Central Precocious Puberty Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Central precocious puberty (CPP), also referred to as gonadotropin dependent precocious puberty, is an endocrine-related developmental disease characterized by the onset of pubertal changes, with development of secondary sexual characteristics and accelerated growth and bone maturation, before the normal age of puberty (8 years in girls and 9 years in boys). (Orphanet Rare Disease Ontology, Orphanet_759)
External Link https://www.disgenet.org/browser/0/1/0/C0342543
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Genes

32 genes associated with the disease Central Precocious Puberty in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AMH anti-Mullerian hormone
BGLAP bone gamma-carboxyglutamate (gla) protein
CREBRF CREB3 regulatory factor
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DLK1 delta-like 1 homolog (Drosophila)
ESR1 estrogen receptor 1
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GH1 growth hormone 1
GNAS GNAS complex locus
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
LEP leptin
LEPR leptin receptor
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
MKRN3 makorin ring finger protein 3
NOTCH1 notch 1
NPY neuropeptide Y
NR0B1 nuclear receptor subfamily 0, group B, member 1
POU1F1 POU class 1 homeobox 1
PROKR2 prokineticin receptor 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RETN resistin
ZBTB7A zinc finger and BTB domain containing 7A