Celecoxib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.0802962
NAV2 neuron navigator 2 0.0594659
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0591199
NDRG1 N-myc downstream regulated 1 0.0576986
GOLGA4 golgin A4 0.053204
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0530694
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0528359
FAM13A family with sequence similarity 13, member A 0.0492693
AKAP12 A kinase (PRKA) anchor protein 12 0.047997
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0442424
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0439885
UBA6 ubiquitin-like modifier activating enzyme 6 0.0395738
KDM2A lysine (K)-specific demethylase 2A 0.0373499
ESYT2 extended synaptotagmin-like protein 2 0.0361855
APLP2 amyloid beta (A4) precursor-like protein 2 0.035596
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0354764
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0343368
ASPH aspartate beta-hydroxylase 0.034332
SMAD3 SMAD family member 3 0.0340462
PRELID2 PRELI domain containing 2 0.0339668
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0325744
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0324585
PIAS2 protein inhibitor of activated STAT, 2 0.0323979
SOD2 superoxide dismutase 2, mitochondrial 0.0321035
AADAC arylacetamide deacetylase 0.0318391
FBXL13 F-box and leucine-rich repeat protein 13 0.0313544
VEGFA vascular endothelial growth factor A 0.0308946
ZNF292 zinc finger protein 292 0.0307649
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0305558
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0302054
EEF2 eukaryotic translation elongation factor 2 0.0295363
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0294789
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0292013
MYOF myoferlin 0.0287087
HELZ helicase with zinc finger 0.0282122
ECE1 endothelin converting enzyme 1 0.0277489
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0276366
ZSWIM6 zinc finger, SWIM-type containing 6 0.0275234
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0273181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0268985
INTS6 integrator complex subunit 6 0.026298
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0257919
PFKP phosphofructokinase, platelet 0.0254116
FAM107B family with sequence similarity 107, member B 0.0253273
MT2A metallothionein 2A 0.0251978
ANGPTL4 angiopoietin-like 4 0.0244506
GLS2 glutaminase 2 (liver, mitochondrial) 0.0244304
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0236671
ZNF638 zinc finger protein 638 0.0236358
LIMCH1 LIM and calponin homology domains 1 0.0235994
RPS6 ribosomal protein S6 0.023556
NBAS neuroblastoma amplified sequence 0.0234505
SOS1 son of sevenless homolog 1 (Drosophila) 0.0233468
PDIA3 protein disulfide isomerase family A, member 3 0.0233357
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0231724
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0231162
BRD2 bromodomain containing 2 0.0230874
CA12 carbonic anhydrase XII 0.0230623
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0230393
RUNX1 runt-related transcription factor 1 0.0228949
RAD51B RAD51 paralog B 0.0223482
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0223244
IFI44L interferon-induced protein 44-like 0.0222773
HILPDA hypoxia inducible lipid droplet-associated 0.0218173
LCOR ligand dependent nuclear receptor corepressor 0.021634
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0214091
PDIA6 protein disulfide isomerase family A, member 6 0.0206695
PDIA4 protein disulfide isomerase family A, member 4 0.0205483
LOXL2 lysyl oxidase-like 2 0.0204782
SLIT2 slit homolog 2 (Drosophila) 0.0199373
NEBL nebulette 0.0197615
KTN1 kinectin 1 (kinesin receptor) 0.0197412
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0194762
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0194684
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0194462
RPL5 ribosomal protein L5 0.0192074
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0191508
MYADM myeloid-associated differentiation marker 0.0190798
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0189758
TGFB1 transforming growth factor, beta 1 0.0188962
FNDC3B fibronectin type III domain containing 3B 0.0187825
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0187069
FNIP1 folliculin interacting protein 1 0.0186089
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 0.018362
TRIO trio Rho guanine nucleotide exchange factor 0.0179995
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0179042
HDAC9 histone deacetylase 9 0.0178495
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.017836
RAB8B RAB8B, member RAS oncogene family 0.0176615
SERTAD2 SERTA domain containing 2 0.0175984
GCLC glutamate-cysteine ligase, catalytic subunit 0.0174352
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0172949
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.0170881
TNIP1 TNFAIP3 interacting protein 1 0.0170432
PTPRM protein tyrosine phosphatase, receptor type, M 0.0170379
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0169984
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0169334
SIK3 SIK family kinase 3 0.0169097
