Celecoxib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.123558
LMO7 LIM domain 7 0.103329
PDE4D phosphodiesterase 4D, cAMP-specific 0.0879539
AHNAK AHNAK nucleoprotein 0.0834986
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0802125
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0774593
DPYD dihydropyrimidine dehydrogenase 0.0700456
MTSS1 metastasis suppressor 1 0.0630592
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0569708
ASPH aspartate beta-hydroxylase 0.0568355
MT2A metallothionein 2A 0.0562597
TPT1 tumor protein, translationally-controlled 1 0.0525716
DOCK5 dedicator of cytokinesis 5 0.0510124
KLF5 Kruppel-like factor 5 (intestinal) 0.0501599
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0491655
MACF1 microtubule-actin crosslinking factor 1 0.0451416
DOK5 docking protein 5 0.0442843
TMSB4X thymosin beta 4, X-linked 0.0438693
PDLIM5 PDZ and LIM domain 5 0.0428944
TMSB10 thymosin beta 10 0.0413701
OSMR oncostatin M receptor 0.0400937
BCAR3 breast cancer anti-estrogen resistance 3 0.0397029
EXT1 exostosin glycosyltransferase 1 0.038901
SMAD3 SMAD family member 3 0.0385372
PRELID2 PRELI domain containing 2 0.0381933
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0372946
EFNA5 ephrin-A5 0.0368468
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0364874
SMYD3 SET and MYND domain containing 3 0.0357043
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0352794
RIN2 Ras and Rab interactor 2 0.0352675
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0345082
FN1 fibronectin 1 0.0343161
CDK6 cyclin-dependent kinase 6 0.0342931
RASAL2 RAS protein activator like 2 0.0334994
MBNL2 muscleblind-like splicing regulator 2 0.0330654
FNIP1 folliculin interacting protein 1 0.0327528
NRIP1 nuclear receptor interacting protein 1 0.0318551
ENO1 enolase 1, (alpha) 0.0317407
MBNL1 muscleblind-like splicing regulator 1 0.0306622
DSCAM Down syndrome cell adhesion molecule 0.0305673
FOXP1 forkhead box P1 0.0305423
SULF1 sulfatase 1 0.0305301
CEMIP cell migration inducing protein, hyaluronan binding 0.0293115
TSC22D1 TSC22 domain family, member 1 0.0283849
NTSR1 neurotensin receptor 1 (high affinity) 0.0280284
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0275396
DST dystonin 0.0274073
AOPEP aminopeptidase O (putative) 0.0266541
EXOC4 exocyst complex component 4 0.026515
RPL37 ribosomal protein L37 0.0263053
RPL5 ribosomal protein L5 0.0263032
RPS19 ribosomal protein S19 0.0261389
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0259681
RAI14 retinoic acid induced 14 0.0259472
CD44 CD44 molecule (Indian blood group) 0.0259189
CNTNAP3 contactin associated protein-like 3 0.0253113
SOS1 son of sevenless homolog 1 (Drosophila) 0.0252989
ATXN1 ataxin 1 0.0252587
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0252348
FOXO1 forkhead box O1 0.024828
PRSS23 protease, serine, 23 0.0248232
IFI16 interferon, gamma-inducible protein 16 0.024538
MECOM MDS1 and EVI1 complex locus 0.0245117
TM4SF1 transmembrane 4 L six family member 1 0.0242321
RPS21 ribosomal protein S21 0.0242163
LMNA lamin A/C 0.0241727
RAD51B RAD51 paralog B 0.0241539
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0241274
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0238353
PTK2 protein tyrosine kinase 2 0.0238047
MYOF myoferlin 0.02379
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0233994
PSD3 pleckstrin and Sec7 domain containing 3 0.0231014
CAVIN1 caveolae associated protein 1 0.0225763
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0224282
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0220084
BLCAP bladder cancer associated protein 0.0219785
TXNRD1 thioredoxin reductase 1 0.0219514
MTAP methylthioadenosine phosphorylase 0.0216755
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0213676
RPL32 ribosomal protein L32 0.0213123
RRBP1 ribosome binding protein 1 0.0210359
MPRIP myosin phosphatase Rho interacting protein 0.0209906
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.0209807
RPL30 ribosomal protein L30 0.0209513
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.020923
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0208523
ZSWIM6 zinc finger, SWIM-type containing 6 0.0205938
HSPA8 heat shock 70kDa protein 8 0.0205199
TRIM56 tripartite motif containing 56 0.0204212
FAM107B family with sequence similarity 107, member B 0.0203518
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0203431
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0200863
ATM ATM serine/threonine kinase 0.0199515
GOLGB1 golgin B1 0.0198331
HMGA2 high mobility group AT-hook 2 0.0198272
BPTF bromodomain PHD finger transcription factor 0.0198069
ANO6 anoctamin 6 0.0196275
STK4 serine/threonine kinase 4 0.0196229

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.110265
CLU clusterin -0.0783099
