Carbohydrate digestion and absorption Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Dietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested to monosaccharides, mostly glucose, galactose and fructose, prior to absorption in the small intestine. Glucose and galactose are initially transported into the enterocyte by SGLT1 located in the apical brush border membrane and then exit through the basolateral membrane by either GLUT2 or exocytosis. In a new model of intestinal glucose absorption, transport by SGLT1 induces rapid insertion and activation of GLUT2 in the brush border membrane by a PKC betaII-dependent mechanism. Moreover, trafficking of apical GLUT2 is rapidly up-regulated by glucose and artificial sweeteners, which act through T1R2 + T1R3/alpha-gustducin to activate PLC-beta2 and PKC-beta II. Fructose is transported separately by the brush border GLUT5 and then released out of the enterocyte into the blood by GLUT2. (Kyoto Encyclopedia of Genes and Genomes, hsa04973)
External Link https://www.kegg.jp/entry/hsa04973
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Genes

47 proteins participating in the Carbohydrate digestion and absorption pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMY1A amylase, alpha 1A (salivary)
AMY1B amylase, alpha 1B (salivary)
AMY1C amylase, alpha 1C (salivary)
AMY2A amylase, alpha 2A (pancreatic)
AMY2B amylase, alpha 2B (pancreatic)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CLSTN1 calsyntenin 1
FXYD2 FXYD domain containing ion transport regulator 2
G6PC1 glucose-6-phosphatase catalytic subunit 1
G6PC2 glucose-6-phosphatase, catalytic, 2
G6PC3 glucose 6 phosphatase, catalytic, 3
GNAT3 guanine nucleotide binding protein, alpha transducing 3
HKDC1 hexokinase domain containing 1
HOOK2 hook microtubule-tethering protein 2
HOOK3 hook microtubule-tethering protein 3
LCT lactase
LNCEGFL7OS lncRNA EGFL7 opposite strand
MGAM maltase-glucoamylase
MGAM2 maltase-glucoamylase 2 (putative)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PMEL premelanosome protein
PRKCB protein kinase C, beta
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
TAC4 tachykinin 4 (hemokinin)
TAS1R2 taste receptor, type 1, member 2
TAS1R3 taste receptor, type 1, member 3