Carcinosarcoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. (Human Disease Ontology, DOID_4236)
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Genes

329 genes co-occuring with the disease Carcinosarcoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TP53 tumor protein p53 2.953
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.812
ARID1A AT rich interactive domain 1A (SWI-like) 2.716
PTEN phosphatase and tensin homolog 2.639
KRAS Kirsten rat sarcoma viral oncogene homolog 2.625
KRT7 keratin 7, type II 2.607
MME membrane metallo-endopeptidase 2.571
PAX8 paired box 8 2.555
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.552
ERBB2 erb-b2 receptor tyrosine kinase 2 2.545
PGR progesterone receptor 2.514
ESR1 estrogen receptor 1 2.485
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.451
BRCA1 breast cancer 1, early onset 2.448
MYOG myogenin (myogenic factor 4) 2.44
CALD1 caldesmon 1 2.435
MSH6 mutS homolog 6 2.42
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.42
MLH1 mutL homolog 1 2.411
WT1 Wilms tumor 1 2.404
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.402
CALB2 calbindin 2 2.331
KRT5 keratin 5, type II 2.329
BRCA2 breast cancer 2, early onset 2.325
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.316
CD99 CD99 molecule 2.312
MSH2 mutS homolog 2 2.295
CD99L2 CD99 molecule-like 2 2.289
KRT20 keratin 20, type I 2.276
CDKN2A cyclin-dependent kinase inhibitor 2A 2.267
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.263
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 2.237
EGFR epidermal growth factor receptor 2.231
SYP synaptophysin 2.202
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.195
CD274 CD274 molecule 2.179
CD34 CD34 molecule 2.171
JAZF1 JAZF zinc finger 1 2.169
NAPSA napsin A aspartic peptidase 2.142
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.118
KRT8 keratin 8, type II 2.07
PARP1 poly (ADP-ribose) polymerase 1 2.06
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.058
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.055
MYOD1 myogenic differentiation 1 2.026
NCAM1 neural cell adhesion molecule 1 2.002
DICER1 dicer 1, ribonuclease type III 2.0
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.984
ALK anaplastic lymphoma receptor tyrosine kinase 1.973
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.967
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.965
NKX2-1 NK2 homeobox 1 1.959
CCNE1 cyclin E1 1.958
GATA3 GATA binding protein 3 1.954
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.95
ENO2 enolase 2 (gamma, neuronal) 1.949
CDX2 caudal type homeobox 2 1.946
ARID1B AT rich interactive domain 1B (SWI1-like) 1.939
ZC3H7B zinc finger CCCH-type containing 7B 1.93
SSX2 synovial sarcoma, X breakpoint 2 1.922
NUTM2A NUT family member 2A 1.922
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.919
ZEB1 zinc finger E-box binding homeobox 1 1.916
MB myoglobin 1.905
AFP alpha-fetoprotein 1.9
CCND1 cyclin D1 1.9
EPCAM epithelial cell adhesion molecule 1.9
CDK4 cyclin-dependent kinase 4 1.899
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.882
SALL4 spalt-like transcription factor 4 1.878
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.849
HMGA2 high mobility group AT-hook 2 1.846
L1CAM L1 cell adhesion molecule 1.834
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.828
KRT19 keratin 19, type I 1.825
ANO1 anoctamin 1, calcium activated chloride channel 1.82
SNAI1 snail family zinc finger 1 1.807
KRT18 keratin 18, type I 1.807
PHF1 PHD finger protein 1 1.806
KRT14 keratin 14, type I 1.805
FGFR2 fibroblast growth factor receptor 2 1.798
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1.794
CHGA chromogranin A 1.793
RAD51C RAD51 paralog C 1.782
BCL2 B-cell CLL/lymphoma 2 1.778
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 1.777
CD68 CD68 molecule 1.772
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.768
PECAM1 platelet/endothelial cell adhesion molecule 1 1.766
NF1 neurofibromin 1 1.756
SNAI2 snail family zinc finger 2 1.753
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.748
RAD51D RAD51 paralog D 1.726
SATB2 SATB homeobox 2 1.721
FOXL2 forkhead box L2 1.715
HNF1B HNF1 homeobox B 1.713
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.711
MUC1 mucin 1, cell surface associated 1.687
ATM ATM serine/threonine kinase 1.683
SUZ12 SUZ12 polycomb repressive complex 2 subunit 1.682
NCOA2 nuclear receptor coactivator 2 1.678
AR androgen receptor 1.673
TP63 tumor protein p63 1.671
SOX10 SRY (sex determining region Y)-box 10 1.669
EWSR1 EWS RNA-binding protein 1 1.668
VIM vimentin 1.662
SSX1 synovial sarcoma, X breakpoint 1 1.66
PALB2 partner and localizer of BRCA2 1.659