POTEF POTE ankyrin domain family, member F -0.0702218
MEF2A myocyte enhancer factor 2A -0.0583455
PTMA prothymosin, alpha -0.0496346
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0439607
SPAG9 sperm associated antigen 9 -0.0426751
HSPG2 heparan sulfate proteoglycan 2 -0.0420998
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.042021
GOLGA4 golgin A4 -0.0417526
CYB5R3 cytochrome b5 reductase 3 -0.0398735
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0377139
SQLE squalene epoxidase -0.0362109
KTN1 kinectin 1 (kinesin receptor) -0.0358992
DSTN destrin (actin depolymerizing factor) -0.0357956
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0351461
ITGA6 integrin, alpha 6 -0.0345236
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0331785
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0328268
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0328042
B2M beta-2-microglobulin -0.0327342
RNF145 ring finger protein 145 -0.0325295
PDIA3 protein disulfide isomerase family A, member 3 -0.0325144
KDM6A lysine (K)-specific demethylase 6A -0.0317537
FOSL1 FOS-like antigen 1 -0.0313884
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0306894
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0302615
SEC31A SEC31 homolog A (S. cerevisiae) -0.0289222
LIMA1 LIM domain and actin binding 1 -0.0271925
KRT17 keratin 17, type I -0.0267972
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.026562
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0265303
GRB10 growth factor receptor-bound protein 10 -0.0264828
PTPRJ protein tyrosine phosphatase, receptor type, J -0.026058
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0254903
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0254733
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0253629
PKM pyruvate kinase, muscle -0.0252186
FNDC3A fibronectin type III domain containing 3A -0.0245236
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0244137
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.024393
YBX1 Y box binding protein 1 -0.0243094
NUCB2 nucleobindin 2 -0.0239613
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0239455
STC1 stanniocalcin 1 -0.0236041
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0235574
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0233504
WASF2 WAS protein family, member 2 -0.0232976
TMEM165 transmembrane protein 165 -0.0231907
SUCO SUN domain containing ossification factor -0.0230885
KRT6A keratin 6A, type II -0.0230111
ARF4 ADP-ribosylation factor 4 -0.0229153
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0228925
NDRG1 N-myc downstream regulated 1 -0.0225423
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0225132
ITCH itchy E3 ubiquitin protein ligase -0.0224462
GLS2 glutaminase 2 (liver, mitochondrial) -0.0224206
TAGLN2 transgelin 2 -0.0224108
NUP58 nucleoporin 58 -0.0223771
PLS3 plastin 3 -0.0222658
ADAM17 ADAM metallopeptidase domain 17 -0.0221727
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0221168
PCBP2 poly(rC) binding protein 2 -0.0220903
IGF2 insulin-like growth factor 2 -0.0220032
LAMA5 laminin, alpha 5 -0.0219351
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.021869
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0215573
PFN1 profilin 1 -0.0211436
TFG TRK-fused gene -0.0209939
RPS6 ribosomal protein S6 -0.0208434
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0206601
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0206532
MYO10 myosin X -0.020618
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.020481
CCNL1 cyclin L1 -0.0204635
RPS12 ribosomal protein S12 -0.0202232
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0201426
FTH1 ferritin, heavy polypeptide 1 -0.0201051
SCARB2 scavenger receptor class B, member 2 -0.0200661
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0200265
TPM4 tropomyosin 4 -0.0198709
CSDE1 cold shock domain containing E1, RNA-binding -0.0197806
INSIG2 insulin induced gene 2 -0.0195843
SETD5 SET domain containing 5 -0.0194937
KMT2C lysine (K)-specific methyltransferase 2C -0.0191003
SRP54 signal recognition particle 54kDa -0.0190994
NOP58 NOP58 ribonucleoprotein -0.0186658
NAMPT nicotinamide phosphoribosyltransferase -0.0186163
GLYAT glycine-N-acyltransferase -0.0183937
HELZ helicase with zinc finger -0.0182991
HLA-A major histocompatibility complex, class I, A -0.01817
CALB1 calbindin 1, 28kDa -0.0180328
NPEPPS aminopeptidase puromycin sensitive -0.0180084
NCOR2 nuclear receptor corepressor 2 -0.0180042
CPOX coproporphyrinogen oxidase -0.0179494
PGK1 phosphoglycerate kinase 1 -0.017877
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0177377
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0173873
GARS1 glycyl-tRNA synthetase 1 -0.0173753
PLTP phospholipid transfer protein -0.0173675