Centrosome Gene Set

Dataset COMPARTMENTS Experimental Protein Localization Evidence Scores 2025
Category proteomics
Type cellular component
Description A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. (Gene Ontology, GO_0005813)
External Link http://purl.obolibrary.org/obo/GO_0005813
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Genes

305 proteins localized to the Centrosome cellular component in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PCNT pericentrin 3.138
CDK5RAP2 CDK5 regulatory subunit associated protein 2 3.102
PCM1 pericentriolar material 1 2.717
TERB2 telomere repeat binding bouquet formation protein 2 2.412
TTI2 TELO2 interacting protein 2 2.303
ZNF766 zinc finger protein 766 2.168
MAP7D3 MAP7 domain containing 3 2.143
MKKS McKusick-Kaufman syndrome 2.138
TACC3 transforming, acidic coiled-coil containing protein 3 2.095
WDR37 WD repeat domain 37 2.082
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.077
CEP170 centrosomal protein 170kDa 2.052
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.032
CEP350 centrosomal protein 350kDa 1.999
ZNF76 zinc finger protein 76 1.993
TBC1D31 TBC1 domain family, member 31 1.986
KIFC1 kinesin family member C1 1.986
RENBP renin binding protein 1.983
KIAA0753 KIAA0753 1.975
CDC45 cell division cycle 45 1.961
MAPRE1 microtubule-associated protein, RP/EB family, member 1 1.958
RAB22A RAB22A, member RAS oncogene family 1.956
PAN3 PAN3 poly(A) specific ribonuclease subunit 1.956
CEMIP cell migration inducing protein, hyaluronan binding 1.895
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 1.867
CEP20 centrosomal protein 20 1.805
TWSG1 twisted gastrulation BMP signaling modulator 1 1.805
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 1.805
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 1.805
RABL6 RAB, member RAS oncogene family-like 6 1.79
CUEDC1 CUE domain containing 1 1.79
ZNF12 zinc finger protein 12 1.786
N4BP3 NEDD4 binding protein 3 1.776
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) 1.774
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.772
INTS6L integrator complex subunit 6 like 1.765
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.763
ZFP90 ZFP90 zinc finger protein 1.759
TMC3 transmembrane channel-like 3 1.751
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa 1.75
APOA4 apolipoprotein A-IV 1.749
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 1.74
EYA3 EYA transcriptional coactivator and phosphatase 3 1.738
ENKD1 enkurin domain containing 1 1.731
FRMD5 FERM domain containing 5 1.72
MED20 mediator complex subunit 20 1.714
CLEC11A C-type lectin domain family 11, member A 1.714
CEP250 centrosomal protein 250kDa 1.714
FKBP11 FK506 binding protein 11, 19 kDa 1.714
CNTROB centrobin, centrosomal BRCA2 interacting protein 1.714
DENND10 DENN domain containing 10 1.714
ALPK1 alpha-kinase 1 1.714
OBSL1 obscurin-like 1 1.714
PXDN peroxidasin 1.69
CEP164 centrosomal protein 164kDa 1.677
WASF1 WAS protein family, member 1 1.677
CEP131 centrosomal protein 131kDa 1.671
TSPYL6 TSPY-like 6 1.669
NCAPG non-SMC condensin I complex, subunit G 1.668
OLA1 Obg-like ATPase 1 1.664
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 1.662
EDRF1 erythroid differentiation regulatory factor 1 1.662
CADPS2 Ca++-dependent secretion activator 2 1.662
SFR1 SWI5-dependent recombination repair 1 1.662
PELI3 pellino E3 ubiquitin protein ligase family member 3 1.66
TUBGCP2 tubulin, gamma complex associated protein 2 1.653
RMDN1 regulator of microtubule dynamics 1 1.653
TTC39A tetratricopeptide repeat domain 39A 1.653
CETN3 centrin, EF-hand protein, 3 1.653
BLTP1 bridge-like lipid transfer protein family member 1 1.653
