Celecoxib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.273649
VCL vinculin 0.11247
TLE4 transducin-like enhancer of split 4 0.0793399
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0789591
FAM13A family with sequence similarity 13, member A 0.0594023
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0592404
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0557382
HELZ helicase with zinc finger 0.0553314
IGF2 insulin-like growth factor 2 0.0468503
ZSWIM6 zinc finger, SWIM-type containing 6 0.0450881
RPS6 ribosomal protein S6 0.0447942
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0429048
SOX9 SRY (sex determining region Y)-box 9 0.0410641
VIM vimentin 0.0397638
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.039572
TOP2A topoisomerase (DNA) II alpha 170kDa 0.037841
HILPDA hypoxia inducible lipid droplet-associated 0.0377409
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0366729
FNBP1 formin binding protein 1 0.0354414
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0350856
PTMA prothymosin, alpha 0.0349928
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.033525
EIF1 eukaryotic translation initiation factor 1 0.0329106
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0322866
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0318994
EEF2 eukaryotic translation elongation factor 2 0.0318509
TIMP3 TIMP metallopeptidase inhibitor 3 0.0312528
TRIB2 tribbles pseudokinase 2 0.0311385
MEIS2 Meis homeobox 2 0.0292766
FAM107B family with sequence similarity 107, member B 0.0285621
EGR1 early growth response 1 0.0282725
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0282232
STK38L serine/threonine kinase 38 like 0.0275835
SLIT2 slit homolog 2 (Drosophila) 0.0275397
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0273362
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0269096
CXXC5 CXXC finger protein 5 0.026817
RPS2 ribosomal protein S2 0.0264655
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0264518
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0259405
TRIM24 tripartite motif containing 24 0.0258889
MED13 mediator complex subunit 13 0.0255943
FERMT2 fermitin family member 2 0.0253196
KTN1 kinectin 1 (kinesin receptor) 0.025276
RPS12 ribosomal protein S12 0.0250332
VEGFA vascular endothelial growth factor A 0.0248792
RNF150 ring finger protein 150 0.0244847
QKI QKI, KH domain containing, RNA binding 0.0244794
VMP1 vacuole membrane protein 1 0.0244279
RPL32 ribosomal protein L32 0.0241593
SEPTIN7 septin 7 0.0241478
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0235716
DTNA dystrobrevin, alpha 0.0233173
TPM1 tropomyosin 1 (alpha) 0.0233116
ZNF148 zinc finger protein 148 0.0231708
SLITRK6 SLIT and NTRK-like family, member 6 0.0231383
TRA2A transformer 2 alpha homolog (Drosophila) 0.0230108
THBS1 thrombospondin 1 0.0230057
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0226226
DDIT4 DNA-damage-inducible transcript 4 0.0225057
PCM1 pericentriolar material 1 0.0222284
RPS23 ribosomal protein S23 0.0219417
PNISR PNN-interacting serine/arginine-rich protein 0.0218368
RYBP RING1 and YY1 binding protein 0.0218251
MED13L mediator complex subunit 13-like 0.0218145
DNMBP dynamin binding protein 0.0213577
PHIP pleckstrin homology domain interacting protein 0.0209109
GATA3 GATA binding protein 3 0.020707
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0206696
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0205639
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0201762
CENPF centromere protein F, 350/400kDa 0.0201114
ZFP36L1 ZFP36 ring finger protein-like 1 0.0200405
RPL27 ribosomal protein L27 0.0200067
LPIN1 lipin 1 0.0199519
ACTN1 actinin, alpha 1 0.0199425
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0198961
CTNND1 catenin (cadherin-associated protein), delta 1 0.0195614
KMT2C lysine (K)-specific methyltransferase 2C 0.0195116
RARA retinoic acid receptor, alpha 0.019495
PUM2 pumilio RNA-binding family member 2 0.019193
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0191415
TFG TRK-fused gene 0.0190992
KDM4C lysine (K)-specific demethylase 4C 0.0190683
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0189454
PELI1 pellino E3 ubiquitin protein ligase 1 0.018839
RPS11 ribosomal protein S11 0.0187755
RPL23 ribosomal protein L23 0.018767
NCOR2 nuclear receptor corepressor 2 0.0187597
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0186296
RSRC2 arginine/serine-rich coiled-coil 2 0.0185908
PDE4D phosphodiesterase 4D, cAMP-specific 0.0184849
KDM5B lysine (K)-specific demethylase 5B 0.0184498
RPLP1 ribosomal protein, large, P1 0.0182745
ASPH aspartate beta-hydroxylase 0.0182669
TLN1 talin 1 0.0182409
WDR45B WD repeat domain 45B 0.0181952
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0181786
KDM3A lysine (K)-specific demethylase 3A 0.0181223
MYO1E myosin IE 0.0180569

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.145277
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0826134
SYT1 synaptotagmin I -0.065923
