| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.171564 |
| VIM | vimentin | 0.151595 |
| STC1 | stanniocalcin 1 | 0.142571 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.118773 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.106074 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0899277 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0812451 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0751613 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0692869 |
| COL1A2 | collagen, type I, alpha 2 | 0.0683648 |
| CD109 | CD109 molecule | 0.0646885 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0574076 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0564474 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0561708 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0511421 |
| FAM13A | family with sequence similarity 13, member A | 0.0481465 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0479027 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.045464 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0445877 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0439915 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0410855 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0404248 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0400242 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0392706 |
| CDK19 | cyclin-dependent kinase 19 | 0.0384902 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0379829 |
| ZNF395 | zinc finger protein 395 | 0.0377472 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0375668 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0375074 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0364525 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.036154 |
| SNX14 | sorting nexin 14 | 0.0360058 |
| PGK1 | phosphoglycerate kinase 1 | 0.0350978 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0337372 |
| TMEM178B | transmembrane protein 178B | 0.0337155 |
| CDCP1 | CUB domain containing protein 1 | 0.033151 |
| INSIG2 | insulin induced gene 2 | 0.0319526 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.031946 |
| NRP1 | neuropilin 1 | 0.0315773 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.030923 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0307123 |
| PLIN2 | perilipin 2 | 0.0304609 |
| SETD5 | SET domain containing 5 | 0.0303627 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0299873 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.029524 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0294119 |
| TRAM2 | translocation associated membrane protein 2 | 0.0285666 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0282405 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0281984 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0280757 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0271136 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.026938 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0262423 |
| ZNF148 | zinc finger protein 148 | 0.0257027 |
| XPO1 | exportin 1 | 0.0252897 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0252325 |
| FBXO42 | F-box protein 42 | 0.0252021 |
| IKBIP | IKBKB interacting protein | 0.0249373 |
| PDE10A | phosphodiesterase 10A | 0.0240905 |
| NBEAL1 | neurobeachin-like 1 | 0.0239954 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0238281 |
| EHD2 | EH-domain containing 2 | 0.0236918 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0235948 |
| NGLY1 | N-glycanase 1 | 0.0234621 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0231878 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0223532 |
| FAM162A | family with sequence similarity 162, member A | 0.0222883 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0219775 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0216574 |
| COPA | coatomer protein complex, subunit alpha | 0.0216385 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0214867 |
| SNX13 | sorting nexin 13 | 0.0213087 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0210498 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0210101 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0209505 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0209277 |
| LNPK | lunapark, ER junction formation factor | 0.0207653 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0207594 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0207043 |
| WDR45B | WD repeat domain 45B | 0.0202452 |
| INSIG1 | insulin induced gene 1 | 0.0200879 |
| USP34 | ubiquitin specific peptidase 34 | 0.020038 |
| TBC1D20 | TBC1 domain family, member 20 | 0.0199372 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0198878 |
| CDC27 | cell division cycle 27 | 0.0198616 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0197241 |
| PHF20 | PHD finger protein 20 | 0.0196539 |
| NUCB2 | nucleobindin 2 | 0.0195772 |
| SH3PXD2B | SH3 and PX domains 2B | 0.0195743 |
| LOXL2 | lysyl oxidase-like 2 | 0.0195402 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0193556 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0193166 |
| NAV2 | neuron navigator 2 | 0.0189578 |
| ITGA1 | integrin, alpha 1 | 0.0189204 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0189144 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0187779 |
| CCL28 | chemokine (C-C motif) ligand 28 | 0.018739 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0186649 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0185898 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | 0.0185815 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.166881 |
| FN1 | fibronectin 1 | -0.141336 |
| CD44 | CD44 molecule (Indian blood group) | -0.121258 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.104657 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.096629 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0924148 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0923223 |
| POTEF | POTE ankyrin domain family, member F | -0.0895431 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0883336 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0817023 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0797453 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0785617 |
| UBC | ubiquitin C | -0.0771399 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0729245 |
| AHNAK | AHNAK nucleoprotein | -0.0618847 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0608428 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0588195 |
| THBS1 | thrombospondin 1 | -0.0583158 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0578823 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0542214 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0519596 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0495403 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0490543 |
| RPS27A | ribosomal protein S27a | -0.0485142 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0482282 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.04815 |
| CLIC4 | chloride intracellular channel 4 | -0.0474468 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0473712 |
| YBX1 | Y box binding protein 1 | -0.0464005 |
| ENO1 | enolase 1, (alpha) | -0.0463038 |
| CUL3 | cullin 3 | -0.0450709 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0446216 |
| H1-0 | H1.0 linker histone | -0.0426504 |
| DST | dystonin | -0.0422024 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0421953 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0414889 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0413891 |
| CCNL1 | cyclin L1 | -0.0413823 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0413247 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0409676 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0409226 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0404604 |
| USP15 | ubiquitin specific peptidase 15 | -0.0391385 |
| SMAD3 | SMAD family member 3 | -0.0390921 |
| MCL1 | myeloid cell leukemia 1 | -0.0387125 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.03869 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0386328 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0386116 |
| APP | amyloid beta (A4) precursor protein | -0.0382873 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0377955 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0375681 |
| ACTN4 | actinin, alpha 4 | -0.0373999 |
| GLIS3 | GLIS family zinc finger 3 | -0.0373795 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0372249 |
| EGR1 | early growth response 1 | -0.0370788 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0368301 |
| IL1B | interleukin 1, beta | -0.0363418 |
| TOP1 | topoisomerase (DNA) I | -0.0362225 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0350891 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0348624 |
| VCL | vinculin | -0.0346947 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0345262 |
| WDR43 | WD repeat domain 43 | -0.0342397 |
| ASPH | aspartate beta-hydroxylase | -0.0339675 |
| FLNA | filamin A, alpha | -0.0336305 |
| MSN | moesin | -0.0334374 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0332371 |
| RRBP1 | ribosome binding protein 1 | -0.0325263 |
| ERBIN | erbb2 interacting protein | -0.0321528 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0318995 |
| ZNF644 | zinc finger protein 644 | -0.0316309 |
| BRD2 | bromodomain containing 2 | -0.0316089 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0315624 |
| RPL4 | ribosomal protein L4 | -0.031245 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0311824 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0306793 |
| CRY1 | cryptochrome circadian clock 1 | -0.0306348 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0301786 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0301458 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0300532 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0298964 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0298574 |
| LDHA | lactate dehydrogenase A | -0.0296556 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0293119 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0291733 |
| B2M | beta-2-microglobulin | -0.0286621 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0284249 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0283233 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0282745 |
| SDC4 | syndecan 4 | -0.0281012 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0280019 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0279578 |
| PKM | pyruvate kinase, muscle | -0.0279352 |
| FAM20C | family with sequence similarity 20, member C | -0.027892 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.027683 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0275039 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0274997 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0273449 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0272793 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0269899 |
