Celecoxib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Celecoxib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Celecoxib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.144999
NRG1 neuregulin 1 0.125695
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122626
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.10743
ZSWIM6 zinc finger, SWIM-type containing 6 0.104161
ASPH aspartate beta-hydroxylase 0.103326
HMGA2 high mobility group AT-hook 2 0.0866022
CXCL8 chemokine (C-X-C motif) ligand 8 0.0761481
TMSB10 thymosin beta 10 0.0690992
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0681034
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0613468
LIMCH1 LIM and calponin homology domains 1 0.058264
VIM vimentin 0.054619
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0502438
ENO1 enolase 1, (alpha) 0.0498493
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0491099
MT2A metallothionein 2A 0.0453151
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0439579
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0430683
TXNIP thioredoxin interacting protein 0.0416356
HLA-B major histocompatibility complex, class I, B 0.0412464
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0407144
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0401579
PTMA prothymosin, alpha 0.0396232
GRB10 growth factor receptor-bound protein 10 0.0391808
S100A10 S100 calcium binding protein A10 0.0380112
ENO2 enolase 2 (gamma, neuronal) 0.0376806
NDRG1 N-myc downstream regulated 1 0.0369757
SQSTM1 sequestosome 1 0.0365231
PDIA4 protein disulfide isomerase family A, member 4 0.034372
AHNAK AHNAK nucleoprotein 0.0343363
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0336672
RPLP1 ribosomal protein, large, P1 0.0332575
LMNA lamin A/C 0.0331523
RPS19 ribosomal protein S19 0.0327081
ABLIM1 actin binding LIM protein 1 0.0325959
FTH1 ferritin, heavy polypeptide 1 0.0323153
FAM13A family with sequence similarity 13, member A 0.0313326
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0312743
EMP1 epithelial membrane protein 1 0.0308184
EFNA5 ephrin-A5 0.0308006
RASAL2 RAS protein activator like 2 0.0306421
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0304274
IER3 immediate early response 3 0.0303655
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0297854
DUSP6 dual specificity phosphatase 6 0.0295901
PALLD palladin, cytoskeletal associated protein 0.0295499
MRPS6 mitochondrial ribosomal protein S6 0.029156
VCL vinculin 0.0290542
PLIN2 perilipin 2 0.0286728
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0286111
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0285742
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0284953
RAI14 retinoic acid induced 14 0.0283619
INTS6 integrator complex subunit 6 0.0277957
ERRFI1 ERBB receptor feedback inhibitor 1 0.0277058
RPS8 ribosomal protein S8 0.0271968
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0271957
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0269125
RPL37A ribosomal protein L37a 0.0268134
TPT1 tumor protein, translationally-controlled 1 0.026396
RPL35A ribosomal protein L35a 0.0257862
CTBP2 C-terminal binding protein 2 0.0256434
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0253155
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0251682
AEBP2 AE binding protein 2 0.0244599
IFI6 interferon, alpha-inducible protein 6 0.0242858
ACTG1 actin gamma 1 0.0241637
ATF6 activating transcription factor 6 0.0240387
EXT1 exostosin glycosyltransferase 1 0.0234092
EZR ezrin 0.0232482
SLC35F3 solute carrier family 35, member F3 0.0232386
PDLIM5 PDZ and LIM domain 5 0.0231365
HILPDA hypoxia inducible lipid droplet-associated 0.0230918
CANX calnexin 0.0228758
SYT1 synaptotagmin I 0.0228671
ATF3 activating transcription factor 3 0.0228164
TMED9 transmembrane emp24 protein transport domain containing 9 0.022797
SH3KBP1 SH3-domain kinase binding protein 1 0.022786
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0226469
SIRT1 sirtuin 1 0.0226108
TPI1 triosephosphate isomerase 1 0.0223152
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0222928
NT5E 5'-nucleotidase, ecto (CD73) 0.0222821
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0222658
RPS27 ribosomal protein S27 0.0221801
FTL ferritin, light polypeptide 0.0221223
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0219316
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0218528
LOC102724023 ES1 protein homolog, mitochondrial 0.0217383
GNAS GNAS complex locus 0.0216818
H1-0 H1.0 linker histone 0.0215625
TMSB4X thymosin beta 4, X-linked 0.021508
RPL12 ribosomal protein L12 0.021463
RPS29 ribosomal protein S29 0.0213066
CALR calreticulin 0.0211545
B2M beta-2-microglobulin 0.0210683
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0210392
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0205042
CLIP2 CAP-GLY domain containing linker protein 2 0.0204609

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.212228
