Celecoxib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Celecoxib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.12553
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0617144
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0334599
ELL2 elongation factor, RNA polymerase II, 2 0.030225
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0192136
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0186102
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.018466
NAMPT nicotinamide phosphoribosyltransferase 0.0172205
SDC4 syndecan 4 0.0161098
TFG TRK-fused gene 0.0158347
FAM13A family with sequence similarity 13, member A 0.0152202
RYBP RING1 and YY1 binding protein 0.015036
NCKAP1 NCK-associated protein 1 0.0139105
FXR1 fragile X mental retardation, autosomal homolog 1 0.0138823
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0136473
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0132805
ZNF292 zinc finger protein 292 0.0130424
UBA6 ubiquitin-like modifier activating enzyme 6 0.0128571
USP3 ubiquitin specific peptidase 3 0.0128314
PDIA4 protein disulfide isomerase family A, member 4 0.0127689
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0126929
HSPA8 heat shock 70kDa protein 8 0.0125441
CCNL1 cyclin L1 0.012103
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0117597
ASPH aspartate beta-hydroxylase 0.0115975
VGLL3 vestigial-like family member 3 0.0110818
TXNRD1 thioredoxin reductase 1 0.011001
MYO5B myosin VB 0.0109063
RLF rearranged L-myc fusion 0.0107485
TRIO trio Rho guanine nucleotide exchange factor 0.0103453
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0101821
MARCHF6 membrane associated ring-CH-type finger 6 0.0101479
IRF6 interferon regulatory factor 6 0.010013
RICTOR RPTOR independent companion of MTOR, complex 2 0.00991258
CDC73 cell division cycle 73 0.00989692
USP9X ubiquitin specific peptidase 9, X-linked 0.00981439
KDM3A lysine (K)-specific demethylase 3A 0.00976217
SMG7 SMG7 nonsense mediated mRNA decay factor 0.00973256
APP amyloid beta (A4) precursor protein 0.00959923
SGMS2 sphingomyelin synthase 2 0.00958164
PAPOLA poly(A) polymerase alpha 0.00956483
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00948792
LAMC2 laminin, gamma 2 0.0093632
MSMO1 methylsterol monooxygenase 1 0.00933962
TOP2B topoisomerase (DNA) II beta 180kDa 0.00928672
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00928309
BHLHE40 basic helix-loop-helix family, member e40 0.00924134
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00900994
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00899654
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.00887429
PPME1 protein phosphatase methylesterase 1 0.00875823
NUP58 nucleoporin 58 0.00874771
H1-4 H1.4 linker histone, cluster member 0.00841974
CORO1C coronin, actin binding protein, 1C 0.00827269
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.00825737
KIAA1217 KIAA1217 0.00823688
ATP13A3 ATPase type 13A3 0.00815323
ANXA5 annexin A5 0.007962
RIPK2 receptor-interacting serine-threonine kinase 2 0.00787962
LRRC1 leucine rich repeat containing 1 0.007862
ANO6 anoctamin 6 0.00785859
ECT2 epithelial cell transforming 2 0.00779254
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00774054
GLS2 glutaminase 2 (liver, mitochondrial) 0.00770807
IL6ST interleukin 6 signal transducer 0.00769215
TMEM39A transmembrane protein 39A 0.00755851
LTA4H leukotriene A4 hydrolase 0.00755344
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.00753235
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0075285
BIRC3 baculoviral IAP repeat containing 3 0.0075271
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.00741634
UGDH UDP-glucose 6-dehydrogenase 0.00740805
SHROOM3 shroom family member 3 0.00737983
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.00737272
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00732365
AHR aryl hydrocarbon receptor 0.00730737
ANXA1 annexin A1 0.00726167
TMEM131L transmembrane 131 like 0.00720494
HBP1 HMG-box transcription factor 1 0.00705132
CLINT1 clathrin interactor 1 0.00696038
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.00695967
GARS1 glycyl-tRNA synthetase 1 0.00692862
HDAC9 histone deacetylase 9 0.00673638
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.00673246
MLF1 myeloid leukemia factor 1 0.0067318
ATF3 activating transcription factor 3 0.00672768
TNIP1 TNFAIP3 interacting protein 1 0.00665145
C3ORF52 chromosome 3 open reading frame 52 0.00661702
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00661562
CPNE8 copine VIII 0.00659386
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00656894
NEK7 NIMA-related kinase 7 0.0065324
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00649447
RYK receptor-like tyrosine kinase 0.00639857
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00632508
