Cardiac Hypertrophy_Myocardial tissue_GSE1621 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1621
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Genes

600 genes differentially expressed during Cardiac Hypertrophy_Myocardial tissue_GSE1621 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
EIF6 eukaryotic translation initiation factor 6 3.10114
RAB5C RAB5C, member RAS oncogene family 3.01694
TMEM176B transmembrane protein 176B 3.00888
TIMELESS timeless circadian clock 3.00579
DSCR3 Down syndrome critical region 3 3.00311
CP ceruloplasmin (ferroxidase) 2.99803
C1QA complement component 1, q subcomponent, A chain 2.95278
PTPRN protein tyrosine phosphatase, receptor type, N 2.94488
KLC1 kinesin light chain 1 2.92631
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.90018
ACTA1 actin, alpha 1, skeletal muscle 2.86222
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.84114
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.7209
NRAP nebulin-related anchoring protein 2.71236
PABPC1 poly(A) binding protein, cytoplasmic 1 2.69085
MFGE8 milk fat globule-EGF factor 8 protein 2.68499
CD63 CD63 molecule 2.66533
REXO2 RNA exonuclease 2 2.66297
PDLIM1 PDZ and LIM domain 1 2.63279
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.62434
PARK7 parkinson protein 7 2.58225
H2AFX H2A histone family, member X 2.52213
SNTA1 syntrophin, alpha 1 2.52004
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 2.48908
SERP1 stress-associated endoplasmic reticulum protein 1 2.48328
DYNLL1 dynein, light chain, LC8-type 1 2.46501
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 2.46461
TUBA1C tubulin, alpha 1c 2.46131
PSME4 proteasome (prosome, macropain) activator subunit 4 2.43578
ANXA5 annexin A5 2.4186
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 2.41266
STXBP3 syntaxin binding protein 3 2.40834
PERP PERP, TP53 apoptosis effector 2.40641
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 2.3984
GUSB glucuronidase, beta 2.38715
COL6A3 collagen, type VI, alpha 3 2.37297
CXXC5 CXXC finger protein 5 2.37036
TSPAN9 tetraspanin 9 2.35497
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.35061
HTT huntingtin 2.33083
TBRG1 transforming growth factor beta regulator 1 2.3307
LMNA lamin A/C 2.33033
SH3GL1 SH3-domain GRB2-like 1 2.31448
BRAP BRCA1 associated protein 2.31389
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.31018
IFITM3 interferon induced transmembrane protein 3 2.2942
C1QC complement component 1, q subcomponent, C chain 2.2829
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 2.28279
RASA4 RAS p21 protein activator 4 2.26931
LRRC59 leucine rich repeat containing 59 2.26508
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.25507
COL5A1 collagen, type V, alpha 1 2.20936
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 2.20482
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.19525
TRAK1 trafficking protein, kinesin binding 1 2.18387
CD14 CD14 molecule 2.17908
MYOM1 myomesin 1 2.17487
STX12 syntaxin 12 2.17218
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.17188
TMEM167A transmembrane protein 167A 2.16311
TSPO translocator protein (18kDa) 2.15859
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 2.14814
ARID4B AT rich interactive domain 4B (RBP1-like) 2.14582
CTTN cortactin 2.14544
HPS4 Hermansky-Pudlak syndrome 4 2.13733
ZNRD1 zinc ribbon domain containing 1 2.11333
UCK2 uridine-cytidine kinase 2 2.11073
CLIC4 chloride intracellular channel 4 2.11013
PPP1R18 protein phosphatase 1, regulatory subunit 18 2.10316
MFAP5 microfibrillar associated protein 5 2.10315
PPA1 pyrophosphatase (inorganic) 1 2.0939
F2R coagulation factor II (thrombin) receptor 2.09067
CXCL12 chemokine (C-X-C motif) ligand 12 2.08253
DDAH2 dimethylarginine dimethylaminohydrolase 2 2.06736
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.06549
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.04838
UBE2M ubiquitin-conjugating enzyme E2M 2.04331
PDE8A phosphodiesterase 8A 2.03987
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.03654
DIAPH1 diaphanous-related formin 1 2.02332
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.01581
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.01311