ZEB2 zinc finger E-box binding homeobox 2 1.653
PXDNL peroxidasin-like 1.645
ESR2 estrogen receptor 2 (ER beta) 1.645
PXDN peroxidasin 1.643
TERT telomerase reverse transcriptase 1.636
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.629
MED12 mediator complex subunit 12 1.621
SS18 synovial sarcoma translocation, chromosome 18 1.617
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.611
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.603
PLAG1 pleiomorphic adenoma gene 1 1.595
ERBB3 erb-b2 receptor tyrosine kinase 3 1.594
SPOP speckle-type POZ protein 1.591
TGFB1 transforming growth factor, beta 1 1.591
STK11 serine/threonine kinase 11 1.589
KDR kinase insert domain receptor 1.588
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.587
CD8A CD8a molecule 1.587
INSM1 insulinoma-associated 1 1.577
CSMD3 CUB and Sushi multiple domains 3 1.575
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.563
EGF epidermal growth factor 1.555
GPC3 glypican 3 1.553
NDC80 NDC80 kinetochore complex component 1.546
RET ret proto-oncogene 1.544
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 1.544
MSLN mesothelin 1.538
BARD1 BRCA1 associated RING domain 1 1.53
PAX2 paired box 2 1.524
TWIST1 twist family bHLH transcription factor 1 1.515
FOLR1 folate receptor 1 (adult) 1.514
ALB albumin 1.505
CD44 CD44 molecule (Indian blood group) 1.504
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 1.499
OVGP1 oviductal glycoprotein 1, 120kDa 1.497
HRAS Harvey rat sarcoma viral oncogene homolog 1.497
CHEK2 checkpoint kinase 2 1.493
PDCD1 programmed cell death 1 1.493
CHD4 chromodomain helicase DNA binding protein 4 1.482
FGFR1 fibroblast growth factor receptor 1 1.48
BAZ1A bromodomain adjacent to zinc finger domain, 1A 1.477
PDCD1LG2 programmed cell death 1 ligand 2 1.476
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.454
ERBB4 erb-b2 receptor tyrosine kinase 4 1.446
GREB1 growth regulation by estrogen in breast cancer 1 1.444
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.442
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.438
MET MET proto-oncogene, receptor tyrosine kinase 1.437
MUC16 mucin 16, cell surface associated 1.436
H2BC21 H2B clustered histone 21 1.431
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.421
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.415
BCORL1 BCL6 corepressor-like 1 1.408
IGF1R insulin-like growth factor 1 receptor 1.405
TBCE tubulin folding cofactor E 1.405
WFDC2 WAP four-disulfide core domain 2 1.4
PCNA proliferating cell nuclear antigen 1.398
H2AC20 H2A clustered histone 20 1.389
NCOA1 nuclear receptor coactivator 1 1.388
H2AC18 H2A clustered histone 18 1.388
RAD51 RAD51 recombinase 1.386
CSF3 colony stimulating factor 3 (granulocyte) 1.383
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 1.383
WEE1 WEE1 G2 checkpoint kinase 1.379
CLDN4 claudin 4 1.374
FN1 fibronectin 1 1.363
IL6 interleukin 6 1.353
CDH3 cadherin 3, type 1, P-cadherin (placental) 1.348
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.347
PDPN podoplanin 1.347
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.345
RAD50 RAD50 homolog (S. cerevisiae) 1.343
CDK12 cyclin-dependent kinase 12 1.341
PTPRC protein tyrosine phosphatase, receptor type, C 1.338
TG thyroglobulin 1.335
MMP9 matrix metallopeptidase 9 1.329
SMAD4 SMAD family member 4 1.326
SSX2B synovial sarcoma, X breakpoint 2B 1.322
PROM1 prominin 1 1.321
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 1.32
KMT2C lysine (K)-specific methyltransferase 2C 1.317
MMP2 matrix metallopeptidase 2 1.317
CHEK1 checkpoint kinase 1 1.315
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.313
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.306
NUTM1 NUT midline carcinoma, family member 1 1.302
TNF tumor necrosis factor 1.301
NCOA3 nuclear receptor coactivator 3 1.293
TACSTD2 tumor-associated calcium signal transducer 2 1.291
ARID5B AT rich interactive domain 5B (MRF1-like) 1.289
PTCH1 patched 1 1.285
AURKA aurora kinase A 1.283
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.282
CDC73 cell division cycle 73 1.28
ZNF217 zinc finger protein 217 1.273
FLT1 fms-related tyrosine kinase 1 1.273
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.272
SOX2 SRY (sex determining region Y)-box 2 1.267
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.267
NOTCH1 notch 1 1.266
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.264
PDGFB platelet-derived growth factor beta polypeptide 1.262
AKT3 v-akt murine thymoma viral oncogene homolog 3 1.261
ACTB actin, beta 1.26
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.259
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.255
GFAP glial fibrillary acidic protein 1.254
