Carbidopa (monohydrate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.121381
PDE10A phosphodiesterase 10A 0.0885112
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0709035
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0617531
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.059898
DLG1 discs, large homolog 1 (Drosophila) 0.0577291
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0557294
RNF213 ring finger protein 213 0.0434862
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0420958
TENT5A terminal nucleotidyltransferase 5A 0.0393974
MMP12 matrix metallopeptidase 12 0.0387956
FNDC3B fibronectin type III domain containing 3B 0.0364582
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0347297
ZMYND8 zinc finger, MYND-type containing 8 0.0331913
SDK1 sidekick cell adhesion molecule 1 0.0329808
IFI16 interferon, gamma-inducible protein 16 0.032112
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0321097
COL8A1 collagen, type VIII, alpha 1 0.0306902
CADM1 cell adhesion molecule 1 0.0305635
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.030553
UBA6 ubiquitin-like modifier activating enzyme 6 0.0304905
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0288607
NPEPPS aminopeptidase puromycin sensitive 0.0282095
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0277048
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0271218
ZHX2 zinc fingers and homeoboxes 2 0.0267408
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0266548
XRN1 5'-3' exoribonuclease 1 0.0245333
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0242876
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.022073
CD2AP CD2-associated protein 0.0217086
DTNA dystrobrevin, alpha 0.0213684
KDM5B lysine (K)-specific demethylase 5B 0.0212606
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0212462
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0209986
SLC38A2 solute carrier family 38, member 2 0.0206445
LRRC7 leucine rich repeat containing 7 0.0203599
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0199813
TRAM2 translocation associated membrane protein 2 0.0197936
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0197698
NRIP1 nuclear receptor interacting protein 1 0.0196593
MBD5 methyl-CpG binding domain protein 5 0.0193725
KDM4C lysine (K)-specific demethylase 4C 0.018768
PRKD3 protein kinase D3 0.0185669
NRP1 neuropilin 1 0.0185079
ESYT2 extended synaptotagmin-like protein 2 0.0184737
GBP1 guanylate binding protein 1, interferon-inducible 0.0181712
ELL2 elongation factor, RNA polymerase II, 2 0.0180703
NGLY1 N-glycanase 1 0.017969
FAM13A family with sequence similarity 13, member A 0.0177991
UBE2O ubiquitin-conjugating enzyme E2O 0.0177178
CDK19 cyclin-dependent kinase 19 0.0176855
FBXO32 F-box protein 32 0.0173343
FHIT fragile histidine triad 0.0171464
RGS17 regulator of G-protein signaling 17 0.0171253
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.0163183
CDC27 cell division cycle 27 0.0162804
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0162596
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0161831
ATXN1 ataxin 1 0.01605
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0157729
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0157655
ANKRD28 ankyrin repeat domain 28 0.0156749
TDRD7 tudor domain containing 7 0.0156332
ANKIB1 ankyrin repeat and IBR domain containing 1 0.015566
IL1RAP interleukin 1 receptor accessory protein 0.0155265
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0154287
TRIM25 tripartite motif containing 25 0.0150553
RUFY2 RUN and FYVE domain containing 2 0.0150284
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0149887
MX1 MX dynamin-like GTPase 1 0.0149869
ZBTB20 zinc finger and BTB domain containing 20 0.0148576
AGTPBP1 ATP/GTP binding protein 1 0.0148473
SAMD8 sterile alpha motif domain containing 8 0.0147735
AHNAK AHNAK nucleoprotein 0.0144959
RFX7 regulatory factor X, 7 0.014423
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0143787
EPSTI1 epithelial stromal interaction 1 (breast) 0.0143553
TSC22D2 TSC22 domain family, member 2 0.0142033
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.014178
FOSL1 FOS-like antigen 1 0.0140217
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0139236
FBXL2 F-box and leucine-rich repeat protein 2 0.0138578
CACUL1 CDK2-associated, cullin domain 1 0.0137891
PPARD peroxisome proliferator-activated receptor delta 0.0137676
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0137485
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0136981
PHF21A PHD finger protein 21A 0.0135098
SP100 SP100 nuclear antigen 0.0134794
PTBP3 polypyrimidine tract binding protein 3 0.0134574
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0133989
OGA O-GlcNAcase 0.0133949
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0133866
NEK6 NIMA-related kinase 6 0.0133446