TAGLN2 transgelin 2 2.01028
BCL7C B-cell CLL/lymphoma 7C 2.00554
CERCAM cerebral endothelial cell adhesion molecule 1.99729
RRP1B ribosomal RNA processing 1B 1.99654
OSMR oncostatin M receptor 1.98155
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 1.98074
SELPLG selectin P ligand 1.96395
TWF2 twinfilin actin binding protein 2 1.95987
COL6A1 collagen, type VI, alpha 1 1.95737
ANXA3 annexin A3 1.94705
ANXA2 annexin A2 1.93963
FXYD1 FXYD domain containing ion transport regulator 1 1.93464
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.93247
RTN4 reticulon 4 1.92999
UBE2G1 ubiquitin-conjugating enzyme E2G 1 1.92976
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 1.92965
SAE1 SUMO1 activating enzyme subunit 1 1.92679
STX2 syntaxin 2 1.92397
BGN biglycan 1.92271
SEPT2 septin 2 1.91849
RCAN1 regulator of calcineurin 1 1.91787
AZIN1 antizyme inhibitor 1 1.90665
MRPL1 mitochondrial ribosomal protein L1 1.90375
LEPROT leptin receptor overlapping transcript 1.90057
FLII flightless I homolog (Drosophila) 1.89842
FBLN2 fibulin 2 1.89393
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.88899
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.88434
VASP vasodilator-stimulated phosphoprotein 1.88298
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 1.87491
ITPK1 inositol-tetrakisphosphate 1-kinase 1.86849
AKAP1 A kinase (PRKA) anchor protein 1 1.86622
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 1.86091
ARF6 ADP-ribosylation factor 6 1.85872
GPC1 glypican 1 1.85412
ARL14EP ADP-ribosylation factor-like 14 effector protein 1.8537
C3AR1 complement component 3a receptor 1 1.84936
FAM101B family with sequence similarity 101, member B 1.84825
PDCD6IP programmed cell death 6 interacting protein 1.84505
UGP2 UDP-glucose pyrophosphorylase 2 1.83731
CNN2 calponin 2 1.8325
LUM lumican 1.8299
TTC7B tetratricopeptide repeat domain 7B 1.82898
ZNF644 zinc finger protein 644 1.82612
CFL1 cofilin 1 (non-muscle) 1.82531
EBP emopamil binding protein (sterol isomerase) 1.81599
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 1.8094
GPN2 GPN-loop GTPase 2 1.80596
PYGO2 pygopus family PHD finger 2 1.8042
SH3BGRL SH3 domain binding glutamate-rich protein like 1.80328
JAK3 Janus kinase 3 1.79194
MTPN myotrophin 1.78748
RAD50 RAD50 homolog (S. cerevisiae) 1.78688
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.78589
TBRG4 transforming growth factor beta regulator 4 1.78554
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 1.78152
BLMH bleomycin hydrolase 1.77383
SIRPA signal-regulatory protein alpha 1.76248
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 1.75908
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 1.75632
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 1.75552
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.75435
CAV3 caveolin 3 1.74427
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 1.73951
CTSS cathepsin S 1.73838
MDN1 MDN1, midasin homolog (yeast) 1.72937
SS18 synovial sarcoma translocation, chromosome 18 1.72461
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.72152
FSTL1 follistatin-like 1 1.71841
PPP4C protein phosphatase 4, catalytic subunit 1.71805
NPDC1 neural proliferation, differentiation and control, 1 1.71046
ACTN1 actinin, alpha 1 1.70618
SF3B2 splicing factor 3b, subunit 2, 145kDa 1.70468
SYNGR2 synaptogyrin 2 1.70428
COL1A2 collagen, type I, alpha 2 1.7037
RSU1 Ras suppressor protein 1 1.69801
COL4A2 collagen, type IV, alpha 2 1.69577
TRAPPC3 trafficking protein particle complex 3 1.69337
SHISA5 shisa family member 5 1.68911
LLGL1 lethal giant larvae homolog 1 (Drosophila) 1.68866
COL1A1 collagen, type I, alpha 1 1.68851
PFKP phosphofructokinase, platelet 1.68658
IPO5 importin 5 1.68326
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 1.68307
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 1.68098
TUBB6 tubulin, beta 6 class V 1.67833
ENAH enabled homolog (Drosophila) 1.67184
RPL18 ribosomal protein L18 1.66661
PTDSS1 phosphatidylserine synthase 1 1.66457
CTPS1 CTP synthase 1 1.65838
CD34 CD34 molecule 1.65646
TRIM25 tripartite motif containing 25 1.65386
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 1.65326