GPR132 G protein-coupled receptor 132 1.651
RAB23 RAB23, member RAS oncogene family 1.647
GINS4 GINS complex subunit 4 (Sld5 homolog) 1.644
KIFAP3 kinesin-associated protein 3 1.643
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 1.636
CROCC ciliary rootlet coiled-coil, rootletin 1.623
ZNF701 zinc finger protein 701 1.623
MYO18B myosin XVIIIB 1.623
CHPF chondroitin polymerizing factor 1.623
ERCC6L excision repair cross-complementation group 6-like 1.623
LONRF1 LON peptidase N-terminal domain and ring finger 1 1.623
HARBI1 harbinger transposase derived 1 1.623
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 1.623
EIPR1 EARP complex and GARP complex interacting protein 1 1.623
RAB15 RAB15, member RAS oncogene family 1.623
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 1.622
USF3 upstream transcription factor family member 3 1.622
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 1.618
ZRANB3 zinc finger, RAN-binding domain containing 3 1.615
ZNF341 zinc finger protein 341 1.615
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 1.613
ARL3 ADP-ribosylation factor-like 3 1.611
TMEM132C transmembrane protein 132C 1.611
UBL4A ubiquitin-like 4A 1.61
DZIP1L DAZ interacting zinc finger protein 1-like 1.606
MYCBP MYC binding protein 1.605
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 1.605
NCAN neurocan 1.605
SMAD4 SMAD family member 4 1.592
SPICE1 spindle and centriole associated protein 1 1.592
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 1.592
DNAL4 dynein, axonemal, light chain 4 1.592
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 1.592
MBNL1 muscleblind-like splicing regulator 1 1.586
ARHGAP29 Rho GTPase activating protein 29 1.584
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.583
SYTL4 synaptotagmin-like 4 1.583
PKNOX1 PBX/knotted 1 homeobox 1 1.58
KXD1 KxDL motif containing 1 1.577
NAE1 NEDD8 activating enzyme E1 subunit 1 1.576
ZC3H8 zinc finger CCCH-type containing 8 1.576
GKAP1 G kinase anchoring protein 1 1.575
ZNF322 zinc finger protein 322 1.568
CNOT10 CCR4-NOT transcription complex, subunit 10 1.562
TCHP trichoplein, keratin filament binding 1.555
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 1.551
IL17RC interleukin 17 receptor C 1.547
ADNP activity-dependent neuroprotector homeobox 1.544
TDRKH tudor and KH domain containing 1.543
CLDND1 claudin domain containing 1 1.536
ATG5 autophagy related 5 1.532
TRIM38 tripartite motif containing 38 1.532
TUBGCP4 tubulin, gamma complex associated protein 4 1.532
RAPSN receptor-associated protein of the synapse 1.532
UNC5CL unc-5 homolog C (C. elegans)-like 1.532
HPS4 Hermansky-Pudlak syndrome 4 1.532
TMEM170B transmembrane protein 170B 1.532
CEP162 centrosomal protein 162kDa 1.532
EMC6 ER membrane protein complex subunit 6 1.532
CRACDL CRACD like 1.532
MTMR11 myotubularin related protein 11 1.532
MYH15 myosin, heavy chain 15 1.532
TMEM63C transmembrane protein 63C 1.532
FBXO9 F-box protein 9 1.532
BRMS1L breast cancer metastasis-suppressor 1-like 1.532
CEP290 centrosomal protein 290kDa 1.532
PRICKLE3 prickle homolog 3 (Drosophila) 1.532
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 1.532
LGI2 leucine-rich repeat LGI family, member 2 1.532
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 1.532
AUNIP aurora kinase A and ninein interacting protein 1.532
ZNF280D zinc finger protein 280D 1.532
CYLD cylindromatosis (turban tumor syndrome) 1.532
ADPGK ADP-dependent glucokinase 1.532
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 1.532
DCTN4 dynactin 4 (p62) 1.532
UBL3 ubiquitin-like 3 1.532
RIC8B RIC8 guanine nucleotide exchange factor B 1.532
ODF2 outer dense fiber of sperm tails 2 1.532
