Carbidopa (monohydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.0578298
ZEB1 zinc finger E-box binding homeobox 1 0.0522047
SMYD3 SET and MYND domain containing 3 0.0499128
ZNF292 zinc finger protein 292 0.0473256
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0455098
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0441484
PRELID2 PRELI domain containing 2 0.0422483
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0406233
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0403295
SPAG9 sperm associated antigen 9 0.0398217
C2CD2 C2 calcium-dependent domain containing 2 0.0391252
OGA O-GlcNAcase 0.0375432
USP34 ubiquitin specific peptidase 34 0.0373776
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0366254
NAV3 neuron navigator 3 0.0365822
UBA6 ubiquitin-like modifier activating enzyme 6 0.0352356
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0347339
USP3 ubiquitin specific peptidase 3 0.0346423
STAT1 signal transducer and activator of transcription 1, 91kDa 0.033662
COG5 component of oligomeric golgi complex 5 0.033629
RIGI RNA sensor RIG-I 0.0330191
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0320395
RNF24 ring finger protein 24 0.0318124
ATP11B ATPase, class VI, type 11B 0.0316992
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0314037
NBAS neuroblastoma amplified sequence 0.0310442
RAB18 RAB18, member RAS oncogene family 0.0309143
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.030866
LRRC8C leucine rich repeat containing 8 family, member C 0.0308223
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0307034
ADAM17 ADAM metallopeptidase domain 17 0.0305916
YEATS2 YEATS domain containing 2 0.0298803
YAP1 Yes-associated protein 1 0.0298653
CERT1 ceramide transporter 1 0.0298421
ANO6 anoctamin 6 0.0293515
KDM7A lysine (K)-specific demethylase 7A 0.029335
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0292684
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0290565
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0287601
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0285173
NUP58 nucleoporin 58 0.0284477
CAPN7 calpain 7 0.0284439
UPP1 uridine phosphorylase 1 0.0284338
AKAP9 A kinase (PRKA) anchor protein 9 0.028056
CDK17 cyclin-dependent kinase 17 0.0276489
MX1 MX dynamin-like GTPase 1 0.0272951
SUCO SUN domain containing ossification factor 0.0269413
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.026886
MAST4 microtubule associated serine/threonine kinase family member 4 0.0268794
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0267928
CDC27 cell division cycle 27 0.0267511
ZMYM2 zinc finger, MYM-type 2 0.0266299
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0263478
SCAF8 SR-related CTD-associated factor 8 0.0258195
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0255826
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0253475
NEK7 NIMA-related kinase 7 0.0253021
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0251806
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0250825
FMNL2 formin-like 2 0.0248599
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.024855
ZNFX1 zinc finger, NFX1-type containing 1 0.0247863
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0247522
GSK3B glycogen synthase kinase 3 beta 0.024579
PIAS1 protein inhibitor of activated STAT, 1 0.0244788
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0242807
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.024179
PREPL prolyl endopeptidase-like 0.0241658
CAPN2 calpain 2, (m/II) large subunit 0.0235603
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0234664
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0234506
SCYL2 SCY1-like 2 (S. cerevisiae) 0.023398
PAWR PRKC, apoptosis, WT1, regulator 0.0233571
FRMD4A FERM domain containing 4A 0.0233292
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0231911
FHL2 four and a half LIM domains 2 0.0230423
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0230274
TMED5 transmembrane emp24 protein transport domain containing 5 0.0229042
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0228028
WAC WW domain containing adaptor with coiled-coil 0.0227921
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0227111
RASA2 RAS p21 protein activator 2 0.0227111
COG6 component of oligomeric golgi complex 6 0.0225964
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0222363
CREB1 cAMP responsive element binding protein 1 0.0221639
CAPRIN2 caprin family member 2 0.0220331
SCAF11 SR-related CTD-associated factor 11 0.0220302
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0219081
NIPBL Nipped-B homolog (Drosophila) 0.0218156
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0216873
NF1 neurofibromin 1 0.0216346
WWOX WW domain containing oxidoreductase 0.0215546
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.021286
ADAR adenosine deaminase, RNA-specific 0.0211716
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0210641
