Celecoxib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.209854
EZR ezrin 0.164221
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.146381
ADAM10 ADAM metallopeptidase domain 10 0.110899
PDE4D phosphodiesterase 4D, cAMP-specific 0.109422
MINDY2 MINDY lysine 48 deubiquitinase 2 0.108592
TXNRD1 thioredoxin reductase 1 0.0957264
PKM pyruvate kinase, muscle 0.0855499
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0852428
TJP1 tight junction protein 1 0.0842308
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0831427
ANXA1 annexin A1 0.0827128
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0796443
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0780552
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0757265
TMSB4X thymosin beta 4, X-linked 0.0716896
TXNIP thioredoxin interacting protein 0.0679852
RTN4 reticulon 4 0.0678664
HDAC9 histone deacetylase 9 0.0676782
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0670169
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0637789
EEF2 eukaryotic translation elongation factor 2 0.0572609
RHOA ras homolog family member A 0.0570264
LDHA lactate dehydrogenase A 0.0567459
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0566607
BMP2K BMP2 inducible kinase 0.0566375
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0544873
GOLGA4 golgin A4 0.0543272
DUSP4 dual specificity phosphatase 4 0.0537205
EML4 echinoderm microtubule associated protein like 4 0.0523512
AHNAK AHNAK nucleoprotein 0.0522299
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0517313
PLK2 polo-like kinase 2 0.0500064
SQSTM1 sequestosome 1 0.0492578
ZNF292 zinc finger protein 292 0.0491974
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0483891
ZEB1 zinc finger E-box binding homeobox 1 0.0452828
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0444072
SOX6 SRY (sex determining region Y)-box 6 0.0439719
POTEF POTE ankyrin domain family, member F 0.0427741
EIF1 eukaryotic translation initiation factor 1 0.042363
VCL vinculin 0.0420602
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0415864
RPL3 ribosomal protein L3 0.0407822
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0405598
LOXL3 lysyl oxidase-like 3 0.0405396
PICALM phosphatidylinositol binding clathrin assembly protein 0.0397796
FLNB filamin B, beta 0.039312
KPNB1 karyopherin (importin) beta 1 0.0389288
ENO2 enolase 2 (gamma, neuronal) 0.0388158
SET SET nuclear proto-oncogene 0.0386828
S100A6 S100 calcium binding protein A6 0.0383055
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.037885
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0367788
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0366664
PGK1 phosphoglycerate kinase 1 0.0350466
KIF5B kinesin family member 5B 0.0347762
FAM91A1 family with sequence similarity 91, member A1 0.034292
RNF145 ring finger protein 145 0.0342521
UBC ubiquitin C 0.0340686
ECT2 epithelial cell transforming 2 0.0333579
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0329917
RPS2 ribosomal protein S2 0.0328908
ZFAND3 zinc finger, AN1-type domain 3 0.0327538
NCEH1 neutral cholesterol ester hydrolase 1 0.0319985
ENO1 enolase 1, (alpha) 0.031858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0316717
TGFBR3 transforming growth factor, beta receptor III 0.0313528
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0310704
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.030416
SRRM2 serine/arginine repetitive matrix 2 0.0303459
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0301825
NUP153 nucleoporin 153kDa 0.0299752
B2M beta-2-microglobulin 0.0299226
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0295874
DSTN destrin (actin depolymerizing factor) 0.0292626
TPD52 tumor protein D52 0.0291092
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0289187
ZFR zinc finger RNA binding protein 0.0283202
DUSP6 dual specificity phosphatase 6 0.0282017
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0280817
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0277102
NCKAP1 NCK-associated protein 1 0.027545
UBA6 ubiquitin-like modifier activating enzyme 6 0.0274142
RB1CC1 RB1-inducible coiled-coil 1 0.0273029
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0270915
TRIM24 tripartite motif containing 24 0.0270376
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0269236
JMJD1C jumonji domain containing 1C 0.0269207
TFG TRK-fused gene 0.0267942
MXI1 MAX interactor 1, dimerization protein 0.0266076
LOC112694756 uncharaterized LOC112694756 0.0265525
RPL4 ribosomal protein L4 0.0264776
MATR3 matrin 3 0.026353
NF1 neurofibromin 1 0.026275
HSPH1 heat shock 105kDa/110kDa protein 1 0.0262106
RPL7 ribosomal protein L7 0.0261986
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0259865
ZNF608 zinc finger protein 608 0.0259462
RAD23B RAD23 homolog B (S. cerevisiae) 0.0259392

decreased expression

Symbol Name Standardized Value
CPED1 cadherin-like and PC-esterase domain containing 1 -0.12362
