Celecoxib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.110531
AKAP12 A kinase (PRKA) anchor protein 12 0.1019
YBX3 Y box binding protein 3 0.101072
ERRFI1 ERBB receptor feedback inhibitor 1 0.0895541
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0706781
PDE4D phosphodiesterase 4D, cAMP-specific 0.0616011
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0607382
THSD4 thrombospondin, type I, domain containing 4 0.0548671
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0528848
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0494293
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0490495
ZCCHC7 zinc finger, CCHC domain containing 7 0.0451893
TFPI2 tissue factor pathway inhibitor 2 0.0450039
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0445166
IGF1R insulin-like growth factor 1 receptor 0.0441986
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0439509
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0437072
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0432127
TAS2R14 taste receptor, type 2, member 14 0.0426163
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0425667
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0420891
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0398841
RIMS2 regulating synaptic membrane exocytosis 2 0.0389743
FMNL2 formin-like 2 0.0389314
TRIO trio Rho guanine nucleotide exchange factor 0.0383207
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.038156
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0371577
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.036589
RAD51B RAD51 paralog B 0.0355108
NIPBL Nipped-B homolog (Drosophila) 0.0347487
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.034218
DOCK5 dedicator of cytokinesis 5 0.0339975
EXOC4 exocyst complex component 4 0.0336281
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0335413
CLTC clathrin, heavy chain (Hc) 0.0328412
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0327962
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0327377
ATP11A ATPase, class VI, type 11A 0.0327061
PDE10A phosphodiesterase 10A 0.0315291
MARCHF4 membrane associated ring-CH-type finger 4 0.031347
GPHN gephyrin 0.0307859
ZFAND3 zinc finger, AN1-type domain 3 0.030675
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0304106
FUS FUS RNA binding protein 0.0300157
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0300008
PRELID2 PRELI domain containing 2 0.0297527
DST dystonin 0.029389
CAMKMT calmodulin-lysine N-methyltransferase 0.0293132
NF1 neurofibromin 1 0.0292788
PUM2 pumilio RNA-binding family member 2 0.0289613
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0278404
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0277807
YAP1 Yes-associated protein 1 0.0274856
SMYD3 SET and MYND domain containing 3 0.0266119
JMJD1C jumonji domain containing 1C 0.026244
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0262094
EXT1 exostosin glycosyltransferase 1 0.0261819
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0259546
HSPA8 heat shock 70kDa protein 8 0.0258841
WDR70 WD repeat domain 70 0.0257697
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0252953
PLCB4 phospholipase C, beta 4 0.0252802
BASP1 brain abundant, membrane attached signal protein 1 0.025045
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.024635
TPM3 tropomyosin 3 0.0244892
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0243483
ANKRD36 ankyrin repeat domain 36 0.0243017
USP9X ubiquitin specific peptidase 9, X-linked 0.0241219
MORF4L2 mortality factor 4 like 2 0.0237495
KDM2A lysine (K)-specific demethylase 2A 0.0234782
COPA coatomer protein complex, subunit alpha 0.0234028
CCND2 cyclin D2 0.0232884
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0232456
HMGA2 high mobility group AT-hook 2 0.0230102
CAMTA1 calmodulin binding transcription activator 1 0.0227433
TRIP12 thyroid hormone receptor interactor 12 0.0227421
TXNRD1 thioredoxin reductase 1 0.022623
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0222963
MACF1 microtubule-actin crosslinking factor 1 0.0222014
SVIL supervillin 0.0221359
PUM1 pumilio RNA-binding family member 1 0.0221208
IPO7 importin 7 0.0220507
ARID1B AT rich interactive domain 1B (SWI1-like) 0.021999
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0219732
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0217675
SFPQ splicing factor proline/glutamine-rich 0.0215395
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0212922
RICTOR RPTOR independent companion of MTOR, complex 2 0.0210877
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0209964
PDLIM5 PDZ and LIM domain 5 0.0208243
STAU1 staufen double-stranded RNA binding protein 1 0.020821
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0208207
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.020776
PTK2 protein tyrosine kinase 2 0.0207621