DAPK1 death-associated protein kinase 1 1.532
NLRC5 NLR family, CARD domain containing 5 1.532
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1.532
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1.532
LRRC45 leucine rich repeat containing 45 1.532
KLHL21 kelch-like family member 21 1.532
CDIP1 cell death-inducing p53 target 1 1.532
POFUT1 protein O-fucosyltransferase 1 1.532
ZNF112 zinc finger protein 112 1.532
CCP110 centriolar coiled coil protein 110kDa 1.532
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.532
FBF1 Fas (TNFRSF6) binding factor 1 1.532
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 1.532
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 1.532
TRIM2 tripartite motif containing 2 1.532
AKAP9 A kinase (PRKA) anchor protein 9 1.529
N4BP2 NEDD4 binding protein 2 1.529
RSRC2 arginine/serine-rich coiled-coil 2 1.524
MED12 mediator complex subunit 12 1.516
FAM204A family with sequence similarity 204, member A 1.513
PGLS 6-phosphogluconolactonase 1.512
WDR83 WD repeat domain 83 1.512
PLK4 polo-like kinase 4 1.51
PPAN-P2RY11 PPAN-P2RY11 readthrough 1.509
AVEN apoptosis, caspase activation inhibitor 1.506
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 1.506
CAPRIN2 caprin family member 2 1.506
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 1.506
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 1.506
SMAD7 SMAD family member 7 1.503
NIN ninein (GSK3B interacting protein) 1.502
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 1.495
ZNF274 zinc finger protein 274 1.495
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1.495
ZNF296 zinc finger protein 296 1.495
DIS3L DIS3 like exosome 3'-5' exoribonuclease 1.491
ANKRD45 ankyrin repeat domain 45 1.49
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.49
COBL cordon-bleu WH2 repeat protein 1.486
ISM2 isthmin 2 1.486
NFE2L2 nuclear factor, erythroid 2-like 2 1.486
TSEN2 TSEN2 tRNA splicing endonuclease subunit 1.486
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 1.486
PDE8B phosphodiesterase 8B 1.486
DCTN2 dynactin 2 (p50) 1.486
ZNF519 zinc finger protein 519 1.486
CHMP1A charged multivesicular body protein 1A 1.486
CIART circadian associated repressor of transcription 1.486
SLAIN2 SLAIN motif family, member 2 1.486
SOGA3 SOGA family member 3 1.486
BORCS6 BLOC-1 related complex subunit 6 1.485
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 1.484
ALMS1 Alstrom syndrome protein 1 1.484
LRRC7 leucine rich repeat containing 7 1.484
IFT81 intraflagellar transport 81 1.483
AKAP7 A kinase (PRKA) anchor protein 7 1.483
MDM1 Mdm1 nuclear protein homolog (mouse) 1.482
DPF2 D4, zinc and double PHD fingers family 2 1.48
THAP6 THAP domain containing 6 1.48
TYSND1 trypsin domain containing 1 1.48
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 1.471
AURKA aurora kinase A 1.471
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 1.471
HAUS7 HAUS augmin-like complex, subunit 7 1.471
DZIP1 DAZ interacting zinc finger protein 1 1.471
EYA4 EYA transcriptional coactivator and phosphatase 4 1.471
APOL6 apolipoprotein L, 6 1.469
SORBS1 sorbin and SH3 domain containing 1 1.464
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.46
BCAR3 breast cancer anti-estrogen resistance 3 1.459
INPP5F inositol polyphosphate-5-phosphatase F 1.459
CEP152 centrosomal protein 152kDa 1.459
KIF19 kinesin family member 19 1.459
UBR4 ubiquitin protein ligase E3 component n-recognin 4 1.459
TECPR2 tectonin beta-propeller repeat containing 2 1.459
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 1.459
VANGL1 VANGL planar cell polarity protein 1 1.454
MEAF6 MYST/Esa1-associated factor 6 1.452
ARHGAP40 Rho GTPase activating protein 40 1.449
