Cepharanthine_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.152131
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.142979
CCN2 cellular communication network factor 2 0.0961165
TMEM41B transmembrane protein 41B 0.0835004
NLGN1 neuroligin 1 0.0804666
YBX3 Y box binding protein 3 0.0726968
CALR calreticulin 0.0665557
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0640193
EEF2 eukaryotic translation elongation factor 2 0.0635803
RTN4 reticulon 4 0.0628175
FTH1 ferritin, heavy polypeptide 1 0.0624539
MKI67 marker of proliferation Ki-67 0.060245
ACTG1 actin gamma 1 0.0597575
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0552565
HSPA8 heat shock 70kDa protein 8 0.0546093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0514316
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0495767
MAP1B microtubule-associated protein 1B 0.0487069
EIF4B eukaryotic translation initiation factor 4B 0.048274
NCAPD2 non-SMC condensin I complex, subunit D2 0.0477529
CCNL1 cyclin L1 0.0462911
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0442487
RPL3 ribosomal protein L3 0.0424629
SRRM2 serine/arginine repetitive matrix 2 0.0421467
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0408399
AKAP12 A kinase (PRKA) anchor protein 12 0.0380678
MARCHF4 membrane associated ring-CH-type finger 4 0.036497
EHBP1L1 EH domain binding protein 1-like 1 0.0357266
RRM2 ribonucleotide reductase M2 0.0342954
TPM3 tropomyosin 3 0.0336823
ANKRD11 ankyrin repeat domain 11 0.0332365
EZR ezrin 0.032899
YBX1 Y box binding protein 1 0.0325067
FUS FUS RNA binding protein 0.0308331
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.030201
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0293194
MAGEA4 melanoma antigen family A4 0.0285725
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0282549
FADS2 fatty acid desaturase 2 0.0281048
ERBIN erbb2 interacting protein 0.0274126
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0267859
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0264368
POTEF POTE ankyrin domain family, member F 0.0261647
MYH9 myosin, heavy chain 9, non-muscle 0.0260966
EDARADD EDAR-associated death domain 0.0257855
SMC4 structural maintenance of chromosomes 4 0.0257591
ANKRD12 ankyrin repeat domain 12 0.0256299
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0255828
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0255639
FDPS farnesyl diphosphate synthase 0.0252992
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.025226
RNF213 ring finger protein 213 0.0251674
FLNA filamin A, alpha 0.0251374
FTL ferritin, light polypeptide 0.0248515
GARS1 glycyl-tRNA synthetase 1 0.0246897
NCOR2 nuclear receptor corepressor 2 0.0245249
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0244401
EGR1 early growth response 1 0.02394
KIF18B kinesin family member 18B 0.0237454
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0233772
RACGAP1 Rac GTPase activating protein 1 0.0231101
TPI1 triosephosphate isomerase 1 0.0230916
NFE2L1 nuclear factor, erythroid 2-like 1 0.0229794
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0229472
KMT2D lysine (K)-specific methyltransferase 2D 0.0228421
MCL1 myeloid cell leukemia 1 0.0227441
FAT1 FAT atypical cadherin 1 0.0226995
ATP11A ATPase, class VI, type 11A 0.0226046
RBMX RNA binding motif protein, X-linked 0.0225473
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0225001
EEF1G eukaryotic translation elongation factor 1 gamma 0.0224017
ANKRD36 ankyrin repeat domain 36 0.0223902
SMC1A structural maintenance of chromosomes 1A 0.022115
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0219079
SFTPA2 surfactant protein A2 0.0217639
STMN1 stathmin 1 0.0215299
FASN fatty acid synthase 0.0214726
NPC1 Niemann-Pick disease, type C1 0.0212216
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0211914
NUMA1 nuclear mitotic apparatus protein 1 0.0211367
KIF1A kinesin family member 1A 0.0211313
GJA1 gap junction protein, alpha 1, 43kDa 0.0211266
TUBB6 tubulin, beta 6 class V 0.0211197
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0211069
CEP250 centrosomal protein 250kDa 0.0208133
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206752
TJP1 tight junction protein 1 0.0203228
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0201872
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0200472
SPIRE1 spire-type actin nucleation factor 1 0.0200377
RPN1 ribophorin I 0.019972
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0199039
BRD2 bromodomain containing 2 0.0198148
YEATS2 YEATS domain containing 2 0.0197059
AAK1 AP2 associated kinase 1 0.0196998
GOLT1A golgi transport 1A 0.0195561
RPS19 ribosomal protein S19 0.0194695
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0194481
EIF5 eukaryotic translation initiation factor 5 0.0192771
DBN1 drebrin 1 0.0192546

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.146808