CEMIP cell migration inducing protein, hyaluronan binding -0.0643505
LIMCH1 LIM and calponin homology domains 1 -0.0558777
GPC5 glypican 5 -0.0550111
LSAMP limbic system-associated membrane protein -0.0548892
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0541399
CADM2 cell adhesion molecule 2 -0.0503568
DLC1 DLC1 Rho GTPase activating protein -0.0474876
ZNF804A zinc finger protein 804A -0.0466704
NREP neuronal regeneration related protein -0.0411322
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0410085
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0407576
ATRNL1 attractin-like 1 -0.0398692
FRMD4A FERM domain containing 4A -0.0398386
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0387903
NCAM2 neural cell adhesion molecule 2 -0.0346786
TENT5A terminal nucleotidyltransferase 5A -0.0327337
GARS1 glycyl-tRNA synthetase 1 -0.0327133
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0320342
ZFAND3 zinc finger, AN1-type domain 3 -0.0300954
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0300756
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.02923
IARS1 isoleucyl-tRNA synthetase 1 -0.0286766
AOPEP aminopeptidase O (putative) -0.0283631
RAI14 retinoic acid induced 14 -0.0271073
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0265559
PHF3 PHD finger protein 3 -0.0262858
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.026221
TBC1D19 TBC1 domain family, member 19 -0.0260811
SVIL supervillin -0.0241029
AEBP2 AE binding protein 2 -0.0238813
AFF3 AF4/FMR2 family, member 3 -0.0228385
RPTOR regulatory associated protein of MTOR, complex 1 -0.022767
PTPRG protein tyrosine phosphatase, receptor type, G -0.022559
COL3A1 collagen, type III, alpha 1 -0.0224043
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0219626
PCDH9 protocadherin 9 -0.0218886
TULP4 tubby like protein 4 -0.0218494
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0213818
GREM2 gremlin 2, DAN family BMP antagonist -0.0211691
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0210385
MBD5 methyl-CpG binding domain protein 5 -0.0206606
GDF15 growth differentiation factor 15 -0.020453
CDK12 cyclin-dependent kinase 12 -0.0202661
EXT1 exostosin glycosyltransferase 1 -0.0199938
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0196725
STC1 stanniocalcin 1 -0.0195823
NBEA neurobeachin -0.0191438
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0189269
SLC39A11 solute carrier family 39, member 11 -0.0188934
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0187365
KPNB1 karyopherin (importin) beta 1 -0.0187071
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0184391
ACBD6 acyl-CoA binding domain containing 6 -0.0181269
ESYT2 extended synaptotagmin-like protein 2 -0.0180961
FHIT fragile histidine triad -0.0180928
RANBP17 RAN binding protein 17 -0.0178781
RUNX1 runt-related transcription factor 1 -0.0174253
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0174173
PTRH2 peptidyl-tRNA hydrolase 2 -0.0173901
DNAH14 dynein, axonemal, heavy chain 14 -0.0173778
ADGRG6 adhesion G protein-coupled receptor G6 -0.0172157
PBX1 pre-B-cell leukemia homeobox 1 -0.0171744
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0171197
ESRRG estrogen-related receptor gamma -0.016978
TPT1 tumor protein, translationally-controlled 1 -0.0167281
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0166001
IGFBP4 insulin-like growth factor binding protein 4 -0.0165351
FGF14 fibroblast growth factor 14 -0.0162552
ADGRB3 adhesion G protein-coupled receptor B3 -0.0162473
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0162131
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0161984
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0161604
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0161474
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.0161189
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0159851
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0159311
MAML2 mastermind-like 2 (Drosophila) -0.0157826
IFI44L interferon-induced protein 44-like -0.0157639
FUBP3 far upstream element (FUSE) binding protein 3 -0.0157509
WDR33 WD repeat domain 33 -0.0157458
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0157165
ITGA1 integrin, alpha 1 -0.0156354
GMDS GDP-mannose 4,6-dehydratase -0.0156051
MCPH1 microcephalin 1 -0.015504
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0154736
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0154383
LRP1B low density lipoprotein receptor-related protein 1B -0.0154
ZNF652 zinc finger protein 652 -0.0153824
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0152759
ANGPT1 angiopoietin 1 -0.0151957
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0151664
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0151005
DLG1 discs, large homolog 1 (Drosophila) -0.0150872
DSCAM Down syndrome cell adhesion molecule -0.014848
BABAM2 BRISC and BRCA1 A complex member 2 -0.014775
ATXN10 ataxin 10 -0.0145461
SPAG16 sperm associated antigen 16 -0.0145453