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.101122
CENPF centromere protein F, 350/400kDa -0.0820507
PRRC2C proline-rich coiled-coil 2C -0.0688016
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0680389
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0582116
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.057517
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0570432
TMEM156 transmembrane protein 156 -0.0554761
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0551153
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0550493
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0547417
SMOX spermine oxidase -0.0529894
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0529061
KMT2E lysine (K)-specific methyltransferase 2E -0.0528562
OSMR oncostatin M receptor -0.0519835
FNBP1 formin binding protein 1 -0.0516278
NEK7 NIMA-related kinase 7 -0.051486
RBM39 RNA binding motif protein 39 -0.0513234
AHR aryl hydrocarbon receptor -0.0505132
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0486881
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0455123
TMEM165 transmembrane protein 165 -0.0447598
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0439658
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0438279
ETNK1 ethanolamine kinase 1 -0.0435971
NUP58 nucleoporin 58 -0.0427414
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0421369
ERBIN erbb2 interacting protein -0.0418331
OGA O-GlcNAcase -0.0394211
ANKRD11 ankyrin repeat domain 11 -0.0392266
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.038095
VEGFA vascular endothelial growth factor A -0.0376628
CLTC clathrin, heavy chain (Hc) -0.0375102
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0374239
KLHL5 kelch-like family member 5 -0.0371742
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0368501
UBE2K ubiquitin-conjugating enzyme E2K -0.0365791
ANLN anillin, actin binding protein -0.0363856
ZMYM2 zinc finger, MYM-type 2 -0.03624
FNDC3B fibronectin type III domain containing 3B -0.0357254
NRP1 neuropilin 1 -0.0355453
PCBP2 poly(rC) binding protein 2 -0.0355062
TM9SF3 transmembrane 9 superfamily member 3 -0.0354016
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0345741
ZNF292 zinc finger protein 292 -0.0345723
TPR translocated promoter region, nuclear basket protein -0.0345222
MYH9 myosin, heavy chain 9, non-muscle -0.0344662
TXNRD1 thioredoxin reductase 1 -0.0342987
FAM168B family with sequence similarity 168, member B -0.0342248
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0337746
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.033517
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0334867
RPS2 ribosomal protein S2 -0.033225
WAC WW domain containing adaptor with coiled-coil -0.0332027
RNF145 ring finger protein 145 -0.0331475
CAB39 calcium binding protein 39 -0.0326558
PTBP3 polypyrimidine tract binding protein 3 -0.0319868
FBXL5 F-box and leucine-rich repeat protein 5 -0.0317893
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0317543
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.0316744
GOLGA4 golgin A4 -0.0316042
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0314556
PUM2 pumilio RNA-binding family member 2 -0.0310421
UGCG UDP-glucose ceramide glucosyltransferase -0.0308881
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0306723
MIS18BP1 MIS18 binding protein 1 -0.0306615
XPO1 exportin 1 -0.0305745
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0298182
TFG TRK-fused gene -0.0292301
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0291668
RTN4 reticulon 4 -0.0288662
NCKAP1 NCK-associated protein 1 -0.0288306
MATR3 matrin 3 -0.0287517
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0287436
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0286644
KIF5B kinesin family member 5B -0.028535
TNPO3 transportin 3 -0.0284947
UBXN4 UBX domain protein 4 -0.028446
CCNL1 cyclin L1 -0.0284333
SRPK2 SRSF protein kinase 2 -0.0284266
RUNX2 runt-related transcription factor 2 -0.028271
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.028269
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0282457
GATAD2B GATA zinc finger domain containing 2B -0.0281958
YME1L1 YME1-like 1 ATPase -0.0280875
TENT2 terminal nucleotidyltransferase 2 -0.0280811
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0280073
ZMYND8 zinc finger, MYND-type containing 8 -0.0280005
JMJD1C jumonji domain containing 1C -0.0278237
ACADVL acyl-CoA dehydrogenase, very long chain -0.0276946
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0276346
KTN1 kinectin 1 (kinesin receptor) -0.0273199
SPAG9 sperm associated antigen 9 -0.0273074
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.027154
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0269952
ZFAND3 zinc finger, AN1-type domain 3 -0.026956
HELZ helicase with zinc finger -0.0269175
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.026834
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.026748