CLIP1 CAP-GLY domain containing linker protein 1 1.65177
HAUS8 HAUS augmin-like complex, subunit 8 1.64966
THBS1 thrombospondin 1 1.64918
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.6408
CSTB cystatin B (stefin B) 1.63682
TSTA3 tissue specific transplantation antigen P35B 1.63635
PKD1 polycystic kidney disease 1 (autosomal dominant) 1.63455
TNIP1 TNFAIP3 interacting protein 1 1.62542
USP3 ubiquitin specific peptidase 3 1.62539
ZCCHC3 zinc finger, CCHC domain containing 3 1.61328
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 1.61258
GARS glycyl-tRNA synthetase 1.60297
CCDC94 coiled-coil domain containing 94 1.60016
NFU1 NFU1 iron-sulfur cluster scaffold 1.59954
C7ORF43 chromosome 7 open reading frame 43 1.59758
GPM6B glycoprotein M6B 1.59666
NHP2 NHP2 ribonucleoprotein 1.59609
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 1.58877
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.58799
ADCY4 adenylate cyclase 4 1.58547
TBCB tubulin folding cofactor B 1.58383
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 1.5801
LDB1 LIM domain binding 1 1.57926
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.57876
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 1.57604
XIRP1 xin actin binding repeat containing 1 1.57288
GRK5 G protein-coupled receptor kinase 5 1.57158
MBTD1 mbt domain containing 1 1.56982
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1.56954
HN1 hematological and neurological expressed 1 1.56904
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.56856
LTA4H leukotriene A4 hydrolase 1.56796
MARCKSL1 MARCKS-like 1 1.56542
RASL11B RAS-like, family 11, member B 1.56231
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 1.56161
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 1.55976
FBXW11 F-box and WD repeat domain containing 11 1.55691
DDA1 DET1 and DDB1 associated 1 1.55497
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 1.55232
GTPBP2 GTP binding protein 2 1.55188
KCTD17 potassium channel tetramerization domain containing 17 1.55154
PLEKHO1 pleckstrin homology domain containing, family O member 1 1.54857
BAG6 BCL2-associated athanogene 6 1.5477
SARS seryl-tRNA synthetase 1.54653
COL4A1 collagen, type IV, alpha 1 1.54408
ITGB1BP1 integrin beta 1 binding protein 1 1.54166
LYRM2 LYR motif containing 2 1.53888
PRKCD protein kinase C, delta 1.53341
MAPK6 mitogen-activated protein kinase 6 1.53328
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 1.53298
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 1.53208
ATPIF1 ATPase inhibitory factor 1 1.53112
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 1.52859
INPP5J inositol polyphosphate-5-phosphatase J 1.52827
BMP1 bone morphogenetic protein 1 1.52685
FAM3A family with sequence similarity 3, member A 1.52669
LSP1 lymphocyte-specific protein 1 1.52263
PTGR1 prostaglandin reductase 1 1.5218
MRC1 mannose receptor, C type 1 1.51187
RAB33B RAB33B, member RAS oncogene family 1.5102
UBE2T ubiquitin-conjugating enzyme E2T 1.50846
ROGDI rogdi homolog (Drosophila) 1.50821
YIPF3 Yip1 domain family, member 3 1.50423
GSTO1 glutathione S-transferase omega 1 1.5008
ZFP36L1 ZFP36 ring finger protein-like 1 1.50019
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 1.49951
RELL1 RELT-like 1 1.49756
EPRS glutamyl-prolyl-tRNA synthetase 1.49731
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.49556
RPL13A ribosomal protein L13a 1.49519
PTRF polymerase I and transcript release factor 1.49461
BAK1 BCL2-antagonist/killer 1 1.49253
FKBP11 FK506 binding protein 11, 19 kDa 1.49229
RNASEK ribonuclease, RNase K 1.4833
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.48032
FAM195B family with sequence similarity 195, member B 1.47966
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.47733
STRN4 striatin, calmodulin binding protein 4 1.47726
MARCH5 membrane-associated ring finger (C3HC4) 5 1.47596
IL18BP interleukin 18 binding protein 1.47082
NECAP1 NECAP endocytosis associated 1 1.46903
CKAP4 cytoskeleton-associated protein 4 1.46834
SCN1B sodium channel, voltage gated, type I beta subunit 1.4647
FZD1 frizzled class receptor 1 1.46455
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 1.46336
