -0.0520537
RACK1 receptor for activated C kinase 1 -0.0510114
RPL36 ribosomal protein L36 -0.0504655
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0501095
RPS21 ribosomal protein S21 -0.0485852
RPL35 ribosomal protein L35 -0.0480235
RPL12 ribosomal protein L12 -0.0476902
IFITM1 interferon induced transmembrane protein 1 -0.0468056
CLDN4 claudin 4 -0.0464349
RPS5 ribosomal protein S5 -0.0462575
MUC16 mucin 16, cell surface associated -0.0457416
RPS25 ribosomal protein S25 -0.04523
FOSL1 FOS-like antigen 1 -0.0450222
S100A9 S100 calcium binding protein A9 -0.0438827
RPS27 ribosomal protein S27 -0.0423835
BRD2 bromodomain containing 2 -0.0423302
EFNA5 ephrin-A5 -0.0411936
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0409531
CCNL1 cyclin L1 -0.0408596
RAB7A RAB7A, member RAS oncogene family -0.0405384
G0S2 G0/G1 switch 2 -0.0397479
RPL11 ribosomal protein L11 -0.0386064
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0380113
MYO1E myosin IE -0.0376697
RPS17 ribosomal protein S17 -0.0373588
RPL37 ribosomal protein L37 -0.0368588
DEK DEK proto-oncogene -0.0366811
LAMA4 laminin, alpha 4 -0.0366791
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0365682
IGFBP3 insulin-like growth factor binding protein 3 -0.0363006
RPL21 ribosomal protein L21 -0.0360713
LMO7 LIM domain 7 -0.0355871
C6ORF132 chromosome 6 open reading frame 132 -0.0350935
FTH1 ferritin, heavy polypeptide 1 -0.0349584
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0348999
LDHA lactate dehydrogenase A -0.0347248
FN1 fibronectin 1 -0.0341352
LOC112694756 uncharaterized LOC112694756 -0.0338508
S100A6 S100 calcium binding protein A6 -0.0337004
RPL32 ribosomal protein L32 -0.0336111
MX1 MX dynamin-like GTPase 1 -0.0332493
RPS16 ribosomal protein S16 -0.032948
RPL36A ribosomal protein L36a -0.0327122
OSMR oncostatin M receptor -0.0318943
WWC1 WW and C2 domain containing 1 -0.0318864
RPL10A ribosomal protein L10a -0.0316426
ACTN4 actinin, alpha 4 -0.0313978
RNF213 ring finger protein 213 -0.0313141
RAD51B RAD51 paralog B -0.0312634
EEF2 eukaryotic translation elongation factor 2 -0.0310876
NDRG1 N-myc downstream regulated 1 -0.031076
YBX1 Y box binding protein 1 -0.0310206
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0309128
RPS10 ribosomal protein S10 -0.0307374
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0306707
RPLP0 ribosomal protein, large, P0 -0.0306238
RPL27 ribosomal protein L27 -0.0304918
ATP5F1B ATP synthase F1 subunit beta -0.0301554