Cardiac Fibrosis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description formation of fibrous tissue within the heart often resulting from inflammation or injury (Mammalian Phenotype Ontology, MP_0003141)
External Link https://www.disgenet.org/browser/0/1/0/C1397307
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Genes

249 genes associated with the disease Cardiac Fibrosis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AARS1 alanyl-tRNA synthetase 1
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACKR3 atypical chemokine receptor 3
ACTB actin, beta
ACVR1B activin A receptor, type IB
ACVRL1 activin A receptor type II-like 1
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADGRL4 adhesion G protein-coupled receptor L4
ADM adrenomedullin
ADRB1 adrenoceptor beta 1
AGER advanced glycosylation end product-specific receptor
AGGF1 angiogenic factor with G patch and FHA domains 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX15 arachidonate 15-lipoxygenase
ANGPT2 angiopoietin 2
APLN apelin
AR androgen receptor
AREG amphiregulin
ATF3 activating transcription factor 3
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
B2M beta-2-microglobulin
BCL10 B-cell CLL/lymphoma 10
BHLHE40 basic helix-loop-helix family, member e40
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRD4 bromodomain containing 4
C5 complement component 5
C5AR1 complement component 5a receptor 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV3 caveolin 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCN1 cellular communication network factor 1
CCN2 cellular communication network factor 2
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL1A1 collagen, type I, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CTF1 cardiotrophin 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCN decorin
DDR2 discoidin domain receptor tyrosine kinase 2
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DMD dystrophin
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ENG endoglin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EVA1A eva-1 homolog A (C. elegans)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBN1 fibrillin 1
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FLNA filamin A, alpha
FN1 fibronectin 1
FOXM1 forkhead box M1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAS6 growth arrest-specific 6
GCG glucagon
GDF2 growth differentiation factor 2
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GJA1 gap junction protein, alpha 1, 43kDa
GRAP2 GRB2-related adaptor protein 2
GREM2 gremlin 2, DAN family BMP antagonist
GRK5 G protein-coupled receptor kinase 5
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HDAC1 histone deacetylase 1
HDAC9 histone deacetylase 9
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DMB major histocompatibility complex, class II, DM beta
HNF4A hepatocyte nuclear factor 4, alpha
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSF1 heat shock transcription factor 1
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL16 interleukin 16
IL17RA interleukin 17 receptor A
IL1B interleukin 1, beta
IL32 interleukin 32
IL33 interleukin 33
IL6 interleukin 6
INSL6 insulin-like 6
ITGA11 integrin, alpha 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JTB jumping translocation breakpoint
KCNK2 potassium channel, two pore domain subfamily K, member 2
KL klotho
KLK1 kallikrein 1
LEP leptin
LGALS13 lectin, galactoside-binding, soluble, 13
LGALS16 lectin, galactoside-binding, soluble, 16
LGALS3 lectin, galactoside-binding, soluble, 3
LOXL2 lysyl oxidase-like 2
LRG1 leucine-rich alpha-2-glycoprotein 1
LUM lumican
LYPD5 LY6/PLAUR domain containing 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2A myocyte enhancer factor 2A
MFN2 mitofusin 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MITF microphthalmia-associated transcription factor
MIXL1 Mix paired-like homeobox
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MRTFA myocardin related transcription factor A
MSC musculin
MSTN myostatin
MTA3 metastasis associated 1 family, member 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC5 NLR family, CARD domain containing 5
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGG1 8-oxoguanine DNA glycosylase
OGN osteoglycin
OSM oncostatin M
PARP1 poly (ADP-ribose) polymerase 1
PDGFD platelet derived growth factor D
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PFN2 profilin 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLAU plasminogen activator, urokinase
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLG plasminogen
PLN phospholamban
PML promyelocytic leukemia
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POSTN periostin, osteoblast specific factor
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRAP1 proline-rich acidic protein 1
PRKCD protein kinase C, delta
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PXDN peroxidasin
RASAL1 RAS protein activator like 1 (GAP1 like)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM24 RNA binding motif protein 24
RCAN3 RCAN family member 3
RCN3 reticulocalbin 3, EF-hand calcium binding domain
REN renin
RETN resistin
RIT1 Ras-like without CAAX 1
RLN2 relaxin 2
RNF111 ring finger protein 111
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RXFP1 relaxin/insulin-like family peptide receptor 1
RYR2 ryanodine receptor 2 (cardiac)
S100A4 S100 calcium binding protein A4
S1PR1 sphingosine-1-phosphate receptor 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGSM3 small G protein signaling modulator 3
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SIRT7 sirtuin 7
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMN1 survival of motor neuron 1, telomeric
SMN2 survival of motor neuron 2, centromeric
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRR2B small proline-rich protein 2B
SRA1 steroid receptor RNA activator 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO1 small ubiquitin-like modifier 1
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TICAM2 toll-like receptor adaptor molecule 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TNF tumor necrosis factor
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAM1 translocation associated membrane protein 1
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TTR transthyretin
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UTS2 urotensin 2
VEGFA vascular endothelial growth factor A
VIM vimentin
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
WISP2 WNT1 inducible signaling pathway protein 2
WNT1 wingless-type MMTV integration site family, member 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2