MINPP1 multiple inositol-polyphosphate phosphatase 1 1.46192
SPATA13 spermatogenesis associated 13 1.46164
MYDGF myeloid-derived growth factor 1.4604
DES desmin 1.46013
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.45871
PQLC1 PQ loop repeat containing 1 1.45843
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.4556
PQLC3 PQ loop repeat containing 3 1.45341
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 1.45253
PDLIM7 PDZ and LIM domain 7 (enigma) 1.44896
CSRP1 cysteine and glycine-rich protein 1 1.44842
IQGAP1 IQ motif containing GTPase activating protein 1 1.44703
STRN striatin, calmodulin binding protein 1.44298
S1PR3 sphingosine-1-phosphate receptor 3 1.44275
RANGAP1 Ran GTPase activating protein 1 1.43868
MAPK12 mitogen-activated protein kinase 12 1.43727
TLN1 talin 1 1.43674
COMT catechol-O-methyltransferase 1.4358
MRPL52 mitochondrial ribosomal protein L52 1.43554
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 1.43096
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 1.42961
BAX BCL2-associated X protein 1.42678
S100A6 S100 calcium binding protein A6 1.42098
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.41824
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 1.41763
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.41561
ANKRD10 ankyrin repeat domain 10 1.41156
TOM1 target of myb1 (chicken) 1.41104
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 1.40842
SEC13 SEC13 homolog (S. cerevisiae) 1.40705
PITPNB phosphatidylinositol transfer protein, beta 1.40571
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 1.40443
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 1.40354
RBM3 RNA binding motif (RNP1, RRM) protein 3 1.39927
TRAPPC4 trafficking protein particle complex 4 1.39737
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.39735
KIAA1191 KIAA1191 1.39614
KCTD20 potassium channel tetramerization domain containing 20 1.39288
MKNK2 MAP kinase interacting serine/threonine kinase 2 1.39275
SOCS3 suppressor of cytokine signaling 3 1.39214

decreased expression

Symbol Name Standardized Value
GTF2I general transcription factor IIi -3.40106
GSTP1 glutathione S-transferase pi 1 -3.13375
RPP21 ribonuclease P/MRP 21kDa subunit -2.94332
OGN osteoglycin -2.89577
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.8762
DGUOK deoxyguanosine kinase -2.87133
TTC3 tetratricopeptide repeat domain 3 -2.84715
TSFM Ts translation elongation factor, mitochondrial -2.82385
CYHR1 cysteine/histidine-rich 1 -2.80391
CRY2 cryptochrome circadian clock 2 -2.80189
EXTL3 exostosin-like glycosyltransferase 3 -2.75851
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -2.75166
GNPAT glyceronephosphate O-acyltransferase -2.73501
EIF1B eukaryotic translation initiation factor 1B -2.7304
ACTL6A actin-like 6A -2.72225
CD59 CD59 molecule, complement regulatory protein -2.67195
RNF8 ring finger protein 8, E3 ubiquitin protein ligase -2.6433
MAGED1 melanoma antigen family D1 -2.60015
HIST1H2BI histone cluster 1, H2bi -2.58692
TMEM98 transmembrane protein 98 -2.57922
AOX1 aldehyde oxidase 1 -2.57546
AHCYL1 adenosylhomocysteinase-like 1 -2.56634
BCKDK branched chain ketoacid dehydrogenase kinase -2.54974
MZT2A mitotic spindle organizing protein 2A -2.53657
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.50878
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -2.48639
SLIRP SRA stem-loop interacting RNA binding protein -2.46975
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.45072
PCYOX1 prenylcysteine oxidase 1 -2.45009
PEX7 peroxisomal biogenesis factor 7 -2.44611
ACAA1 acetyl-CoA acyltransferase 1 -2.42357
MRPS21 mitochondrial ribosomal protein S21 -2.39614
ATAD1 ATPase family, AAA domain containing 1 -2.39332
CAV1 caveolin 1, caveolae protein, 22kDa -2.38393
SUCLG1 succinate-CoA ligase, alpha subunit -2.38018
ATG5 autophagy related 5 -2.37069
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.36158
RWDD4 RWD domain containing 4 -2.34509
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.32131
ATXN2 ataxin 2 -2.31728
CCDC12 coiled-coil domain containing 12 -2.31373
AK4 adenylate kinase 4 -2.31327
CLCN3 chloride channel, voltage-sensitive 3 -2.30447
USP9X ubiquitin specific peptidase 9, X-linked -2.30381
