Celecoxib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.12356
COL6A3 collagen, type VI, alpha 3 0.102489
TRIO trio Rho guanine nucleotide exchange factor 0.0907952
PDE10A phosphodiesterase 10A 0.0871487
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.072243
DST dystonin 0.0697321
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0677958
VCAN versican 0.0610899
FRMD4A FERM domain containing 4A 0.0605822
FNDC3B fibronectin type III domain containing 3B 0.0581767
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0579328
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0558202
MYH9 myosin, heavy chain 9, non-muscle 0.0512181
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0492374
NAV2 neuron navigator 2 0.0462264
IGFBP3 insulin-like growth factor binding protein 3 0.042393
MYOF myoferlin 0.041055
FTH1 ferritin, heavy polypeptide 1 0.0406313
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0404995
SMAD3 SMAD family member 3 0.0394394
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0386196
FNIP1 folliculin interacting protein 1 0.0375713
CD44 CD44 molecule (Indian blood group) 0.0366467
GLIS3 GLIS family zinc finger 3 0.0366458
TENT5A terminal nucleotidyltransferase 5A 0.0354024
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0351989
MSN moesin 0.0351397
JMJD1C jumonji domain containing 1C 0.0351144
RUNX1 runt-related transcription factor 1 0.0348376
ATXN1 ataxin 1 0.0342385
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0341927
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0339582
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.032997
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0323784
NAV1 neuron navigator 1 0.0321986
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0317997
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0317675
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0309906
UBA6 ubiquitin-like modifier activating enzyme 6 0.0306415
VEGFA vascular endothelial growth factor A 0.0304505
CD109 CD109 molecule 0.0302684
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0302393
HDAC9 histone deacetylase 9 0.0301198
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.029864
ASPH aspartate beta-hydroxylase 0.0296825
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0295852
USP9X ubiquitin specific peptidase 9, X-linked 0.0285206
LAMP2 lysosomal-associated membrane protein 2 0.0277853
NDRG1 N-myc downstream regulated 1 0.0268295
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.026578
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0260856
ZNF292 zinc finger protein 292 0.0259862
APLP2 amyloid beta (A4) precursor-like protein 2 0.02598
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0257585
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.025208
ZMIZ1 zinc finger, MIZ-type containing 1 0.0242416
MMP12 matrix metallopeptidase 12 0.0241823
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.024056
GPC6 glypican 6 0.0239385
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0233559
ANO6 anoctamin 6 0.0230462
ARRDC3 arrestin domain containing 3 0.0223543
ZSWIM6 zinc finger, SWIM-type containing 6 0.0222528
MACF1 microtubule-actin crosslinking factor 1 0.0213826
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0210953
MYO1B myosin IB 0.0207045
TPM1 tropomyosin 1 (alpha) 0.0206898
PSD3 pleckstrin and Sec7 domain containing 3 0.0206563
GOLGB1 golgin B1 0.0203268
CADM1 cell adhesion molecule 1 0.0202963
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0201787
PRELID2 PRELI domain containing 2 0.0201445
RND3 Rho family GTPase 3 0.0200094
SDK1 sidekick cell adhesion molecule 1 0.0199962
TRAM2 translocation associated membrane protein 2 0.0198481
HELZ helicase with zinc finger 0.0197427
FMNL2 formin-like 2 0.0194755
LPP LIM domain containing preferred translocation partner in lipoma 0.0193976
SBF2 SET binding factor 2 0.0192223
ENO1 enolase 1, (alpha) 0.0190528
ESYT2 extended synaptotagmin-like protein 2 0.0190436
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.018947
ZBTB38 zinc finger and BTB domain containing 38 0.0186326
LCOR ligand dependent nuclear receptor corepressor 0.0181258
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0179984
CDCP1 CUB domain containing protein 1 0.0179833
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0178352
TPM3 tropomyosin 3 0.0176686
PPARD peroxisome proliferator-activated receptor delta 0.01754
RAI14 retinoic acid induced 14 0.0174283
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0174261
PTPRK protein tyrosine phosphatase, receptor type, K 0.0172937
DUSP10 dual specificity phosphatase 10 0.0172714
AHR aryl hydrocarbon receptor 0.0169881
KLF12 Kruppel-like factor 12 0.0169475
