Celecoxib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0452835
SAMD4A sterile alpha motif domain containing 4A 0.0412136
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0407049
NDRG1 N-myc downstream regulated 1 0.037833
WAC WW domain containing adaptor with coiled-coil 0.0372466
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0363244
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0362893
COPA coatomer protein complex, subunit alpha 0.0360326
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0333492
GOLGA4 golgin A4 0.0325642
ZSWIM6 zinc finger, SWIM-type containing 6 0.0290095
FMNL2 formin-like 2 0.0289796
TRIO trio Rho guanine nucleotide exchange factor 0.0287096
MCL1 myeloid cell leukemia 1 0.0285674
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0285353
PUM2 pumilio RNA-binding family member 2 0.0270034
IL6 interleukin 6 0.0262641
SNX14 sorting nexin 14 0.0253268
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.025322
FNDC3B fibronectin type III domain containing 3B 0.0251288
SMOC1 SPARC related modular calcium binding 1 0.025102
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0235844
KTN1 kinectin 1 (kinesin receptor) 0.0225986
CTBP2 C-terminal binding protein 2 0.0225285
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0210051
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0209798
MT2A metallothionein 2A 0.020738
UBA6 ubiquitin-like modifier activating enzyme 6 0.0206016
IGFBP3 insulin-like growth factor binding protein 3 0.0204642
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0200568
CCNY cyclin Y 0.0199456
RCOR1 REST corepressor 1 0.0196891
USP36 ubiquitin specific peptidase 36 0.0194818
HELZ helicase with zinc finger 0.0194387
SRP54 signal recognition particle 54kDa 0.0189812
GLS2 glutaminase 2 (liver, mitochondrial) 0.0186683
CHD1 chromodomain helicase DNA binding protein 1 0.018649
MT1X metallothionein 1X 0.0185071
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0184167
MSN moesin 0.0183775
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0183458
TOP1 topoisomerase (DNA) I 0.0178961
DOCK4 dedicator of cytokinesis 4 0.0178705
BMP6 bone morphogenetic protein 6 0.0178018
ELL2 elongation factor, RNA polymerase II, 2 0.0174385
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.017366
ANKRD11 ankyrin repeat domain 11 0.0171508
SBF2 SET binding factor 2 0.0170166
FOXO3 forkhead box O3 0.0169373
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0166521
SEC23A Sec23 homolog A (S. cerevisiae) 0.0166464
SLMAP sarcolemma associated protein 0.0165683
SOD2 superoxide dismutase 2, mitochondrial 0.016566
UBASH3B ubiquitin associated and SH3 domain containing B 0.0165605
RICTOR RPTOR independent companion of MTOR, complex 2 0.0164565
SPDYA speedy/RINGO cell cycle regulator family member A 0.016403
KMT2C lysine (K)-specific methyltransferase 2C 0.0163803
ATXN1 ataxin 1 0.0163786
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0163383
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0162563
MYO1E myosin IE 0.0158724
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.015817
PDE4D phosphodiesterase 4D, cAMP-specific 0.0158059
RAB5A RAB5A, member RAS oncogene family 0.0155906
TENT2 terminal nucleotidyltransferase 2 0.0154934
ANGPTL4 angiopoietin-like 4 0.0153969
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0153014
MT1F metallothionein 1F 0.0152173
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0151903
GLG1 golgi glycoprotein 1 0.0149969
FLNB filamin B, beta 0.0148596
ATF4 activating transcription factor 4 0.0148219
BASP1 brain abundant, membrane attached signal protein 1 0.0148178
AKAP9 A kinase (PRKA) anchor protein 9 0.0145811
EIF5 eukaryotic translation initiation factor 5 0.0145587
MED13 mediator complex subunit 13 0.0145036
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0143984
PRELID2 PRELI domain containing 2 0.0142597
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0141503
HLA-B major histocompatibility complex, class I, B 0.0141075
MAP7 microtubule-associated protein 7 0.0141009
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0140122
KIF13A kinesin family member 13A 0.0136908
EXT1 exostosin glycosyltransferase 1 0.0136864
ARHGAP26 Rho GTPase activating protein 26 0.0136403
EPAS1 endothelial PAS domain protein 1 0.0135408
TBC1D23 TBC1 domain family, member 23 0.013537
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0134358
RAP1GAP2 RAP1 GTPase activating protein 2 0.0133726
GOLGB1 golgin B1 0.0133284
ANKRD12 ankyrin repeat domain 12 0.0133164
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0133162
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0131961
STRN3 striatin, calmodulin binding protein 3 0.0130977
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0128915
ITGA6 integrin, alpha 6 0.012813