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.29428
GHR growth hormone receptor -2.28985
TCEA3 transcription elongation factor A (SII), 3 -2.27558
DYM dymeclin -2.27146
SCP2 sterol carrier protein 2 -2.25691
RBM8A RNA binding motif protein 8A -2.24515
RAP1A RAP1A, member of RAS oncogene family -2.24098
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.2348
EPN2 epsin 2 -2.2327
OAT ornithine aminotransferase -2.2246
TOLLIP toll interacting protein -2.22374
MRPL4 mitochondrial ribosomal protein L4 -2.21938
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.21926
IFT81 intraflagellar transport 81 -2.21539
COQ9 coenzyme Q9 -2.20678
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.19816
VDAC3 voltage-dependent anion channel 3 -2.19077
CDK4 cyclin-dependent kinase 4 -2.17988
ZFR2 zinc finger RNA binding protein 2 -2.17946
NPC1 Niemann-Pick disease, type C1 -2.17612
ZMYND11 zinc finger, MYND-type containing 11 -2.17223
PLIN4 perilipin 4 -2.17187
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) -2.15714
TSPYL4 TSPY-like 4 -2.15381
PSTK phosphoseryl-tRNA kinase -2.15353
PKP4 plakophilin 4 -2.15225
PTCH1 patched 1 -2.15114
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 -2.125
TMEM222 transmembrane protein 222 -2.12146
F11R F11 receptor -2.1192
CREG1 cellular repressor of E1A-stimulated genes 1 -2.09847
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.09658
MRPS11 mitochondrial ribosomal protein S11 -2.09544
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.0883
TMX2 thioredoxin-related transmembrane protein 2 -2.08144
GAB1 GRB2-associated binding protein 1 -2.08097
THRSP thyroid hormone responsive -2.07732
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.07731
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -2.05937
NUDCD3 NudC domain containing 3 -2.05907
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -2.05322
C11ORF73 chromosome 11 open reading frame 73 -2.0531
MRPL37 mitochondrial ribosomal protein L37 -2.04789
MDP1 magnesium-dependent phosphatase 1 -2.04552
C12ORF57 chromosome 12 open reading frame 57 -2.04441
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.0314
SEC62 SEC62 homolog (S. cerevisiae) -2.03054
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -2.02518
PRDX1 peroxiredoxin 1 -2.02254
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.01739
ABLIM1 actin binding LIM protein 1 -2.01209
TALDO1 transaldolase 1 -2.00532
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 -2.00462
AKIRIN2 akirin 2 -1.99871
FEM1A fem-1 homolog a (C. elegans) -1.99457
EIF3D eukaryotic translation initiation factor 3, subunit D -1.99211
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -1.97706
PGLS 6-phosphogluconolactonase -1.97464
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -1.9706
ANKH ANKH inorganic pyrophosphate transport regulator -1.9618
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -1.95462
NT5DC3 5'-nucleotidase domain containing 3 -1.95347
NUMA1 nuclear mitotic apparatus protein 1 -1.94215
RAB24 RAB24, member RAS oncogene family -1.93823
ISYNA1 inositol-3-phosphate synthase 1 -1.93658
TMPO thymopoietin -1.93567
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -1.93426
TPP1 tripeptidyl peptidase I -1.93392
CUL1 cullin 1 -1.93302
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic -1.93164
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -1.93099
CDKN2AIPNL CDKN2A interacting protein N-terminal like -1.93051
ITFG1 integrin alpha FG-GAP repeat containing 1 -1.92876
MRPL50 mitochondrial ribosomal protein L50 -1.92414
ZC3H3 zinc finger CCCH-type containing 3 -1.9203
LGALS4 lectin, galactoside-binding, soluble, 4 -1.91954
PCBP2 poly(rC) binding protein 2 -1.91451
MFN1 mitofusin 1 -1.91113
PTOV1 prostate tumor overexpressed 1 -1.90638
KDM1A lysine (K)-specific demethylase 1A -1.89201
SIVA1 SIVA1, apoptosis-inducing factor -1.8916
NKX2-5 NK2 homeobox 5 -1.8912
SFXN4 sideroflexin 4 -1.88586
MARVELD1 MARVEL domain containing 1 -1.87833
TMEM131 transmembrane protein 131 -1.87497
MAPK9 mitogen-activated protein kinase 9 -1.87472
ANKRD40 ankyrin repeat domain 40 -1.87461
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase -1.87435
