Carbidopa (monohydrate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IL6 interleukin 6 0.0763928
FNDC3B fibronectin type III domain containing 3B 0.0527428
FRMD6 FERM domain containing 6 0.0492832
SCAF11 SR-related CTD-associated factor 11 0.0424118
RSF1 remodeling and spacing factor 1 0.0398203
CYLD cylindromatosis (turban tumor syndrome) 0.0396038
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0369519
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0364307
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0360676
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0321619
CDC73 cell division cycle 73 0.0317964
FOSL1 FOS-like antigen 1 0.031696
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0307882
NPEPPS aminopeptidase puromycin sensitive 0.0301947
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0301737
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0298768
PDE10A phosphodiesterase 10A 0.029833
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0298237
MPZL1 myelin protein zero-like 1 0.0297705
MYLK myosin light chain kinase 0.0294663
MBNL1 muscleblind-like splicing regulator 1 0.0294124
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0290363
PARD3 par-3 family cell polarity regulator 0.0289478
FNDC3A fibronectin type III domain containing 3A 0.0284743
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0283422
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.0282467
ARHGAP32 Rho GTPase activating protein 32 0.0279421
AKAP12 A kinase (PRKA) anchor protein 12 0.0276123
MORC3 MORC family CW-type zinc finger 3 0.0274993
NEMF nuclear export mediator factor 0.0274254
PTBP2 polypyrimidine tract binding protein 2 0.0273638
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.026932
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0267232
SOCS5 suppressor of cytokine signaling 5 0.0265995
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0263204
MEF2A myocyte enhancer factor 2A 0.0259559
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0255635
CCDC14 coiled-coil domain containing 14 0.0255511
LNPEP leucyl/cystinyl aminopeptidase 0.0253349
FAM13A family with sequence similarity 13, member A 0.02497
BBX bobby sox homolog (Drosophila) 0.0244449
SYNJ2 synaptojanin 2 0.0243789
TOP1 topoisomerase (DNA) I 0.0243494
BIRC6 baculoviral IAP repeat containing 6 0.0243295
N4BP1 NEDD4 binding protein 1 0.0242577
UBA6 ubiquitin-like modifier activating enzyme 6 0.0239276
BBS9 Bardet-Biedl syndrome 9 0.0236762
NF1 neurofibromin 1 0.0235581
NAV2 neuron navigator 2 0.0233955
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0233255
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0233139
ZDHHC17 zinc finger, DHHC-type containing 17 0.0231375
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0230024
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0229359
SNX13 sorting nexin 13 0.0228491
RAP1B RAP1B, member of RAS oncogene family 0.0227534
BIRC3 baculoviral IAP repeat containing 3 0.0224662
WDR41 WD repeat domain 41 0.0224516
EXOC1 exocyst complex component 1 0.022447
RPS17 ribosomal protein S17 0.0224069
SKAP2 src kinase associated phosphoprotein 2 0.0223516
NBAS neuroblastoma amplified sequence 0.0222735
ELL2 elongation factor, RNA polymerase II, 2 0.0222679
USP25 ubiquitin specific peptidase 25 0.0218684
PTK2 protein tyrosine kinase 2 0.0216955
NDRG1 N-myc downstream regulated 1 0.0215111
BTBD9 BTB (POZ) domain containing 9 0.0213837
NCOA3 nuclear receptor coactivator 3 0.0213151
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.0212075
COG5 component of oligomeric golgi complex 5 0.0211914
EPAS1 endothelial PAS domain protein 1 0.0211754
WDFY2 WD repeat and FYVE domain containing 2 0.0207059
KDM6A lysine (K)-specific demethylase 6A 0.0206541
NCOR1 nuclear receptor corepressor 1 0.0205296
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.020464
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0204053
PATJ PATJ crumbs cell polarity complex component 0.0203711
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0203424
FBXL5 F-box and leucine-rich repeat protein 5 0.0202412
SFXN1 sideroflexin 1 0.0201648
ABLIM3 actin binding LIM protein family, member 3 0.0201497
UST uronyl-2-sulfotransferase 0.0200925
SEC24B SEC24 family member B 0.0199914
UGP2 UDP-glucose pyrophosphorylase 2 0.0199491
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0199173
SPPL3 signal peptide peptidase like 3 0.0199055
PHF14 PHD finger protein 14 0.0198193
NKTR natural killer cell triggering receptor 0.019753
ESYT2 extended synaptotagmin-like protein 2 0.0197411
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0195587
CUL3 cullin 3 0.0195516
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0195421
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0194363
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0193923
BLTP1 bridge-like lipid transfer protein family member 1 0.0193519
TANK TRAF family member-associated NFKB activator 0.0193449
WDPCP WD repeat containing planar cell polarity effector 0.0193101