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.112673
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0799256
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0752767
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0644533
PDE4B phosphodiesterase 4B, cAMP-specific -0.064035
TPT1 tumor protein, translationally-controlled 1 -0.06128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0566833
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0521427
TTC28 tetratricopeptide repeat domain 28 -0.047175
CAMKMT calmodulin-lysine N-methyltransferase -0.0467841
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0451782
BMP10 bone morphogenetic protein 10 -0.0450136
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0423582
RFC3 replication factor C (activator 1) 3, 38kDa -0.0411221
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0397404
FHIT fragile histidine triad -0.0389575
VIM vimentin -0.0362648
CENPE centromere protein E, 312kDa -0.0356771
PDE10A phosphodiesterase 10A -0.0355362
INTS6 integrator complex subunit 6 -0.03422
NFIA nuclear factor I/A -0.0324145
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0309962
PRELID2 PRELI domain containing 2 -0.0308909
AEBP2 AE binding protein 2 -0.0304511
CAMTA1 calmodulin binding transcription activator 1 -0.029104
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0288825
TAS2R14 taste receptor, type 2, member 14 -0.028875
MSI2 musashi RNA-binding protein 2 -0.0284519
FUS FUS RNA binding protein -0.0277339
NAV2 neuron navigator 2 -0.0266534
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0260358
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0255979
RRBP1 ribosome binding protein 1 -0.0255208
APLF aprataxin and PNKP like factor -0.0251255
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0248926
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.02453
SMYD3 SET and MYND domain containing 3 -0.0239966
PRUNE2 prune homolog 2 (Drosophila) -0.0238144
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0233562
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0229754
RBM6 RNA binding motif protein 6 -0.0228184
RPL37A ribosomal protein L37a -0.0225854
RPS27A ribosomal protein S27a -0.0224099
KLF3 Kruppel-like factor 3 (basic) -0.0222606
TMSB10 thymosin beta 10 -0.0221083
PATJ PATJ crumbs cell polarity complex component -0.0220801
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0220487
HLA-B major histocompatibility complex, class I, B -0.0219232
PSPC1 paraspeckle component 1 -0.0218048
TBC1D22A TBC1 domain family, member 22A -0.021667
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0216115
RPL31 ribosomal protein L31 -0.0215964
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0214043
FOXP1 forkhead box P1 -0.0211927
LINC02798 long intergenic non-protein coding RNA 2798 -0.0210374
XXYLT1 xyloside xylosyltransferase 1 -0.0209029
RAD51B RAD51 paralog B -0.0208113
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0206581
CCDC138 coiled-coil domain containing 138 -0.0204948
BPTF bromodomain PHD finger transcription factor -0.0203645
NEBL nebulette -0.0199758
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0199272
DIAPH3 diaphanous-related formin 3 -0.0197947
FN1 fibronectin 1 -0.019743
MRPS6 mitochondrial ribosomal protein S6 -0.0196768
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0196612
SDK1 sidekick cell adhesion molecule 1 -0.0196031
C6ORF62 chromosome 6 open reading frame 62 -0.0195884
RPL9 ribosomal protein L9 -0.0194695
SCLT1 sodium channel and clathrin linker 1 -0.0191668
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0191598
CFAP44 cilia and flagella associated protein 44 -0.0190841
ASPH aspartate beta-hydroxylase -0.0190263
EXT1 exostosin glycosyltransferase 1 -0.0187049
BCL2 B-cell CLL/lymphoma 2 -0.0186002
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0185696
TTC3 tetratricopeptide repeat domain 3 -0.0185406
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0183836
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.0179352
EHBP1 EH domain binding protein 1 -0.0178937
RAD18 RAD18 E3 ubiquitin protein ligase -0.0178881
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.017883
GLI3 GLI family zinc finger 3 -0.0178459
RPS10 ribosomal protein S10 -0.0177599
GNAS GNAS complex locus -0.0176811
LARP1B La ribonucleoprotein domain family, member 1B -0.0176695
MSH4 mutS homolog 4 -0.017427
FKBP10 FK506 binding protein 10, 65 kDa -0.0174247
CREBBP CREB binding protein -0.017416
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0173531
SRP19 signal recognition particle 19kDa -0.0172934
HM13 histocompatibility (minor) 13 -0.0172078
RYR2 ryanodine receptor 2 (cardiac) -0.0170405
KIAA1328 KIAA1328 -0.016891
NPAS2 neuronal PAS domain protein 2 -0.016807
KIAA1958 KIAA1958 -0.0167008
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0166436
FTL ferritin, light polypeptide -0.0166327
GMDS GDP-mannose 4,6-dehydratase -0.0166148