ART1 ADP-ribosyltransferase 1 -1.8682
CNBP CCHC-type zinc finger, nucleic acid binding protein -1.86595
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -1.86229
SAMM50 SAMM50 sorting and assembly machinery component -1.85595
CANX calnexin -1.85226
AK1 adenylate kinase 1 -1.85195
LDHAL6A lactate dehydrogenase A-like 6A -1.849
CAPN3 calpain 3, (p94) -1.84641
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -1.84639
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -1.83592
NEO1 neogenin 1 -1.83557
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 -1.83165
C6ORF89 chromosome 6 open reading frame 89 -1.83121
PDHB pyruvate dehydrogenase (lipoamide) beta -1.82743
LIPE lipase, hormone-sensitive -1.82445
HSPB2 heat shock 27kDa protein 2 -1.82409
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) -1.82219
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -1.81984
ADARB1 adenosine deaminase, RNA-specific, B1 -1.80802
DDHD2 DDHD domain containing 2 -1.80237
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -1.80202
SNCG synuclein, gamma (breast cancer-specific protein 1) -1.79379
NMT1 N-myristoyltransferase 1 -1.78464
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -1.7796
MLF1 myeloid leukemia factor 1 -1.77827
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -1.77542
JMJD6 jumonji domain containing 6 -1.77404
COPS8 COP9 signalosome subunit 8 -1.77396
PHF1 PHD finger protein 1 -1.76836
REEP5 receptor accessory protein 5 -1.76475
AIP aryl hydrocarbon receptor interacting protein -1.74395
NAMPT nicotinamide phosphoribosyltransferase -1.74319
MTOR mechanistic target of rapamycin (serine/threonine kinase) -1.73767
DAP3 death associated protein 3 -1.73735
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -1.73674
MYH11 myosin, heavy chain 11, smooth muscle -1.72969
MYZAP myocardial zonula adherens protein -1.72916
TPST1 tyrosylprotein sulfotransferase 1 -1.72867
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -1.72564
ELOF1 elongation factor 1 homolog (S. cerevisiae) -1.72446
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -1.72394
FHOD3 formin homology 2 domain containing 3 -1.71964
PPOX protoporphyrinogen oxidase -1.71887
DPP8 dipeptidyl-peptidase 8 -1.70845
BCL2L13 BCL2-like 13 (apoptosis facilitator) -1.70838
CDK5 cyclin-dependent kinase 5 -1.70196
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 -1.70158
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -1.69707
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -1.69527
CPNE3 copine III -1.69171
YIPF1 Yip1 domain family, member 1 -1.69165
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) -1.68669
NEK7 NIMA-related kinase 7 -1.68201
GGCT gamma-glutamylcyclotransferase -1.68026
PAIP2B poly(A) binding protein interacting protein 2B -1.68
MRPS17 mitochondrial ribosomal protein S17 -1.67614
PEX11A peroxisomal biogenesis factor 11 alpha -1.66986
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 -1.6693
INTS7 integrator complex subunit 7 -1.66756
LMO7 LIM domain 7 -1.66594
SPAG7 sperm associated antigen 7 -1.66489
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -1.6617
EZR ezrin -1.66125
RNF14 ring finger protein 14 -1.66031
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -1.65775
CCDC93 coiled-coil domain containing 93 -1.6572
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -1.65669
ACVR2A activin A receptor, type IIA -1.65653
MTM1 myotubularin 1 -1.65349
SOX4 SRY (sex determining region Y)-box 4 -1.65231
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -1.65202
KDM5A lysine (K)-specific demethylase 5A -1.65184
PER3 period circadian clock 3 -1.64998
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -1.64924
PRDX2 peroxiredoxin 2 -1.64899
STC2 stanniocalcin 2 -1.64767
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -1.64678
FAM98A family with sequence similarity 98, member A -1.64532
RAE1 ribonucleic acid export 1 -1.64521
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -1.6425
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -1.63735
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -1.63719
ANAPC13 anaphase promoting complex subunit 13 -1.63674
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -1.63276