EHBP1 EH domain binding protein 1 -0.11782
HMGA2 high mobility group AT-hook 2 -0.111433
VIM vimentin -0.0981239
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0960947
PDE4D phosphodiesterase 4D, cAMP-specific -0.0897834
RPS27A ribosomal protein S27a -0.084449
MGAT4C MGAT4 family, member C -0.0832474
TAS2R14 taste receptor, type 2, member 14 -0.0824211
ZNF804A zinc finger protein 804A -0.0673804
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0665568
NAP1L1 nucleosome assembly protein 1-like 1 -0.0658096
ASPH aspartate beta-hydroxylase -0.0654437
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.061083
PCDH7 protocadherin 7 -0.0578472
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0559762
NHSL1 NHS-like 1 -0.0557829
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0542177
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0509202
ZBTB20 zinc finger and BTB domain containing 20 -0.0494078
CLDN1 claudin 1 -0.049387
CXADR coxsackie virus and adenovirus receptor -0.0490548
IFIH1 interferon induced with helicase C domain 1 -0.0488297
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0484126
CANX calnexin -0.0475262
UBC ubiquitin C -0.0463996
SPDYA speedy/RINGO cell cycle regulator family member A -0.0453465
MMP12 matrix metallopeptidase 12 -0.0448685
BIRC6 baculoviral IAP repeat containing 6 -0.044015
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0439337
SYT1 synaptotagmin I -0.0434181
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0431745
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0423067
RPS24 ribosomal protein S24 -0.0408405
ADGRG6 adhesion G protein-coupled receptor G6 -0.0400546
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0374387
NF1 neurofibromin 1 -0.0370957
RAB10 RAB10, member RAS oncogene family -0.0367791
MTAP methylthioadenosine phosphorylase -0.0358729
DPYD dihydropyrimidine dehydrogenase -0.035039
AHNAK AHNAK nucleoprotein -0.0349469
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0348643
CDK6 cyclin-dependent kinase 6 -0.0342476
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0342163
S100A6 S100 calcium binding protein A6 -0.0341613
DTNA dystrobrevin, alpha -0.0339136
LRPPRC leucine-rich pentatricopeptide repeat containing -0.033528
INTS6 integrator complex subunit 6 -0.0333832
MBD5 methyl-CpG binding domain protein 5 -0.0333554
ELP4 elongator acetyltransferase complex subunit 4 -0.0328132
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0327695
PCNP PEST proteolytic signal containing nuclear protein -0.0323855
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0321697
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0317231
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.031462
USP34 ubiquitin specific peptidase 34 -0.0309745
LRRC23 leucine rich repeat containing 23 -0.0309561
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.029555
RPL34 ribosomal protein L34 -0.0293315
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0287051
CAMKMT calmodulin-lysine N-methyltransferase -0.0286908
RPS12 ribosomal protein S12 -0.0285681
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0282289
HDAC9 histone deacetylase 9 -0.0277737
RPS8 ribosomal protein S8 -0.0274886
ARB2A ARB2 cotranscriptional regulator A -0.0268764
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0268741
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0267021
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.026609
MARCHF6 membrane associated ring-CH-type finger 6 -0.0265973
ARHGAP12 Rho GTPase activating protein 12 -0.0265674
RTN3 reticulon 3 -0.0263665
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0260927
RPLP0 ribosomal protein, large, P0 -0.0259496
BCHE butyrylcholinesterase -0.0258172
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0257287
FBXO11 F-box protein 11 -0.0254076
EPHA5 EPH receptor A5 -0.0253317
SNX14 sorting nexin 14 -0.0252788
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0252291
ENO1 enolase 1, (alpha) -0.0252211
LARS1 leucyl-tRNA synthetase 1 -0.0251482
SBF2 SET binding factor 2 -0.0246798
RYK receptor-like tyrosine kinase -0.0246375
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0244136
HSPA4 heat shock 70kDa protein 4 -0.0244116
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0243805
MSRB3 methionine sulfoxide reductase B3 -0.0243597
BIRC3 baculoviral IAP repeat containing 3 -0.0238332
RPS16 ribosomal protein S16 -0.0233535
FXR1 fragile X mental retardation, autosomal homolog 1 -0.023267
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0232513
VCL vinculin -0.0231073
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0230997
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0230525
PHF3 PHD finger protein 3 -0.0229371
RPL27A ribosomal protein L27a -0.0226183
CSMD3 CUB and Sushi multiple domains 3 -0.0224968
TMEM123 transmembrane protein 123 -0.0224258
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0223679