Celecoxib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.154769
IGFBP3 insulin-like growth factor binding protein 3 0.0800438
TMSB10 thymosin beta 10 0.0765108
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0672063
MT2A metallothionein 2A 0.0656113
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0650735
VIM vimentin 0.061053
BIRC3 baculoviral IAP repeat containing 3 0.0579218
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0523507
AKAP12 A kinase (PRKA) anchor protein 12 0.0481316
FMNL2 formin-like 2 0.0450045
ERRFI1 ERBB receptor feedback inhibitor 1 0.0447502
B2M beta-2-microglobulin 0.0438857
RPS12 ribosomal protein S12 0.0421692
SVIL supervillin 0.0417182
SLC38A2 solute carrier family 38, member 2 0.0414715
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0388251
LOC102724023 ES1 protein homolog, mitochondrial 0.0380776
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0372889
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.036414
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0353917
NDRG1 N-myc downstream regulated 1 0.0347213
PTMA prothymosin, alpha 0.034673
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0339279
PBX3 pre-B-cell leukemia homeobox 3 0.0336101
MACF1 microtubule-actin crosslinking factor 1 0.0334031
ACTG1 actin gamma 1 0.0329695
KTN1 kinectin 1 (kinesin receptor) 0.0327618
IFIH1 interferon induced with helicase C domain 1 0.0325654
HILPDA hypoxia inducible lipid droplet-associated 0.0323257
RPL36 ribosomal protein L36 0.0318448
ANGPTL4 angiopoietin-like 4 0.0317855
ENO1 enolase 1, (alpha) 0.0313061
MYH9 myosin, heavy chain 9, non-muscle 0.0307094
EIF1 eukaryotic translation initiation factor 1 0.0294673
DNER delta/notch-like EGF repeat containing 0.029262
APLP2 amyloid beta (A4) precursor-like protein 2 0.0292162
DDIT4 DNA-damage-inducible transcript 4 0.029123
RDX radixin 0.0290084
CERT1 ceramide transporter 1 0.0289033
IRAK2 interleukin-1 receptor-associated kinase 2 0.0287587
CLIP1 CAP-GLY domain containing linker protein 1 0.0286064
TPI1 triosephosphate isomerase 1 0.0283535
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0282379
SH3KBP1 SH3-domain kinase binding protein 1 0.0281172
RPS6 ribosomal protein S6 0.0266929
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0266733
JMJD1C jumonji domain containing 1C 0.0266544
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0266093
ENO2 enolase 2 (gamma, neuronal) 0.0264001
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0263207
KMT2E lysine (K)-specific methyltransferase 2E 0.0262408
ANXA1 annexin A1 0.0254806
MAP2K5 mitogen-activated protein kinase kinase 5 0.0254763
RAI1 retinoic acid induced 1 0.0249895
ESYT2 extended synaptotagmin-like protein 2 0.0248724
RPS23 ribosomal protein S23 0.0241387
RIN2 Ras and Rab interactor 2 0.0240462
TXNIP thioredoxin interacting protein 0.0239714
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0238491
UHMK1 U2AF homology motif (UHM) kinase 1 0.0237938
NBR1 neighbor of BRCA1 gene 1 0.0237617
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0231806
RPS3 ribosomal protein S3 0.0230712
ADM adrenomedullin 0.023071
DSTN destrin (actin depolymerizing factor) 0.0230399
TRAF3 TNF receptor-associated factor 3 0.0228991
ANKRD37 ankyrin repeat domain 37 0.0228895
PNN pinin, desmosome associated protein 0.0226595
ATG5 autophagy related 5 0.0225476
AGO2 argonaute RISC catalytic component 2 0.0222289
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0222016
RPLP1 ribosomal protein, large, P1 0.0221828
DARS1 aspartyl-tRNA synthetase 1 0.0221265
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0219881
KIF3A kinesin family member 3A 0.021805
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0217233
INSIG1 insulin induced gene 1 0.0214723
NCOR1 nuclear receptor corepressor 1 0.0213508
NSD1 nuclear receptor binding SET domain protein 1 0.0213496
CANX calnexin 0.02125
LOC112694756 uncharaterized LOC112694756 0.0211479
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0210409
AXL AXL receptor tyrosine kinase 0.0210271
RPL8 ribosomal protein L8 0.0210145
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0208326
TPM3 tropomyosin 3 0.0205867
ELL2 elongation factor, RNA polymerase II, 2 0.0204644
CXCL8 chemokine (C-X-C motif) ligand 8 0.0204605
POTEF POTE ankyrin domain family, member F 0.0204232
CD9 CD9 molecule 0.0203575
NALCN sodium leak channel, non selective 0.020263
NPTN neuroplastin 0.0202485
NSRP1 nuclear speckle splicing regulatory protein 1 0.0201642
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0200575
RPL34 ribosomal protein L34 0.0200089
HLA-B major histocompatibility complex, class I, B 0.0199659
RNF145 ring finger protein 145 0.0197781
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0197128
PYGL phosphorylase, glycogen, liver 0.0195923

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0806266
RAD51B RAD51 paralog B -0.0668638
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0600865
