| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure. (Chemical Entities of Biological Interest Ontology, CHEBI_3441) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2585 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Carvedilol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 2.18 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.69 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.59 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.48 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.43 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.43 |
| TSPAN3 | tetraspanin 3 | 1.34 |
| MSMO1 | methylsterol monooxygenase 1 | 1.34 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.33 |
| ABHD2 | abhydrolase domain containing 2 | 1.24 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.2 |
| SQLE | squalene epoxidase | 1.12 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.04 |
| TNNC2 | troponin C type 2 (fast) | 1.03 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 1.01 |
| LPIN1 | lipin 1 | 0.99 |
| TMEM59 | transmembrane protein 59 | 0.98 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.92 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.9 |
| MVK | mevalonate kinase | 0.88 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.87 |
| LDLR | low density lipoprotein receptor | 0.86 |
| PAH | phenylalanine hydroxylase | 0.84 |
| FADS1 | fatty acid desaturase 1 | 0.79 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.78 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.78 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.77 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.77 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.74 |
| CD63 | CD63 molecule | 0.73 |
| RWDD1 | RWD domain containing 1 | 0.71 |
| PTMS | parathymosin | 0.7 |
| NCOA4 | nuclear receptor coactivator 4 | 0.69 |
| SC5D | sterol-C5-desaturase | 0.68 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.66 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.65 |
| RNF145 | ring finger protein 145 | 0.63 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.63 |
| SCARB1 | scavenger receptor class B, member 1 | 0.61 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.61 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.61 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.6 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.6 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.6 |
| BID | BH3 interacting domain death agonist | 0.59 |
| MVD | mevalonate (diphospho) decarboxylase | 0.59 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.58 |
| ITM2B | integral membrane protein 2B | 0.58 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.57 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.57 |
| PTMA | prothymosin, alpha | 0.56 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.55 |
| ZNF428 | zinc finger protein 428 | 0.55 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.53 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.53 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.53 |
| ITM2C | integral membrane protein 2C | 0.52 |
| RNF13 | ring finger protein 13 | 0.52 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.51 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.5 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.48 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.47 |
| FAR1 | fatty acyl CoA reductase 1 | 0.47 |
| TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) | 0.46 |
| PLPP2 | phospholipid phosphatase 2 | 0.46 |
| FASN | fatty acid synthase | 0.46 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.46 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.45 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.45 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | 0.44 |
| PRELID1 | PRELI domain containing 1 | 0.44 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.44 |
| MICA | MHC class I polypeptide-related sequence A | 0.44 |
| CD81 | CD81 molecule | 0.43 |
| GINM1 | glycoprotein integral membrane 1 | 0.43 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.43 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.43 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | 0.42 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.42 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.42 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.42 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 0.42 |
| MCL1 | myeloid cell leukemia 1 | 0.41 |
| TRIM2 | tripartite motif containing 2 | 0.41 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.41 |
| TMEM128 | transmembrane protein 128 | 0.4 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.4 |
| HYKK | hydroxylysine kinase | 0.4 |
| FDPS | farnesyl diphosphate synthase | 0.4 |
| TLR9 | toll-like receptor 9 | 0.4 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.39 |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | 0.39 |
| SLC49A4 | solute carrier family 49 member 4 | 0.39 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.39 |
| RTN4R | reticulon 4 receptor | 0.39 |
| TPM4 | tropomyosin 4 | 0.39 |
| GSTT2 | glutathione S-transferase theta 2 (gene/pseudogene) | 0.38 |
| MEGF9 | multiple EGF-like-domains 9 | 0.38 |