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0168866
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0167484

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.117209
GLCCI1 glucocorticoid induced 1 -0.116032
NRG1 neuregulin 1 -0.103996
NAMPT nicotinamide phosphoribosyltransferase -0.0950478
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0946775
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0944027
OSMR oncostatin M receptor -0.0874697
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0861271
ARHGAP5 Rho GTPase activating protein 5 -0.0809574
STC1 stanniocalcin 1 -0.0784172
FAM20C family with sequence similarity 20, member C -0.0711221
ZEB2 zinc finger E-box binding homeobox 2 -0.0710551
WSB1 WD repeat and SOCS box containing 1 -0.0660914
PDE4D phosphodiesterase 4D, cAMP-specific -0.0660361
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0655828
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0633866
NRP1 neuropilin 1 -0.0624789
AOPEP aminopeptidase O (putative) -0.0602061
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0593156
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0583509
ZMYND8 zinc finger, MYND-type containing 8 -0.0565047
TM4SF1 transmembrane 4 L six family member 1 -0.0559283
DPYD dihydropyrimidine dehydrogenase -0.0559146
NPC1 Niemann-Pick disease, type C1 -0.0544431
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0541174
ETV6 ets variant 6 -0.0532165
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0529937
TPT1 tumor protein, translationally-controlled 1 -0.0525967
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0518959
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0506481
VIM vimentin -0.0491007
VRK2 vaccinia related kinase 2 -0.0477107
RAB27B RAB27B, member RAS oncogene family -0.0472239
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0457931
MTSS1 metastasis suppressor 1 -0.0444861
ENOSF1 enolase superfamily member 1 -0.0444186
DNER delta/notch-like EGF repeat containing -0.0438272
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0432452
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0421185
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0416354
CDH13 cadherin 13 -0.0411449
NUMB numb homolog (Drosophila) -0.0402987
ANTXR2 anthrax toxin receptor 2 -0.0397281
LOX lysyl oxidase -0.039592
S100A6 S100 calcium binding protein A6 -0.0384921
ZC3H12C zinc finger CCCH-type containing 12C -0.0383672
EREG epiregulin -0.0378308
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0376749
RAI14 retinoic acid induced 14 -0.0370847
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.036997
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0359807
EXT1 exostosin glycosyltransferase 1 -0.0356963
RBM39 RNA binding motif protein 39 -0.0354079
HMGA2 high mobility group AT-hook 2 -0.0352088
HIPK2 homeodomain interacting protein kinase 2 -0.0351646
HLA-B major histocompatibility complex, class I, B -0.0346529
NTN4 netrin 4 -0.0341614
CP ceruloplasmin (ferroxidase) -0.0334214
PCNX1 pecanex 1 -0.0332838
CLMP CXADR-like membrane protein -0.0332113
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.033049
PSD3 pleckstrin and Sec7 domain containing 3 -0.0330401
NPAS2 neuronal PAS domain protein 2 -0.0327617
BTG1 B-cell translocation gene 1, anti-proliferative -0.0321932
FN1 fibronectin 1 -0.0321318
ANXA10 annexin A10 -0.0318564
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0315793
RUNX2 runt-related transcription factor 2 -0.0313807
IGF1R insulin-like growth factor 1 receptor -0.0308938
SNX9 sorting nexin 9 -0.0304946
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0304909
MECOM MDS1 and EVI1 complex locus -0.0304899
RAP1B RAP1B, member of RAS oncogene family -0.0304696
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0304117
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0302366
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0297215
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0292054
PID1 phosphotyrosine interaction domain containing 1 -0.0291824
FDPS farnesyl diphosphate synthase -0.0291056
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0285926
DENND4A DENN/MADD domain containing 4A -0.0284438
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0284316
BZW1 basic leucine zipper and W2 domains 1 -0.0284166
CD44 CD44 molecule (Indian blood group) -0.028312
THBD thrombomodulin -0.0282404
IFI16 interferon, gamma-inducible protein 16 -0.0282049
RIGI RNA sensor RIG-I -0.0281814
BASP1 brain abundant, membrane attached signal protein 1 -0.0279604
FRMD4A FERM domain containing 4A -0.027807
LTBP1 latent transforming growth factor beta binding protein 1 -0.0276467
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0273587
CEMIP cell migration inducing protein, hyaluronan binding -0.0270193
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0269414
GCC2 GRIP and coiled-coil domain containing 2 -0.0268548
HPCAL1 hippocalcin-like 1 -0.0268067
SOX4 SRY (sex determining region Y)-box 4 -0.0267635
DOCK5 dedicator of cytokinesis 5 -0.0263597
TMEM131 transmembrane protein 131 -0.0259036
AHNAK AHNAK nucleoprotein -0.0255695
CDK14 cyclin-dependent kinase 14 -0.0254665