MED6 mediator complex subunit 6 0.0192989
GMDS GDP-mannose 4,6-dehydratase 0.0191795
IQGAP1 IQ motif containing GTPase activating protein 1 0.019109

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.221192
VIM vimentin -0.196888
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.179659
TMSB10 thymosin beta 10 -0.164513
IGFBP3 insulin-like growth factor binding protein 3 -0.163052
MT2A metallothionein 2A -0.160945
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116145
COL6A3 collagen, type VI, alpha 3 -0.113297
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.113069
CALU calumenin -0.105626
CANX calnexin -0.104603
FN1 fibronectin 1 -0.0919694
ENO1 enolase 1, (alpha) -0.0782989
HLA-B major histocompatibility complex, class I, B -0.0774524
HDLBP high density lipoprotein binding protein -0.0764971
LOX lysyl oxidase -0.0754431
PTMA prothymosin, alpha -0.0742375
HLA-C major histocompatibility complex, class I, C -0.0662638
FTL ferritin, light polypeptide -0.0662152
COL1A1 collagen, type I, alpha 1 -0.0655054
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0651289
B2M beta-2-microglobulin -0.0637615
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0615511
TGFBI transforming growth factor, beta-induced, 68kDa -0.0610027
S100A10 S100 calcium binding protein A10 -0.0602583
LMAN1 lectin, mannose-binding, 1 -0.059483
SEC24D SEC24 family member D -0.0577534
LDHA lactate dehydrogenase A -0.0564602
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0561768
COL6A2 collagen, type VI, alpha 2 -0.0559916
FTH1 ferritin, heavy polypeptide 1 -0.0558406
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0556736
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0531039
LOC112694756 uncharaterized LOC112694756 -0.0525745
PDIA3 protein disulfide isomerase family A, member 3 -0.0525421
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0514721
EIF1 eukaryotic translation initiation factor 1 -0.0513946
POTEF POTE ankyrin domain family, member F -0.0506965
TOP2A topoisomerase (DNA) II alpha 170kDa -0.04951
F3 coagulation factor III (thromboplastin, tissue factor) -0.0492038
CAVIN1 caveolae associated protein 1 -0.0486677
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0485392
TPM4 tropomyosin 4 -0.0466567
GNAS GNAS complex locus -0.0466238
DDIT4 DNA-damage-inducible transcript 4 -0.0460575
VCL vinculin -0.0454368
HLA-A major histocompatibility complex, class I, A -0.0451884
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.044553
SDC4 syndecan 4 -0.044138
PRRC1 proline-rich coiled-coil 1 -0.0439022
UBC ubiquitin C -0.0435877
ANXA2 annexin A2 -0.0434241
WSB1 WD repeat and SOCS box containing 1 -0.0431821
PRSS23 protease, serine, 23 -0.0431303
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0422868
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0420088
CLIC4 chloride intracellular channel 4 -0.0412996
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0408187
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.040509
HMGA2 high mobility group AT-hook 2 -0.039426
RPL34 ribosomal protein L34 -0.039147
CDH13 cadherin 13 -0.0383042
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0381764
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0380349
ARF1 ADP-ribosylation factor 1 -0.0380188
RRBP1 ribosome binding protein 1 -0.0378057
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0375264
AHNAK AHNAK nucleoprotein -0.0372253
TM4SF1 transmembrane 4 L six family member 1 -0.0370841
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0369619
COL1A2 collagen, type I, alpha 2 -0.0367781
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.036747
TPT1 tumor protein, translationally-controlled 1 -0.036515
RLF rearranged L-myc fusion -0.0364416
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0364397
RND3 Rho family GTPase 3 -0.0359887
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0357112
EXT1 exostosin glycosyltransferase 1 -0.0349753
RAB1A RAB1A, member RAS oncogene family -0.0344327
H3-3B H3.3 histone B -0.0332602
MORF4L2 mortality factor 4 like 2 -0.0331822
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0328921
MAP1B microtubule-associated protein 1B -0.032877
HM13 histocompatibility (minor) 13 -0.0325174
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0321781
GARS1 glycyl-tRNA synthetase 1 -0.0318992
SFTPA2 surfactant protein A2 -0.0315948
HMGB2 high mobility group box 2 -0.0312104
IGFBP7 insulin-like growth factor binding protein 7 -0.0308587
HBP1 HMG-box transcription factor 1 -0.0297368
AKAP13 A kinase (PRKA) anchor protein 13 -0.0292358
SQSTM1 sequestosome 1 -0.0289341
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0286935
PTGES2 prostaglandin E synthase 2 -0.0286541
COL6A1 collagen, type VI, alpha 1 -0.0285291
TPM2 tropomyosin 2 (beta) -0.0283702
TMEM165 transmembrane protein 165 -0.0283505
FUS FUS RNA binding protein -0.0279173
GPBP1 GC-rich promoter binding protein 1 -0.0276481
WTAP Wilms tumor 1 associated protein -0.0275959