CORO1C coronin, actin binding protein, 1C 0.0209638
SCARB2 scavenger receptor class B, member 2 0.0209317
SBF2 SET binding factor 2 0.0209076
NEMF nuclear export mediator factor 0.0206034
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.020603

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.194087
RPS6 ribosomal protein S6 -0.123666
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.121915
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.114984
HDAC9 histone deacetylase 9 -0.113853
FTL ferritin, light polypeptide -0.0980598
TMSB10 thymosin beta 10 -0.0927732
RPL12 ribosomal protein L12 -0.0910064
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0816198
FRMD6 FERM domain containing 6 -0.0808487
RPL11 ribosomal protein L11 -0.0793793
RPS3 ribosomal protein S3 -0.0787971
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0737644
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0733065
RPL8 ribosomal protein L8 -0.0715247
RPLP1 ribosomal protein, large, P1 -0.0702277
ENO1 enolase 1, (alpha) -0.0675549
LOC112694756 uncharaterized LOC112694756 -0.0674189
ENO2 enolase 2 (gamma, neuronal) -0.0656521
RPL7 ribosomal protein L7 -0.0642731
IARS1 isoleucyl-tRNA synthetase 1 -0.0641943
HMGA1 high mobility group AT-hook 1 -0.062195
EGR1 early growth response 1 -0.0618344
NABP1 nucleic acid binding protein 1 -0.0614169
RPL23 ribosomal protein L23 -0.0606417
CALD1 caldesmon 1 -0.0597691
RPL26 ribosomal protein L26 -0.0594578
RPS19 ribosomal protein S19 -0.058944
TXNRD1 thioredoxin reductase 1 -0.0583346
RPL13A ribosomal protein L13a -0.0571006
RPLP2 ribosomal protein, large, P2 -0.0565999
RPS8 ribosomal protein S8 -0.0559923
EEF2 eukaryotic translation elongation factor 2 -0.0559101
RPL7A ribosomal protein L7a -0.0548394
RPL35A ribosomal protein L35a -0.0528161
EIF1 eukaryotic translation initiation factor 1 -0.0527901
RPL37A ribosomal protein L37a -0.052661
ACTG1 actin gamma 1 -0.0525435
TPT1 tumor protein, translationally-controlled 1 -0.0521047
RPL30 ribosomal protein L30 -0.0500152
TTR transthyretin -0.0494853
RPS29 ribosomal protein S29 -0.0476371
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0458026
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0454996
TRIO trio Rho guanine nucleotide exchange factor -0.044997
RPL36 ribosomal protein L36 -0.0444811
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0441179
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0436959
PGK1 phosphoglycerate kinase 1 -0.0431477
PFN1 profilin 1 -0.0431206
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0426488
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.042494
RPL9 ribosomal protein L9 -0.0420121
RPS21 ribosomal protein S21 -0.0419925
RPL32 ribosomal protein L32 -0.0419758
RPS13 ribosomal protein S13 -0.0418655
RACK1 receptor for activated C kinase 1 -0.0417832
BRD2 bromodomain containing 2 -0.0414072
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.040847
RPL10A ribosomal protein L10a -0.040407
POTEF POTE ankyrin domain family, member F -0.0401094
S100A2 S100 calcium binding protein A2 -0.0398646
JMJD1C jumonji domain containing 1C -0.0395135
RPL34 ribosomal protein L34 -0.0393178
RPS23 ribosomal protein S23 -0.0393178
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0390677
RPL35 ribosomal protein L35 -0.0389478
RPLP0 ribosomal protein, large, P0 -0.0385227
RPS12 ribosomal protein S12 -0.0381918
RPS4X ribosomal protein S4, X-linked -0.0371521
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0370987
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0356772
PTMA prothymosin, alpha -0.0356594
DIAPH3 diaphanous-related formin 3 -0.0355118
RPL19 ribosomal protein L19 -0.0349222
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.034633
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0342725
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0339615
RPL27A ribosomal protein L27a -0.0338305
RPL31 ribosomal protein L31 -0.0337912
LDHB lactate dehydrogenase B -0.0335806
RPS14 ribosomal protein S14 -0.0328133
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0326937
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.032515
BLZF1 basic leucine zipper nuclear factor 1 -0.0323041
ERBIN erbb2 interacting protein -0.0322559
FLNB filamin B, beta -0.0320853
RPS27A ribosomal protein S27a -0.0312841
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0312594
RBM25 RNA binding motif protein 25 -0.0309049
MCTP1 multiple C2 domains, transmembrane 1 -0.030836
LAMB3 laminin, beta 3 -0.0308039
SAMD4A sterile alpha motif domain containing 4A -0.0307963
CANX calnexin -0.0306811
RPS16 ribosomal protein S16 -0.0305242
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0302885
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0301689
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0300572
RPL28 ribosomal protein L28 -0.0299949
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0298056