Carbidopa (monohydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 0.10244
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0904347
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0754735
FLNB filamin B, beta 0.073962
DSCAM Down syndrome cell adhesion molecule 0.072846
PDE4B phosphodiesterase 4B, cAMP-specific 0.0716208
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0688884
HDAC9 histone deacetylase 9 0.0659306
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0658638
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0653685
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0580684
VCL vinculin 0.0577608
DLG1 discs, large homolog 1 (Drosophila) 0.0567121
GOLGA4 golgin A4 0.0560619
ECT2 epithelial cell transforming 2 0.0558907
LPP LIM domain containing preferred translocation partner in lipoma 0.053817
PRELID2 PRELI domain containing 2 0.0522721
NBAS neuroblastoma amplified sequence 0.0518057
PICALM phosphatidylinositol binding clathrin assembly protein 0.0518009
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0512411
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0494163
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0480452
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0480054
CAMTA1 calmodulin binding transcription activator 1 0.0475559
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0470514
NUP58 nucleoporin 58 0.0470333
RNF145 ring finger protein 145 0.0469549
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0457079
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0449844
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0441779
PDE4D phosphodiesterase 4D, cAMP-specific 0.044176
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0435755
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0428636
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0424479
KMT2E lysine (K)-specific methyltransferase 2E 0.0423929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0420294
NCEH1 neutral cholesterol ester hydrolase 1 0.0419359
GARS1 glycyl-tRNA synthetase 1 0.0418387
SMYD3 SET and MYND domain containing 3 0.0416023
TMEM41B transmembrane protein 41B 0.0414734
EVI5 ecotropic viral integration site 5 0.0405283
BIRC6 baculoviral IAP repeat containing 6 0.0389587
PARD3 par-3 family cell polarity regulator 0.0388547
ZCCHC7 zinc finger, CCHC domain containing 7 0.0388167
NBEA neurobeachin 0.0379353
PYGB phosphorylase, glycogen; brain 0.037476
EGFR epidermal growth factor receptor 0.03681
NFIA nuclear factor I/A 0.0365295
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0364146
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0364029
ZFAND3 zinc finger, AN1-type domain 3 0.0362809
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0357997
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0357666
XPO1 exportin 1 0.0354973
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0353238
GSK3B glycogen synthase kinase 3 beta 0.0351642
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0348
ANK2 ankyrin 2, neuronal 0.0346113
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0345496
EFNA5 ephrin-A5 0.0343769
PUM2 pumilio RNA-binding family member 2 0.0341059
USP34 ubiquitin specific peptidase 34 0.0340817
CDC73 cell division cycle 73 0.0340012
SREBF2 sterol regulatory element binding transcription factor 2 0.0337933
ECPAS Ecm29 proteasome adaptor and scaffold 0.0335342
SETD5 SET domain containing 5 0.0331856
ZMYM2 zinc finger, MYM-type 2 0.0328444
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0328234
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0326929
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0325824
TGFBR3 transforming growth factor, beta receptor III 0.0325057
TMEM65 transmembrane protein 65 0.0323318
STRN3 striatin, calmodulin binding protein 3 0.0323065
GLS2 glutaminase 2 (liver, mitochondrial) 0.0321997
CCNL1 cyclin L1 0.03215
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0320253
SOX6 SRY (sex determining region Y)-box 6 0.0316236
MSI2 musashi RNA-binding protein 2 0.0314894
NCKAP1 NCK-associated protein 1 0.0313252
SAMD4A sterile alpha motif domain containing 4A 0.030963
RHBDD1 rhomboid domain containing 1 0.0308195
PTBP2 polypyrimidine tract binding protein 2 0.030645
KDM3A lysine (K)-specific demethylase 3A 0.0304432
ZEB1 zinc finger E-box binding homeobox 1 0.0304124
BRWD1 bromodomain and WD repeat domain containing 1 0.0301304
ADAM9 ADAM metallopeptidase domain 9 0.030095
RBM39 RNA binding motif protein 39 0.0296283
MED13L mediator complex subunit 13-like 0.0295695
EXT1 exostosin glycosyltransferase 1 0.0293204
NCOR1 nuclear receptor corepressor 1 0.0292534
NF1 neurofibromin 1 0.0289005
MED13 mediator complex subunit 13 0.0288835
AKAP9 A kinase (PRKA) anchor protein 9 0.0287194