ADAM17 ADAM metallopeptidase domain 17 0.0127859
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0127255
ITCH itchy E3 ubiquitin protein ligase 0.0126229
TTC3 tetratricopeptide repeat domain 3 0.0126116

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215554
FTL ferritin, light polypeptide -0.202852
TXNRD1 thioredoxin reductase 1 -0.166926
VIM vimentin -0.13706
GRAMD1B GRAM domain containing 1B -0.135846
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.121826
PM20D1 peptidase M20 domain containing 1 -0.0973002
TFPI2 tissue factor pathway inhibitor 2 -0.0837232
TM4SF1 transmembrane 4 L six family member 1 -0.0725993
FGB fibrinogen beta chain -0.0692745
RPL19 ribosomal protein L19 -0.0683589
TOP2A topoisomerase (DNA) II alpha 170kDa -0.062936
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0575378
IER3 immediate early response 3 -0.0563453
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0525794
HDAC9 histone deacetylase 9 -0.0521924
RPLP1 ribosomal protein, large, P1 -0.051961
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.051734
RPS27A ribosomal protein S27a -0.0517075
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0490396
RPL23 ribosomal protein L23 -0.0487121
RTN4 reticulon 4 -0.0451112
RPS21 ribosomal protein S21 -0.0415022
LDHA lactate dehydrogenase A -0.041483
RAD21 RAD21 homolog (S. pombe) -0.0411807
NAMPT nicotinamide phosphoribosyltransferase -0.0410641
TMSB10 thymosin beta 10 -0.0407557
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0406169
PTMA prothymosin, alpha -0.0399928
BICC1 BicC family RNA binding protein 1 -0.0397378
SVIL supervillin -0.0393049
ANXA2 annexin A2 -0.0391959
PKM pyruvate kinase, muscle -0.0390449
YBX1 Y box binding protein 1 -0.0388503
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0385715
IGF2 insulin-like growth factor 2 -0.0379354
RPL35A ribosomal protein L35a -0.0363516
EFNA5 ephrin-A5 -0.0360735
RPLP0 ribosomal protein, large, P0 -0.0348316
TPT1 tumor protein, translationally-controlled 1 -0.0346681
TUBB tubulin, beta class I -0.0330263
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0330206
RPL26 ribosomal protein L26 -0.0327873
RACK1 receptor for activated C kinase 1 -0.0323784
CYRIB CYFIP related Rac1 interactor B -0.0323471
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0319859
S100A6 S100 calcium binding protein A6 -0.0319441
RPS5 ribosomal protein S5 -0.031902
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0316307
ENO1 enolase 1, (alpha) -0.0314833
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.030822
EIF1 eukaryotic translation initiation factor 1 -0.0306549
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0305569
RPS20 ribosomal protein S20 -0.0303461
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0302495
SRGN serglycin -0.0301219
MYL12B myosin, light chain 12B, regulatory -0.0297485
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0295094
CAVIN1 caveolae associated protein 1 -0.0294419
GNAS GNAS complex locus -0.0294086
BHLHE40 basic helix-loop-helix family, member e40 -0.0293187
DENND4A DENN/MADD domain containing 4A -0.0292747
RHOA ras homolog family member A -0.0291138
TPM4 tropomyosin 4 -0.0290651
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0287679
KLF6 Kruppel-like factor 6 -0.0286043
RPL4 ribosomal protein L4 -0.0284998
RPS16 ribosomal protein S16 -0.0280457
RPS29 ribosomal protein S29 -0.0279084
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0279077
KIF5B kinesin family member 5B -0.0278974
RPS25 ribosomal protein S25 -0.027785
RPS12 ribosomal protein S12 -0.0277249
TMEM123 transmembrane protein 123 -0.0273797
RPL12 ribosomal protein L12 -0.0272207
LOC112694756 uncharaterized LOC112694756 -0.0270803
RPL11 ribosomal protein L11 -0.0269613
SLC38A1 solute carrier family 38, member 1 -0.0267725
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0265113
S100A9 S100 calcium binding protein A9 -0.0263386
RPS2 ribosomal protein S2 -0.0261981
BIRC3 baculoviral IAP repeat containing 3 -0.0259213
OSMR oncostatin M receptor -0.025759
RPL8 ribosomal protein L8 -0.0255957
EEF1G eukaryotic translation elongation factor 1 gamma -0.0255641
RRM2 ribonucleotide reductase M2 -0.0254697
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253392
RPS8 ribosomal protein S8 -0.0252911
FAM168A family with sequence similarity 168, member A -0.0250096
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0248338
ACTG1 actin gamma 1 -0.0245773
MORF4L1 mortality factor 4 like 1 -0.0241331
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0240184
WDR43 WD repeat domain 43 -0.0240136
LDHB lactate dehydrogenase B -0.0240101
RPS3 ribosomal protein S3 -0.0237856
RPL31 ribosomal protein L31 -0.0237474
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0235965
MKI67 marker of proliferation Ki-67 -0.0235854
FTH1 ferritin, heavy polypeptide 1 -0.0235716