| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs. (Chemical Entities of Biological Interest Ontology, CHEBI_364453) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2581 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Carprofen relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| POF1B | premature ovarian failure, 1B | 1.86 |
| TEN1 | TEN1 CST complex subunit | 1.26 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 1.21 |
| COL7A1 | collagen, type VII, alpha 1 | 1.17 |
| TRIM29 | tripartite motif containing 29 | 1.12 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.1 |
| NPHP3 | nephronophthisis 3 (adolescent) | 1.05 |
| ANK2 | ankyrin 2, neuronal | 1.03 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.84 |
| CCDC110 | coiled-coil domain containing 110 | 0.83 |
| KALRN | kalirin, RhoGEF kinase | 0.55 |
| TATDN2 | TatD DNase domain containing 2 | 0.5 |
| SLC25A46 | solute carrier family 25, member 46 | 0.48 |
| DCHS1 | dachsous cadherin-related 1 | 0.48 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.47 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.46 |
| VIM | vimentin | 0.45 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.45 |
| FCHO1 | FCH domain only 1 | 0.44 |
| SYN2 | synapsin II | 0.43 |
| LMO4 | LIM domain only 4 | 0.43 |
| CLCN6 | chloride channel, voltage-sensitive 6 | 0.42 |
| ZNF341 | zinc finger protein 341 | 0.42 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | 0.41 |
| SMTN | smoothelin | 0.4 |
| MYRF | myelin regulatory factor | 0.4 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.4 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.39 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.39 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.39 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.39 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | 0.35 |
| STK40 | serine/threonine kinase 40 | 0.35 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.34 |
| FAM110C | family with sequence similarity 110, member C | 0.34 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.34 |
| COMMD9 | COMM domain containing 9 | 0.34 |
| DYRK2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | 0.34 |
| OSER1 | oxidative stress responsive serine-rich 1 | 0.34 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.32 |
| SF1 | splicing factor 1 | 0.31 |
| RGS12 | regulator of G-protein signaling 12 | 0.31 |
| KIF21B | kinesin family member 21B | 0.31 |
| PEX26 | peroxisomal biogenesis factor 26 | 0.31 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | 0.3 |
| TTN | titin | 0.3 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.29 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.29 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.29 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.29 |
| RCAN1 | regulator of calcineurin 1 | 0.29 |
| INVS | inversin | 0.29 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | 0.28 |
| SPEG | SPEG complex locus | 0.28 |
| ERCC6 | excision repair cross-complementation group 6 | 0.28 |
| TIGD5 | tigger transposable element derived 5 | 0.27 |
| CFAP410 | cilia and flagella associated protein 410 | 0.27 |
| XIRP2 | xin actin binding repeat containing 2 | 0.26 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 0.26 |
| ZBED8L | ZBED8 like | 0.26 |
| CHRD | chordin | 0.26 |
| ENKD1 | enkurin domain containing 1 | 0.26 |
| SOX12 | SRY (sex determining region Y)-box 12 | 0.26 |
| ZNF669 | zinc finger protein 669 | 0.26 |
| SUSD1 | sushi domain containing 1 | 0.25 |
| DST | dystonin | 0.25 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.25 |
| COL1A1 | collagen, type I, alpha 1 | 0.25 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | 0.24 |
| ZNF600 | zinc finger protein 600 | 0.24 |
| SNX19 | sorting nexin 19 | 0.24 |
| ZNF100 | zinc finger protein 100 | 0.24 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.24 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 0.23 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 0.23 |
| TRIB3 | tribbles pseudokinase 3 | 0.23 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.23 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.23 |
| TMEM64 | transmembrane protein 64 | 0.23 |
| SYNPO | synaptopodin | 0.22 |
| C1ORF226 | chromosome 1 open reading frame 226 | 0.22 |
| MAST3 | microtubule associated serine/threonine kinase 3 | 0.22 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.22 |
| GLRX5 | glutaredoxin 5 | 0.22 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.22 |
| WDR60 | WD repeat domain 60 | 0.22 |
| RETREG1 | reticulophagy regulator 1 | 0.22 |
| ARSD | arylsulfatase D | 0.22 |
| ZNF320 | zinc finger protein 320 | 0.22 |
| CYTH3 | cytohesin 3 | 0.22 |
| ENDOV | endonuclease V | 0.21 |
| SATB1 | SATB homeobox 1 | 0.21 |
| PRDM4 | PR domain containing 4 | 0.21 |
| CASKIN1 | CASK interacting protein 1 | 0.21 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | 0.21 |
| ABHD15 | abhydrolase domain containing 15 | 0.2 |
| C11ORF98 | chromosome 11 open reading frame 98 | 0.2 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | 0.2 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | -0.82 |