FGFR3 fibroblast growth factor receptor 3 1.248
RPL22 ribosomal protein L22 1.244
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.239
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.238
IGF1 insulin-like growth factor 1 (somatomedin C) 1.237
NOTCH3 notch 3 1.232
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 1.231
SMIM20 small integral membrane protein 20 1.226
NUTM2B NUT family member 2B 1.224
CD4 CD4 molecule 1.219
PTHLH parathyroid hormone-like hormone 1.217
WDR38 WD repeat domain 38 1.213
INS insulin 1.209
KLK3 kallikrein-related peptidase 3 1.209
BRD8 bromodomain containing 8 1.208
BAX BCL2-associated X protein 1.205
REEP5 receptor accessory protein 5 1.203
EML4 echinoderm microtubule associated protein like 4 1.199
KMT2D lysine (K)-specific methyltransferase 2D 1.197
PIP prolactin-induced protein 1.197
IGF2 insulin-like growth factor 2 1.192
S100A4 S100 calcium binding protein A4 1.191
AMACR alpha-methylacyl-CoA racemase 1.189
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.187
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 1.182
KRT17 keratin 17, type I 1.179
CD24 CD24 molecule 1.173
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.172
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.171
POU5F1 POU class 5 homeobox 1 1.169
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.166
FOXM1 forkhead box M1 1.161
MSH3 mutS homolog 3 1.158
IDO1 indoleamine 2,3-dioxygenase 1 1.157
RB1 retinoblastoma 1 1.154
PTPRN protein tyrosine phosphatase, receptor type, N 1.153
MRE11 MRE11 homolog, double strand break repair nuclease 1.146
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.142
MEAF6 MYST/Esa1-associated factor 6 1.139
GLI1 GLI family zinc finger 1 1.139
LAMB4 laminin, beta 4 1.138
FLT4 fms-related tyrosine kinase 4 1.133
CDK2 cyclin-dependent kinase 2 1.126
FANCA Fanconi anemia, complementation group A 1.125
MRPL19 mitochondrial ribosomal protein L19 1.125
MAPK3 mitogen-activated protein kinase 3 1.124
FOXO1 forkhead box O1 1.122
GPER1 G protein-coupled estrogen receptor 1 1.121
XAGE2 X antigen family, member 2 1.117
IFNG interferon, gamma 1.117
RAD51B RAD51 paralog B 1.116
VCAN versican 1.107
CDH4 cadherin 4, type 1, R-cadherin (retinal) 1.106
BMI1 BMI1 proto-oncogene, polycomb ring finger 1.103
CTAG1B cancer/testis antigen 1B 1.103
TSC2 tuberous sclerosis 2 1.102
HMGA1 high mobility group AT-hook 1 1.102
MYH14 myosin, heavy chain 14, non-muscle 1.1
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.098
ESS2 ess-2 splicing factor homolog 1.095
MAGEA4 melanoma antigen family A4 1.095
COMMD3-BMI1 COMMD3-BMI1 readthrough 1.094
BIRC5 baculoviral IAP repeat containing 5 1.088
MUTYH mutY homolog 1.088
CLDN3 claudin 3 1.087
MUC6 mucin 6, oligomeric mucus/gel-forming 1.086
SETD2 SET domain containing 2 1.086
FGFR4 fibroblast growth factor receptor 4 1.085
CTNND1 catenin (cadherin-associated protein), delta 1 1.085
CREBBP CREB binding protein 1.083
FSCN1 fascin actin-bundling protein 1 1.079
ARHGAP35 Rho GTPase activating protein 35 1.075
S100A6 S100 calcium binding protein A6 1.075
GSK3B glycogen synthase kinase 3 beta 1.071
CDK6 cyclin-dependent kinase 6 1.069
ATR ATR serine/threonine kinase 1.062
MLH3 mutL homolog 3 1.061
GNAS GNAS complex locus 1.061
H3-3B H3.3 histone B 1.061
H3C12 H3 clustered histone 12 1.059
EZHIP EZH inhibitory protein 1.057
R3HCC1 R3H domain and coiled-coil containing 1 1.056
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.053
ETV6 ets variant 6 1.052
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 1.047
MDM4 MDM4, p53 regulator 1.046
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.043
H3-5 H3.5 histone 1.042
TCHP trichoplein, keratin filament binding 1.038
CTCF CCCTC-binding factor (zinc finger protein) 1.035
SMAP1 small ArfGAP 1 1.035
FAT3 FAT atypical cadherin 3 1.034
MAP2K1 mitogen-activated protein kinase kinase 1 1.034
ESRRB estrogen-related receptor beta 1.033
IL2 interleukin 2 1.032
RSF1 remodeling and spacing factor 1 1.032
NKX3-1 NK3 homeobox 1 1.032
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 1.031
FOXP3 forkhead box P3 1.029
FGF3 fibroblast growth factor 3 1.028
BCL2L1 BCL2-like 1 1.025
SCGB2A1 secretoglobin, family 2A, member 1 1.025
H3-4 H3.4 histone, cluster member 1.022
PTPA protein phosphatase 2 phosphatase activator 1.018
MYB v-myb avian myeloblastosis viral oncogene homolog 1.018
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.018
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.017
H3C13 H3 clustered histone 13 1.012
CD163 CD163 molecule 1.007
LEF1 lymphoid enhancer-binding factor 1 1.005
JAK2 Janus kinase 2 1.005
CLDN7 claudin 7 1.005
FGF7 fibroblast growth factor 7 1.003
IL1B interleukin 1, beta 1.002