USP33 ubiquitin specific peptidase 33 0.0132772
TMOD3 tropomodulin 3 (ubiquitous) 0.0131896
CERT1 ceramide transporter 1 0.0130777
RIGI RNA sensor RIG-I 0.0130657
COL7A1 collagen, type VII, alpha 1 0.0130277
MBNL2 muscleblind-like splicing regulator 2 0.0129471

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.207958
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.170883
MYH9 myosin, heavy chain 9, non-muscle -0.142337
CD44 CD44 molecule (Indian blood group) -0.139575
AKAP12 A kinase (PRKA) anchor protein 12 -0.132927
TMSB10 thymosin beta 10 -0.129026
FTL ferritin, light polypeptide -0.128883
MT2A metallothionein 2A -0.118802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.118092
RPS6 ribosomal protein S6 -0.113845
FTH1 ferritin, heavy polypeptide 1 -0.0958952
TPT1 tumor protein, translationally-controlled 1 -0.094446
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0928428
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0921271
LDHA lactate dehydrogenase A -0.0895721
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0878806
HLA-B major histocompatibility complex, class I, B -0.0858607
RPS12 ribosomal protein S12 -0.085619
B2M beta-2-microglobulin -0.0828334
RPS2 ribosomal protein S2 -0.0798671
SFTPA2 surfactant protein A2 -0.079014
ICAM1 intercellular adhesion molecule 1 -0.0782377
PTMA prothymosin, alpha -0.0771171
RPL23 ribosomal protein L23 -0.0769886
EEF2 eukaryotic translation elongation factor 2 -0.0752246
ADM adrenomedullin -0.0751636
EIF1 eukaryotic translation initiation factor 1 -0.0737957
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0720636
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0714542
MSN moesin -0.0711634
RPLP2 ribosomal protein, large, P2 -0.0711061
CALR calreticulin -0.0689054
ENO1 enolase 1, (alpha) -0.0661969
IER3 immediate early response 3 -0.0658298
RPS24 ribosomal protein S24 -0.065659
RPS3 ribosomal protein S3 -0.0649039
POTEF POTE ankyrin domain family, member F -0.0644831
RPS8 ribosomal protein S8 -0.0630804
SPAG9 sperm associated antigen 9 -0.0627947
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0615334
RPS23 ribosomal protein S23 -0.0604166
RPL37A ribosomal protein L37a -0.0603772
RPL11 ribosomal protein L11 -0.0596726
HLA-A major histocompatibility complex, class I, A -0.059328
NAP1L1 nucleosome assembly protein 1-like 1 -0.0591468
RPS4X ribosomal protein S4, X-linked -0.0587237
STC1 stanniocalcin 1 -0.0586639
RPL12 ribosomal protein L12 -0.0582095
FRMD4A FERM domain containing 4A -0.0569891
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 -0.0559666
RPL26 ribosomal protein L26 -0.0551605
RPL36A ribosomal protein L36a -0.0540666
LOC112694756 uncharaterized LOC112694756 -0.0539064
RACK1 receptor for activated C kinase 1 -0.0538982
RPLP0 ribosomal protein, large, P0 -0.0528601
NAMPT nicotinamide phosphoribosyltransferase -0.0524056
RPL27A ribosomal protein L27a -0.0517944
RPLP1 ribosomal protein, large, P1 -0.0515848
PCBP2 poly(rC) binding protein 2 -0.0502563
NAV2 neuron navigator 2 -0.0501748
TRIO trio Rho guanine nucleotide exchange factor -0.0497889
RPL7 ribosomal protein L7 -0.048861
TMSB4X thymosin beta 4, X-linked -0.0488082
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0487175
ACTG1 actin gamma 1 -0.0458521
RPL19 ribosomal protein L19 -0.0448081
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0442708
PKM pyruvate kinase, muscle -0.0440872
APP amyloid beta (A4) precursor protein -0.0440014
RPL32 ribosomal protein L32 -0.0439933
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.043839
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0427181
LAMP2 lysosomal-associated membrane protein 2 -0.0423365
RPS19 ribosomal protein S19 -0.0420906
SERINC1 serine incorporator 1 -0.0413875
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0413197
RPL5 ribosomal protein L5 -0.0408993
RPL38 ribosomal protein L38 -0.0399649
RPL31 ribosomal protein L31 -0.0398714
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0397072
HLA-E major histocompatibility complex, class I, E -0.0392838
RPS13 ribosomal protein S13 -0.0392706
PRRC2C proline-rich coiled-coil 2C -0.0392306
FN1 fibronectin 1 -0.0391988
UBC ubiquitin C -0.0391282
TNIP1 TNFAIP3 interacting protein 1 -0.0388792
DSTN destrin (actin depolymerizing factor) -0.0385394
RPL37 ribosomal protein L37 -0.0384017
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0374445
RPS5 ribosomal protein S5 -0.0371222
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0370787
ANXA2 annexin A2 -0.0369865
RPL35 ribosomal protein L35 -0.036782
MORF4L2 mortality factor 4 like 2 -0.0358517
RPL9 ribosomal protein L9 -0.0358379
EEF1G eukaryotic translation elongation factor 1 gamma -0.0356596
RPL7A ribosomal protein L7a -0.0355528
ACTN1 actinin, alpha 1 -0.035291
HSPA8 heat shock 70kDa protein 8 -0.0349848
CLTC clathrin, heavy chain (Hc) -0.0349555