PGK1 phosphoglycerate kinase 1 0.0281538
PTK2 protein tyrosine kinase 2 0.027986
MBD5 methyl-CpG binding domain protein 5 0.0279043
CAMKMT calmodulin-lysine N-methyltransferase 0.0278432
SBF2 SET binding factor 2 0.0275763
ZNF292 zinc finger protein 292 0.0272045
EZR ezrin 0.0270955

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.34967
PTMA prothymosin, alpha -0.190225
TPT1 tumor protein, translationally-controlled 1 -0.127521
RPS6 ribosomal protein S6 -0.10971
RPS8 ribosomal protein S8 -0.0837591
RPLP1 ribosomal protein, large, P1 -0.0814035
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0779804
RPL35A ribosomal protein L35a -0.0774298
ACTG1 actin gamma 1 -0.0664622
RPL34 ribosomal protein L34 -0.0626634
BMP10 bone morphogenetic protein 10 -0.0602412
RPS19 ribosomal protein S19 -0.0598282
PKM pyruvate kinase, muscle -0.0592958
RPL31 ribosomal protein L31 -0.0532364
RPLP2 ribosomal protein, large, P2 -0.0513877
TMSB10 thymosin beta 10 -0.0509214
RPL12 ribosomal protein L12 -0.0501471
RPL13A ribosomal protein L13a -0.0500047
RPS23 ribosomal protein S23 -0.0491487
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0481559
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0470967
FTL ferritin, light polypeptide -0.0470059
HSPB1 heat shock 27kDa protein 1 -0.0453807
AHNAK AHNAK nucleoprotein -0.0451898
RPS11 ribosomal protein S11 -0.0421016
MKI67 marker of proliferation Ki-67 -0.0410384
RPL32 ribosomal protein L32 -0.0385613
RPLP0 ribosomal protein, large, P0 -0.0370366
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.036804
RPS27A ribosomal protein S27a -0.036524
RPL19 ribosomal protein L19 -0.0361289
MT2A metallothionein 2A -0.0358556
RPL9 ribosomal protein L9 -0.0351479
ENO1 enolase 1, (alpha) -0.0346294
EIF1 eukaryotic translation initiation factor 1 -0.0345545
RPL36 ribosomal protein L36 -0.0339269
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0339126
RPL8 ribosomal protein L8 -0.0332681
RPS25 ribosomal protein S25 -0.0329388
NAV2 neuron navigator 2 -0.0327911
CCND1 cyclin D1 -0.03262
JUN jun proto-oncogene -0.0325375
RPL23 ribosomal protein L23 -0.0322591
ARL4C ADP-ribosylation factor-like 4C -0.0318609
RPS3 ribosomal protein S3 -0.0317571
LOC102724023 ES1 protein homolog, mitochondrial -0.0316592
RPS24 ribosomal protein S24 -0.0315816
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0314252
PRDX2 peroxiredoxin 2 -0.0310929
RPS29 ribosomal protein S29 -0.030697
HMGB1 high mobility group box 1 -0.0304352
RPS13 ribosomal protein S13 -0.0302484
VIM vimentin -0.0294441
RPS14 ribosomal protein S14 -0.0294308
RPL27A ribosomal protein L27a -0.0288726
IFI16 interferon, gamma-inducible protein 16 -0.0275438
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0274487
RSL1D1 ribosomal L1 domain containing 1 -0.0272132
LOC112694756 uncharaterized LOC112694756 -0.0271298
RPS5 ribosomal protein S5 -0.0269838
HJURP Holliday junction recognition protein -0.0268523
RPS21 ribosomal protein S21 -0.0268117
FN1 fibronectin 1 -0.0267233
S100A9 S100 calcium binding protein A9 -0.0265573
DEK DEK proto-oncogene -0.0264891
PFN1 profilin 1 -0.0263074
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0261673
RACK1 receptor for activated C kinase 1 -0.0259797
S100A10 S100 calcium binding protein A10 -0.0259055
RPL26 ribosomal protein L26 -0.0255871
TUBB4B tubulin, beta 4B class IVb -0.0255776
S100A4 S100 calcium binding protein A4 -0.0254052
EMP3 epithelial membrane protein 3 -0.0253749
RPL4 ribosomal protein L4 -0.025347
RPL38 ribosomal protein L38 -0.0253456
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0252528
IFI6 interferon, alpha-inducible protein 6 -0.0251134
TUBB tubulin, beta class I -0.0248108
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0245848
RPS27 ribosomal protein S27 -0.0245674
RPS16 ribosomal protein S16 -0.0244506
RPL28 ribosomal protein L28 -0.02442
FUS FUS RNA binding protein -0.0241447
RPS15 ribosomal protein S15 -0.0241398
IGF2 insulin-like growth factor 2 -0.0239863
RPL7A ribosomal protein L7a -0.023694
MYL12B myosin, light chain 12B, regulatory -0.023651
HMGA1 high mobility group AT-hook 1 -0.0233084
RPL37A ribosomal protein L37a -0.0232636
SMC4 structural maintenance of chromosomes 4 -0.0231219
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0230858
RPL11 ribosomal protein L11 -0.0228514
TMSB4X thymosin beta 4, X-linked -0.0224973
IFITM3 interferon induced transmembrane protein 3 -0.0224972
TM4SF1 transmembrane 4 L six family member 1 -0.0222759
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0221292
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0218151
RPL36A ribosomal protein L36a -0.0216666
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0215971
S100A6 S100 calcium binding protein A6 -0.0215142