Carbidopa (monohydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.135215
FNDC3B fibronectin type III domain containing 3B 0.0860658
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0683175
LINGO2 leucine rich repeat and Ig domain containing 2 0.0670585
MSI2 musashi RNA-binding protein 2 0.0621977
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0484767
NGLY1 N-glycanase 1 0.0479032
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0468776
PRELID2 PRELI domain containing 2 0.0464918
PHF21A PHD finger protein 21A 0.0456927
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0407521
KMT2E lysine (K)-specific methyltransferase 2E 0.0404945
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0395866
CLEC2D C-type lectin domain family 2, member D 0.038595
CFAP20DC CFAP20 domain containing 0.0377718
MMP12 matrix metallopeptidase 12 0.0375476
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.034606
DLG1 discs, large homolog 1 (Drosophila) 0.0342576
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0341641
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0334842
SETD5 SET domain containing 5 0.0319363
FMNL2 formin-like 2 0.0316796
UBA6 ubiquitin-like modifier activating enzyme 6 0.0316091
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0303663
ANKRD28 ankyrin repeat domain 28 0.0292079
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0290404
NOTCH2 notch 2 0.028164
SREBF2 sterol regulatory element binding transcription factor 2 0.0276175
MAP4 microtubule-associated protein 4 0.0250146
PDE8A phosphodiesterase 8A 0.0245951
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0245172
ITGB5 integrin, beta 5 0.0242878
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.024233
BIRC6 baculoviral IAP repeat containing 6 0.0237058
STXBP3 syntaxin binding protein 3 0.0233108
SOX10 SRY (sex determining region Y)-box 10 0.0230235
KDM7A lysine (K)-specific demethylase 7A 0.0229275
RTN4 reticulon 4 0.0226722
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0222539
MEF2A myocyte enhancer factor 2A 0.0222253
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0217931
PDIA3 protein disulfide isomerase family A, member 3 0.0215245
ESYT2 extended synaptotagmin-like protein 2 0.0210425
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0210365
CCDC14 coiled-coil domain containing 14 0.0209624
KDM4C lysine (K)-specific demethylase 4C 0.0208691
SSH1 slingshot protein phosphatase 1 0.02046
DOCK7 dedicator of cytokinesis 7 0.0201271
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0199124
PNPLA8 patatin-like phospholipase domain containing 8 0.0195873
TSC22D2 TSC22 domain family, member 2 0.0192919
TMEM165 transmembrane protein 165 0.0192229
FLNB filamin B, beta 0.019195
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.0191136
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0190425
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0186436
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0186412
KIAA1958 KIAA1958 0.0184465
NPEPPS aminopeptidase puromycin sensitive 0.01829
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.0182474
TENM3 teneurin transmembrane protein 3 0.0182207
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0181508
CALD1 caldesmon 1 0.0181391
DOT1L DOT1-like histone H3K79 methyltransferase 0.0180761
ADAM17 ADAM metallopeptidase domain 17 0.0180392
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0180045
PNISR PNN-interacting serine/arginine-rich protein 0.0178111
ASPH aspartate beta-hydroxylase 0.0177141
USP32 ubiquitin specific peptidase 32 0.0176375
CDK19 cyclin-dependent kinase 19 0.0175777
LNPEP leucyl/cystinyl aminopeptidase 0.0174854
AGTPBP1 ATP/GTP binding protein 1 0.0174782
ZMYM2 zinc finger, MYM-type 2 0.0174295
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0173787
SH2B3 SH2B adaptor protein 3 0.0170981
AKAP10 A kinase (PRKA) anchor protein 10 0.0170267
HELZ helicase with zinc finger 0.0169145
RYBP RING1 and YY1 binding protein 0.0168337
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0168042
SEC24A SEC24 family member A 0.0167829
NBAS neuroblastoma amplified sequence 0.0167337
DACH1 dachshund family transcription factor 1 0.0163438
PTBP3 polypyrimidine tract binding protein 3 0.0162424
MACROD2 MACRO domain containing 2 0.0161845
ELL2 elongation factor, RNA polymerase II, 2 0.0161643
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0159827
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0159811
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0159297
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0158914
CHD1 chromodomain helicase DNA binding protein 1 0.0158829
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0156969
ATXN1 ataxin 1 0.0156566
SMAD4 SMAD family member 4 0.0155536
ZNF292 zinc finger protein 292 0.0155125
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0154944
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0154617