| ZG16B | zymogen granule protein 16B | -0.68 |
| ZNF566 | zinc finger protein 566 | -0.52 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.47 |
| NEB | nebulin | -0.46 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.46 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.45 |
| ZNF483 | zinc finger protein 483 | -0.43 |
| PTK6 | protein tyrosine kinase 6 | -0.42 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.41 |
| MED29 | mediator complex subunit 29 | -0.38 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.37 |
| GLMP | glycosylated lysosomal membrane protein | -0.37 |
| TSPYL4 | TSPY-like 4 | -0.35 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.35 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | -0.33 |
| MYNN | myoneurin | -0.33 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.31 |
| CMC4 | C-x(9)-C motif containing 4 | -0.31 |
| TMSB10 | thymosin beta 10 | -0.3 |
| APLF | aprataxin and PNKP like factor | -0.3 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | -0.29 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.29 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | -0.29 |
| SUCO | SUN domain containing ossification factor | -0.28 |
| UROS | uroporphyrinogen III synthase | -0.28 |
| DAP | death-associated protein | -0.28 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.28 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.28 |
| PDE7A | phosphodiesterase 7A | -0.28 |
| MFSD8 | major facilitator superfamily domain containing 8 | -0.27 |
| ANKLE1 | ankyrin repeat and LEM domain containing 1 | -0.27 |
| E2F8 | E2F transcription factor 8 | -0.27 |
| BAIAP2 | BAI1-associated protein 2 | -0.27 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.26 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.26 |
| BICRA | BRD4 interacting chromatin remodeling complex associated protein | -0.26 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.26 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -0.26 |
| RNF135 | ring finger protein 135 | -0.25 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | -0.25 |
| RAB36 | RAB36, member RAS oncogene family | -0.25 |
| WDR90 | WD repeat domain 90 | -0.25 |
| ABHD3 | abhydrolase domain containing 3 | -0.24 |
| KPTN | kaptin (actin binding protein) | -0.24 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | -0.24 |
| ZNF136 | zinc finger protein 136 | -0.24 |
| PDIK1L | PDLIM1 interacting kinase 1 like | -0.24 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.23 |
| TUB | tubby bipartite transcription factor | -0.23 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.23 |
| MLXIPL | MLX interacting protein-like | -0.23 |
| ARG2 | arginase 2 | -0.23 |
| ZNF823 | zinc finger protein 823 | -0.23 |
| GMCL1 | germ cell-less, spermatogenesis associated 1 | -0.23 |
| ABAT | 4-aminobutyrate aminotransferase | -0.23 |
| PITX2 | paired-like homeodomain 2 | -0.23 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.23 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.23 |
| FANCC | Fanconi anemia, complementation group C | -0.22 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.22 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.22 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | -0.22 |
| FAM89A | family with sequence similarity 89, member A | -0.22 |
| ZNF142 | zinc finger protein 142 | -0.22 |
| NLGN2 | neuroligin 2 | -0.22 |
| SIRT3 | sirtuin 3 | -0.22 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | -0.22 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.21 |
| IFI35 | interferon-induced protein 35 | -0.21 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.21 |
| TCTN1 | tectonic family member 1 | -0.21 |
| CBR1 | carbonyl reductase 1 | -0.21 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.21 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | -0.21 |
| ZNF296 | zinc finger protein 296 | -0.21 |
| SGCE | sarcoglycan, epsilon | -0.21 |
| HMBOX1 | homeobox containing 1 | -0.21 |
| CHDH | choline dehydrogenase | -0.2 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.2 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | -0.2 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | -0.2 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.2 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.2 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | -0.2 |
| ACOX3 | acyl-CoA oxidase 3, pristanoyl | -0.2 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.2 |
| ZNF576 | zinc finger protein 576 | -0.2 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.2 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -0.2 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | -0.19 |
| PTGES | prostaglandin E synthase | -0.19 |
| FHIT | fragile histidine triad | -0.19 |
| NEBL | nebulette | -0.19 |
| C19ORF25 | chromosome 19 open reading frame 25 | -0.19 |
| TDG | thymine-DNA glycosylase | -0.19 |
| DENND5A | DENN/MADD domain containing 5A | -0.19 |
| ARRDC1 | arrestin domain containing 1 | -0.19 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.19 |
| LAMA3 | laminin, alpha 3 | -0.19 |