| BSDC1 | BSD domain containing 1 | 0.38 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GREB1 | growth regulation by estrogen in breast cancer 1 | -3.88 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | -1.42 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -1.39 |
| ZNF225 | zinc finger protein 225 | -1.15 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | -1.02 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -1.02 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | -0.98 |
| IMPAD1 | inositol monophosphatase domain containing 1 | -0.89 |
| ANKRD24 | ankyrin repeat domain 24 | -0.88 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.86 |
| BET1L | Bet1 golgi vesicular membrane trafficking protein-like | -0.79 |
| CFAP57 | cilia and flagella associated protein 57 | -0.73 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | -0.73 |
| PLIN2 | perilipin 2 | -0.71 |
| SBSN | suprabasin | -0.7 |
| LYRM1 | LYR motif containing 1 | -0.64 |
| NFYA | nuclear transcription factor Y, alpha | -0.61 |
| CUX2 | cut-like homeobox 2 | -0.59 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.59 |
| ESPN | espin | -0.58 |
| INAVA | innate immunity activator | -0.58 |
| ZNF302 | zinc finger protein 302 | -0.58 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.56 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -0.56 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.55 |
| NAAA | N-acylethanolamine acid amidase | -0.55 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.53 |
| ZFHX2 | zinc finger homeobox 2 | -0.52 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.52 |
| IDUA | iduronidase, alpha-L- | -0.52 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | -0.52 |
| ZNF766 | zinc finger protein 766 | -0.5 |
| OSTF1 | osteoclast stimulating factor 1 | -0.49 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.49 |
| PRDX1 | peroxiredoxin 1 | -0.48 |
| ANKLE1 | ankyrin repeat and LEM domain containing 1 | -0.48 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.48 |
| JUN | jun proto-oncogene | -0.45 |
| ARSK | arylsulfatase family, member K | -0.44 |
| MCEE | methylmalonyl CoA epimerase | -0.44 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | -0.44 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -0.44 |
| VGF | VGF nerve growth factor inducible | -0.44 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | -0.43 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.43 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -0.43 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.43 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -0.43 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.42 |
| TBCA | tubulin folding cofactor A | -0.41 |
| COQ4 | coenzyme Q4 | -0.41 |
| YDJC | YdjC homolog (bacterial) | -0.41 |
| DNLZ | DNL-type zinc finger | -0.41 |
| NDUFAF3 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 | -0.41 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | -0.41 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.4 |
| MMAA | methylmalonic aciduria (cobalamin deficiency) cblA type | -0.4 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.4 |
| VHL | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | -0.4 |
| COMMD2 | COMM domain containing 2 | -0.4 |
| ARG2 | arginase 2 | -0.4 |
| TXNL4B | thioredoxin-like 4B | -0.39 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.39 |
| DES | desmin | -0.39 |
| ZNF431 | zinc finger protein 431 | -0.39 |
| VWA3B | von Willebrand factor A domain containing 3B | -0.39 |
| ZNF320 | zinc finger protein 320 | -0.39 |
| SRXN1 | sulfiredoxin 1 | -0.39 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -0.38 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | -0.38 |
| MT1E | metallothionein 1E | -0.38 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.38 |
| KAZN | kazrin, periplakin interacting protein | -0.38 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.38 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.38 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.38 |
| SDF4 | stromal cell derived factor 4 | -0.38 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.37 |
| HSH2D | hematopoietic SH2 domain containing | -0.37 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.37 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.37 |
| TMPO | thymopoietin | -0.37 |
| PUSL1 | pseudouridylate synthase-like 1 | -0.37 |
| WDR73 | WD repeat domain 73 | -0.37 |
| MT2A | metallothionein 2A | -0.37 |
| CETN2 | centrin, EF-hand protein, 2 | -0.37 |
| NAGS | N-acetylglutamate synthase | -0.37 |
| SMIM19 | small integral membrane protein 19 | -0.37 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | -0.37 |
| PARK7 | parkinson protein 7 | -0.36 |
| CDON | cell adhesion associated, oncogene regulated | -0.36 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.36 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.36 |
| FASTKD3 | FAST kinase domains 3 | -0.36 |
| MTRF1L | mitochondrial translational release factor 1-like | -0.36 |
| RPS12 | ribosomal protein S12 | -0.36 |
| CAPRIN2 | caprin family member 2 | -0.36 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.36 |
| ALDOA | aldolase A, fructose-bisphosphate | -0.35 |
