Cepharanthine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cepharanthine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cepharanthine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.175283
ACTG1 actin gamma 1 0.106142
AKAP12 A kinase (PRKA) anchor protein 12 0.0955934
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0893452
RNF213 ring finger protein 213 0.0871744
EEF2 eukaryotic translation elongation factor 2 0.0841102
TRIO trio Rho guanine nucleotide exchange factor 0.0812179
FMN1 formin 1 0.0731137
IGF2 insulin-like growth factor 2 0.0709844
PLAT plasminogen activator, tissue 0.063609
TPST1 tyrosylprotein sulfotransferase 1 0.0618285
TLE4 transducin-like enhancer of split 4 0.0577023
TBX2 T-box 2 0.0523403
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0491101
RPL7A ribosomal protein L7a 0.0470495
THBS1 thrombospondin 1 0.0451903
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0448028
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0441737
AOPEP aminopeptidase O (putative) 0.0441
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0417054
RPL23 ribosomal protein L23 0.0407432
EXT1 exostosin glycosyltransferase 1 0.0404207
MYH9 myosin, heavy chain 9, non-muscle 0.0398446
CRH corticotropin releasing hormone 0.039772
AMOTL1 angiomotin like 1 0.0393931
CEMIP cell migration inducing protein, hyaluronan binding 0.0391756
ANTXR1 anthrax toxin receptor 1 0.0391252
RIGI RNA sensor RIG-I 0.0390285
CTSB cathepsin B 0.0387212
B2M beta-2-microglobulin 0.0385703
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0381302
NFE2L1 nuclear factor, erythroid 2-like 1 0.0379764
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.037946
MEIS2 Meis homeobox 2 0.0378854
PRRC2B proline-rich coiled-coil 2B 0.0376779
NALF1 NALCN channel auxiliary factor 1 0.0370503
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0365757
GLCCI1 glucocorticoid induced 1 0.0365347
PTPRE protein tyrosine phosphatase, receptor type, E 0.0363549
SRRM2 serine/arginine repetitive matrix 2 0.0350286
PLPP1 phospholipid phosphatase 1 0.0344027
KLHL13 kelch-like family member 13 0.034378
SIK2 salt-inducible kinase 2 0.0318799
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0318505
SEPTIN9 septin 9 0.0318465
COL4A2 collagen, type IV, alpha 2 0.0315853
RPL19 ribosomal protein L19 0.0315069
SMAD3 SMAD family member 3 0.0312095
TPR translocated promoter region, nuclear basket protein 0.0310806
EIF1 eukaryotic translation initiation factor 1 0.0309398
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0308265
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.030601
RPL35A ribosomal protein L35a 0.030094
DNMBP dynamin binding protein 0.0300804
PRRC2C proline-rich coiled-coil 2C 0.0300631
PDE10A phosphodiesterase 10A 0.0297761
THSD4 thrombospondin, type I, domain containing 4 0.0291557
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0289937
BPTF bromodomain PHD finger transcription factor 0.0287584
AUTS2 autism susceptibility candidate 2 0.0284527
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0281772
IFI16 interferon, gamma-inducible protein 16 0.0278263
PTEN phosphatase and tensin homolog 0.0275059
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0274229
PRKCA protein kinase C, alpha 0.0272571
USP36 ubiquitin specific peptidase 36 0.0268007
HSPA8 heat shock 70kDa protein 8 0.0267908
RPS6 ribosomal protein S6 0.0267304
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0264009
APP amyloid beta (A4) precursor protein 0.0261448
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0259915
RPL12 ribosomal protein L12 0.0259136
VEGFA vascular endothelial growth factor A 0.0254681
NES nestin 0.0254542
TGFB1 transforming growth factor, beta 1 0.0254037
PTMA prothymosin, alpha 0.0253545
GATA3 GATA binding protein 3 0.0253312
NPAS2 neuronal PAS domain protein 2 0.0252366
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0251018
FTH1 ferritin, heavy polypeptide 1 0.024778
RPL3 ribosomal protein L3 0.0247144
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0245909
CALR calreticulin 0.0245352
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0245078
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0239746
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0239637
RPL4 ribosomal protein L4 0.0238468
EEF1G eukaryotic translation elongation factor 1 gamma 0.0237853
TIMP3 TIMP metallopeptidase inhibitor 3 0.0237404
BCAS3 breast carcinoma amplified sequence 3 0.023579
RGS4 regulator of G-protein signaling 4 0.0233057
SETBP1 SET binding protein 1 0.0232438
TRIB2 tribbles pseudokinase 2 0.0227812
ARHGAP9 Rho GTPase activating protein 9 0.0227166
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0226609
RPS3 ribosomal protein S3 0.0223906
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0222924
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0222311
RPL38 ribosomal protein L38 0.0222227
SFTPA2 surfactant protein A2 0.0220997

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0744015
NRG1 neuregulin 1 -0.0676978