EYA2 EYA transcriptional coactivator and phosphatase 2 1.441
SNAP91 synaptosomal-associated protein, 91kDa 1.441
ENGASE endo-beta-N-acetylglucosaminidase 1.441
DHRS1 dehydrogenase/reductase (SDR family) member 1 1.441
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 1.441
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.441
NUP107 nucleoporin 107kDa 1.441
ZFAND1 zinc finger, AN1-type domain 1 1.441
FRMD4B FERM domain containing 4B 1.441
CNTRL centriolin 1.441
TAPT1 transmembrane anterior posterior transformation 1 1.441
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.441
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.441
ZNF14 zinc finger protein 14 1.441
CPE carboxypeptidase E 1.441
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 1.441
CEP192 centrosomal protein 192kDa 1.441
RPL32 ribosomal protein L32 1.441
CSPP1 centrosome and spindle pole associated protein 1 1.441
TCEA2 transcription elongation factor A (SII), 2 1.441
KLHL35 kelch-like family member 35 1.44
ZNF366 zinc finger protein 366 1.44
MAF1 MAF1 homolog (S. cerevisiae) 1.436
PACRGL PARK2 co-regulated-like 1.435
MCM3 minichromosome maintenance complex component 3 1.431
CARD16 caspase recruitment domain family, member 16 1.428
RAB6A RAB6A, member RAS oncogene family 1.428
TXLNA taxilin alpha 1.428
MPHOSPH9 M-phase phosphoprotein 9 1.428
CPA4 carboxypeptidase A4 1.428
ELL2 elongation factor, RNA polymerase II, 2 1.427
GNB5 guanine nucleotide binding protein (G protein), beta 5 1.423
GP1BA glycoprotein Ib (platelet), alpha polypeptide 1.423
HSPA4L heat shock 70kDa protein 4-like 1.423
TSPYL2 TSPY-like 2 1.418
TTC21A tetratricopeptide repeat domain 21A 1.418
SNAP29 synaptosomal-associated protein, 29kDa 1.418
TGIF2 TGFB-induced factor homeobox 2 1.418
AATF apoptosis antagonizing transcription factor 1.416
CSK c-src tyrosine kinase 1.415
TOPBP1 topoisomerase (DNA) II binding protein 1 1.415
PLPPR5 phospholipid phosphatase related 5 1.411
NDRG2 NDRG family member 2 1.411
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 1.411
FAM117B family with sequence similarity 117, member B 1.411
ADCK2 aarF domain containing kinase 2 1.411
HIPK1 homeodomain interacting protein kinase 1 1.411
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 1.411
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 1.411
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 1.407
SH3RF3 SH3 domain containing ring finger 3 1.404
PKN2 protein kinase N2 1.401
OSGEP O-sialoglycoprotein endopeptidase 1.395
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 1.395
SYNJ1 synaptojanin 1 1.395
NECTIN3 nectin cell adhesion molecule 3 1.395
DVL3 dishevelled segment polarity protein 3 1.395
GNPAT glyceronephosphate O-acyltransferase 1.395
NIT2 nitrilase family, member 2 1.395
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 1.395
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 1.395
TUB tubby bipartite transcription factor 1.395
PEAR1 platelet endothelial aggregation receptor 1 1.395
TUBGCP5 tubulin, gamma complex associated protein 5 1.386
TRDMT1 tRNA aspartic acid methyltransferase 1 1.386
USP37 ubiquitin specific peptidase 37 1.386
NEFH neurofilament, heavy polypeptide 1.386
PDE12 phosphodiesterase 12 1.386
AXIN2 axin 2 1.383
CYB5D2 cytochrome b5 domain containing 2 1.38
AAAS achalasia, adrenocortical insufficiency, alacrimia 1.38
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 1.38
DCAF13 DDB1 and CUL4 associated factor 13 1.376
BUD31 BUD31 homolog (S. cerevisiae) 1.376
FAM111B family with sequence similarity 111, member B 1.376
ABI3BP ABI family, member 3 (NESH) binding protein 1.376
HAUS2 HAUS augmin-like complex, subunit 2 1.373