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0572999
FUS FUS RNA binding protein -0.0562282
DST dystonin -0.052014
WAC WW domain containing adaptor with coiled-coil -0.0519901
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0517709
ZBTB20 zinc finger and BTB domain containing 20 -0.051538
THSD4 thrombospondin, type I, domain containing 4 -0.0493184
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0451884
HMGA2 high mobility group AT-hook 2 -0.0446707
ATM ATM serine/threonine kinase -0.044072
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0433317
SPAG9 sperm associated antigen 9 -0.0428339
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0428277
GOLGA4 golgin A4 -0.0426058
INTS6 integrator complex subunit 6 -0.0418639
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0399572
GNAS GNAS complex locus -0.0398517
ZNF638 zinc finger protein 638 -0.0381741
WNK1 WNK lysine deficient protein kinase 1 -0.0375446
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0360482
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0359087
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0358648
TRIP12 thyroid hormone receptor interactor 12 -0.0356322
ARB2A ARB2 cotranscriptional regulator A -0.0356026
EEF2 eukaryotic translation elongation factor 2 -0.0355362
EFNA5 ephrin-A5 -0.0351557
GPC6 glypican 6 -0.0348316
ZFAND3 zinc finger, AN1-type domain 3 -0.0343364
SMYD3 SET and MYND domain containing 3 -0.0343021
PRELID2 PRELI domain containing 2 -0.0330786
DIAPH3 diaphanous-related formin 3 -0.0329341
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0322898
PCBP2 poly(rC) binding protein 2 -0.0312589
PRSS23 protease, serine, 23 -0.0311219
LRPPRC leucine-rich pentatricopeptide repeat containing -0.030967
LMO7 LIM domain 7 -0.0304728
TCF12 transcription factor 12 -0.0304107
UBC ubiquitin C -0.0302236
DPYD dihydropyrimidine dehydrogenase -0.0298868
NF1 neurofibromin 1 -0.0296807
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0296012
EXOC4 exocyst complex component 4 -0.0292502
AEBP2 AE binding protein 2 -0.0290645
PICALM phosphatidylinositol binding clathrin assembly protein -0.0289358
TAS2R14 taste receptor, type 2, member 14 -0.0281411
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0280456
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0278408
MYO9A myosin IXA -0.0277269
SEC31A SEC31 homolog A (S. cerevisiae) -0.0275685
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0272051
SOD2 superoxide dismutase 2, mitochondrial -0.0268776
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0266779
PRH1 proline-rich protein HaeIII subfamily 1 -0.0266
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0265717
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0265605
RAB10 RAB10, member RAS oncogene family -0.0265595
PRKCE protein kinase C, epsilon -0.0262658
RABGAP1L RAB GTPase activating protein 1-like -0.0262415
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0262303
IARS1 isoleucyl-tRNA synthetase 1 -0.0260655
SCLT1 sodium channel and clathrin linker 1 -0.0257949
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0257834
RPS27A ribosomal protein S27a -0.0257057
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0252514
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0252207
DENND1A DENN/MADD domain containing 1A -0.0249272
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0248784
PTPRK protein tyrosine phosphatase, receptor type, K -0.0247953
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0247824
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0245716
USP34 ubiquitin specific peptidase 34 -0.0243943
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0243767
KMT2C lysine (K)-specific methyltransferase 2C -0.0242127
DENND5A DENN/MADD domain containing 5A -0.023293
NINL ninein-like -0.0232387
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0232353
CTNNBL1 catenin, beta like 1 -0.0231867
SEM1 SEM1 26S proteasome subunit -0.0230277
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0229104
MCTP1 multiple C2 domains, transmembrane 1 -0.0229084
ANKRD36C ankyrin repeat domain 36C -0.0228771
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0228056
CMIP c-Maf inducing protein -0.0228034
SRPK2 SRSF protein kinase 2 -0.0227581
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0225728
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0225314
CAMTA1 calmodulin binding transcription activator 1 -0.0222719
ASXL1 additional sex combs like transcriptional regulator 1 -0.0221944
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0220112
ACBD6 acyl-CoA binding domain containing 6 -0.0219779
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0219527
MBNL1 muscleblind-like splicing regulator 1 -0.021938
MSN moesin -0.0218978
RPTOR regulatory associated protein of MTOR, complex 1 -0.021859
PDCD6IP programmed cell death 6 interacting protein -0.0216256
NAV2 neuron navigator 2 -0.0215579
WWOX WW domain containing oxidoreductase -0.0214151