Celecoxib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0565572
RPL36 ribosomal protein L36 0.0331891
RPS12 ribosomal protein S12 0.0307452
RPS19 ribosomal protein S19 0.030114
RPS6 ribosomal protein S6 0.027864
CADM2 cell adhesion molecule 2 0.0228122
TP63 tumor protein p63 0.0214822
RPL37A ribosomal protein L37a 0.0191921
DST dystonin 0.0191304
INTS6 integrator complex subunit 6 0.0188561
RPS23 ribosomal protein S23 0.0186417
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0182416
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0170675
RPS29 ribosomal protein S29 0.0157809
ENO2 enolase 2 (gamma, neuronal) 0.0154676
TXNIP thioredoxin interacting protein 0.0150699
RPL31 ribosomal protein L31 0.0149117
ZSWIM6 zinc finger, SWIM-type containing 6 0.0147135
B2M beta-2-microglobulin 0.0146431
RPS2 ribosomal protein S2 0.014452
RPL18 ribosomal protein L18 0.0144102
ZDHHC14 zinc finger, DHHC-type containing 14 0.0143854
DPYD dihydropyrimidine dehydrogenase 0.0142422
RPL32 ribosomal protein L32 0.0135531
CFAP299 cilia and flagella associated protein 299 0.0135293
RPS17 ribosomal protein S17 0.013285
DPH6 diphthamine biosynthesis 6 0.0130191
RPS10 ribosomal protein S10 0.0128563
CSMD3 CUB and Sushi multiple domains 3 0.0127985
TTC3 tetratricopeptide repeat domain 3 0.0126276
TSC22D1 TSC22 domain family, member 1 0.0123486
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0120015
HLA-B major histocompatibility complex, class I, B 0.0119002
SDK1 sidekick cell adhesion molecule 1 0.0118033
RPS8 ribosomal protein S8 0.0114033
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0113805
RAD51B RAD51 paralog B 0.0113328
EFNA5 ephrin-A5 0.011128
LOC102724023 ES1 protein homolog, mitochondrial 0.0111079
SLK STE20-like kinase 0.0111018
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0109509
PRELID2 PRELI domain containing 2 0.0108102
GOLGB1 golgin B1 0.010707
PSD3 pleckstrin and Sec7 domain containing 3 0.0104369
RPL38 ribosomal protein L38 0.0101604
RPL27 ribosomal protein L27 0.00968868
RUNX1 runt-related transcription factor 1 0.00952685
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00917477
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.00900073
CEP290 centrosomal protein 290kDa 0.00843087
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.00840645
PCDH1 protocadherin 1 0.00835053
HILPDA hypoxia inducible lipid droplet-associated 0.00823712
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.00810251
RPS13 ribosomal protein S13 0.00802284
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.00801448
NEK10 NIMA-related kinase 10 0.00796271
SQSTM1 sequestosome 1 0.00779954
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.00775176
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00759975
AKAP12 A kinase (PRKA) anchor protein 12 0.00746337
ZBTB1 zinc finger and BTB domain containing 1 0.00745421
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00739334
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.00739025
NPAS2 neuronal PAS domain protein 2 0.00735684
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.00720093
PDE10A phosphodiesterase 10A 0.00712077
EPHA4 EPH receptor A4 0.00705914
ZNF337 zinc finger protein 337 0.00692127
NEBL nebulette 0.00667512
AFF3 AF4/FMR2 family, member 3 0.00666429
CALD1 caldesmon 1 0.00658746
ACAD11 acyl-CoA dehydrogenase family, member 11 0.0065759
BBS9 Bardet-Biedl syndrome 9 0.00656468
FAM219A family with sequence similarity 219, member A 0.00645815
ZNF146 zinc finger protein 146 0.00627277
RPL28 ribosomal protein L28 0.00621165
RAD50 RAD50 homolog (S. cerevisiae) 0.00620737
GYS1 glycogen synthase 1 (muscle) 0.00617482
H1-4 H1.4 linker histone, cluster member 0.00609575
ZNF75D zinc finger protein 75D 0.00596575
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.00595359
LRRC23 leucine rich repeat containing 23 0.00593612
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00573001
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.00570162
ZNF248 zinc finger protein 248 0.00566867
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.00564569
CAPRIN2 caprin family member 2 0.00561136
FAM114A1 family with sequence similarity 114, member A1 0.00558973
ANKRD26 ankyrin repeat domain 26 0.00555731
RPS15 ribosomal protein S15 0.00554561
HMGA2 high mobility group AT-hook 2 0.00553362
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0055324
FAM53C family with sequence similarity 53, member C 0.00552841
SCAPER S-phase cyclin A-associated protein in the ER 0.005484
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.00548321
HOMER1 homer scaffolding protein 1 0.00545418
WWOX WW domain containing oxidoreductase 0.00542895
LMO7 LIM domain 7 0.00540044
COG6 component of oligomeric golgi complex 6 0.00534581

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.263131
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184095
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0924096
