| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.252404 |
| TENM1 | teneurin transmembrane protein 1 | 0.100927 |
| CENPF | centromere protein F, 350/400kDa | 0.0820238 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0737617 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0659531 |
| PEG10 | paternally expressed 10 | 0.0600145 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0555776 |
| ZNF292 | zinc finger protein 292 | 0.0536627 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0532797 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.052568 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0484868 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0474975 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0445377 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0431016 |
| RTN4 | reticulon 4 | 0.0424518 |
| CALCA | calcitonin-related polypeptide alpha | 0.0415974 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0398028 |
| MTMR7 | myotubularin related protein 7 | 0.0388426 |
| XPO1 | exportin 1 | 0.0388146 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0387442 |
| CCDC88A | coiled-coil domain containing 88A | 0.037882 |
| WDR45B | WD repeat domain 45B | 0.0372887 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0372614 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0365484 |
| PCM1 | pericentriolar material 1 | 0.0362824 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0349898 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0347102 |
| NUF2 | NUF2, NDC80 kinetochore complex component | 0.0328157 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0325149 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0325073 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0311177 |
| MKI67 | marker of proliferation Ki-67 | 0.0310406 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0307372 |
| PRKD1 | protein kinase D1 | 0.030706 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0292631 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.028961 |
| PHIP | pleckstrin homology domain interacting protein | 0.028566 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0284617 |
| NFIA | nuclear factor I/A | 0.0283541 |
| CDK8 | cyclin-dependent kinase 8 | 0.0282369 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0281586 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0279157 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0275899 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0272114 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0271752 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0271713 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0271447 |
| NUP58 | nucleoporin 58 | 0.02691 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0266728 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0264686 |
| SYT4 | synaptotagmin IV | 0.0260509 |
| OGA | O-GlcNAcase | 0.0258378 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0254653 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0252548 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0252332 |
| FAM162A | family with sequence similarity 162, member A | 0.0251813 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0250531 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | 0.0247443 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0246451 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0240241 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0236239 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0232996 |
| GRAMD4 | GRAM domain containing 4 | 0.0231225 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0229967 |
| TTK | TTK protein kinase | 0.0228653 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0228103 |
| JAM3 | junctional adhesion molecule 3 | 0.0227911 |
| DIAPH3 | diaphanous-related formin 3 | 0.0223784 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.0222268 |
| TPD52 | tumor protein D52 | 0.0219196 |
| NUBPL | nucleotide binding protein-like | 0.0218826 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0216752 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0216701 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0215974 |
| RNF145 | ring finger protein 145 | 0.0215517 |
| ANAPC5 | anaphase promoting complex subunit 5 | 0.0215306 |
| PDS5B | PDS5 cohesin associated factor B | 0.0214358 |
| PBK | PDZ binding kinase | 0.0214332 |
| KNL1 | kinetochore scaffold 1 | 0.0213913 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0213238 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0212175 |
| CDCA2 | cell division cycle associated 2 | 0.0211457 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0211367 |
| MATR3 | matrin 3 | 0.0209605 |
| MT1X | metallothionein 1X | 0.020739 |
| FAT1 | FAT atypical cadherin 1 | 0.0207096 |
| ANLN | anillin, actin binding protein | 0.0206501 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | 0.0206429 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0204439 |
| RBM25 | RNA binding motif protein 25 | 0.0202933 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0202865 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | 0.0200187 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0196924 |
| BBX | bobby sox homolog (Drosophila) | 0.0196667 |
| USP3 | ubiquitin specific peptidase 3 | 0.0196628 |
| ETV1 | ets variant 1 | 0.0195719 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0194707 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.019128 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.0190857 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0189585 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.152458 |
| MCL1 | myeloid cell leukemia 1 | -0.139161 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.129851 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.128918 |
| GPC6 | glypican 6 | -0.127515 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.101091 |
| ACTG1 | actin gamma 1 | -0.0939108 |
| STC1 | stanniocalcin 1 | -0.0907889 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0816058 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0802904 |
| RORA | RAR-related orphan receptor A | -0.0769219 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0744654 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0729694 |
| PTCHD4 | patched domain containing 4 | -0.0726331 |
| SMYD3 | SET and MYND domain containing 3 | -0.0719945 |
| SNTG1 | syntrophin, gamma 1 | -0.0695358 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0681393 |
| ENO1 | enolase 1, (alpha) | -0.0629118 |
| EGR1 | early growth response 1 | -0.0618362 |
| ESRRG | estrogen-related receptor gamma | -0.0616226 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0597281 |
| NBEA | neurobeachin | -0.0579503 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.057663 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0563185 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0527699 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0514989 |
| RPL37A | ribosomal protein L37a | -0.051135 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0502548 |
| SCG2 | secretogranin II | -0.0500374 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0497823 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0496174 |
| GPC5 | glypican 5 | -0.0487641 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0456939 |
| SETX | senataxin | -0.0452073 |
| CPE | carboxypeptidase E | -0.0438071 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0430821 |
| CHGA | chromogranin A | -0.0429069 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0427464 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0416651 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0414837 |
| ASPH | aspartate beta-hydroxylase | -0.0414823 |
| INHBA | inhibin, beta A | -0.0408269 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0408056 |
| CHGB | chromogranin B | -0.0404547 |
| KIF26B | kinesin family member 26B | -0.04017 |
| KLHL29 | kelch-like family member 29 | -0.0398589 |
| EFNA5 | ephrin-A5 | -0.0397487 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0396891 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0395787 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0393144 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0383696 |
| ZFHX3 | zinc finger homeobox 3 | -0.0371242 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0370218 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0367086 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0350228 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0336267 |
| RPL37 | ribosomal protein L37 | -0.0335139 |
| CNKSR3 | CNKSR family member 3 | -0.0334668 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0333827 |
| NCKAP5 | NCK-associated protein 5 | -0.0329274 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0327041 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0325264 |
| SP100 | SP100 nuclear antigen | -0.0325038 |
| NAV2 | neuron navigator 2 | -0.0320117 |
| CANX | calnexin | -0.0318444 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0315871 |
| SCFD1 | sec1 family domain containing 1 | -0.0315214 |
| HM13 | histocompatibility (minor) 13 | -0.0313914 |
| CDK13 | cyclin-dependent kinase 13 | -0.0313355 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0311033 |
| MYT1L | myelin transcription factor 1-like | -0.0310855 |
| HOMER1 | homer scaffolding protein 1 | -0.0310082 |
| SIK3 | SIK family kinase 3 | -0.0309133 |
| GOLGB1 | golgin B1 | -0.0307766 |
| SQSTM1 | sequestosome 1 | -0.0305687 |
| APP | amyloid beta (A4) precursor protein | -0.0305015 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0303853 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.030306 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.0302244 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0302079 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0301571 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0300075 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.0293343 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0291682 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0291505 |
| RACK1 | receptor for activated C kinase 1 | -0.0289944 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0288682 |
| TMSB4X | thymosin beta 4, X-linked | -0.0281372 |
| SLC38A2 | solute carrier family 38, member 2 | -0.028013 |
| TOP1 | topoisomerase (DNA) I | -0.0279799 |
| RPL31 | ribosomal protein L31 | -0.0276502 |
| PALLD | palladin, cytoskeletal associated protein | -0.0268357 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0260984 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0258268 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0256188 |
| MAP1B | microtubule-associated protein 1B | -0.02557 |
| ATF6 | activating transcription factor 6 | -0.0255483 |
| CALR | calreticulin | -0.0252868 |
| ARFGEF3 | ARFGEF family member 3 | -0.0252696 |
| EPHA6 | EPH receptor A6 | -0.025085 |