LZTFL1 leucine zipper transcription factor-like 1 -1.62956
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -1.62867
DQX1 DEAQ box RNA-dependent ATPase 1 -1.62816
TRA2B transformer 2 beta homolog (Drosophila) -1.62176
LUC7L LUC7-like (S. cerevisiae) -1.61631
LTK leukocyte receptor tyrosine kinase -1.61584
LAPTM4B lysosomal protein transmembrane 4 beta -1.61429
PRDX6 peroxiredoxin 6 -1.61085
VPRBP Vpr (HIV-1) binding protein -1.6089
FDX1 ferredoxin 1 -1.60777
RYR2 ryanodine receptor 2 (cardiac) -1.60661
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -1.60623
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) -1.60593
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -1.60364
SELENBP1 selenium binding protein 1 -1.60338
TBL1X transducin (beta)-like 1X-linked -1.59921
TMEM141 transmembrane protein 141 -1.59913
SMC6 structural maintenance of chromosomes 6 -1.59637
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -1.59536
IRF2BP1 interferon regulatory factor 2 binding protein 1 -1.59345
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -1.59208
CR1L complement component (3b/4b) receptor 1-like -1.58803
AHNAK AHNAK nucleoprotein -1.58706
ATL2 atlastin GTPase 2 -1.587
IVD isovaleryl-CoA dehydrogenase -1.58423
ABHD8 abhydrolase domain containing 8 -1.5841
POLR1D polymerase (RNA) I polypeptide D, 16kDa -1.57867
LARP1 La ribonucleoprotein domain family, member 1 -1.5773
RPL21 ribosomal protein L21 -1.57244
TXNDC16 thioredoxin domain containing 16 -1.56863
PDYN prodynorphin -1.56725
C19ORF43 chromosome 19 open reading frame 43 -1.56461
ZNF444 zinc finger protein 444 -1.55848
C8ORF37 chromosome 8 open reading frame 37 -1.55517
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -1.554
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -1.55281
SDHAF2 succinate dehydrogenase complex assembly factor 2 -1.55162
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -1.55118
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -1.54998
SLBP stem-loop binding protein -1.54905
NGRN neugrin, neurite outgrowth associated -1.54812
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 -1.54278
ISOC1 isochorismatase domain containing 1 -1.54154
PENK proenkephalin -1.53754
NLK nemo-like kinase -1.53534
MTX2 metaxin 2 -1.535
NR1D2 nuclear receptor subfamily 1, group D, member 2 -1.53412
DPEP1 dipeptidase 1 (renal) -1.53001
NCAM1 neural cell adhesion molecule 1 -1.52961
NUP85 nucleoporin 85kDa -1.52612
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -1.52377
STX18 syntaxin 18 -1.52128
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -1.52058
HBS1L HBS1-like translational GTPase -1.52002
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -1.51898
RHOT1 ras homolog family member T1 -1.51742
TUBGCP3 tubulin, gamma complex associated protein 3 -1.51342
WDR43 WD repeat domain 43 -1.51208
CES1 carboxylesterase 1 -1.51064
RBPMS RNA binding protein with multiple splicing -1.50456
NDRG2 NDRG family member 2 -1.50355
MEN1 multiple endocrine neoplasia I -1.50282
FAM50A family with sequence similarity 50, member A -1.50204
MAL mal, T-cell differentiation protein -1.5017
DOHH deoxyhypusine hydroxylase/monooxygenase -1.50089
FBXO9 F-box protein 9 -1.49936
BATF basic leucine zipper transcription factor, ATF-like -1.49921
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -1.49898
MBP myelin basic protein -1.49456
MRPS15 mitochondrial ribosomal protein S15 -1.49325
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -1.49131
SSBP1 single-stranded DNA binding protein 1, mitochondrial -1.49084
RPS11 ribosomal protein S11 -1.49063
EPHX2 epoxide hydrolase 2, cytoplasmic -1.4875
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -1.48449
FBXL3 F-box and leucine-rich repeat protein 3 -1.48405
C11ORF58 chromosome 11 open reading frame 58 -1.48186
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit -1.48012
GRIA2 glutamate receptor, ionotropic, AMPA 2 -1.474
TRAPPC10 trafficking protein particle complex 10 -1.47316
CTSF cathepsin F -1.47265
CACUL1 CDK2-associated, cullin domain 1 -1.46506
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -1.46497
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -1.46359
Funding