Celecoxib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.122092
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.102427
DST dystonin 0.0827769
SVIL supervillin 0.0787748
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0714329
MAML2 mastermind-like 2 (Drosophila) 0.0687891
FRMD5 FERM domain containing 5 0.0685298
DSPP dentin sialophosphoprotein 0.0656754
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0644902
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0617195
DOCK4 dedicator of cytokinesis 4 0.0602767
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0598634
GPC6 glypican 6 0.0545023
GRB10 growth factor receptor-bound protein 10 0.0525811
RUNX1 runt-related transcription factor 1 0.0505343
PAWR PRKC, apoptosis, WT1, regulator 0.0502136
TRIO trio Rho guanine nucleotide exchange factor 0.0476839
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0469607
ITGAV integrin, alpha V 0.0454969
VCL vinculin 0.044873
LRMDA leucine rich melanocyte differentiation associated 0.0447603
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.044748
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0418567
FAM107B family with sequence similarity 107, member B 0.0402064
APLP2 amyloid beta (A4) precursor-like protein 2 0.0396443
ERRFI1 ERBB receptor feedback inhibitor 1 0.0396097
TNS1 tensin 1 0.0382119
PDLIM5 PDZ and LIM domain 5 0.0369055
CRY1 cryptochrome circadian clock 1 0.0361925
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0350647
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0350349
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0332548
VMP1 vacuole membrane protein 1 0.0327742
MYH9 myosin, heavy chain 9, non-muscle 0.0319615
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0315404
JMJD1C jumonji domain containing 1C 0.0314115
ARHGAP9 Rho GTPase activating protein 9 0.0304199
LIMS1 LIM and senescent cell antigen-like domains 1 0.029906
RAD51B RAD51 paralog B 0.0294078
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0293953
POTEF POTE ankyrin domain family, member F 0.0291571
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0290549
C3 complement component 3 0.0284533
PSME4 proteasome (prosome, macropain) activator subunit 4 0.028343
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0281673
PRELID2 PRELI domain containing 2 0.027499
PUM2 pumilio RNA-binding family member 2 0.0272344
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0267656
DNAH17 dynein, axonemal, heavy chain 17 0.0266387
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0265212
PRKCA protein kinase C, alpha 0.0263997
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0263478
FAT1 FAT atypical cadherin 1 0.0262094
ZNF644 zinc finger protein 644 0.0260893
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0258823
AFF1 AF4/FMR2 family, member 1 0.0252557
MBNL1 muscleblind-like splicing regulator 1 0.025231
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0251689
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0250323
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0249936
RASA2 RAS p21 protein activator 2 0.0248019
SMYD3 SET and MYND domain containing 3 0.0247168
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0246974
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0242138
LMO7 LIM domain 7 0.0240543
PPARD peroxisome proliferator-activated receptor delta 0.0240062
DOCK5 dedicator of cytokinesis 5 0.0236156
FNIP1 folliculin interacting protein 1 0.0235031
ITCH itchy E3 ubiquitin protein ligase 0.0234746
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0234046
EHBP1 EH domain binding protein 1 0.0227592
ANO6 anoctamin 6 0.0222994
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0222978
ZBTB20 zinc finger and BTB domain containing 20 0.0220985
MALRD1 MAM and LDL receptor class A domain containing 1 0.0220591
RTN4 reticulon 4 0.0216082
KIF1B kinesin family member 1B 0.0215386
LCOR ligand dependent nuclear receptor corepressor 0.0214195
RPL3 ribosomal protein L3 0.0211888
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0209083
CEMIP2 cell migration inducing hyaluronidase 2 0.0205954
AKAP13 A kinase (PRKA) anchor protein 13 0.0204791
MALT1 MALT1 paracaspase 0.0204645
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0202951
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0202293
NBAS neuroblastoma amplified sequence 0.0201884
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0201595
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.02003
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0197928
FOXP1 forkhead box P1 0.0197566
MSI2 musashi RNA-binding protein 2 0.0194371
ERBIN erbb2 interacting protein 0.0193477
TBC1D22A TBC1 domain family, member 22A 0.0189752
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0188191
AHR aryl hydrocarbon receptor 0.0188014
PSEN1 presenilin 1 0.0187433