CDK17 cyclin-dependent kinase 17 0.0207218
ELL2 elongation factor, RNA polymerase II, 2 0.0204534
TBC1D5 TBC1 domain family, member 5 0.0198179
SRPK2 SRSF protein kinase 2 0.0196024
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0195996
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0194973

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.341298
RPL37A ribosomal protein L37a -0.0964646
EGR1 early growth response 1 -0.071857
RPS8 ribosomal protein S8 -0.066147
RPL35A ribosomal protein L35a -0.0655412
RPS27 ribosomal protein S27 -0.0615222
RPS3 ribosomal protein S3 -0.0601622
VIM vimentin -0.056962
RPL31 ribosomal protein L31 -0.0528402
RPLP1 ribosomal protein, large, P1 -0.0526786
FTL ferritin, light polypeptide -0.0516489
RPS29 ribosomal protein S29 -0.0503938
RPL37 ribosomal protein L37 -0.0494591
PTMA prothymosin, alpha -0.0493602
RPL26 ribosomal protein L26 -0.0469993
RPS21 ribosomal protein S21 -0.0462249
RPL23 ribosomal protein L23 -0.0461441
RPS27A ribosomal protein S27a -0.0457481
RPS10 ribosomal protein S10 -0.0444426
RPS12 ribosomal protein S12 -0.0428737
RPS15 ribosomal protein S15 -0.0410759
HLA-B major histocompatibility complex, class I, B -0.0406734
RPS6 ribosomal protein S6 -0.0378498
RACK1 receptor for activated C kinase 1 -0.0367536
RPS13 ribosomal protein S13 -0.0365983
RPS17 ribosomal protein S17 -0.0365726
TPT1 tumor protein, translationally-controlled 1 -0.0355225
RPS25 ribosomal protein S25 -0.0351767
RPL34 ribosomal protein L34 -0.0346924
YBX1 Y box binding protein 1 -0.0341398
RPS19 ribosomal protein S19 -0.0324281
RPL11 ribosomal protein L11 -0.0318708
MT2A metallothionein 2A -0.0310773
RPL12 ribosomal protein L12 -0.0308729
RPL9 ribosomal protein L9 -0.0306802
TMSB10 thymosin beta 10 -0.0301773
RPL27 ribosomal protein L27 -0.0300241
RPL8 ribosomal protein L8 -0.0298829
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0290629
MYL12B myosin, light chain 12B, regulatory -0.0271659
RPL38 ribosomal protein L38 -0.0268678
POTEF POTE ankyrin domain family, member F -0.0259321
RPL35 ribosomal protein L35 -0.0255536
RPS23 ribosomal protein S23 -0.0254633
RPL28 ribosomal protein L28 -0.0246776
RPS14 ribosomal protein S14 -0.024429
IFI6 interferon, alpha-inducible protein 6 -0.023726
RPL13A ribosomal protein L13a -0.023609
RPL5 ribosomal protein L5 -0.0232264
RPS24 ribosomal protein S24 -0.0227707
RPS16 ribosomal protein S16 -0.0225901
GNAS GNAS complex locus -0.0222582
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0220897
RPL36 ribosomal protein L36 -0.0219936
RPLP0 ribosomal protein, large, P0 -0.0218339
TPM2 tropomyosin 2 (beta) -0.0218166
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0214538
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0206175
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0201823
RPLP2 ribosomal protein, large, P2 -0.0197966
RPS20 ribosomal protein S20 -0.0196245
EIF1 eukaryotic translation initiation factor 1 -0.0195555
S100A11 S100 calcium binding protein A11 -0.0192657
RPL19 ribosomal protein L19 -0.0184537
RPS11 ribosomal protein S11 -0.0176875
P4HB prolyl 4-hydroxylase, beta polypeptide -0.017649
ACTG1 actin gamma 1 -0.0172788
LDHB lactate dehydrogenase B -0.0170736
B2M beta-2-microglobulin -0.0167826
HDGF hepatoma-derived growth factor -0.0165547
WSB1 WD repeat and SOCS box containing 1 -0.0163326
HLA-A major histocompatibility complex, class I, A -0.016328
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0162158
ANKRD12 ankyrin repeat domain 12 -0.0160928
EEF1G eukaryotic translation elongation factor 1 gamma -0.0159481
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0156287
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0149808
GSTP1 glutathione S-transferase pi 1 -0.0149086
MEF2D myocyte enhancer factor 2D -0.014788
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0142509
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0142124
RPL27A ribosomal protein L27a -0.0141235
RPL21 ribosomal protein L21 -0.0138928
SRRM2 serine/arginine repetitive matrix 2 -0.0137385
BPTF bromodomain PHD finger transcription factor -0.0136578
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0136285
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0133803
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0132652
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0131514
IER3 immediate early response 3 -0.0130973
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0128247
ATP5F1E ATP synthase F1 subunit epsilon -0.0127577
HMGA1 high mobility group AT-hook 1 -0.012757
RPL39 ribosomal protein L39 -0.0127299
RPL30 ribosomal protein L30 -0.01271
COX6C cytochrome c oxidase subunit VIc -0.0125501
PKM pyruvate kinase, muscle -0.0124859
WNT2B wingless-type MMTV integration site family, member 2B -0.0123933
RPS2 ribosomal protein S2 -0.0123488
RPL10A ribosomal protein L10a -0.012317