Cepharanthine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.181281
CALR calreticulin 0.162641
COL5A1 collagen, type V, alpha 1 0.122177
TRIO trio Rho guanine nucleotide exchange factor 0.113
FLNA filamin A, alpha 0.0905017
MYH9 myosin, heavy chain 9, non-muscle 0.079719
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0710747
FLNB filamin B, beta 0.0702635
TMSB4X thymosin beta 4, X-linked 0.0699264
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0690186
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0684199
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0681744
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0649475
BHLHE40 basic helix-loop-helix family, member e40 0.0643636
ANKRD11 ankyrin repeat domain 11 0.0617707
APP amyloid beta (A4) precursor protein 0.0614495
MT2A metallothionein 2A 0.0607099
THBS2 thrombospondin 2 0.0601684
FTH1 ferritin, heavy polypeptide 1 0.0598962
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0597412
CD44 CD44 molecule (Indian blood group) 0.0567351
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0548866
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0531091
NFE2L1 nuclear factor, erythroid 2-like 1 0.0529044
EEF2 eukaryotic translation elongation factor 2 0.0504079
PLEC plectin 0.0493454
MPRIP myosin phosphatase Rho interacting protein 0.0492661
HLA-B major histocompatibility complex, class I, B 0.0480091
C1D C1D nuclear receptor corepressor 0.0476097
AHNAK AHNAK nucleoprotein 0.0468697
AHNAK2 AHNAK nucleoprotein 2 0.0462429
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0456227
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0450306
NAV1 neuron navigator 1 0.0442403
SEPTIN9 septin 9 0.0417447
FSTL1 follistatin-like 1 0.0413717
LOXL2 lysyl oxidase-like 2 0.0405412
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.040344
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0403192
ADM adrenomedullin 0.039749
HDAC9 histone deacetylase 9 0.0396107
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0395991
SMAD3 SMAD family member 3 0.037076
CDH13 cadherin 13 0.0369404
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0369152
PTMA prothymosin, alpha 0.0363963
TPM3 tropomyosin 3 0.0362834
BCL2L1 BCL2-like 1 0.0348623
NAV2 neuron navigator 2 0.0346489
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0337068
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0325005
RRM2 ribonucleotide reductase M2 0.031909
EIF4H eukaryotic translation initiation factor 4H 0.0317025
JUN jun proto-oncogene 0.0308383
ZMIZ1 zinc finger, MIZ-type containing 1 0.030244
ANXA2 annexin A2 0.0302137
HLA-C major histocompatibility complex, class I, C 0.0297389
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0294609
MYOF myoferlin 0.0293475
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0292327
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.029186
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0291231
FAM107B family with sequence similarity 107, member B 0.0289453
MACF1 microtubule-actin crosslinking factor 1 0.0282157
DOCK5 dedicator of cytokinesis 5 0.0277785
TGFB1 transforming growth factor, beta 1 0.0269332
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0266576
ACTG1 actin gamma 1 0.0264857
RNF213 ring finger protein 213 0.0264636
SRRM2 serine/arginine repetitive matrix 2 0.0264395
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0263688
L1CAM L1 cell adhesion molecule 0.025569
COL4A2 collagen, type IV, alpha 2 0.0255454
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0254126
RND3 Rho family GTPase 3 0.025287
EIF3A eukaryotic translation initiation factor 3, subunit A 0.025152
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0251387
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0249359
ASPH aspartate beta-hydroxylase 0.0249256
EZR ezrin 0.0249017
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0248874
ANKRD36 ankyrin repeat domain 36 0.0246348
RHOBTB3 Rho-related BTB domain containing 3 0.0245383
RPN1 ribophorin I 0.0245235
SFXN3 sideroflexin 3 0.024453
NCOR2 nuclear receptor corepressor 2 0.0244484
VEGFA vascular endothelial growth factor A 0.0242441
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.024234
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0242321
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0240412
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0239747
CSNK1A1 casein kinase 1, alpha 1 0.0239729
PRELID2 PRELI domain containing 2 0.0238674
DDIT4 DNA-damage-inducible transcript 4 0.0238232
EHBP1L1 EH domain binding protein 1-like 1 0.0237935
DBN1 drebrin 1 0.0236288
HELZ helicase with zinc finger 0.0234563
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0234061
ANXA5 annexin A5 0.022982
MSN moesin 0.0229577

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.253158
IGFBP3 insulin-like growth factor binding protein 3 -0.201329