RFX7 regulatory factor X, 7 0.0154385
CHD1L chromodomain helicase DNA binding protein 1-like 0.0152906
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.0151743
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0151672

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.201073
MT2A metallothionein 2A -0.147505
RPS3 ribosomal protein S3 -0.142248
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113594
FN1 fibronectin 1 -0.112836
TMSB10 thymosin beta 10 -0.110147
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0990663
ENO1 enolase 1, (alpha) -0.0811955
FTL ferritin, light polypeptide -0.080774
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.078638
EIF1 eukaryotic translation initiation factor 1 -0.0757296
RPLP1 ribosomal protein, large, P1 -0.0734153
NRG3 neuregulin 3 -0.0727285
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0713563
RPL35A ribosomal protein L35a -0.0709777
PGK1 phosphoglycerate kinase 1 -0.0699897
RPS6 ribosomal protein S6 -0.0676211
RPL12 ribosomal protein L12 -0.0672931
PTMA prothymosin, alpha -0.0631681
ICAM1 intercellular adhesion molecule 1 -0.0611035
RPL23 ribosomal protein L23 -0.0610584
TPT1 tumor protein, translationally-controlled 1 -0.0594833
SQSTM1 sequestosome 1 -0.0573309
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0561592
RACK1 receptor for activated C kinase 1 -0.0537741
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0519618
RPL11 ribosomal protein L11 -0.0484533
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0483219
RPL31 ribosomal protein L31 -0.0480074
LSAMP limbic system-associated membrane protein -0.0469842
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0448494
ACTG1 actin gamma 1 -0.0446764
RPL34 ribosomal protein L34 -0.0446199
RPS8 ribosomal protein S8 -0.0442358
NAP1L1 nucleosome assembly protein 1-like 1 -0.044038
RPLP2 ribosomal protein, large, P2 -0.0438115
POTEF POTE ankyrin domain family, member F -0.0436339
RPS21 ribosomal protein S21 -0.0431298
RUNX1 runt-related transcription factor 1 -0.0427489
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0410875
RPL37A ribosomal protein L37a -0.0406976
RPS14 ribosomal protein S14 -0.0392313
CSDE1 cold shock domain containing E1, RNA-binding -0.0390498
RPS12 ribosomal protein S12 -0.0389157
RPS13 ribosomal protein S13 -0.0386065
LOC112694756 uncharaterized LOC112694756 -0.0384675
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0381561
RPL19 ribosomal protein L19 -0.0381458
RPL32 ribosomal protein L32 -0.0380472
RPL5 ribosomal protein L5 -0.0379858
KLF6 Kruppel-like factor 6 -0.0371953
RPS29 ribosomal protein S29 -0.0369422
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0364099
RPS24 ribosomal protein S24 -0.0361059
RPL13A ribosomal protein L13a -0.0353848
TM4SF1 transmembrane 4 L six family member 1 -0.0352298
EEF2 eukaryotic translation elongation factor 2 -0.034833
ENO2 enolase 2 (gamma, neuronal) -0.0348147
RPL36 ribosomal protein L36 -0.0346086
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0343202
RAB7A RAB7A, member RAS oncogene family -0.0341628
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0341607
FRMD5 FERM domain containing 5 -0.0340294
VDAC1 voltage-dependent anion channel 1 -0.0337028
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0332246
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0319244
FRMD4A FERM domain containing 4A -0.031846
RPS19 ribosomal protein S19 -0.0316622
S100A9 S100 calcium binding protein A9 -0.0310258
RPS27A ribosomal protein S27a -0.0306479
RPLP0 ribosomal protein, large, P0 -0.0305429
TPI1 triosephosphate isomerase 1 -0.0304449
CALU calumenin -0.0303499
SFTPA2 surfactant protein A2 -0.0300933
RPS4X ribosomal protein S4, X-linked -0.0299215
B2M beta-2-microglobulin -0.0297014
RPL37 ribosomal protein L37 -0.0289081
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0288807
RPL27 ribosomal protein L27 -0.0288787
HDAC9 histone deacetylase 9 -0.0287546
RPL38 ribosomal protein L38 -0.0284811
RPS23 ribosomal protein S23 -0.028316
RPS16 ribosomal protein S16 -0.0280837
RASAL2 RAS protein activator like 2 -0.0279801
EIF5B eukaryotic translation initiation factor 5B -0.027655
TFPI2 tissue factor pathway inhibitor 2 -0.0275687
SLC38A1 solute carrier family 38, member 1 -0.027452
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0274243
RPL8 ribosomal protein L8 -0.0272477
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0271747
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.0270106
COMMD10 COMM domain containing 10 -0.0268516
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0266454
EXOC4 exocyst complex component 4 -0.0260837
CA8 carbonic anhydrase VIII -0.0259709
RPL27A ribosomal protein L27a -0.0258703
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0255053
RSL1D1 ribosomal L1 domain containing 1 -0.0248509
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0244712
CANX calnexin -0.0240413