WWOX WW domain containing oxidoreductase 0.01694
AKAP12 A kinase (PRKA) anchor protein 12 0.0167514
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0166468
ERBIN erbb2 interacting protein 0.0165857
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0165066

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.220483
TPT1 tumor protein, translationally-controlled 1 -0.169604
HLA-B major histocompatibility complex, class I, B -0.14664
FTL ferritin, light polypeptide -0.112831
IER3 immediate early response 3 -0.10961
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0997478
PTMA prothymosin, alpha -0.0972952
TMSB10 thymosin beta 10 -0.0962209
MT2A metallothionein 2A -0.0882577
RPS24 ribosomal protein S24 -0.0819747
RPL35A ribosomal protein L35a -0.0815021
RPL23 ribosomal protein L23 -0.0714186
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0712813
RPL37A ribosomal protein L37a -0.0673818
RPS6 ribosomal protein S6 -0.0669982
RPLP2 ribosomal protein, large, P2 -0.0601675
RPLP1 ribosomal protein, large, P1 -0.0559539
RPL36A ribosomal protein L36a -0.0559375
RPS3 ribosomal protein S3 -0.0554989
RPS8 ribosomal protein S8 -0.053181
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0529748
ACTG1 actin gamma 1 -0.0528385
RPS23 ribosomal protein S23 -0.0520948
RPS12 ribosomal protein S12 -0.0516447
RPL26 ribosomal protein L26 -0.0515215
EIF1 eukaryotic translation initiation factor 1 -0.0509993
RPS13 ribosomal protein S13 -0.0507329
RPL7A ribosomal protein L7a -0.0505456
HLA-A major histocompatibility complex, class I, A -0.0498068
RPL31 ribosomal protein L31 -0.0468581
RPL19 ribosomal protein L19 -0.0464303
RPL9 ribosomal protein L9 -0.044802
RPL38 ribosomal protein L38 -0.0442962
WSB1 WD repeat and SOCS box containing 1 -0.0420997
RPS27A ribosomal protein S27a -0.041817
RPS19 ribosomal protein S19 -0.0405068
RPL11 ribosomal protein L11 -0.040469
NAP1L1 nucleosome assembly protein 1-like 1 -0.0400508
RPL36 ribosomal protein L36 -0.0397401
RPS21 ribosomal protein S21 -0.0388882
RPS25 ribosomal protein S25 -0.0387924
RPS29 ribosomal protein S29 -0.0373183
RPL34 ribosomal protein L34 -0.036927
RACK1 receptor for activated C kinase 1 -0.0363775
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0363159
HLA-E major histocompatibility complex, class I, E -0.0359954
RPL12 ribosomal protein L12 -0.0358678
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0355052
RPS4X ribosomal protein S4, X-linked -0.0342954
RPL28 ribosomal protein L28 -0.0342486
IFITM3 interferon induced transmembrane protein 3 -0.0333176
RPL27A ribosomal protein L27a -0.0332509
RPLP0 ribosomal protein, large, P0 -0.0329531
BTG1 B-cell translocation gene 1, anti-proliferative -0.0326875
COL1A1 collagen, type I, alpha 1 -0.0319477
GNAS GNAS complex locus -0.0318985
RPS10 ribosomal protein S10 -0.0309642
RPL37 ribosomal protein L37 -0.0309212
RPS16 ribosomal protein S16 -0.0299771
VCL vinculin -0.0297396
RPS14 ribosomal protein S14 -0.0296156
NT5C2 5'-nucleotidase, cytosolic II -0.0279678
TPM4 tropomyosin 4 -0.0279618
S100A9 S100 calcium binding protein A9 -0.0275437
RPL15 ribosomal protein L15 -0.0272336
RPS20 ribosomal protein S20 -0.0268014
KPNB1 karyopherin (importin) beta 1 -0.026449
RPL32 ribosomal protein L32 -0.0263184
RPS27 ribosomal protein S27 -0.0260585
ADM adrenomedullin -0.0257709
UGCG UDP-glucose ceramide glucosyltransferase -0.0257219
RPL13A ribosomal protein L13a -0.0255048
RPL5 ribosomal protein L5 -0.0250402
RPL35 ribosomal protein L35 -0.0249965
CTSD cathepsin D -0.0249238
RPS5 ribosomal protein S5 -0.0240474
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0237731
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0237584
VDAC1 voltage-dependent anion channel 1 -0.0232898
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.022918
B2M beta-2-microglobulin -0.0228687
ENO2 enolase 2 (gamma, neuronal) -0.0223218
SLC38A1 solute carrier family 38, member 1 -0.02206
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0220069
RPS11 ribosomal protein S11 -0.0218596
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0218218
RPL8 ribosomal protein L8 -0.0216761
RPS15 ribosomal protein S15 -0.0216494
INTS6 integrator complex subunit 6 -0.0215568
RPL30 ribosomal protein L30 -0.0215208
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0211654
RPS17 ribosomal protein S17 -0.0210042
CAVIN1 caveolae associated protein 1 -0.0207973
CD63 CD63 molecule -0.0203783
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0196187
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0196032
RPL10A ribosomal protein L10a -0.0195084
PNISR PNN-interacting serine/arginine-rich protein -0.0192459
KDM3A lysine (K)-specific demethylase 3A -0.0191323
MARCHF6 membrane associated ring-CH-type finger 6 -0.018809