COL8A1 collagen, type VIII, alpha 1 -0.129599
FBN1 fibrillin 1 -0.108487
LOX lysyl oxidase -0.103535
ZBTB20 zinc finger and BTB domain containing 20 -0.0908184
COL1A2 collagen, type I, alpha 2 -0.0811212
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0784224
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0711647
SUCNR1 succinate receptor 1 -0.0709924
MYADM myeloid-associated differentiation marker -0.0658099
S100A6 S100 calcium binding protein A6 -0.0635238
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0621805
DLG1 discs, large homolog 1 (Drosophila) -0.0621324
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0614599
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0591736
COL5A2 collagen, type V, alpha 2 -0.0583959
SOD2 superoxide dismutase 2, mitochondrial -0.0578019
TAGLN2 transgelin 2 -0.054658
TMSB10 thymosin beta 10 -0.0532264
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0478737
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0470404
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0458634
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0443149
MRPS6 mitochondrial ribosomal protein S6 -0.0439418
MX2 MX dynamin-like GTPase 2 -0.0425563
ABI3BP ABI family, member 3 (NESH) binding protein -0.0410328
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0405367
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0403979
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0403903
UBC ubiquitin C -0.039941
CSTB cystatin B (stefin B) -0.039668
FRMD5 FERM domain containing 5 -0.0393283
POTEF POTE ankyrin domain family, member F -0.0393009
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0387603
AKAP12 A kinase (PRKA) anchor protein 12 -0.0379292
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0379069
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0377111
ARL15 ADP-ribosylation factor-like 15 -0.0375469
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0371861
SAMD9 sterile alpha motif domain containing 9 -0.0370422
PFN1 profilin 1 -0.0362238
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0360711
MEIS2 Meis homeobox 2 -0.0343435
AUTS2 autism susceptibility candidate 2 -0.0325958
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0324779
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0317781
CD99 CD99 molecule -0.0308959
S100A4 S100 calcium binding protein A4 -0.0308155
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0305921
SBF2 SET binding factor 2 -0.030304
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0301312
JAZF1 JAZF zinc finger 1 -0.0298017
STC1 stanniocalcin 1 -0.0293542
INSIG1 insulin induced gene 1 -0.0292871
ARL4C ADP-ribosylation factor-like 4C -0.0283239
TAPBP TAP binding protein (tapasin) -0.0275493
HSPB1 heat shock 27kDa protein 1 -0.0274478
KIFAP3 kinesin-associated protein 3 -0.0270418
IFITM1 interferon induced transmembrane protein 1 -0.0262461
SEC31A SEC31 homolog A (S. cerevisiae) -0.0253764
EHBP1 EH domain binding protein 1 -0.0253069
MMP12 matrix metallopeptidase 12 -0.0251229
CCND1 cyclin D1 -0.0246105
PDE4D phosphodiesterase 4D, cAMP-specific -0.024167
MAP4 microtubule-associated protein 4 -0.0237371
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0237141
FRMD4A FERM domain containing 4A -0.0236386
FNDC3B fibronectin type III domain containing 3B -0.0234289
HLA-E major histocompatibility complex, class I, E -0.0227043
PDIA6 protein disulfide isomerase family A, member 6 -0.0226817
FNDC3A fibronectin type III domain containing 3A -0.022652
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0225342
DPYSL3 dihydropyrimidinase-like 3 -0.0221735
CHD9 chromodomain helicase DNA binding protein 9 -0.0221076
SORBS2 sorbin and SH3 domain containing 2 -0.0220299
FAM114A1 family with sequence similarity 114, member A1 -0.021861
BSG basigin (Ok blood group) -0.0214698
PSD3 pleckstrin and Sec7 domain containing 3 -0.0214626
NAP1L1 nucleosome assembly protein 1-like 1 -0.0213213
PDIA3 protein disulfide isomerase family A, member 3 -0.0212666
NBEAL1 neurobeachin-like 1 -0.0212083
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0212063
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0210879
LMAN1 lectin, mannose-binding, 1 -0.0209975
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0205013
SYT1 synaptotagmin I -0.0203875
IFIH1 interferon induced with helicase C domain 1 -0.0202254
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0199127
TPM1 tropomyosin 1 (alpha) -0.0197533
IFITM3 interferon induced transmembrane protein 3 -0.0195937
NRP1 neuropilin 1 -0.0195659
FTL ferritin, light polypeptide -0.0195375
TNS3 tensin 3 -0.0194383
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0194019
ZNF207 zinc finger protein 207 -0.0193453
COL3A1 collagen, type III, alpha 1 -0.0193164
ADAR adenosine deaminase, RNA-specific -0.0192358
PRRX1 paired related homeobox 1 -0.019137
BIRC6 baculoviral IAP repeat containing 6 -0.0191169