TXNRD1 thioredoxin reductase 1 -0.0917859
TM4SF1 transmembrane 4 L six family member 1 -0.089127
EEF2 eukaryotic translation elongation factor 2 -0.0794786
UBC ubiquitin C -0.0793274
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0772984
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.063919
CD44 CD44 molecule (Indian blood group) -0.0637489
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0593857
AHNAK AHNAK nucleoprotein -0.0581671
APP amyloid beta (A4) precursor protein -0.0580468
RAI1 retinoic acid induced 1 -0.0570556
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.053851
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0537993
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0533049
POTEF POTE ankyrin domain family, member F -0.0527423
LDHA lactate dehydrogenase A -0.0517794
LOC112694756 uncharaterized LOC112694756 -0.0495957
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0448099
PTMA prothymosin, alpha -0.044653
JUN jun proto-oncogene -0.0412682
ENO1 enolase 1, (alpha) -0.0409662
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0409476
ACTG1 actin gamma 1 -0.0406863
TMSB10 thymosin beta 10 -0.0389855
ZMYND8 zinc finger, MYND-type containing 8 -0.0389086
TMSB4X thymosin beta 4, X-linked -0.038848
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0388149
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0376354
ERRFI1 ERBB receptor feedback inhibitor 1 -0.037438
RTN4 reticulon 4 -0.0372592
PGK1 phosphoglycerate kinase 1 -0.0371316
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0370089
USP34 ubiquitin specific peptidase 34 -0.0365226
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0362377
EIF4A1 eukaryotic translation initiation factor 4A1 -0.03492
WARS1 tryptophanyl-tRNA synthetase 1 -0.0347559
EREG epiregulin -0.0345602
EZR ezrin -0.0345089
RPS27A ribosomal protein S27a -0.0338985
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0332326
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0331751
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0329028
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0326816
CANX calnexin -0.0320357
SRPK2 SRSF protein kinase 2 -0.031121
PRRC2C proline-rich coiled-coil 2C -0.0308521
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0306191
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0303208
SPAG9 sperm associated antigen 9 -0.0302602
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0297612
XPO1 exportin 1 -0.0293816
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0291562
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0287825
TRIP12 thyroid hormone receptor interactor 12 -0.0286862
MATR3 matrin 3 -0.0286856
CENPF centromere protein F, 350/400kDa -0.0282394
ADAM17 ADAM metallopeptidase domain 17 -0.0282123
PCBP2 poly(rC) binding protein 2 -0.0273131
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0266812
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0266305
MKI67 marker of proliferation Ki-67 -0.0259591
SFPQ splicing factor proline/glutamine-rich -0.0258021
NAMPT nicotinamide phosphoribosyltransferase -0.0256562
GARS1 glycyl-tRNA synthetase 1 -0.0255847
BRWD1 bromodomain and WD repeat domain containing 1 -0.0255392
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.025446
SLC38A2 solute carrier family 38, member 2 -0.0254377
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0253999
EMP1 epithelial membrane protein 1 -0.0253382
BCAR3 breast cancer anti-estrogen resistance 3 -0.0250539
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0250259
GSK3B glycogen synthase kinase 3 beta -0.0249279
TMEM41B transmembrane protein 41B -0.0246957
FBXO11 F-box protein 11 -0.0245249
ZFAND3 zinc finger, AN1-type domain 3 -0.0244703
FLNB filamin B, beta -0.0243014
KMT2E lysine (K)-specific methyltransferase 2E -0.0241167
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0240433
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0238857
MYH9 myosin, heavy chain 9, non-muscle -0.0236267
CSDE1 cold shock domain containing E1, RNA-binding -0.0235165
DSCAM Down syndrome cell adhesion molecule -0.0233475
S100A6 S100 calcium binding protein A6 -0.0230485
DLG1 discs, large homolog 1 (Drosophila) -0.0227465
RPL23 ribosomal protein L23 -0.0224931
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0224563
ANXA1 annexin A1 -0.02242
CSNK1A1 casein kinase 1, alpha 1 -0.0223697
MACF1 microtubule-actin crosslinking factor 1 -0.0223501
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0221369
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0220929
KDM3A lysine (K)-specific demethylase 3A -0.0219828
RBM25 RNA binding motif protein 25 -0.0216672
SMC4 structural maintenance of chromosomes 4 -0.0212002
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0211075
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0210747
TPT1 tumor protein, translationally-controlled 1 -0.0210386