OSBPL10 oxysterol binding protein-like 10 0.0186865
ESYT2 extended synaptotagmin-like protein 2 0.0186206
METTL15 methyltransferase like 15 0.01829
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0182277

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.130395
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127625
TPT1 tumor protein, translationally-controlled 1 -0.119455
MT2A metallothionein 2A -0.115756
RPS6 ribosomal protein S6 -0.112003
RPS8 ribosomal protein S8 -0.107539
RPL37A ribosomal protein L37a -0.106352
APOA2 apolipoprotein A-II -0.0985581
RPS24 ribosomal protein S24 -0.0805609
GPC3 glypican 3 -0.0795191
CP ceruloplasmin (ferroxidase) -0.0774127
AHSG alpha-2-HS-glycoprotein -0.0755045
RPLP1 ribosomal protein, large, P1 -0.0699651
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0696172
PLIN2 perilipin 2 -0.0665719
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0662186
RPLP2 ribosomal protein, large, P2 -0.0636671
RPS12 ribosomal protein S12 -0.0627351
IGFBP1 insulin-like growth factor binding protein 1 -0.0614065
PEG3 paternally expressed 3 -0.0608769
RPLP0 ribosomal protein, large, P0 -0.0605809
RPL35A ribosomal protein L35a -0.059417
CCL20 chemokine (C-C motif) ligand 20 -0.0580077
FBF1 Fas (TNFRSF6) binding factor 1 -0.0576584
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0569964
APOE apolipoprotein E -0.054757
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0539564
RPS29 ribosomal protein S29 -0.053738
RPS19 ribosomal protein S19 -0.053661
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0535367
RPL34 ribosomal protein L34 -0.0527806
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0518066
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0517303
RPS3 ribosomal protein S3 -0.0514154
RPS27A ribosomal protein S27a -0.0504148
RPL38 ribosomal protein L38 -0.0502854
FTL ferritin, light polypeptide -0.0497272
RPL23 ribosomal protein L23 -0.0490071
RPS14 ribosomal protein S14 -0.0472103
RRBP1 ribosome binding protein 1 -0.0467746
A2M alpha-2-macroglobulin -0.0467599
PTMA prothymosin, alpha -0.0466928
RPS23 ribosomal protein S23 -0.04597
RACK1 receptor for activated C kinase 1 -0.0456895
RPL31 ribosomal protein L31 -0.0456492
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0449935
RPL5 ribosomal protein L5 -0.0447336
TM4SF1 transmembrane 4 L six family member 1 -0.0431143
RPL9 ribosomal protein L9 -0.0425567
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0419804
SLC38A1 solute carrier family 38, member 1 -0.0415343
APOB apolipoprotein B -0.0413041
RPS21 ribosomal protein S21 -0.0394472
AMBP alpha-1-microglobulin/bikunin precursor -0.0388897
ACTG1 actin gamma 1 -0.0388485
RPL12 ribosomal protein L12 -0.0387934
DDIT4 DNA-damage-inducible transcript 4 -0.038669
TMEM123 transmembrane protein 123 -0.0386041
RPL26 ribosomal protein L26 -0.0380415
RPS10 ribosomal protein S10 -0.0379413
FN1 fibronectin 1 -0.037598
RPS13 ribosomal protein S13 -0.0370751
EML4 echinoderm microtubule associated protein like 4 -0.0367395
APOA1 apolipoprotein A-I -0.0366887
RBM39 RNA binding motif protein 39 -0.0355854
GNAS GNAS complex locus -0.0354059
IER3 immediate early response 3 -0.035037
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0347892
AKAP12 A kinase (PRKA) anchor protein 12 -0.0346475
RPL11 ribosomal protein L11 -0.0345327
RBM25 RNA binding motif protein 25 -0.0343938
SDC4 syndecan 4 -0.0343629
CALR calreticulin -0.0342974
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0340525
RPL32 ribosomal protein L32 -0.0331592
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.033133
RSL1D1 ribosomal L1 domain containing 1 -0.032968
MARCKS myristoylated alanine-rich protein kinase C substrate -0.032558
KDM3A lysine (K)-specific demethylase 3A -0.0322174
INTS6 integrator complex subunit 6 -0.0321835
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.031933
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0314243
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0313042
RPL19 ribosomal protein L19 -0.0305372
EIF5B eukaryotic translation initiation factor 5B -0.0304957
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0303933
WDR45B WD repeat domain 45B -0.0297212
RPL37 ribosomal protein L37 -0.0292802
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0291805
NPR2 natriuretic peptide receptor 2 -0.0291468
RPS11 ribosomal protein S11 -0.0290261
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.028967
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0288922
STAU1 staufen double-stranded RNA binding protein 1 -0.0288828
HDLBP high density lipoprotein binding protein -0.0286129
RPS25 ribosomal protein S25 -0.0286056
HM13 histocompatibility (minor) 13 -0.028446
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0283282
CANX calnexin -0.0282244
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0277791