Cardiac conduction Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. (Gene Ontology, GO_0061337)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-5576891
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Genes

130 proteins participating in the Cardiac conduction pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
AHCYL1 adenosylhomocysteinase-like 1
AKAP9 A kinase (PRKA) anchor protein 9
ASPH aspartate beta-hydroxylase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CACNG6 calcium channel, voltage-dependent, gamma subunit 6
CACNG7 calcium channel, voltage-dependent, gamma subunit 7
CACNG8 calcium channel, voltage-dependent, gamma subunit 8
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CASQ2 calsequestrin 2 (cardiac muscle)
CES1 carboxylesterase 1
CLIC2 chloride intracellular channel 2
CORIN corin, serine peptidase
DMPK dystrophia myotonica-protein kinase
FGF11 fibroblast growth factor 11
FGF12 fibroblast growth factor 12
FGF13 fibroblast growth factor 13
FGF14 fibroblast growth factor 14
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD1 FXYD domain containing ion transport regulator 1
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
FXYD4 FXYD domain containing ion transport regulator 4
FXYD6 FXYD domain containing ion transport regulator 6
FXYD7 FXYD domain containing ion transport regulator 7
GATA4 GATA binding protein 4
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT2B K(lysine) acetyltransferase 2B
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP1 Kv channel interacting protein 1
KCNIP2 Kv channel interacting protein 2
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNIP4 Kv channel interacting protein 4
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNK13 potassium channel, two pore domain subfamily K, member 13
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNK16 potassium channel, two pore domain subfamily K, member 16
KCNK17 potassium channel, two pore domain subfamily K, member 17
KCNK18 potassium channel, two pore domain subfamily K, member 18
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNK4 potassium channel, two pore domain subfamily K, member 4
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNK7 potassium channel, two pore domain subfamily K, member 7
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
MME membrane metallo-endopeptidase
NKX2-5 NK2 homeobox 5
NOS1 nitric oxide synthase 1 (neuronal)
NPPA natriuretic peptide A
NPPC natriuretic peptide C
NPR1 natriuretic peptide receptor 1
NPR2 natriuretic peptide receptor 2
ORAI1 ORAI calcium release-activated calcium modulator 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PLN phospholamban
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RANGRF RAN guanine nucleotide release factor
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SCN3A sodium channel, voltage gated, type III alpha subunit
SCN3B sodium channel, voltage gated, type III beta subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN4B sodium channel, voltage gated, type IV beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN7A sodium channel, voltage gated, type VII alpha subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLN sarcolipin
SRI sorcin
STIM1 stromal interaction molecule 1
TBX5 T-box 5
TNNI3 troponin I type 3 (cardiac)
TRDN triadin
TRPC1 transient receptor potential cation channel, subfamily C, member 1
WWTR1 WW domain containing transcription regulator 1