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0512028
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.036219
SEC31A SEC31 homolog A (S. cerevisiae) -0.0350314
MAML2 mastermind-like 2 (Drosophila) -0.0348274
HELZ helicase with zinc finger -0.0327268
SOS1 son of sevenless homolog 1 (Drosophila) -0.0320794
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0282421
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0272603
GOLGA4 golgin A4 -0.0268078
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0263465
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.025695
DTNA dystrobrevin, alpha -0.0250017
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0245569
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0238399
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0234844
GDF15 growth differentiation factor 15 -0.0230541
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.023028
P4HB prolyl 4-hydroxylase, beta polypeptide -0.022957
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0222293
PIBF1 progesterone immunomodulatory binding factor 1 -0.0219454
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0212598
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0204653
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0198513
SEC24D SEC24 family member D -0.0193287
ZNF804A zinc finger protein 804A -0.0192942
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0189724
ADGRG6 adhesion G protein-coupled receptor G6 -0.0188016
BRWD1 bromodomain and WD repeat domain containing 1 -0.0187257
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0182664
KMT2C lysine (K)-specific methyltransferase 2C -0.0182482
LCORL ligand dependent nuclear receptor corepressor-like -0.0179386
BMPR1A bone morphogenetic protein receptor, type IA -0.0179157
RNF150 ring finger protein 150 -0.0179026
HMGA2 high mobility group AT-hook 2 -0.0178586
ANK2 ankyrin 2, neuronal -0.0178434
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0177752
COPS2 COP9 signalosome subunit 2 -0.0176938
TM9SF3 transmembrane 9 superfamily member 3 -0.0176636
SRP54 signal recognition particle 54kDa -0.0172042
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0168963
ARF1 ADP-ribosylation factor 1 -0.0168396
MORF4L2 mortality factor 4 like 2 -0.016705
KCNIP4 Kv channel interacting protein 4 -0.0166993
LMAN1 lectin, mannose-binding, 1 -0.0166855
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0159454
XPO1 exportin 1 -0.01587
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0158512
IARS1 isoleucyl-tRNA synthetase 1 -0.0158397
TRA2A transformer 2 alpha homolog (Drosophila) -0.0157464
CSMD3 CUB and Sushi multiple domains 3 -0.0156619
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0156007
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0155833
TOB1 transducer of ERBB2, 1 -0.0155618
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.015426
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0154234
RNF145 ring finger protein 145 -0.0150922
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0150443
PRTG protogenin -0.0149593
ZMAT3 zinc finger, matrin-type 3 -0.0148636
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0147888
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0144413
CD36 CD36 molecule (thrombospondin receptor) -0.0143571
KIAA1217 KIAA1217 -0.0142758
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0142518
GPR75-ASB3 GPR75-ASB3 readthrough -0.0142083
SEC63 SEC63 homolog (S. cerevisiae) -0.0141647
CDK8 cyclin-dependent kinase 8 -0.0141426
COL4A6 collagen, type IV, alpha 6 -0.0140353
MARCHF6 membrane associated ring-CH-type finger 6 -0.0139964
PCDH9 protocadherin 9 -0.0137474
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0137335
WDR49 WD repeat domain 49 -0.0136927
TOR1AIP2 torsin A interacting protein 2 -0.0135104
SMAD5 SMAD family member 5 -0.0133658
CDC27 cell division cycle 27 -0.0133475
KMT2E lysine (K)-specific methyltransferase 2E -0.0132822
TMEM123 transmembrane protein 123 -0.0132495
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0131972
WDR45B WD repeat domain 45B -0.0131632
TFRC transferrin receptor -0.0131066
PCNP PEST proteolytic signal containing nuclear protein -0.0130516
SEC24A SEC24 family member A -0.0130001
USP34 ubiquitin specific peptidase 34 -0.0129764
OGA O-GlcNAcase -0.0128927
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.0128479
TTC3 tetratricopeptide repeat domain 3 -0.0128275
CSNK1G1 casein kinase 1, gamma 1 -0.0128145
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0128085
FNDC3B fibronectin type III domain containing 3B -0.0128042
RTN3 reticulon 3 -0.0127589
SCFD1 sec1 family domain containing 1 -0.0127358
DPY19L3 dpy-19-like 3 (C. elegans) -0.0126809
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0126576
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0126285
GOLPH3L golgi phosphoprotein 3-like -0.0124793
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0123919
IKBIP IKBKB interacting protein -0.0123438
VDAC1 voltage-dependent anion channel 1 -0.0123245