Cellular senescence Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. (Gene Ontology, GO_0090398)
External Link https://www.kegg.jp/entry/hsa04218
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Genes

156 proteins participating in the Cellular senescence pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARTN artemin
ATM ATM serine/threonine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNB3 cyclin B3
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDPF1 cysteine-rich, DPF motif domain containing 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLSTN1 calsyntenin 1
CXCL8 chemokine (C-X-C motif) ligand 8
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXW11 F-box and WD repeat domain containing 11
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA4 GATA binding protein 4
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HIPK3 homeodomain interacting protein kinase 3
HIPK4 homeodomain interacting protein kinase 4
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HRAS Harvey rat sarcoma viral oncogene homolog
HUS1 HUS1 checkpoint homolog (S. pombe)
IGFBP3 insulin-like growth factor binding protein 3
IL1A interleukin 1, alpha
IL6 interleukin 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
LIN37 lin-37 DREAM MuvB core complex component
LIN52 lin-52 DREAM MuvB core complex component
LIN54 lin-54 DREAM MuvB core complex component
LIN9 lin-9 DREAM MuvB core complex component
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCU mitochondrial calcium uniporter
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MRAS muscle RAS oncogene homolog
MRE11 MRE11 homolog, double strand break repair nuclease
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PPID peptidylprolyl isomerase D
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PTEN phosphatase and tensin homolog
RAD50 RAD50 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHEB Ras homolog enriched in brain
RNASE3 ribonuclease, RNase A family, 3
RRAD Ras-related associated with diabetes
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT1 sirtuin 1
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TP53 tumor protein p53
TRAF3IP2 TRAF3 interacting protein 2
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2