| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.161175 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.138332 |
| NDRG1 | N-myc downstream regulated 1 | 0.129559 |
| HMGA2 | high mobility group AT-hook 2 | 0.111111 |
| HLA-B | major histocompatibility complex, class I, B | 0.104445 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0919699 |
| MMP12 | matrix metallopeptidase 12 | 0.0791256 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0739639 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0634095 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0629755 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0621086 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0610148 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0596381 |
| NAV2 | neuron navigator 2 | 0.0591639 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0574653 |
| NGLY1 | N-glycanase 1 | 0.0548013 |
| FAM13A | family with sequence similarity 13, member A | 0.0530081 |
| FMNL2 | formin-like 2 | 0.0529595 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0521304 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0513541 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0467437 |
| TMEM165 | transmembrane protein 165 | 0.0448338 |
| NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit | 0.041896 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0408239 |
| KIAA1217 | KIAA1217 | 0.0398927 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0396634 |
| PTMA | prothymosin, alpha | 0.0390301 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0386043 |
| NBEAL1 | neurobeachin-like 1 | 0.0384025 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0382036 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0380796 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0377268 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0369514 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0369171 |
| FNIP1 | folliculin interacting protein 1 | 0.035625 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0351577 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0341088 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0341056 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0339948 |
| HDAC9 | histone deacetylase 9 | 0.0336745 |
| CA12 | carbonic anhydrase XII | 0.0333975 |
| STC1 | stanniocalcin 1 | 0.0332721 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.031792 |
| VEGFA | vascular endothelial growth factor A | 0.0314678 |
| RPS12 | ribosomal protein S12 | 0.0314109 |
| LRRC49 | leucine rich repeat containing 49 | 0.031115 |
| PRELID2 | PRELI domain containing 2 | 0.0307491 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0299768 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0283015 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0279184 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0274912 |
| MTSS1 | metastasis suppressor 1 | 0.0274035 |
| INTS6 | integrator complex subunit 6 | 0.0272463 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0269692 |
| RPL26 | ribosomal protein L26 | 0.0269515 |
| RPS8 | ribosomal protein S8 | 0.0268835 |
| SPAG9 | sperm associated antigen 9 | 0.0265555 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0258368 |
| IGF2 | insulin-like growth factor 2 | 0.0257546 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0254436 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0247998 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0247161 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0245896 |
| TNS1 | tensin 1 | 0.024406 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0243469 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0237537 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0237009 |
| INSIG1 | insulin induced gene 1 | 0.0236309 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0234119 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0232638 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.023177 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0230457 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.022761 |
| MRC2 | mannose receptor, C type 2 | 0.0227349 |
| RAD51B | RAD51 paralog B | 0.0225029 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.022482 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0221214 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0220955 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0220909 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0220162 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0218679 |
| STC2 | stanniocalcin 2 | 0.0215271 |
| CALR | calreticulin | 0.0212032 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0211695 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0209712 |
| AEBP2 | AE binding protein 2 | 0.0209582 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.020749 |
| SNX14 | sorting nexin 14 | 0.0206653 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0205815 |
| ATXN1 | ataxin 1 | 0.0204261 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0201073 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0200597 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.019835 |
| BBX | bobby sox homolog (Drosophila) | 0.0198197 |
| PCDH7 | protocadherin 7 | 0.0197855 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0196507 |
| SUCO | SUN domain containing ossification factor | 0.0196477 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0195987 |
| YEATS2 | YEATS domain containing 2 | 0.0195124 |
| ZNF638 | zinc finger protein 638 | 0.0194777 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.265806 |
| COL6A3 | collagen, type VI, alpha 3 | -0.193819 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.166606 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.142359 |
| INHBA | inhibin, beta A | -0.121564 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0900895 |
| MYO10 | myosin X | -0.0883843 |
| EMP1 | epithelial membrane protein 1 | -0.0855082 |
| CALD1 | caldesmon 1 | -0.0739368 |
| FTL | ferritin, light polypeptide | -0.0730637 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.071009 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0692245 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0666814 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0654316 |
| COL1A2 | collagen, type I, alpha 2 | -0.0624882 |
| LOC112694756 | uncharaterized LOC112694756 | -0.060196 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0555566 |
| MMP1 | matrix metallopeptidase 1 | -0.0528709 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0498936 |
| SEPTIN11 | septin 11 | -0.0497782 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0473562 |
| MAP1B | microtubule-associated protein 1B | -0.046345 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.046312 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0450767 |
| PFN1 | profilin 1 | -0.0444515 |
| COL5A3 | collagen, type V, alpha 3 | -0.0426972 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0423914 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0421578 |
| CALU | calumenin | -0.0402007 |
| TMSB10 | thymosin beta 10 | -0.0393853 |
| CLTC | clathrin, heavy chain (Hc) | -0.0386269 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0384958 |
| EGFR | epidermal growth factor receptor | -0.03793 |
| TPI1 | triosephosphate isomerase 1 | -0.0370478 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0370371 |
| LDHA | lactate dehydrogenase A | -0.0361079 |
| CD44 | CD44 molecule (Indian blood group) | -0.0348189 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0337466 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0332183 |
| RPLP1 | ribosomal protein, large, P1 | -0.0324709 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0321981 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0318694 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0317733 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0306666 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0304781 |
| PCBP2 | poly(rC) binding protein 2 | -0.0301732 |
| CCDC102B | coiled-coil domain containing 102B | -0.0300498 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0299237 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0299048 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0297793 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -0.02827 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0279203 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0275322 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.027403 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0273787 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0272406 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0263569 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0262541 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0258035 |
| VIM | vimentin | -0.0257402 |
| PKM | pyruvate kinase, muscle | -0.0254014 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0253754 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0253388 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0249369 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0248554 |
| MT2A | metallothionein 2A | -0.0248168 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0245132 |
| VDAC1 | voltage-dependent anion channel 1 | -0.024433 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.024382 |
| EGR1 | early growth response 1 | -0.0243654 |
| VCL | vinculin | -0.0239671 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0239343 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0235146 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0232078 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0231631 |
| ETV3 | ets variant 3 | -0.0229669 |
| CLIC4 | chloride intracellular channel 4 | -0.0228975 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0228151 |
| SRPK2 | SRSF protein kinase 2 | -0.0227396 |
| JAK1 | Janus kinase 1 | -0.0226991 |
| S100A6 | S100 calcium binding protein A6 | -0.0226422 |
| JMJD1C | jumonji domain containing 1C | -0.0224757 |
| ZNF644 | zinc finger protein 644 | -0.022442 |
| RAB10 | RAB10, member RAS oncogene family | -0.022334 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0222634 |
| FAT1 | FAT atypical cadherin 1 | -0.0221027 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0220934 |
| PLPP3 | phospholipid phosphatase 3 | -0.0220562 |
| NEK7 | NIMA-related kinase 7 | -0.021908 |
| OXR1 | oxidation resistance 1 | -0.0218125 |
| RAI14 | retinoic acid induced 14 | -0.0216424 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0216027 |
| AHNAK | AHNAK nucleoprotein | -0.0215478 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0213226 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0212742 |
| CDK6 | cyclin-dependent kinase 6 | -0.021248 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0211698 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0211515 |
| POTEF | POTE ankyrin domain family, member F | -0.0211502 |
| NPTN | neuroplastin | -0.0210907 |