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00631051
RBM33 RNA binding motif protein 33 0.00625129
FAR1 fatty acyl CoA reductase 1 0.00621941
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.00620488
USP12 ubiquitin specific peptidase 12 0.00619985

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.197623
PTMA prothymosin, alpha -0.153861
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148083
ACTG1 actin gamma 1 -0.130253
TMSB10 thymosin beta 10 -0.116024
POTEF POTE ankyrin domain family, member F -0.115716
RPL35A ribosomal protein L35a -0.0787012
LPP LIM domain containing preferred translocation partner in lipoma -0.073206
IFI27 interferon, alpha-inducible protein 27 -0.0696543
S100A6 S100 calcium binding protein A6 -0.0655452
TPT1 tumor protein, translationally-controlled 1 -0.06067
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0598091
LIMCH1 LIM and calponin homology domains 1 -0.0589475
S100A10 S100 calcium binding protein A10 -0.0571253
RPS8 ribosomal protein S8 -0.0569869
RPLP1 ribosomal protein, large, P1 -0.0559558
ISG15 ISG15 ubiquitin-like modifier -0.0535452
FBXO32 F-box protein 32 -0.0524945
RPS6 ribosomal protein S6 -0.0523523
FN1 fibronectin 1 -0.0516618
RPS23 ribosomal protein S23 -0.0514308
RPLP2 ribosomal protein, large, P2 -0.0512693
RPS29 ribosomal protein S29 -0.0507102
RPL23 ribosomal protein L23 -0.0502778
TPM4 tropomyosin 4 -0.0501631
RPS19 ribosomal protein S19 -0.0496547
RPL34 ribosomal protein L34 -0.0495701
IFI6 interferon, alpha-inducible protein 6 -0.0483703
IGFBP3 insulin-like growth factor binding protein 3 -0.0465683
HLA-A major histocompatibility complex, class I, A -0.0460012
RPS13 ribosomal protein S13 -0.0459681
RPL37A ribosomal protein L37a -0.0458793
EIF1 eukaryotic translation initiation factor 1 -0.0440745
HLA-B major histocompatibility complex, class I, B -0.0437899
RPS3 ribosomal protein S3 -0.0430772
IFITM3 interferon induced transmembrane protein 3 -0.0425573
RPL8 ribosomal protein L8 -0.0422953
SOX4 SRY (sex determining region Y)-box 4 -0.0410072
EXT1 exostosin glycosyltransferase 1 -0.0406903
RPL9 ribosomal protein L9 -0.0403417
IFITM1 interferon induced transmembrane protein 1 -0.0403409
RPL37 ribosomal protein L37 -0.0395257
RPS27 ribosomal protein S27 -0.0381587
RPS25 ribosomal protein S25 -0.0374996
CCND1 cyclin D1 -0.0374762
RACK1 receptor for activated C kinase 1 -0.0374349
RPS27A ribosomal protein S27a -0.037174
VIM vimentin -0.0368364
RPL31 ribosomal protein L31 -0.0357821
RPS12 ribosomal protein S12 -0.034968
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0345053
KRT7 keratin 7, type II -0.033978
RPS14 ribosomal protein S14 -0.0333608
PKM pyruvate kinase, muscle -0.0332881
S100A9 S100 calcium binding protein A9 -0.0332213
CSTB cystatin B (stefin B) -0.0323715
MDK midkine (neurite growth-promoting factor 2) -0.0322612
TMSB4X thymosin beta 4, X-linked -0.0316388
RPS17 ribosomal protein S17 -0.0312557
HSPB1 heat shock 27kDa protein 1 -0.0308699
VEGFA vascular endothelial growth factor A -0.0307822
RPL19 ribosomal protein L19 -0.0307818
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0307343
UBC ubiquitin C -0.030704
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0306794
RPL15 ribosomal protein L15 -0.0306402
RPL12 ribosomal protein L12 -0.0303358
TPI1 triosephosphate isomerase 1 -0.0286965
RPL11 ribosomal protein L11 -0.0278458
RPS21 ribosomal protein S21 -0.0274891
HMGA1 high mobility group AT-hook 1 -0.0273754
UQCRB ubiquinol-cytochrome c reductase binding protein -0.02696
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0265991
LDHA lactate dehydrogenase A -0.0265914
GNAS GNAS complex locus -0.0264794
SACK1A scaffolding CK1 anchoring protein A -0.0263908
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0262788
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.026274
LMNA lamin A/C -0.0260963
F3 coagulation factor III (thromboplastin, tissue factor) -0.0259542
SLC38A1 solute carrier family 38, member 1 -0.0257124
RPS10 ribosomal protein S10 -0.0254806
RPL28 ribosomal protein L28 -0.0254746
ZBTB20 zinc finger and BTB domain containing 20 -0.0252034
ENO2 enolase 2 (gamma, neuronal) -0.0250171
RPS15 ribosomal protein S15 -0.0248019
TM4SF1 transmembrane 4 L six family member 1 -0.0247259
RPL27A ribosomal protein L27a -0.0247244
RPS11 ribosomal protein S11 -0.0246683
RPS16 ribosomal protein S16 -0.0245801
RPLP0 ribosomal protein, large, P0 -0.0244728
WSB1 WD repeat and SOCS box containing 1 -0.0244193
FTH1 ferritin, heavy polypeptide 1 -0.0242266
SAMD4A sterile alpha motif domain containing 4A -0.0241397
CD63 CD63 molecule -0.0239295
ALCAM activated leukocyte cell adhesion molecule -0.0238352
RPS24 ribosomal protein S24 -0.0237411
YY1 YY1 transcription factor -0.0236909
TMEM165 transmembrane protein 165 -0.023454
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.023295